Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMRIMLJ)

Drug Name
BX-795 Drug Info
Synonyms BX795; BX 795
Cross-matching ID
PubChem CID
10077147
ChEBI ID
CHEMBL91439
CAS Number
CAS 702675-74-9
TTD Drug ID
D0RG0Z

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Viral protein interaction with cytokine and cytokine re... 2.59 0.00e+0 84/100 (84%) CXCL8;CCL20;CXCL6;...
TNF signaling pathway 2.54 0.00e+0 103/112 (91.96%) NFKBIA;CCL20;BIRC3;...
Cytokine-cytokine receptor interaction 2.52 0.00e+0 246/295 (83.39%) CXCL8;CCL20;IL32;...
Rheumatoid arthritis 2.36 0.00e+0 78/93 (83.87%) CXCL8;CCL20;CXCL6;...
NF-kappa B signaling pathway 2.26 0.00e+0 90/104 (86.54%) CXCL8;NFKBIA;BIRC3;...
IL-17 signaling pathway 2.18 0.00e+0 84/94 (89.36%) CXCL8;NFKBIA;CCL20;...
Chemokine signaling pathway 2.18 0.00e+0 163/192 (84.9%) CXCL8;NFKBIA;CCL20;...
Graft-versus-host disease 2.08 0.00e+0 32/42 (76.19%) IL6;FAS;IL1A;...
Cytosolic DNA-sensing pathway 2.02 2.83e-3 52/63 (82.54%) NFKBIA;CCL5;CXCL10;...
Herpes simplex virus 1 infection 1.97 3.82e-3 165/498 (33.13%) NFKBIA;BIRC3;CCL5;...
Epithelial cell signaling in Helicobacter pylori infect... 1.97 3.47e-3 62/70 (88.57%) CXCL8;NFKBIA;CCL5;...
Toll-like receptor signaling pathway 1.93 3.18e-3 94/104 (90.38%) CXCL8;NFKBIA;CCL5;...
Kaposi sarcoma-associated herpesvirus infection 1.92 3.91e-3 172/193 (89.12%) CXCL8;NFKBIA;CDKN1A;...
Staphylococcus aureus infection 1.92 3.63e-3 72/95 (75.79%) KRT17;CFB;DEFB1;...
Oxidative phosphorylation 1.91 3.39e-3 93/133 (69.92%) ATP6AP1;NDUFA1;COX6B1;...
Amoebiasis 1.90 3.18e-3 99/102 (97.06%) CXCL8;CXCL1;CXCL2;...
Ferroptosis 1.89 2.99e-3 36/41 (87.8%) SAT1;SLC39A8;FTH1;...
Pertussis 1.88 3.53e-3 64/76 (84.21%) CXCL8;CXCL6;CXCL5;...
NOD-like receptor signaling pathway 1.87 3.35e-3 145/181 (80.11%) CXCL8;NFKBIA;BIRC3;...
C-type lectin receptor signaling pathway 1.86 3.18e-3 93/104 (89.42%) NFKBIA;RELB;BCL3;...
Human cytomegalovirus infection 1.83 3.63e-3 201/225 (89.33%) CXCL8;NFKBIA;CDKN1A;...
Tryptophan metabolism 1.83 5.78e-3 35/42 (83.33%) CYP1B1;KYNU;ALDH2;...
Diabetic cardiomyopathy 1.82 6.64e-3 162/203 (79.8%) PDK4;MMP9;PIK3R1;...
Natural killer cell mediated cytotoxicity 1.81 6.36e-3 99/131 (75.57%) TNFRSF10B;ICAM1;TNFSF10;...
Other glycan degradation 1.81 6.11e-3 13/18 (72.22%) FUCA1;MAN2B1;HEXA;...
RIG-I-like receptor signaling pathway 1.81 5.87e-3 64/70 (91.43%) CXCL8;NFKBIA;CXCL10;...
Influenza A 1.80 8.48e-3 156/172 (90.7%) CXCL8;NFKBIA;TNFRSF10B;...
Sulfur metabolism 1.78 9.09e-3 9/10 (90%) SELENBP1;ETHE1;TST
Small cell lung cancer 1.77 9.65e-3 90/92 (97.83%) NFKBIA;BIRC3;CDKN1A;...
Malaria 1.74 1.19e-2 44/50 (88%) CXCL8;VCAM1;ICAM1;...
Oocyte meiosis -1.70 3.33e-2 90/129 (69.77%) RPS6KA3;MAPK13;PPP3R1;...
Protein processing in endoplasmic reticulum -1.75 2.38e-2 127/171 (74.27%) CAPN2;DNAJB2;EIF2S1;...
RNA transport -1.81 1.44e-2 128/186 (68.82%) EIF2B3;RPP40;EIF3B;...
Non-homologous end-joining -1.87 9.32e-3 11/13 (84.62%) POLM;MRE11;DCLRE1C;...
Fanconi anemia pathway -2.08 0.00e+0 36/54 (66.67%) FAN1;RAD51C;ERCC4;...
Cell cycle -2.23 0.00e+0 110/124 (88.71%) EP300;CREBBP;CDC25C;...
Spliceosome -2.26 0.00e+0 101/150 (67.33%) DHX38;THOC2;LSM5;...
DNA replication -2.27 0.00e+0 34/36 (94.44%) RPA3;DNA2;RFC4;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-673 CVCL_0080 Homo sapiens 10uM 6H
Bone marrow
Neuroblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SH-SY5Y CVCL_0019 Homo sapiens 0.04uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.04uM - 10uM 6H, 24H
Normal (Epithelial)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HME1 CVCL_2950 Homo sapiens 0.04uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.04uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.04uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CL-34 CVCL_1123 Homo sapiens 10uM 6H
HT-29 CVCL_0320 Homo sapiens 0.04uM - 10uM 6H, 24H
LoVo CVCL_0399 Homo sapiens 10uM 6H
MDST8 CVCL_1400 Homo sapiens 10uM 6H
NCI-H508 CVCL_1561 Homo sapiens 10uM 6H
SNU-1040 CVCL_5001 Homo sapiens 10uM 6H
SNU-C4 CVCL_5008 Homo sapiens 10uM 6H
SNU-C5 CVCL_5009 Homo sapiens 10uM 6H
SW480 CVCL_0546 Homo sapiens 10uM 6H
SW620 CVCL_0547 Homo sapiens 10uM 6H
SW948 CVCL_0550 Homo sapiens 10uM 6H
Colorectal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCT 116 CVCL_0291 Homo sapiens 10uM 6H
HT115 CVCL_1294 Homo sapiens 10uM 6H
RKO CVCL_0504 Homo sapiens 10uM 6H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 10uM 6H
SNG-M CVCL_1707 Homo sapiens 10uM 6H
Endometrial carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHUEM-2 CVCL_1327 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 0.04uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.04uM - 10uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
1HAEo- CVCL_0128 Homo sapiens 10uM 24H
HEK293 CVCL_0045 Homo sapiens 0.04uM - 10uM 24H
NL20 CVCL_0461 Homo sapiens 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.04uM - 10uM 6H, 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.04uM - 10uM 6H, 24H
A549/Asc-1 CVCL_YA87 Homo sapiens 0.04uM - 10uM 24H
DV-90 CVCL_1184 Homo sapiens 10uM 6H
SK-LU-1 CVCL_0624 Homo sapiens 10uM 6H
Lung adenosquamous carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H596 CVCL_1571 Homo sapiens 10uM 6H
Lung large cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COR-L23 CVCL_1133 Homo sapiens 10uM 6H
T3M-10 CVCL_1729 Homo sapiens 10uM 6H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC15 CVCL_1253 Homo sapiens 10uM 6H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1299 CVCL_0060 Homo sapiens 10uM 6H
HCC515 CVCL_5134 Homo sapiens 0.04uM - 10uM 6H, 24H
NCI-H2073 CVCL_1523 Homo sapiens 10uM 6H
Normal (Fibroblast)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HFL1 CVCL_4295 Homo sapiens 10uM 24H
IMR-90 CVCL_0347 Homo sapiens 10uM 24H
WI-38 CVCL_0579 Homo sapiens 10uM 24H
Small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1694 CVCL_1495 Homo sapiens 10uM 6H
NCI-H1836 CVCL_1502 Homo sapiens 10uM 6H
Lymph node
Diffuse large B-cell lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
WSU-DLCL2 CVCL_1787 Homo sapiens 10uM 6H
Ovary
Ovarian carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
EFO-27 CVCL_1194 Homo sapiens 10uM 6H
OV7 CVCL_1623 Homo sapiens 10uM 6H
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
RMG-I CVCL_1663 Homo sapiens 10uM 6H
Ovarian mucinous cystadenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COV644 CVCL_2011 Homo sapiens 10uM 6H
RMUG-S CVCL_1666 Homo sapiens 10uM 6H
Ovarian undifferentiated carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
TYK-nu CVCL_1774 Homo sapiens 10uM 6H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.04uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.04uM - 10uM 6H, 24H
Acute myeloid leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NOMO-1 CVCL_1609 Homo sapiens 10uM 6H
PL-21 CVCL_2161 Homo sapiens 10uM 6H
SKM-1 CVCL_0010 Homo sapiens 10uM 6H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.04uM - 10uM 24H
Pleural effusion
Histiocytic lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-937 CVCL_0007 Homo sapiens 10uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.04uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.04uM - 10uM 6H, 24H
SK-L CVCL_1699 Homo sapiens 0.04uM - 10uM 24H
SK-MEL-1 CVCL_0523 Homo sapiens 10uM 6H
SK-MEL-28 CVCL_0526 Homo sapiens 10uM 6H
Stomach
Gastric adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
AGS CVCL_0139 Homo sapiens 10uM 6H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.04uM - 10uM 24H