Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMQWS6U)

Drug Name
KU-0060648 Drug Info
Synonyms KU 0060648
Cross-matching ID
PubChem CID
11964036
ChEBI ID
CHEMBL1086377
TTD Drug ID
D0R0TW

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Steroid biosynthesis 2.35 0.00e+0 19/20 (95%) MSMO1;TM7SF2;DHCR7;...
Lysosome 2.12 0.00e+0 115/128 (89.84%) NPC1;NEU1;FUCA1;...
Mitophagy 2.09 0.00e+0 56/68 (82.35%) BNIP3L;FOXO3;PINK1;...
Autophagy 2.06 0.00e+0 113/169 (66.86%) DAPK1;RRAGC;IRS2;...
Synaptic vesicle cycle 2.00 0.00e+0 63/78 (80.77%) STXBP1;ATP6V1G1;ATP6V1H;...
FoxO signaling pathway 1.97 2.27e-3 118/131 (90.08%) CCNG2;FOXO3;CDKN1B;...
AMPK signaling pathway 1.95 1.95e-3 106/120 (88.33%) SCD;FOXO3;EEF2;...
Cholesterol metabolism 1.81 1.19e-2 44/50 (88%) NPC1;ABCA1;NPC2;...
Endometrial cancer 1.80 1.36e-2 56/58 (96.55%) FOXO3;PDPK1;MAP2K2;...
Basal cell carcinoma 1.78 1.50e-2 41/63 (65.08%) FZD7;CDKN1A;PTCH1;...
mTOR signaling pathway 1.76 1.49e-2 114/154 (74.03%) RRAGC;LPIN1;INSR;...
Insulin signaling pathway 1.74 1.93e-2 121/137 (88.32%) INSR;IRS2;SREBF1;...
Cushing syndrome 1.72 3.15e-2 125/155 (80.65%) CDKN1B;MAP2K2;FZD7;...
Breast cancer 1.71 3.60e-2 119/147 (80.95%) NCOA3;FRAT2;FRAT1;...
Vibrio cholerae infection 1.71 3.36e-2 44/50 (88%) ATP6V1G1;ATP6V1H;ATP6V0D1;...
Oxidative phosphorylation 1.70 3.58e-2 93/133 (69.92%) ATP6V1G1;ATP6V1H;ATP6V0D1;...
Terpenoid backbone biosynthesis 1.69 3.61e-2 18/22 (81.82%) IDI1;HMGCS1;PCYOX1;...
B cell receptor signaling pathway 1.69 3.56e-2 71/81 (87.65%) NFKBIA;IFITM1;MAP2K2;...
Viral carcinogenesis 1.68 3.59e-2 149/203 (73.4%) CDKN1B;NFKBIA;JAK1;...
Other glycan degradation 1.68 3.48e-2 13/18 (72.22%) NEU1;FUCA1;MANBA;...
Proteoglycans in cancer 1.68 3.63e-2 172/205 (83.9%) FN1;PDPK1;MAP2K2;...
Gastric cancer 1.66 4.52e-2 122/149 (81.88%) CDKN1B;FRAT2;FRAT1;...
Inositol phosphate metabolism 1.65 4.39e-2 66/73 (90.41%) ALDH6A1;PIP5K1B;PIK3C3;...
Biosynthesis of unsaturated fatty acids 1.65 4.66e-2 21/27 (77.78%) SCD;TECR;FADS2;...
Glycerolipid metabolism 1.65 4.53e-2 44/61 (72.13%) LPIN1;PNPLA2;LPIN2;...
Type I diabetes mellitus -1.60 4.02e-2 38/43 (88.37%) LTA;PRF1;HLA-DRB1;...
Spliceosome -1.61 4.11e-2 101/150 (67.33%) ACIN1;DHX38;SNRPA;...
Inflammatory bowel disease -1.62 3.81e-2 58/65 (89.23%) IL12RB2;IL2;IL21R;...
Folate biosynthesis -1.63 3.69e-2 23/26 (88.46%) GGH;MOCS2;FPGS;...
Malaria -1.64 3.69e-2 44/50 (88%) CD40;THBS1;IFNG;...
DNA replication -1.66 3.18e-2 34/36 (94.44%) MCM2;DNA2;RNASEH2B;...
Pyrimidine metabolism -1.67 3.13e-2 40/56 (71.43%) DTYMK;CMPK1;ENTPD6;...
Graft-versus-host disease -1.67 3.20e-2 32/42 (76.19%) PRF1;HLA-DRB1;HLA-DQA1;...
Proteasome -1.75 1.64e-2 44/46 (95.65%) ADRM1;PSMD8;PSMC4;...
Cytokine-cytokine receptor interaction -1.80 1.23e-2 246/295 (83.39%) TNFSF12;TNFRSF25;TGFBR2;...
Hematopoietic cell lineage -1.80 1.32e-2 90/99 (90.91%) CD33;KITLG;IL11;...
Viral protein interaction with cytokine and cytokine re... -1.94 3.08e-3 84/100 (84%) CCR7;TNFRSF1A;CCL25;...
Asthma -1.95 3.69e-3 25/31 (80.65%) IL13;IL5;HLA-DOB;...
Staphylococcus aureus infection -2.00 3.08e-3 72/95 (75.79%) C1QB;DEFA5;FCGR2B;...
Systemic lupus erythematosus -2.14 0.00e+0 45/135 (33.33%) CD80;SSB;CD40LG;...
Intestinal immune network for IgA production -2.16 0.00e+0 38/48 (79.17%) MADCAM1;IL2;IL4;...
Ribosome biogenesis in eukaryotes -2.17 0.00e+0 52/108 (48.15%) BMS1;MDN1;NOP56;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-673 CVCL_0080 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.002uM - 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CL-34 CVCL_1123 Homo sapiens 10uM 6H
HT-29 CVCL_0320 Homo sapiens 10uM 6H, 24H
LoVo CVCL_0399 Homo sapiens 10uM 6H
MDST8 CVCL_1400 Homo sapiens 10uM 6H
SNU-1040 CVCL_5001 Homo sapiens 10uM 6H
SNU-C4 CVCL_5008 Homo sapiens 10uM 6H
SNU-C5 CVCL_5009 Homo sapiens 10uM 6H
SW480 CVCL_0546 Homo sapiens 10uM 6H
SW620 CVCL_0547 Homo sapiens 10uM 6H
SW948 CVCL_0550 Homo sapiens 10uM 6H
Colorectal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCT 116 CVCL_0291 Homo sapiens 10uM 6H
HT115 CVCL_1294 Homo sapiens 10uM 6H
RKO CVCL_0504 Homo sapiens 10uM 6H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 10uM 6H
SNG-M CVCL_1707 Homo sapiens 10uM 6H
Endometrial carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHUEM-2 CVCL_1327 Homo sapiens 10uM 6H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.002uM - 10uM 6H, 24H
DV-90 CVCL_1184 Homo sapiens 10uM 6H
SK-LU-1 CVCL_0624 Homo sapiens 10uM 6H
Lung adenosquamous carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H596 CVCL_1571 Homo sapiens 10uM 6H
Lung large cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COR-L23 CVCL_1133 Homo sapiens 10uM 6H
T3M-10 CVCL_1729 Homo sapiens 10uM 6H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC15 CVCL_1253 Homo sapiens 10uM 6H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1299 CVCL_0060 Homo sapiens 10uM 6H
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
NCI-H2073 CVCL_1523 Homo sapiens 10uM 6H
Small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1694 CVCL_1495 Homo sapiens 10uM 6H
NCI-H1836 CVCL_1502 Homo sapiens 10uM 6H
Lymph node
Diffuse large B-cell lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
WSU-DLCL2 CVCL_1787 Homo sapiens 10uM 6H
Ovary
Ovarian carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
EFO-27 CVCL_1194 Homo sapiens 10uM 6H
OV7 CVCL_1623 Homo sapiens 10uM 6H
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
RMG-I CVCL_1663 Homo sapiens 10uM 6H
Ovarian mucinous cystadenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COV644 CVCL_2011 Homo sapiens 10uM 6H
RMUG-S CVCL_1666 Homo sapiens 10uM 6H
Ovarian undifferentiated carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
TYK-nu CVCL_1774 Homo sapiens 10uM 6H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 10uM 6H
Acute myeloid leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NOMO-1 CVCL_1609 Homo sapiens 10uM 6H
PL-21 CVCL_2161 Homo sapiens 10uM 6H
SKM-1 CVCL_0010 Homo sapiens 10uM 6H
Pleural effusion
Histiocytic lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-937 CVCL_0007 Homo sapiens 10uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H, 24H
SK-MEL-1 CVCL_0523 Homo sapiens 10uM 6H
SK-MEL-28 CVCL_0526 Homo sapiens 10uM 6H
Stomach
Gastric adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
AGS CVCL_0139 Homo sapiens 10uM 6H