Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMQLT4N)

Drug Name
Brimonidine Drug Info
Synonyms
brimonidine; 59803-98-4; Bromoxidine; UK 14,304; 5-Bromo-N-(4,5-dihydro-1H-imidazol-2-yl)-6-quinoxalinamine; 5-Bromo-6-(2-imidazolin-2-ylamino)quinoxaline; UK-14304; AGN 190342; UNII-E6GNX3HHTE; Brimonidine [INN:BAN]; UK 14304; C11H10BrN5; MLS000069370; 6-Quinoxalinamine, 5-bromo-N-(4,5-dihydro-1H-imidazol-2-yl)-; E6GNX3HHTE; CHEMBL844; AGN-190342; BRN 0751629; SMR000058355; CHEBI:3175; LK 14304-18; Brimonidine, 98%; NCGC00016069-09; EN300-50880; DSSTox_RID_80758; Brimonidine (bioerodible, extended release); [3H]brimonidine
Cross-matching ID
PubChem CID
2435
ChEBI ID
CHEMBL844
CAS Number
CAS 59803-98-4
TTD Drug ID
D0AE3X

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Cell cycle 2.12 0.00e+0 110/124 (88.71%) CDC20;CHEK1;CCNA2;...
Oocyte meiosis 2.02 2.99e-3 90/129 (69.77%) CDC20;CCNB1;AURKA;...
DNA replication 2.02 1.99e-3 34/36 (94.44%) MCM7;MCM5;MCM2;...
Progesterone-mediated oocyte maturation 1.81 8.96e-3 75/100 (75%) CCNA2;CCNB1;PIK3CD;...
Synthesis and degradation of ketone bodies 1.81 7.17e-3 9/10 (90%) HMGCS1;HMGCS2;ACAT1;...
Fanconi anemia pathway 1.73 2.49e-2 36/54 (66.67%) FANCI;HES1;RAD51;...
Tyrosine metabolism 1.68 3.84e-2 30/36 (83.33%) MAOB;HGD;AOX1;...
PPAR signaling pathway -1.80 4.80e-2 66/74 (89.19%) ACOX2;ILK;ACSL4;...
Legionellosis -1.87 3.29e-2 51/57 (89.47%) IL18;NFKB2;HSPD1;...
Arginine and proline metabolism -2.01 0.00e+0 39/50 (78%) CKB;OAT;ALDH3A2;...
Mineral absorption -2.37 0.00e+0 48/60 (80%) SLC5A1;STEAP1;SLC31A1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H