Details of the Drug

General Information of Drug (ID: DMRIMLJ)

Drug Name
BX-795
Synonyms BX795; BX 795
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Drug Type
Small molecular drug
Structure
3D MOL is unavailable 2D MOL
#Ro5 Violations (Lipinski): 1 Molecular Weight (mw) 591.5
Logarithm of the Partition Coefficient (xlogp) 4.6
Rotatable Bond Count (rotbonds) 9
Hydrogen Bond Donor Count (hbonddonor) 4
Hydrogen Bond Acceptor Count (hbondacc) 7
Chemical Identifiers
Formula
C23H26IN7O2S
IUPAC Name
N-[3-[[5-iodo-4-[3-(thiophene-2-carbonylamino)propylamino]pyrimidin-2-yl]amino]phenyl]pyrrolidine-1-carboxamide
Canonical SMILES
C1CCN(C1)C(=O)NC2=CC=CC(=C2)NC3=NC=C(C(=N3)NCCCNC(=O)C4=CC=CS4)I
InChI
InChI=1S/C23H26IN7O2S/c24-18-15-27-22(30-20(18)25-9-5-10-26-21(32)19-8-4-13-34-19)28-16-6-3-7-17(14-16)29-23(33)31-11-1-2-12-31/h3-4,6-8,13-15H,1-2,5,9-12H2,(H,26,32)(H,29,33)(H2,25,27,28,30)
InChIKey
VAVXGGRQQJZYBL-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
10077147
ChEBI ID
CHEBI:91439
CAS Number
702675-74-9
TTD ID
D0RG0Z
Combinatorial Drugs (CBD) Click to Jump to the Detailed CBD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Checkpoint kinase-1 (CHK1) TTTU902 CHK1_HUMAN Inhibitor [2]
Cyclin-dependent kinase 2 (CDK2) TT7HF4W CDK2_HUMAN Inhibitor [2]
Fungal Protein kinase A (Fung ypkA) TTYVI76 Q56921_YEREN Inhibitor [2]
Glycogen synthase kinase-3 beta (GSK-3B) TTRSMW9 GSK3B_HUMAN Inhibitor [2]
Phosphoinositide dependent protein kinase-1 (PDPK1) TT9QBI6 PDPK1_HUMAN Inhibitor [2]
Vascular endothelial growth factor receptor 2 (KDR) TTUTJGQ VGFR2_HUMAN Inhibitor [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
3-phosphoinositide-dependent protein kinase 1 (PDPK1) OTT09ZVP PDPK1_HUMAN Gene/Protein Processing [3]
Inhibitor of nuclear factor kappa-B kinase subunit epsilon (IKBKE) OT5VYOSM IKKE_HUMAN Gene/Protein Processing [4]
Serine/threonine-protein kinase TBK1 (TBK1) OT1P06NV TBK1_HUMAN Gene/Protein Processing [4]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Glycogen synthase kinase-3 beta (GSK-3B) DTT GSK3B 1.26E-01 -0.23 -0.77
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 40 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RPMI-3460/CS1 GDSC1 1.2513 2.9813 0.9251 15.6298
ES8 GDSC1 -0.0723 2.0359 -0.2187 30.8429
ES7 GDSC1 0.3609 2.1513 0.2259 25.3856
HOS GDSC1 0.6056 3.3752 0.084 24.9414
G-292 clone A141B1 GDSC1 0.7022 2.6433 0.4571 21.876
TC-71 GDSC1 0.7351 2.3894 0.5713 20.9124
MG-63 GDSC1 0.7525 4.3944 -0.1994 25.9863
ES1 GDSC1 1.0017 2.8188 0.7204 18.4064
CHSA0011 GDSC1; GDSC2 1.1019 3.3817 0.8825 23.4312
CHSA8926 GDSC1 1.4095 3.9857 0.6456 16.9089
SK-PN-DW GDSC1 1.4823 4.9151 0.273 19.2824
EW-22 GDSC1 1.4897 3.8361 0.7945 15.4269
EW-12 GDSC2 1.521 3.9505 1.155 20.0534
CAL-72 GDSC1 1.5292 4.1238 0.6978 15.969
EW-18 GDSC1 1.5706 6.8846 -0.6123 24.5408
CAL-78 GDSC1 1.6785 3.267 1.245 11.1518
HuO-3N1 GDSC1 1.7881 5.0275 0.502 16.295
A-673 GDSC1 1.8222 3.8868 1.0921 11.671
SK-ES-1 GDSC1 1.8424 7.3249 -0.5895 23.2646
MHH-ES-1 GDSC1; GDSC2 1.8463 5.1371 1.0109 19.5248
EW-16 GDSC1 1.8713 5.699 0.2446 17.8078
SaOS-2 GDSC1 1.985 4.0066 1.1846 10.2668
HuO9 GDSC1 2.0194 5.0485 0.699 13.8739
CHSA0108 GDSC1; GDSC2 2.0509 5.6522 0.9809 18.9036
ES5 GDSC1; GDSC2 2.0771 7.2254 0.2557 22.8021
NOS-1 [Human HNSCC] GDSC1 2.1751 4.6742 1.0213 10.7882
SJSA-1 GDSC1 2.186 3.2368 1.7468 5.0529
NY GDSC1 2.3531 4.7432 1.1371 9.2234
U2OS GDSC1; GDSC2; CTRP1 2.414 7.2009 1.3982 27.1547
ES6 GDSC1 2.4157 4.4419 1.339 7.4175
H-EMC-SS GDSC1 2.5169 5.9519 0.6667 12.2619
ES4 GDSC1 2.6815 5.1607 1.1899 7.6991
EW-11 GDSC1 2.8 6.4234 0.6547 11.3961
EW-7 GDSC1 2.8489 8.2385 -0.2094 17.2017
EW-3 GDSC1 3.0039 7.2713 0.3901 12.6612
EW-1 GDSC1 3.2935 5.6716 1.371 4.6212
EW-13 GDSC1 3.3296 8.153 0.1976 12.9892
EW-24 GDSC1 3.3922 5.5608 1.4836 3.592
CADO-ES1 GDSC1 3.8991 8.8219 0.2739 10.8676
U-CH2 GDSC2 4.1522 8.2624 1.5048 9.2459
⏷ Show the Full List of 40 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 169 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JM1 GDSC1; GDSC2 1.2547 3.6413 0.9712 22.2525
MV4-11 GDSC1 -4.4522 -1.4457 -4.4714 78.9419
EoL-1 GDSC1 -4.1725 -1.4174 -4.1866 77.1447
MOLM-13 GDSC1 -2.5502 -0.4472 -2.562 60.5284
Mono-Mac-6 GDSC1 -1.7787 0.9401 -1.8655 51.1618
ALL-PO GDSC1 -1.4159 2.2524 -1.7386 47.2723
NKM-1 GDSC1 -1.0501 3.0253 -1.5717 43.8009
ATN-1 GDSC1 -1.0429 1.7631 -1.2141 42.7487
Karpas-45 GDSC1 -0.8519 1.1418 -0.9052 39.9551
BV-173 GDSC1 -0.7372 2.3067 -1.0125 39.5626
OCI-Ly7 GDSC1; GDSC2 -0.6532 0.7101 -0.6552 39.9007
NALM-6 GDSC1 -0.642 1.4631 -0.7252 37.5183
JeKo-1 GDSC1; GDSC2 -0.5911 3.973 -1.1425 41.1151
BE-13 GDSC1 -0.5628 1.8316 -0.7072 36.8676
RS4;11 GDSC1 -0.5369 2.2633 -0.7821 37.0621
RCH-ACV GDSC1; GDSC2 -0.4176 2.0265 -0.4922 37.8656
697 GDSC1 -0.3069 1.4139 -0.3596 33.185
CRO-AP2 GDSC1; GDSC2 -0.2569 1.5813 -0.2798 36.0256
SUP-M2 GDSC1 -0.2391 2.3257 -0.474 33.417
SU-DHL-5 GDSC1; CTRP1 -0.1098 2.0775 -0.1208 48.1561
Kasumi-1 GDSC2 -0.0419 1.7157 -0.0654 33.8729
L-1236 GDSC1 0.0349 2.5637 -0.244 30.3359
NCI-H929 GDSC1 0.049 2.7896 -0.3004 30.5904
P30/OHK GDSC1 0.1193 1.8227 0.0337 28.0775
RPMI-8402 GDSC1 0.1252 1.9088 0.0235 28.1066
SIG-M5 GDSC2 0.2362 1.8048 0.2175 31.0597
BL-41 GDSC1 0.2577 1.0678 0.255 25.8194
SR GDSC1 0.2762 2.4924 0.0406 27.0956
ALL-SIL GDSC1 0.2839 1.8453 0.2075 25.9637
MOLT-13 GDSC1 0.2894 2.7989 -0.0427 27.5561
P32/ISH GDSC1 0.2988 1.9452 0.2043 25.8948
BL-70 CTRP1 0.3349 2.6656 0.3105 65.9802
SU-DHL-6 GDSC1 0.3508 2.0452 0.2395 25.3561
MOLT-4 GDSC1 0.44 3.1441 -0.0031 26.4356
Karpas-1106P GDSC1 0.4806 3.0374 0.08 25.6615
OCI-M1 GDSC1 0.5167 2.1642 0.3925 23.371
Karpas-231 GDSC1 0.551 1.857 0.4935 22.5045
SUP-B15 GDSC1 0.5761 3.0743 0.1688 24.5373
MOLM-16 GDSC1; GDSC2; CTRP1 0.593 4.4287 0.3416 39.0415
LAMA-84 GDSC1 0.6276 4.0462 -0.1732 26.4865
YT GDSC1 0.6432 3.7572 -0.0333 25.5083
P12-Ichikawa GDSC1 0.6568 4.1195 -0.1751 26.3412
NK-92MI GDSC2 0.6824 2.2909 0.6437 26.6842
L-363 GDSC1 0.6871 3.4448 0.1422 24.1091
OCI-AML-2 GDSC1 0.7365 2.722 0.468 21.6109
L-540 GDSC1 0.7643 2.9425 0.4197 21.7914
Ku812 GDSC1 0.7833 4.2361 -0.0972 25.178
A3/Kawakami GDSC1 0.784 3.1439 0.3646 22.067
BC-3 GDSC2 0.7885 2.2192 0.7624 25.5556
SUP-HD1 GDSC1 0.79 4.3687 -0.1498 25.4787
Ramos.2G6.4C10 GDSC1 0.8036 3.433 0.2697 22.6192
DoHH2 GDSC1; GDSC2 0.8302 1.8555 0.8257 25.0275
DND-41 GDSC1 0.8555 3.5662 0.2685 22.3546
NB4 GDSC1; GDSC2 0.8717 2.2645 0.8457 24.72
OCI-AML-5 GDSC1 0.9107 2.9763 0.5641 19.9943
EM-2 GDSC1 0.9154 5.6246 -0.61 27.5691
KOPN-8 GDSC1 0.961 2.4857 0.7889 18.1533
JJN-3 GDSC1 1.0139 2.7457 0.7598 18.0641
NU-DUL-1 GDSC1; GDSC2; CTRP1 1.0719 2.792 1.0624 34.1115
CTB-1 GDSC1; GDSC2 1.0912 4.8309 0.357 26.2831
SU-DHL-16 GDSC1; GDSC2 1.0991 2.8941 0.9981 22.8284
KY821 GDSC1 1.1056 3.6359 0.4976 19.4601
KE-37 GDSC1 1.1172 2.7856 0.8568 16.8244
JVM-3 GDSC1 1.1248 4.5252 0.113 22.0661
SU-DHL-10 GDSC1 1.1502 2.5094 0.9875 15.7299
DB GDSC1 1.1504 3.6847 0.522 19.061
MOLP-8 GDSC1 1.1589 3.4528 0.632 18.223
TALL-1 [Human adult T-ALL] GDSC2 1.2186 5.2906 0.2985 26.0254
Granta-519 GDSC1 1.27 4.1334 0.4389 19.0792
HL-60 GDSC1 1.287 4.6172 0.2286 20.4937
Karpas-422 GDSC1 1.2973 2.8424 1.0284 14.6475
Loucy GDSC1 1.3445 3.9785 0.5846 17.6647
GR-ST GDSC1 1.3516 5.7912 -0.2754 23.5252
SUP-B8 GDSC1; GDSC2 1.3814 4.1736 0.923 21.9567
WSU-DLCL2 GDSC1; CTRP1 1.3877 3.1082 1.3735 34.2576
GDM-1 GDSC1; CTRP1 1.4294 3.6243 1.378 34.0384
TUR GDSC1 1.4773 4.6885 0.3776 18.5585
KG-1 GDSC1 1.4836 3.8973 0.76 15.7133
CCRF-CEM GDSC1 1.5265 6.0886 -0.2594 22.6387
JURL-MK1 GDSC1 1.5271 4.3198 0.6023 16.6893
OPM-2 GDSC1 1.5338 3.4822 1.0016 13.6663
HH [Human lymphoma] GDSC1 1.5396 4.9412 0.3143 18.7328
CMK GDSC1 1.5613 3.6622 0.9462 13.9544
H9 GDSC1 1.5899 5.383 0.1455 19.6959
WSU-NHL GDSC1 1.5918 3.796 0.9137 14.0591
SKM-1 GDSC1; GDSC2; CTRP1 1.5923 4.5784 1.3952 30.4697
HDLM-2 GDSC1 1.6577 4.8253 0.4812 17.0051
NOMO-1 GDSC1; CTRP1 1.6795 5.4241 1.265 33.3111
MOLT-16 GDSC1 1.6928 5.4887 0.1878 18.9561
OCI-Ly19 GDSC1; GDSC2 1.7176 4.085 1.3164 18.2944
ST486 GDSC1 1.7331 4.2708 0.8218 14.1275
JSC-1 GDSC1 1.7391 4.6692 0.6331 15.5279
KMOE-2 GDSC1 1.759 5.4027 0.2904 17.9517
BONNA-12 GDSC2 1.7598 4.4783 1.205 18.755
Reh GDSC1 1.7974 4.3594 0.8387 13.7224
VAL GDSC1 1.8105 3.6177 1.2105 10.8114
MY-M12 GDSC1; GDSC2 1.8143 4.4561 1.2714 18.1474
QIMR-WIL GDSC1; GDSC2 1.8843 5.7477 0.7715 20.7417
MHH-PREB-1 GDSC1 1.9016 5.6611 0.2903 17.3598
Farage GDSC1; GDSC2 1.9072 3.3313 1.7755 14.8912
KCL-22 GDSC1 1.9267 3.5195 1.3686 9.0833
MEG-01 GDSC1 1.9481 6.8789 -0.2751 20.9551
LC4-1 GDSC1 1.9486 6.0677 0.1295 18.2948
OCI-AML-3 GDSC1; CTRP1 1.9871 5.1609 1.6782 30.0583
MC116 GDSC1; GDSC2 2.0067 2.9264 1.972 13.3761
A4/Fukuda GDSC1 2.076 6.5734 -0.0121 18.745
AMO1 GDSC1; CTRP1 2.1273 5.9637 1.5737 29.9002
MM1.S GDSC1 2.2577 5.0722 0.8929 11.4727
HAL-01 GDSC1 2.2723 4.6827 1.0999 9.8088
JVM-2 GDSC1 2.3084 5.3293 0.8069 11.9458
EJM GDSC1; CTRP1 2.3496 5.7604 1.8847 27.4778
GA-10 GDSC1 2.371 4.2606 1.3931 7.1484
SUP-T1 GDSC1 2.3893 5.0574 1.0099 10.0862
CML-T1 GDSC1 2.4057 6.1903 0.4571 14.2107
U-937 CTRP1 2.4073 8.5674 0.7958 43.3204
RPMI-8866 GDSC1 2.4593 5.531 0.8304 11.2231
MLMA GDSC1 2.4868 5.0643 1.0856 9.1561
BALL-1 GDSC1 2.4938 5.9604 0.6438 12.5144
SU-DHL-1 GDSC2 2.4964 12.5328 -1.9884 30.2883
U266B1 GDSC1 2.4971 3.8905 1.6784 4.4753
PL21 CTRP1 2.5046 5.6872 2.0776 38.8243
Daudi GDSC1 2.507 3.8264 1.7178 4.1349
Jiyoye GDSC1 2.5615 5.7819 0.7873 11.1962
BC-1 GDSC1 2.6613 5.0963 1.2064 7.6349
U-698-M GDSC1 2.7073 6.0362 0.7753 10.7967
ML-2 GDSC1 2.7507 5.3787 1.1345 7.9094
SK-MM-2 GDSC1 2.7873 4.8795 1.4072 5.692
Karpas-620 GDSC1 2.8249 5.5047 1.1278 7.7312
CA46 GDSC1 2.8809 5.6897 1.0781 7.9416
MN-60 GDSC1 2.9339 8.0117 -0.0304 15.7637
KMS-11 GDSC1; GDSC2; CTRP1 2.95 7.7605 1.7082 23.8373
PL-21 GDSC1; GDSC2 2.9769 9.7286 -0.1733 21.8354
RPMI-6666 GDSC1 3.0522 8.3202 -0.0925 15.7796
SU-DHL-4 GDSC1; GDSC2; CTRP1 3.0734 6.583 2.3458 20.3959
RPMI-8226 GDSC1; CTRP1 3.1317 5.8935 2.6806 20.2265
DG-75 GDSC1 3.1377 5.4007 1.3978 4.8068
CTV-1 GDSC1 3.1749 6.9655 0.6669 10.1419
P31/FUJ GDSC1 3.1873 6.3171 0.9915 7.7067
Namalwa GDSC1 3.1952 5.4933 1.3916 4.7092
MHH-CALL-4 GDSC2 3.2702 7.7362 1.0715 14.2445
K-562 GDSC1 3.3078 5.2875 1.558 3.2518
Raji GDSC1 3.3772 4.9607 1.7435 1.8741
PF-382 GDSC1 3.4152 9.1486 -0.2286 15.5009
HEL GDSC1; GDSC2 3.4389 8.4377 0.8608 14.9756
EHEB GDSC1 3.4497 6.4676 1.0968 6.2374
IM-9 GDSC1 3.5446 6.7597 1.0205 6.5551
HC-1 GDSC1 3.6668 5.4603 1.6811 1.7963
OCI-Ly10 CTRP1 3.7365 5.3925 3.5125 20.6037
HT GDSC1; GDSC2 3.788 7.7706 1.4731 10.3618
ME1 GDSC1 3.8555 5.2014 1.8728 0.602
RL GDSC1; GDSC2 3.8601 10.5791 0.1316 17.7149
TK [Human B-cell lymphoma] GDSC1 3.917 5.6746 1.7148 1.2762
RC-K8 GDSC1 3.9574 5.2028 1.9134 0.3849
VL51 GDSC1 3.9781 6.3617 1.4581 2.6641
THP-1 GDSC1; GDSC2; CTRP1 4.0228 5.1922 3.8892 9.4606
KM-H2 GDSC1 4.0812 8.6977 0.4539 9.1952
WIL2 NS GDSC1 4.2094 5.5578 1.8826 0.3461
SU-DHL-8 GDSC1 4.3613 8.2273 0.8459 5.9295
LP-1 GDSC1; GDSC2; CTRP1 4.3925 9.3365 2.3422 16.2432
Jurkat GDSC1 4.5649 6.7792 1.5704 1.2913
ARH-77 GDSC1 4.5685 6.2731 1.7631 0.5214
EB2 GDSC1 4.597 5.9368 1.892 0.1805
L-428 GDSC1 4.599 6.1451 1.8205 0.3393
MHH-CALL-2 GDSC1 4.7182 6.2079 1.8422 0.2437
Karpas-299 GDSC1 4.7231 12.6943 -1.0252 16.3567
DEL GDSC1 4.9975 11.9141 -0.4697 12.7005
CESS GDSC1 5.0267 6.6223 1.8099 0.2163
Sc-1 GDSC1 5.5134 6.9601 1.863 0.0644
ROS-50 GDSC1; GDSC2 5.9042 11.5994 1.0861 7.97
⏷ Show the Full List of 169 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 11 Cell Line(s) in Aero Dig Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KYSE-220 GDSC1 1.0046 2.9601 0.6707 18.7423
ESO-26 GDSC1 1.0701 3.7917 0.3926 20.3876
OACP4 C GDSC1 1.3398 4.1558 0.4975 18.3241
FLO-1 GDSC1 1.4731 4.3223 0.549 17.3286
KYSE-50 GDSC1 1.935 3.6631 1.3068 9.5262
SK-GT-4 GDSC1 2.1693 4.5502 1.0782 10.366
HCE-4 GDSC1; GDSC2 2.5253 6.157 1.1959 15.9064
ESO-51 GDSC1 2.5473 5.331 1.0008 9.607
TE-12 GDSC1; GDSC2 3.4026 6.9763 1.5615 10.8802
KYAE-1 GDSC1 3.4541 5.0796 1.7331 1.812
OACM5.1 C GDSC1 4.3228 6.3495 1.6313 1.2472
⏷ Show the Full List of 11 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 684 GDSC1 2.7871 5.9045 0.902 9.5777
Cancer Drug Sensitivity Data Curated from 32 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CHP-212 GDSC1 -0.2322 2.1581 -0.4225 33.0774
SJNB-14 GDSC1 0.071 2.5848 -0.2112 29.9151
NB69 GDSC1 0.1137 2.1377 -0.0403 28.5839
CHP-134 GDSC1 0.6513 2.7177 0.3771 22.7072
SK-N-SH GDSC1 0.7527 2.8548 0.4391 21.721
NH-12 GDSC1 0.8527 3.6606 0.2256 22.6643
GI-ME-N GDSC1 0.9235 2.9364 0.5929 19.724
SJNB-7 GDSC1 1.1151 2.5336 0.9415 16.2429
SJNB-10 GDSC1 1.3568 4.37 0.4135 18.8528
SJNB-5 GDSC1; GDSC2 1.3967 3.506 1.1678 20.5343
MHH-NB-11 GDSC1; GDSC2 1.4236 3.6183 1.1623 20.443
TGW GDSC1 1.4286 3.3665 0.947 14.5789
SJNB-6 GDSC1; GDSC2 1.4468 3.7644 1.1397 20.4648
Kelly GDSC1 1.5253 3.0094 1.2015 12.2214
KP-N-YS GDSC1; GDSC2 1.677 3.699 1.4113 17.935
CHP-126 GDSC1; GDSC2 1.735 4.5041 1.1683 19.0692
SJNB-13 GDSC1 1.746 4.8823 0.535 16.2296
KP-N-RT-BM-1 GDSC2 1.8228 3.8631 1.5117 16.7338
SK-N-MC-IXC GDSC1; GDSC2 2.0885 4.76 1.4255 16.1428
SK-N-BE(2)-M17 GDSC1 2.3687 6.7375 0.153 16.5064
SJNB-17 GDSC1; GDSC2 2.4188 5.0082 1.6443 13.5711
SJNB-12 GDSC1 2.792 8.4188 -0.3441 18.2336
IMR-5 GDSC1 3.2603 5.2302 1.5554 3.3722
SK-N-AS GDSC1 3.3019 6.3765 1.0418 7.0219
SiMa GDSC1 3.642 6.5201 1.1944 5.0817
GOTO GDSC1 3.6556 6.5349 1.1959 5.0406
NB1 GDSC1 3.7957 7.8454 0.6707 8.4182
SK-N-FI GDSC1 4.2583 5.7681 1.8254 0.4982
SK-N-DZ GDSC1 4.4271 5.6036 1.9456 0.13
KP-N-YN GDSC1 4.5747 6.4493 1.7007 0.7347
NB(TU)1 GDSC1 4.9789 6.6334 1.789 0.2722
LA-N-6 GDSC1; GDSC2 6.0533 7.6562 2.8077 0.1712
⏷ Show the Full List of 32 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuCC-T1 GDSC1 2.3259 4.6334 1.1695 9.0681
Cancer Drug Sensitivity Data Curated from 50 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CAL-51 GDSC1 0.3648 3.0702 -0.0566 27.209
DU4475 GDSC1 0.7457 2.1598 0.6432 20.3683
MDA-MB-468 GDSC1 0.7672 2.1897 0.6594 20.1361
MDA-MB-157 GDSC1 0.8239 4.644 -0.2409 25.8738
Hs 578T GDSC1 1.3473 3.0083 1.0155 14.4813
HCC1187 GDSC1 1.4025 3.3407 0.9317 14.8195
Evsa-T GDSC1 1.5724 3.5097 1.0277 13.2883
MDA-MB-175-VII GDSC1 1.6766 2.9224 1.3958 10.0372
CAL-120 GDSC1 1.6878 3.6355 1.0832 12.3348
BT-549 GDSC1 1.9529 3.4776 1.4137 8.6218
OCUB-M GDSC1 2.4284 4.3769 1.3818 7.0369
MFM-223 GDSC1 2.4725 4.8914 1.1604 8.6213
JIMT-1 GDSC1 2.493 4.9745 1.1354 8.7465
MDA-MB-231 GDSC1 2.4959 6.522 0.3651 14.5515
MDA-MB-436 GDSC1 2.5218 3.8386 1.723 4.0475
HCC38 GDSC1 2.5516 5.1461 1.0964 8.8514
HCC1419 GDSC1 2.7705 4.3261 1.6646 3.7672
COLO 824 GDSC1 2.8953 6.8752 0.5037 12.1944
EFM-192A GDSC1 2.9157 5.8637 1.0182 8.2931
HDQ-P1 GDSC1 2.9715 5.1844 1.3892 5.3079
HCC1806 GDSC1 3.0162 6.3367 0.8596 9.189
HCC2157 GDSC1 3.0315 5.9393 1.0651 7.5961
HCC1143 GDSC1 3.07 6.3761 0.8795 8.8803
HCC1954 GDSC1 3.0722 5.7398 1.1907 6.5322
HCC1569 GDSC1; GDSC2 3.2111 11.3264 -0.7731 23.7647
CAL-85-1 GDSC1 3.2254 6.0073 1.167 6.2958
HCC2218 GDSC1; GDSC2 3.301 6.761 1.5849 11.0304
HCC1428 GDSC1 3.3893 5.863 1.3422 4.6042
AU565 GDSC1 3.3996 5.5153 1.5089 3.4003
T-47D GDSC1 3.4107 5.7288 1.4177 4.017
CAMA-1 GDSC1 3.553 8.0464 0.4094 10.887
MRK-nu-1 GDSC1 3.645 5.7179 1.5586 2.593
BT-483 GDSC1 3.7782 7.0666 1.0255 5.9635
BT-20 GDSC1 3.9 6.2492 1.4651 2.7493
MDA-MB-453 GDSC1 3.9505 6.1822 1.5206 2.3264
BT-474 GDSC1 3.9731 6.2964 1.4835 2.5162
HCC1395 GDSC1 3.9885 7.0453 1.1621 4.5703
MCF-7 GDSC1; CTRP1 4.0848 9.4909 1.9866 20.4364
HCC1500 GDSC1 4.0855 7.0329 1.2231 3.977
UACC-893 GDSC1; GDSC2 4.0896 7.5726 1.7974 7.618
EFM-19 GDSC1 4.1678 7.3136 1.1448 4.3361
MDA-MB-330 GDSC1; GDSC2 4.1936 6.3587 2.454 3.4177
HCC70 GDSC1 4.3302 13.5219 -1.7053 20.6123
HCC1599 GDSC2 4.4768 9.0911 1.334 9.494
ZR-75-30 GDSC1 4.5137 6.3403 1.7165 0.7187
MDA-MB-361 GDSC1 4.5383 6.9778 1.4794 1.7663
MDA-MB-415 GDSC1 4.6331 6.3596 1.7568 0.5054
YMB-1-E GDSC2 4.6669 7.9627 2.0038 5.1419
HCC1937 GDSC1 4.6945 6.718 1.6492 0.8438
HCC202 GDSC1 5.1135 7.1197 1.6678 0.5243
⏷ Show the Full List of 50 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 55 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
YH-13 GDSC1 -0.6172 1.1565 -0.6585 36.9811
H4 GDSC1 0.0495 1.6953 -0.0193 28.841
D283 Med GDSC1 0.4602 2.4475 0.2545 24.6171
DK-MG GDSC1 0.472 4.0927 -0.3541 28.4401
M059J GDSC1 0.5254 2.3213 0.3615 23.5266
SW1088 GDSC1 0.6447 6.0289 -1.0645 31.2371
D-566MG GDSC1; GDSC2 0.6777 2.3158 0.636 26.747
SK-MG-1 GDSC1 0.6795 2.2609 0.5458 21.4031
KS-1 [Human Krukenberg tumour] GDSC1 0.7692 3.48 0.2141 23.1824
MOG-G-CCM GDSC1 0.7964 2.5777 0.5808 20.502
D-245MG GDSC2 0.8478 5.6492 -0.2394 30.2546
YKG-1 GDSC1; GDSC2 0.8749 2.5395 0.8173 24.8504
42-MG-BA GDSC1 0.8843 2.6847 0.6409 19.6008
MOG-G-UVW GDSC1 0.9269 2.4675 0.7573 18.5612
D-263MG GDSC1 0.969 2.7659 0.7041 18.6977
T98G GDSC1 1.0353 3.2891 0.5723 19.2824
D-423MG GDSC1; GDSC2 1.0965 4.7489 0.3957 26.0587
8-MG-BA GDSC1 1.1078 3.0454 0.7475 17.6518
Becker GDSC1 1.3268 4.4105 0.3651 19.3408
Hs 683 GDSC1; GDSC2 1.3895 3.8673 1.0424 21.2582
SF126 GDSC1; GDSC2 1.4463 3.2565 1.2925 19.6298
CAS-1 GDSC1 1.4834 3.3033 1.031 13.6885
D-336MG GDSC1; GDSC2 1.6243 4.2136 1.1674 19.5385
SF539 GDSC1 1.7836 4.4808 0.7666 14.3308
SW1783 GDSC1 1.794 3.7419 1.1352 11.4622
SF268 GDSC1 1.7975 4.0332 0.9978 12.5031
KINGS-1 GDSC1 1.8604 4.508 0.8239 13.5705
GB-1 GDSC1 1.9099 5.5396 0.358 16.8407
ONS-76 GDSC1 1.9112 5.5603 0.3489 16.9012
LN-18 GDSC1 1.9405 3.025 1.6177 7.1098
D-247MG GDSC1; GDSC2 1.9469 4.5938 1.3518 17.1397
A-172 GDSC1 2.0471 6.9054 -0.2026 20.1013
KALS-1 GDSC1 2.0558 6.3826 0.0658 18.3009
GI-1 GDSC1 2.0816 3.7358 1.4059 8.144
LNZTA3WT4 GDSC1 2.1191 4.4511 1.0839 10.5158
Daoy GDSC1 2.2709 6.2998 0.2903 15.9104
U-118MG GDSC1 2.3245 4.9626 1.0037 10.368
SNB-75 GDSC1; GDSC2 2.4078 5.3172 1.4882 14.559
D-392MG GDSC1 2.4867 7.8249 -0.2935 19.0017
AM-38 GDSC1 2.5561 4.5443 1.3994 6.4692
SF295 GDSC1; GDSC2 2.6466 7.0776 0.8554 17.4968
U-87MG ATCC GDSC1 2.6766 4.7145 1.4068 6.029
DBTRG-05MG GDSC1 2.6871 5.1089 1.2199 7.4485
PFSK-1 GDSC1 2.8707 5.8767 0.9786 8.7321
Onda 10 GDSC1; GDSC2 3.04 5.1063 2.1851 8.0616
LN-405 GDSC1 3.0794 5.9753 1.0816 7.3347
GaMG GDSC1; CTRP1 3.1569 6.8117 2.3366 21.9243
U-251MG GDSC1 3.3813 7.9219 0.3482 11.8029
NMC-G1 GDSC1; GDSC2 3.7326 6.8735 1.8756 8.0205
LN-229 GDSC1; CTRP1 3.9566 8.1981 2.4971 18.1962
D-542MG GDSC1; GDSC2 3.9832 7.7564 1.6287 8.9092
Onda 11 GDSC1; GDSC2 4.241 7.1519 2.1082 5.3841
D-502MG GDSC1; GDSC2 4.4468 12.4468 -0.3403 18.4185
KNS-81-FD GDSC1; GDSC2 4.9834 12.3264 0.1181 14.9164
KNS-42 GDSC1; GDSC2 5.3479 10.8328 1.091 9.0018
⏷ Show the Full List of 55 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Digestive System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TGBC24TKB GDSC1 2.3727 4.2043 1.4227 6.9092
ETK-1 GDSC1 2.6848 5.2494 1.1485 8.0094
TGBC1TKB GDSC1 3.0709 5.5971 1.2587 6.0228
Cancer Drug Sensitivity Data Curated from 13 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
AN3-CA GDSC1 0.7994 3.6583 0.1712 23.3161
JHUEM-2 CTRP1 1.3139 4.6532 1.075 52.8621
MFE-296 GDSC1 2.131 4.4826 1.0786 10.5108
RL95-2 GDSC1 2.319 5.509 0.7259 12.5242
ESS-1 GDSC1 2.4025 3.3259 1.8854 3.1614
EN GDSC1 2.4219 5.0777 1.0264 9.8425
MFE-319 GDSC1 2.512 3.6051 1.831 3.2353
MFE-280 GDSC1 2.7128 5.0987 1.2443 7.1778
KLE GDSC1; CTRP1 3.118 6.0487 2.6071 20.6649
HEC-151 CTRP1 3.4586 6.9857 2.5713 29.2843
HEC-108 CTRP1 4.112 7.2384 3.1059 21.6698
HEC-59 CTRP1 5.3457 9.6388 3.0034 16.7105
Ishikawa (Heraklio) 02 ER- CTRP1 3.2597 6.4299 2.6046 30.3538
⏷ Show the Full List of 13 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 33 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
LB1047-RCC GDSC1; GDSC2 0.6478 2.8344 0.5207 27.4867
NCC021 GDSC1; GDSC2 0.6709 2.5304 0.6001 26.9645
KTCTL-140 GDSC1; GDSC2 1.1157 3.9637 0.7127 24.2856
KMRC-20 GDSC1 1.181 3.1814 0.7697 17.1144
Caki-1 GDSC1; GDSC2 1.2412 3.9179 0.8644 22.8973
BFTC-909 GDSC1 1.2652 2.8444 0.9934 15.0669
KTCTL-195 GDSC1 1.5124 3.1387 1.1328 12.7921
A-704 GDSC1 1.6607 3.2808 1.2208 11.4184
VMRC-RCZ GDSC1 1.6657 4.9255 0.4396 17.2749
A-498 GDSC1 1.807 3.3361 1.3408 9.8294
LB996-RCC GDSC1 1.9266 4.3919 0.9415 12.3923
NCC010 GDSC1; GDSC2 1.9455 3.9379 1.6159 15.6152
769-P GDSC1 2.0289 3.0313 1.701 6.0731
KTCTL-26A GDSC1; GDSC2 2.0882 4.6532 1.4721 15.8688
SN12C GDSC1 2.1963 4.8932 0.9301 11.4154
TK-10 GDSC1 2.2622 4.8279 1.0188 10.479
HA7-RCC GDSC1; GDSC2 2.3143 7.7471 0.2222 22.112
786-O GDSC1 2.3252 4.7104 1.1304 9.3768
KMRC-1 GDSC1 2.5642 4.3663 1.494 5.7027
SW13 GDSC1 2.5972 4.2185 1.5922 4.8318
KTCTL-1M GDSC1; GDSC2 2.6926 5.0586 1.8861 11.1009
CAL-54 GDSC1 2.8088 4.6166 1.5506 4.5294
LB2241-RCC GDSC1; GDSC2 3.2177 11.6796 -0.9441 24.4382
RXF 393L GDSC1; GDSC2 3.2327 6.9618 1.4271 12.208
VMRC-RCW GDSC1; GDSC2 3.3343 9.2619 0.3623 18.0406
OS-RC-2 GDSC1 3.4583 10.2708 -0.7498 18.4251
UO-31 GDSC1; GDSC2 3.4604 6.1282 2.0324 7.7677
KTCTL-13 GDSC1; GDSC2 3.5644 5.7176 2.3197 5.6742
SW156 GDSC1; GDSC2 3.6756 5.7192 2.4038 4.862
KTCTL-21 GDSC1; GDSC2 4.0545 8.0604 1.5321 9.3206
ACHN GDSC1 4.855 6.4265 1.8159 0.2552
BB65-RCC GDSC1; GDSC2 4.8827 18.2586 -2.8889 26.4452
RCC10RGB GDSC1; CTRP1 4.9751 6.5727 4.2311 5.0953
⏷ Show the Full List of 33 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 54 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SW48 GDSC1 0.8814 3.5442 0.3049 21.967
SNU-175 CTRP1 0.9935 2.5876 0.9882 57.9351
SNU-407 GDSC1 1.8488 3.4037 1.3496 9.5731
KM12 GDSC1; CTRP1 1.8936 4.8039 1.6707 30.5215
HCT 15 GDSC1 1.9152 3.4085 1.4111 8.8057
NCI-H716 GDSC1 2.0856 4.202 1.1784 9.9089
CaR-1 GDSC1 2.2612 4.9273 0.9683 10.8762
CL-11 GDSC1 2.3375 3.9222 1.5347 6.1518
COLO205 GDSC1 2.3589 9.9508 -1.4618 25.6815
SNU-1040 CTRP1 2.4163 5.1331 2.1544 39.2081
C2BBe1 GDSC1 2.4785 7.3162 -0.046 17.4465
SW948 GDSC1; CTRP1 2.4971 4.0006 2.4655 24.0085
LS411N GDSC1 2.5408 13.535 -3.1033 30.9377
LS513 GDSC1 2.5551 4.0811 1.6283 4.6822
SK-CO-1 GDSC1 2.581 5.5892 0.8989 10.2784
HCT 116 GDSC1; CTRP1 2.665 6.5603 1.9246 25.9522
DiFi GDSC1 2.7182 5.5655 1.0174 8.915
SW626 GDSC1 2.719 4.7526 1.4195 5.8006
NCI-H747 GDSC1 2.7633 4.4549 1.5972 4.3016
CL-34 CTRP1 2.7887 5.9809 2.2801 35.5959
COLO 320HSR GDSC1 2.8023 4.5184 1.5937 4.2191
SW620 GDSC1; GDSC2; CTRP1 2.8509 5.5063 2.5137 20.4056
SNU-C1 GDSC1 3.0067 6.5676 0.7392 10.1155
CCK-81 GDSC1 3.0483 5.2882 1.3918 5.0826
SW480 CTRP1 3.0889 7.1264 2.1306 34.2234
SW1463 GDSC1 3.2718 5.8227 1.2857 5.2978
SW1116 GDSC1 3.4367 5.2294 1.6584 2.3169
HT-29 GDSC1; GDSC2; CTRP1 3.5178 5.2703 3.3149 14.0912
HT115 GDSC1; GDSC2; CTRP1 3.6322 6.2841 3.055 14.9481
MDST8 GDSC1; CTRP1 3.6888 6.1484 3.1711 15.4453
SNU-C5 GDSC1; CTRP1 3.7408 6.1386 3.2294 14.932
COLO 320 CTRP1 3.7542 9.0588 1.8894 31.3543
LS1034 GDSC1 3.7674 5.2578 1.8127 0.9512
NCI-H508 GDSC1; GDSC2; CTRP1 3.7766 6.7465 3.0014 14.7333
HCT 8 CTRP1 3.9885 6.2664 3.4309 19.7544
SNU-81 GDSC1; GDSC2; CTRP1 4.0173 7.257 3.0051 13.9451
SNU-C4 CTRP1 4.0992 7.5217 2.9584 22.8623
LoVo GDSC1; CTRP1 4.1414 8.0955 2.7216 16.3572
LS180 GDSC1; CTRP1 4.1499 7.9517 2.7993 15.8981
SW837 GDSC1 4.1569 7.0641 1.2491 3.6788
HCC2998 GDSC1 4.1748 6.5822 1.4659 2.3153
SNU-C2B GDSC1 4.21 7.9944 0.862 6.1375
RKO GDSC1; CTRP1 4.3058 5.8606 3.9345 8.9671
RCM-1 [Human ESC] GDSC1; CTRP1 4.3379 4.9997 4.2874 6.9599
CL-40 CTRP1 4.4521 5.823 4.1007 11.5266
GP5d GDSC1 4.533 6.2255 1.7665 0.5307
SNU-61 GDSC1; CTRP1 4.5843 5.6745 4.3014 5.923
HT-55 GDSC1; CTRP1 4.5853 6.4374 3.9439 7.9528
SW1417 GDSC1 4.6143 5.9251 1.9021 0.1581
CW-2 GDSC1; CTRP1 4.6538 5.5247 4.4389 4.9073
SNU-283 GDSC2 4.7751 6.7595 2.6098 1.6531
LS123 GDSC1; CTRP1 4.9115 8.8543 3.037 12.2391
COLO 678 GDSC1; CTRP1 4.9193 7.985 3.4779 9.667
T84 GDSC1 5.49 7.347 1.7262 0.2459
⏷ Show the Full List of 54 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Leukemia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MO-T GDSC1 3.6141 6.8411 1.0271 6.3382
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SK-HEP-1 GDSC1 1.1981 3.1219 0.8121 16.7194
HuH-1 GDSC1 1.2677 3.3701 0.7802 16.6003
JHH-4 GDSC1 1.3709 3.4882 0.8342 15.6955
SNU-387 GDSC1 1.6182 3.7905 0.9421 13.7234
Hep 3B2.1-7 GDSC1; GDSC2 1.6357 4.1269 1.2129 19.2318
HLE GDSC1 1.9311 3.6293 1.3195 9.4442
SNU-423 GDSC1 2.0118 4.2574 1.0849 10.9335
Huh-7 GDSC1 2.0221 5.1363 0.6576 14.1763
JHH-7 GDSC1 2.0662 3.4398 1.5378 7.177
JHH-1 GDSC1 2.562 4.3948 1.4781 5.8339
JHH-2 GDSC1 2.632 6.2608 0.6045 12.3282
SNU-398 GDSC1; CTRP1 2.8536 7.7133 1.6312 26.5775
SNU-449 GDSC1; CTRP1 3.6895 5.4899 3.428 14.0682
Hep-G2/C3A GDSC1 4.2289 5.6324 1.8632 0.3935
JHH-6 GDSC1; CTRP1 4.3132 4.903 4.2817 7.0961
Hep-G2 CTRP1 4.7058 6.4781 4.0371 10.7799
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 198 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HCC44 GDSC1 -0.4676 4.5391 -1.5214 39.4538
HOP-92 GDSC1 -0.2471 5.2909 -1.6165 38.3642
EMC-BAC-2 GDSC1 -0.0576 3.6947 -0.746 33.6977
NCI-H1703 GDSC1 0.2557 4.2887 -0.6622 31.3866
NCI-H524 GDSC1 0.4346 2.4793 0.2172 25.0131
NCI-H2170 GDSC1 0.5305 3.0982 0.1111 25.1766
VMRC-LCD GDSC1 0.6292 2.1216 0.5252 21.8334
NCI-H1048 GDSC1 0.6826 2.4371 0.5002 21.6933
LK-2 GDSC1 0.7115 1.5557 0.7001 20.2022
A-549 GDSC1 0.7409 2.7002 0.4802 21.5026
LXF 289 GDSC1; CTRP1 0.75 3.3905 0.6852 40.384
A-427 GDSC1; GDSC2 0.8575 3.017 0.7091 25.4985
SBC-3 GDSC1 0.9023 3.6078 0.2996 21.8956
IST-SL1 GDSC1; GDSC2 0.9662 2.3499 0.937 23.7883
NCI-H810 GDSC1 1.0047 2.8218 0.7224 18.3762
SCLC-21H CTRP1 1.0621 5.1256 0.6786 55.2244
NCI-H2171 GDSC2 1.0639 2.4167 1.0333 22.8151
NCI-H1155 GDSC1 1.2037 3.3904 0.7052 17.4677
NCI-H211 GDSC1 1.2625 2.8561 0.986 15.1343
NCI-H23 GDSC1 1.2986 3.6751 0.677 17.2056
NCI-H1755 GDSC1; CTRP1 1.3303 3.8142 1.2497 35.0872
HARA [Human squamous cell lung carcinoma] GDSC1 1.3934 3.9331 0.6541 16.9216
LC-2/ad GDSC1; GDSC2 1.4006 4.2107 0.9296 21.8369
NCI-H2073 CTRP1 1.4262 5.4683 0.9754 51.4036
UMC-11 GDSC1 1.4508 3.5988 0.8651 15.0817
SK-MES-1 GDSC1 1.484 3.6216 0.888 14.7527
LCLC-103H GDSC1 1.4886 4.7544 0.3567 18.6575
NCI-H1963 CTRP1 1.5144 4.9264 1.226 50.5154
Lu-135 GDSC1 1.5158 4.1963 0.6503 16.3837
NCI-H647 GDSC1; GDSC2 1.5183 3.3195 1.3543 18.9633
NCI-H720 GDSC1 1.5547 3.6952 0.9244 14.1486
NCI-H1975 GDSC1 1.6142 3.631 1.013 13.2047
HCC15 GDSC1; CTRP1 1.6337 4.0925 1.5335 32.3628
HOP-62 GDSC1 1.653 3.7298 1.0048 13.0894
NCI-H650 GDSC1 1.6754 5.0067 0.4089 17.4565
ABC-1 GDSC1; GDSC2 1.7337 4.6195 1.119 19.3575
NCI-H2081 GDSC1; GDSC2; CTRP1 1.7732 4.5492 1.5984 28.8369
NCI-H2085 GDSC1 1.7896 3.941 1.0349 12.252
NCI-H847 GDSC1 1.821 4.8679 0.6106 15.3499
NCI-H661 GDSC1 1.8269 4.8932 0.6036 15.3777
NCI-H292 GDSC1; GDSC2 1.8325 3.0779 1.7561 15.3428
NCI-H209 GDSC1 1.8346 4.1315 0.9846 12.4456
EBC-1 GDSC1 1.8494 3.5374 1.2864 10.0556
NCI-H2795 GDSC1 1.8577 4.4885 0.831 13.5276
NCI-H290 GDSC1; GDSC2 1.8938 5.0601 1.0937 18.8579
NCI-H2731 GDSC1 1.9177 4.2601 0.9983 11.9904
NCI-H510A GDSC1; GDSC2 1.9255 5.4264 0.9604 19.5047
KNS-62 GDSC1 1.9284 6.0522 0.1195 18.4454
NCI-H2405 GDSC1 1.9366 4.9759 0.6616 14.49
LB647-SCLC GDSC1; GDSC2 1.9369 4.5449 1.3623 17.1193
SW1271 GDSC1 1.9607 5.7732 0.2868 17.1443
NCI-H838 GDSC1; GDSC2 1.9798 5.884 0.8026 20.1976
EPLC-272H GDSC1 1.9864 5.332 0.5289 15.2809
Lu-134-A GDSC1; GDSC2 2.0078 4.9023 1.28 17.319
NCI-H2347 GDSC1 2.0106 4.6179 0.9051 12.3324
NCI-H2009 GDSC1 2.0739 4.6533 0.9436 11.7832
CPC-N GDSC1 2.1184 5.1422 0.7387 13.1838
PC-14 GDSC1; GDSC2 2.1828 4.5856 1.5989 14.7441
NCI-H1869 GDSC1 2.1875 3.2886 1.7225 5.2382
LCLC-97TM1 GDSC1 2.2045 6.3945 0.187 16.8888
NCI-H1792 GDSC1 2.2092 3.8008 1.4866 7.0082
NCI-H1568 GDSC1 2.2142 4.4053 1.1891 9.3277
NCI-H1876 GDSC1; CTRP1 2.2192 8.8389 0.4833 33.7108
EMC-BAC-1 GDSC1; GDSC2 2.2299 6.8401 0.5866 20.4742
NCI-H1694 GDSC1; CTRP1 2.2633 5.4209 1.902 27.7716
NCI-H446 GDSC1 2.2794 4.5132 1.1906 9.0722
NCI-H1299 GDSC1 2.3166 5.1261 0.9154 11.0814
NCI-H2373 GDSC1 2.3367 4.6359 1.1772 8.9681
HCC78 GDSC1 2.3374 4.1813 1.4051 7.174
COR-L279 GDSC1 2.3413 4.0021 1.4979 6.4286
NCI-H1435 GDSC1; CTRP1 2.3419 3.943 2.3077 25.4662
NCI-H526 GDSC1 2.3668 6.9346 0.0529 17.1969
NCI-H596 GDSC1; CTRP1 2.3672 5.7054 1.9225 27.2202
NCI-H1341 GDSC1 2.38 5.0515 1.0052 10.1556
SBC-5 GDSC1 2.3803 5.3527 0.8549 11.3169
DMS 273 GDSC1 2.3853 4.394 1.3382 7.5303
Lu-99A GDSC1 2.4213 4.6417 1.2438 8.1458
IA-LM GDSC1 2.47 4.8667 1.1707 8.5496
NCI-H2595 GDSC1 2.4863 6.771 0.2328 15.5227
BEN GDSC1; GDSC2 2.4901 7.0885 0.7073 18.8775
NCI-H69 GDSC1 2.4927 5.3438 0.9508 10.1809
NCI-H64 GDSC1 2.5032 4.9269 1.1673 8.4625
NCI-H2286 CTRP1 2.5219 4.9958 2.3072 37.5445
COR-L51 CTRP1 2.5262 9.7798 0.3579 43.3281
SBC-1 GDSC1; GDSC2 2.5383 5.0337 1.7493 12.4932
SW1573 GDSC1 2.5657 4.8177 1.2709 7.4428
NCI-H226 GDSC1 2.5748 6.5259 0.4268 13.8286
NCI-H1581 GDSC1 2.6166 10.5326 -1.5405 25.1178
NCI-H187 GDSC1 2.6343 5.4175 1.0262 9.12
Calu-3 GDSC1 2.6402 5.5392 0.9702 9.5323
COLO 668 GDSC1; CTRP1 2.6448 6.1055 2.0794 25.2778
LOU-NH91 GDSC1 2.6467 4.4366 1.5215 5.229
NCI-H1944 GDSC1 2.6579 4.6861 1.4068 6.0867
LC-1/sq GDSC1 2.6614 5.3502 1.0806 8.6106
NCI-H1693 GDSC1 2.6818 5.0384 1.2507 7.2255
NCI-H2461 GDSC1 2.6834 5.1675 1.188 7.7077
NCI-H82 GDSC1 2.7153 7.6373 -0.0155 16.4054
COR-L321 GDSC1; GDSC2 2.7329 6.3394 1.298 14.5817
NCI-H748 GDSC2 2.7549 5.48 1.7403 11.7884
NCI-H1436 GDSC1; GDSC2 2.767 4.6261 2.1646 9.1185
NCI-H2818 GDSC1 2.7676 5.1924 1.239 7.0495
HCC2108 CTRP1 2.7736 8.1426 1.3577 39.4716
NCI-H2722 GDSC1 2.8311 4.4679 1.6379 3.8054
NCI-H1105 GDSC1; GDSC2; CTRP1 2.8386 6.0819 2.2958 21.4845
NCI-H1650 GDSC1 2.8421 4.8361 1.4676 5.0704
NCI-H513 GDSC1 2.8422 7.5028 0.1512 14.8525
NCI-H2369 GDSC1 2.8669 4.6976 1.5519 4.3599
Ms-1 GDSC1 2.868 5.5471 1.1387 7.5167
NCI-H727 GDSC1 2.8726 10.7985 -1.4667 23.9161
NCI-H2122 GDSC1; CTRP1 2.8843 5.4038 2.5833 21.7404
NCI-H2227 GDSC1; GDSC2 2.9132 5.7813 1.737 11.2813
DMS 114 GDSC1 2.9447 6.2632 0.8432 9.5296
COR-L88 GDSC1 2.9512 6.9018 0.5329 11.8038
NCI-H1437 GDSC1; GDSC2 2.9936 8.6041 0.4024 18.8802
NCI-H3255 GDSC1; GDSC2; CTRP1 3.0004 6.3434 2.3664 20.5572
NCI-H1651 GDSC1 3.0158 5.3 1.364 5.378
NCI-H835 GDSC1 3.0531 6.1691 0.9685 8.2623
RERF-LC-MS GDSC1; GDSC2 3.0659 7.6131 0.9594 15.5298
NCI-H1838 GDSC1 3.0927 6.1849 0.989 7.993
NCI-H3122 GDSC1 3.139 5.602 1.3027 5.5115
NCI-H841 GDSC1; CTRP1 3.1454 7.7856 1.8945 24.1979
NCI-H1688 GDSC1 3.1684 5.5965 1.325 5.2687
COR-L105 GDSC1 3.182 5.6236 1.3211 5.2633
NCI-H1648 GDSC1 3.1825 8.0616 0.1339 13.8707
HCC366 GDSC1; GDSC2 3.2016 5.8938 1.9344 9.1375
NCI-H2087 GDSC1 3.2641 5.8023 1.2904 5.283
RERF-LC-KJ GDSC1; CTRP1 3.3142 5.5555 2.9993 17.8271
NCI-H146 GDSC1; GDSC2 3.3162 6.6511 1.6525 10.5649
NCI-H1770 GDSC1; GDSC2 3.3655 7.2891 1.3745 12.1378
NCI-H1092 GDSC1 3.388 9.5667 -0.4549 16.9578
NCI-H522 GDSC1 3.4031 8.9737 -0.1515 15.0545
NCI-H1563 GDSC1 3.4571 5.7766 1.424 3.8711
SK-LU-1 GDSC1; CTRP1 3.4597 7.6811 2.2571 21.2041
NCI-H1623 GDSC1 3.4861 5.7756 1.4418 3.685
HCC33 GDSC2 3.49 7.9188 1.1621 13.0621
Calu-6 GDSC1 3.511 5.3351 1.6529 2.2214
NCI-H250 GDSC2 3.5451 7.2697 1.5308 10.6664
NCI-H1304 GDSC1 3.5456 5.4821 1.6074 2.4534
NCI-H1836 GDSC1; GDSC2; CTRP1 3.6013 7.299 2.574 17.4725
NCI-H2803 GDSC2 3.7052 10.6353 -0.0205 18.9062
NCI-H1930 CTRP1 3.7089 4.5196 3.6904 19.4179
NCI-H2135 GDSC1; GDSC2 3.713 6.1761 2.2062 6.0041
RERF-LC-Sq1 GDSC1 3.7145 6.4499 1.2706 4.3916
NCI-H2066 GDSC1 3.7304 5.4797 1.705 1.5663
NCI-H1781 GDSC1; CTRP1 3.7432 6.2623 3.1797 15.1942
NCI-H1915 GDSC1; CTRP1 3.7812 6.2706 3.2155 14.8576
IST-SL2 GDSC1; GDSC2 3.7845 7.4864 1.6115 9.5224
NCI-H2810 GDSC1; GDSC2 3.8579 10.647 0.0959 17.9
EKVX GDSC1; GDSC2 3.8617 9.0545 0.8922 13.6077
NCI-H1355 GDSC1 3.8763 9.1097 0.1199 11.9453
CAL-12T GDSC1; GDSC2; CTRP1 3.9049 10.2112 1.4674 21.81
DMS 53 GDSC1 3.9381 6.2911 1.4674 2.6719
NCI-H1734 GDSC2 3.9667 6.8399 2.067 6.2516
NCI-H1573 GDSC1 3.9683 5.9538 1.6253 1.6929
NCI-H196 GDSC1 3.9898 5.1875 1.9315 0.3123
NCI-H2869 GDSC1; GDSC2 4.0172 6.7264 2.1586 5.5711
NCI-H2228 GDSC1 4.0355 10.5459 -0.4643 15.1194
NCI-H1666 GDSC1 4.0426 7.5187 0.979 5.701
ChaGo-K-1 GDSC1; GDSC2 4.122 8.5112 1.3601 10.1888
NCI-H2030 GDSC1; GDSC2; CTRP1 4.1338 8.6196 2.459 16.4011
T3M-10 CTRP1 4.1656 7.2647 3.1451 21.0776
NCI-H1793 GDSC1 4.248 7.4373 1.135 4.2498
NCI-H345 GDSC1; GDSC2 4.2547 7.7707 1.8188 7.1052
HCC1833 CTRP1 4.2817 9.0206 2.3981 25.7318
NCI-H740 GDSC2 4.2864 8.3813 1.544 8.6906
NCI-H2444 GDSC1; GDSC2 4.3361 7.6697 1.9242 6.2888
NCI-H2029 GDSC1; GDSC2 4.3461 11.4121 0.0954 16.5963
SHP-77 GDSC1 4.3461 5.5942 1.9202 0.1984
Sq-1 CTRP1 4.3718 6.0735 3.9065 13.6281
COR-L95 GDSC1 4.4733 6.1793 1.7598 0.5894
NCI-H441 GDSC1; CTRP1 4.4771 7.407 3.3707 11.6043
HCC827 GDSC1; CTRP1 4.48 7.3752 3.3889 11.4902
HCC4006 CTRP1 4.4814 7.4189 3.3688 17.6491
NCI-H2342 GDSC1; CTRP1 4.4866 9.0396 2.5735 16.0837
DMS 79 GDSC1; GDSC2 4.5345 6.9168 2.4063 3.0763
COR-L23 GDSC1; CTRP1 4.5442 6.495 3.877 8.471
HCC1195 CTRP1 4.5616 5.0849 4.5088 7.5021
Lu-165 GDSC1 4.5625 6.182 1.7936 0.4306
NCI-H2804 GDSC1; GDSC2 4.5734 15.2152 -1.6166 23.24
NCI-H2141 GDSC1; CTRP1 4.5774 7.0362 3.645 9.7047
NCI-H2291 GDSC1; GDSC2 4.617 7.9701 1.9682 5.4467
NCI-H2591 GDSC1 4.629 17.388 -3.3855 25.952
NCI-H358 GDSC1 4.6341 6.7698 1.6042 1.0764
PaCa-3 GDSC1 4.66 7.4796 1.3327 2.3993
HCC1359 CTRP1 4.6632 5.4246 4.4921 7.0246
HCC2935 CTRP1 4.6808 5.9135 4.2865 8.7023
NCI-H2196 GDSC2 4.6984 6.8901 2.5123 2.2462
NCI-H2023 GDSC1; CTRP1 4.7031 6.3873 4.079 6.7956
Lu-65 GDSC1 4.9775 6.7139 1.7606 0.3372
COLO 699 CTRP1 4.9896 10.9362 2.0623 24.4211
NCI-H1993 GDSC1 5.0173 6.7832 1.7509 0.3452
NCI-H2172 GDSC1; GDSC2; CTRP1 5.0416 9.453 2.8474 11.9158
NCI-H520 GDSC1 5.2653 6.8024 1.8318 0.1292
NCI-H322M GDSC1 5.3368 14.9535 -1.6923 18.0143
COR-L303 GDSC2 5.6386 7.1469 2.8345 0.2318
NCI-H2110 GDSC1; GDSC2; CTRP1 5.8944 14.0327 1.2479 17.5157
COR-L32 GDSC2 5.9038 7.8125 2.6978 0.4353
NCI-H460 GDSC1; GDSC2; CTRP1 6.1517 11.2703 2.8102 9.5902
⏷ Show the Full List of 198 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Lymphoma Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CBTCi002-A GDSC1 5.2557 6.995 1.7636 0.2401
Cancer Drug Sensitivity Data Curated from 24 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TE-8 GDSC1 0.8771 2.1756 0.7826 18.6746
TE-11 GDSC1; GDSC2 0.9984 5.4268 0.0119 28.4153
KYSE-150 GDSC1 1.2876 3.0535 0.9343 15.3766
T.T GDSC1 1.4111 3.6243 0.8137 15.6539
OE21 GDSC1 1.7058 6.8937 -0.4958 23.293
TE-15 GDSC1 1.9258 3.8018 1.2306 10.1564
KYSE-140 GDSC1 1.9403 5.0911 0.6077 14.8801
KYSE-410 GDSC1 2.0508 4.8934 0.8038 12.9516
EC-GI-10 GDSC1 2.0677 5.1645 0.6836 13.7996
KYSE-270 GDSC1 2.0721 4.3249 1.1053 10.5329
KYSE-180 GDSC1 2.2848 10.0519 -1.5741 26.444
TE-1 GDSC1 2.3704 3.9838 1.531 6.0639
TE-9 GDSC1 2.5063 11.4079 -2.0683 27.6554
OE33 GDSC1 2.5221 3.8752 1.7052 4.1858
TE-4 GDSC1 2.5847 6.2056 0.5945 12.5652
TE-5 GDSC1 2.5933 4.229 1.584 4.9076
COLO 680N GDSC1 2.7439 5.0319 1.3005 6.6466
TE-10 GDSC1; GDSC2 2.8361 6.4403 1.3414 13.9764
KYSE-520 GDSC1 2.8409 8.5756 -0.3837 18.3071
TE-6 GDSC1 2.9789 7.3523 0.3311 13.1578
KYSE-450 GDSC1 3.1132 5.104 1.5221 3.9512
OE19 GDSC1 3.46 5.7682 1.4296 3.8255
KYSE-70 GDSC1 5.0263 6.8282 1.7385 0.3721
KYSE-510 GDSC1; GDSC2 8.2067 18.4567 -0.6657 12.1803
⏷ Show the Full List of 24 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 40 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TOV-21G GDSC1 -0.6488 1.4939 -0.7374 37.6305
OVTOKO GDSC1 0.6663 2.7524 0.3816 22.5926
DOV13 GDSC1 1.1248 2.5493 0.947 16.1513
OVCAR-5 GDSC1 1.1556 4.2667 0.2636 20.8769
TOV-112D GDSC1 1.4286 5.4337 -0.0293 21.5964
Caov-3 GDSC2; CTRP1 1.5476 2.838 1.5446 30.0189
OV56 GDSC1 1.8954 4.2188 0.9982 12.0842
JHOS-2 GDSC1; GDSC2 1.995 4.6034 1.3976 16.678
OC 314 GDSC1 2.0025 3.4864 1.4559 8.0818
OVCAR-4 GDSC1; CTRP1 2.0067 4.8102 1.7925 29.4376
ES-2 GDSC1 2.024 3.6238 1.4086 8.3599
OVKATE GDSC1; CTRP1 2.314 5.3276 1.9858 27.1467
EFO-21 GDSC1 2.4011 4.4604 1.3179 7.6338
OVCAR-8 GDSC1; CTRP1 2.4169 6.1936 1.8021 27.5808
SK-OV-3 GDSC1 2.5634 5.5667 0.8962 10.359
OV-90 GDSC1; CTRP1 2.6072 6.3801 1.9343 26.1447
OVCAR-3 GDSC1 2.6769 4.8007 1.3645 6.357
A2780 GDSC1; CTRP1 2.8905 6.7841 2.0706 24.3206
Kuramochi GDSC1 2.9915 5.0951 1.4459 4.8263
JHOS-4 GDSC1; GDSC2; CTRP1 3.202 5.0245 3.0417 16.5862
COV644 CTRP1 3.5477 6.3307 2.9472 26.1458
OVMANA CTRP1 3.5782 6.3881 2.9547 25.8992
TYK-nu GDSC1; CTRP1 3.5965 6.2488 3.0325 16.5455
OAW28 GDSC1 4.0339 9.0631 0.2492 10.6799
JHOM-1 CTRP1 4.0872 9.0172 2.2212 27.7924
RMUG-S CTRP1 4.1539 8.64 2.4677 25.9541
RMG-I GDSC1; CTRP1 4.2289 6.4839 3.5751 11.2509
FU-OV-1 GDSC1 4.2625 6.7927 1.4216 2.4458
OV7 CTRP1 4.267 6.9105 3.4119 18.385
COV434 CTRP1 4.3565 9.8782 2.0415 27.4349
Caov-4 GDSC1 4.3893 6.6273 1.5512 1.5706
OVK18 GDSC1; GDSC2; CTRP1 4.5571 11.4967 1.4128 20.1696
COV362 CTRP1 4.8115 7.2455 3.7532 12.799
COV318 CTRP1 4.8158 7.5602 3.6003 14.1083
JHOC-5 CTRP1 4.8987 8.1366 3.3846 15.5648
EFO-27 GDSC1; GDSC2; CTRP1 5.2799 8.477 3.5303 7.7067
IGROV-1 GDSC1; CTRP1 5.3899 10.6208 2.5487 13.6698
OAW42 GDSC1; CTRP1 5.3947 8.7974 3.4616 8.5072
OVISE GDSC1 5.4289 13.0681 -0.7351 13.1606
SNU-840 CTRP1 5.9809 12.3756 2.1377 20.1046
⏷ Show the Full List of 40 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 31 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MIA PaCa-2 GDSC1 1.0451 2.975 0.7083 18.2608
SW1990 GDSC1 1.0719 3.5752 0.4893 19.6891
PSN1 GDSC1 1.2973 3.1675 0.8972 15.5963
HPAC GDSC1 1.3409 4.835 0.1768 20.6021
KP-4 GDSC1 1.5442 2.4572 1.4327 10.4654
KP-2 GDSC1 1.8752 3.4366 1.3593 9.3812
Panc 03.27 GDSC1 1.9914 3.4811 1.4482 8.1891
KP-1N GDSC1 2.0482 3.8491 1.3197 8.9542
Panc 08.13 GDSC1 2.327 6.3646 0.3048 15.5975
SUIT-2 GDSC1 2.3423 4.61 1.1948 8.8101
PaTu 8988t GDSC1 2.3672 9.4982 -1.2286 24.572
DAN-G GDSC1 2.3727 4.6292 1.2103 8.5795
HuP-T4 GDSC1 2.3883 4.389 1.3431 7.4807
Panc 02.03 GDSC1 2.4051 4.5763 1.2633 8.0492
KP-3 GDSC1 2.4356 4.6763 1.238 8.141
HuP-T3 GDSC1 2.46 4.6925 1.2497 7.9652
BxPC-3 GDSC1 2.6387 5.5417 0.9678 9.5552
Hs 766T GDSC1 2.6662 5.0354 1.2404 7.3558
PL4 GDSC1 2.778 5.0292 1.327 6.3385
SU.86.86 GDSC1 2.7985 4.4854 1.607 4.1284
CFPAC-1 GDSC1 2.9714 4.275 1.8189 2.141
Capan-2 GDSC1 3.0135 5.7163 1.1609 6.9221
AsPC-1 GDSC1 3.2361 5.6114 1.3624 4.8231
YAPC GDSC1 3.6018 9.9003 -0.4608 16.3431
Panc 04.03 GDSC1 3.7641 6.142 1.4377 3.1646
Panc 10.05 GDSC1 3.7859 7.3261 0.9093 6.7644
PaTu 8902 GDSC1; CTRP1 3.8966 6.1643 3.3807 13.5235
QGP-1 GDSC1; GDSC2 3.9744 6.2137 2.377 4.3305
Capan-1 GDSC1 4.2915 6.1867 1.6812 1.0465
HPAF-II GDSC1 4.7808 6.6864 1.6957 0.6184
MZ-PC-1 GDSC1; GDSC2 5.0817 8.2714 2.1143 3.7902
⏷ Show the Full List of 31 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 6 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H28 GDSC1 1.3695 4.5955 0.3188 19.4729
NCI-H2452 GDSC1 2.1035 4.3814 1.1049 10.4125
MSTO-211H GDSC1 2.4018 4.8784 1.1096 9.2646
NCI-H2052 GDSC1 2.7022 4.1706 1.6921 3.7477
MPP 89 GDSC1 3.2393 7.1064 0.6445 10.1159
IST-Mes1 GDSC1 3.6404 5.6252 1.5965 2.3588
⏷ Show the Full List of 6 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 7 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
PC-3 GDSC1 1.7464 4.4379 0.7529 14.594
PaCa-3 CTRP1 2.8313 6.3686 2.1771 35.8077
VCaP GDSC1 2.9831 6.192 0.9065 8.9366
LNCaP clone FGC GDSC1 3.067 5.5347 1.2861 5.8271
22Rv1 GDSC1 3.2233 6.7422 0.8105 8.9478
NCI-H660 GDSC2 4.092 6.3821 2.3762 4.084
DU145 GDSC1 4.9722 6.6058 1.7961 0.2594
⏷ Show the Full List of 7 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-253 GDSC1 2.5061 4.5308 1.367 6.8888
Cancer Drug Sensitivity Data Curated from 58 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
LOX-IMVI GDSC1 0.6705 2.8758 0.3429 22.8342
CHL-1 GDSC1 0.9646 3.8678 0.2511 21.9126
A2058 GDSC1 1.2199 2.4249 1.0896 14.6383
Hs 940.T GDSC1; GDSC2 1.2255 3.318 1.0352 22.0378
WM35 GDSC1 1.2691 2.8465 0.9968 15.0222
COLO 800 GDSC1; GDSC2 1.2766 5.1881 0.4025 25.2363
A-431 GDSC1; GDSC2 1.3757 4.7624 0.6846 23.2989
RPMI-7951 GDSC1 1.5219 3.6235 0.9249 14.2981
A101D GDSC1 1.659 5.2784 0.2604 18.5915
IGR-37 GDSC1 1.8113 4.4824 0.7913 14.0254
WM115 GDSC1 1.8385 5.5278 0.3002 17.5488
Mel JuSo GDSC1 1.8571 4.7229 0.715 14.4131
G-mel GDSC1; GDSC2 1.9274 3.9587 1.5887 15.8475
M14 GDSC1 1.9298 3.948 1.1628 10.6657
WM793 GDSC1 1.9519 3.5209 1.3918 8.7954
SK-MEL-2 GDSC1 1.9595 4.5756 0.8804 12.7288
CP50-MEL-B GDSC1; GDSC2 2.2128 4.4833 1.6744 14.1774
IGR-1 GDSC1 2.278 5.6577 0.6173 13.4951
MZ-MEL-2 GDSC1; GDSC2 2.2872 4.8196 1.6002 14.3321
WM1552C GDSC1 2.2884 4.072 1.4188 7.2441
UACC-62 GDSC1 2.425 4.3654 1.3848 7.0247
IST-MEL1 GDSC1 2.4326 5.0053 1.0713 9.4557
WM278 GDSC1 2.4463 5.8344 0.6682 12.4997
G-361 GDSC1 2.4678 3.56 1.8198 3.4622
Mel Ho GDSC1; GDSC2 2.5195 6.4868 1.0295 16.9164
HMV-II GDSC1 2.5581 4.1264 1.6081 4.8299
COLO 679 GDSC1 2.5687 4.3015 1.5295 5.4106
Hs 852.T CTRP1 2.6375 6.7902 1.8026 38.9118
COLO 829 GDSC1 2.6475 5.5207 0.9851 9.3938
SH-4 GDSC1 2.6866 5.0974 1.2251 7.4093
HT-144 GDSC1 2.7 6.0712 0.7523 10.9947
MeWo GDSC1 2.8461 5.5128 1.1394 7.5773
A-375 GDSC1; GDSC2; CTRP1 2.9913 7.0749 2.0522 22.0942
SK-MEL-24 GDSC1 3.0566 4.8717 1.595 3.5542
GAK GDSC1 3.1283 5.9351 1.1352 6.7943
COLO 792 GDSC1 3.1839 5.4289 1.4147 4.5673
UACC-257 GDSC1 3.2602 6.2135 1.0916 6.7633
DJM-1 GDSC1; GDSC2 3.336 8.8884 0.5505 17.0224
A-388 GDSC1; GDSC2 3.4413 6.7195 1.7216 9.7736
VMRC-MELG GDSC2 3.4866 5.3463 2.4435 5.1012
451Lu GDSC1; GDSC2 3.8484 7.5448 1.6316 9.2333
LB2518-MEL GDSC1; GDSC2 3.8712 5.5518 2.6249 3.0487
WT2-iPS GDSC1; GDSC2 3.89 8.4903 1.1946 11.7685
IPC-298 GDSC1; GDSC2 3.9857 7.4855 1.7641 8.0729
Hs 938.T GDSC1; GDSC2 4.0667 7.791 1.6736 8.4299
SK-MEL-3 GDSC1; GDSC2 4.2078 6.6248 2.3376 4.078
SK-MEL-30 GDSC1; GDSC2 4.4657 8.8367 1.4499 8.8372
MMAc-SF GDSC1; GDSC2 4.56 6.4661 2.6223 1.8726
SK-MEL-31 GDSC1; GDSC2 4.8232 8.8495 1.6868 6.6797
RVH-421 GDSC1; GDSC2 4.839 8.5066 1.8585 5.6547
SK-MEL-5 GDSC1; GDSC2; CTRP1 4.9899 9.9674 2.5469 13.602
COLO 783 GDSC1; GDSC2 5.0394 6.7876 2.7257 0.8727
LB373-MEL-D GDSC1; GDSC2 5.5265 6.8198 2.907 0.1379
CP66-MEL GDSC1; GDSC2 5.5552 7.1878 2.7887 0.3603
MZ-MEL-7 GDSC1; GDSC2 5.673 7.3289 2.7831 0.3269
SK-MEL-1 GDSC1; CTRP1 6.2089 12.1041 2.4427 12.2392
SK-MEL-28 GDSC1; GDSC2; CTRP1 7.3994 14.5444 2.0964 10.655
EquiPSC Line K2 GDSC1; GDSC2 5.0228 7.7469 2.3146 2.8112
⏷ Show the Full List of 58 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Small Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuTu 80 GDSC1; GDSC2 -0.5736 2.4046 -0.7186 39.6856
Cancer Drug Sensitivity Data Curated from 23 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Hs 633.T GDSC1 -0.4072 2.0077 -0.5769 35.102
SW982 GDSC1 0.0285 1.9402 -0.088 29.4054
VA-ES-BJ GDSC1 0.0758 1.7306 0.0031 28.5378
A-204 GDSC1 0.1125 3.8423 -0.625 32.0352
G-402 GDSC1 0.7062 2.8363 0.3955 22.277
EW-8 GDSC1 0.8396 2.3377 0.6999 19.4464
SK-UT-1 GDSC1 1.1403 4.2647 0.2493 21.0506
SW872 GDSC1 1.2451 3.2487 0.8086 16.5064
SK-LMS-1 GDSC1 1.3197 3.6469 0.7111 16.8523
G-401 GDSC1 1.3883 4.1575 0.5444 17.7543
MES-SA GDSC1 1.3987 4.1208 0.5718 17.5038
KYM-1 GDSC1 1.6644 2.5681 1.5247 9.1658
Rh30 GDSC1 1.9915 4.7789 0.8082 13.1539
RD GDSC1 2.015 5.2495 0.5951 14.6742
STS-0421 GDSC1; GDSC2 2.095 5.5703 1.0627 18.2595
MFH-ino GDSC1 2.1135 3.7523 1.4264 7.8558
Rh41 GDSC1 2.1431 9.2215 -1.278 25.6409
GCT GDSC1 2.3059 3.9154 1.5118 6.4474
HT-1080 GDSC1; CTRP1 2.4055 5.5098 2.0286 26.5413
SW684 GDSC1 2.6404 4.7825 1.346 6.6155
Rh18 GDSC1 2.7303 5.8647 0.8783 9.9409
RKN GDSC1; CTRP1 3.6944 7.5738 2.5395 18.8694
TE 441.T GDSC2 4.0597 8.6424 1.2487 11.008
⏷ Show the Full List of 23 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 30 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HSC-39 GDSC1 0.2847 1.545 0.2527 25.6683
HGC-27 GDSC1 0.6698 1.4573 0.6627 20.696
ECC10 GDSC1 0.7274 3.0621 0.3356 22.5731
KATO III GDSC1 0.9407 2.7042 0.6953 18.9134
SNU-16 GDSC1 1.487 3.7627 0.8259 15.2042
AGS GDSC1; CTRP1 1.604 5.8761 1.0374 34.585
Fu97 GDSC1 1.8873 5.1771 0.5177 15.7669
MKN1 GDSC1 1.9827 3.2279 1.5625 7.3431
Hs 746.T GDSC1 2.0052 4.2446 1.0854 10.9565
SK-GT-2 GDSC1 2.0225 5.3018 0.5756 14.7897
OCUM-1 GDSC1 2.2483 5.1041 0.8691 11.691
GCIY GDSC1 2.4023 4.2646 1.4167 6.8528
TMK-1 GDSC1; GDSC2 2.4924 5.1317 1.6582 13.2164
SNU-1 GDSC1 2.527 5.5263 0.8872 10.5522
23132/87 GDSC1 2.6099 4.0332 1.6928 4.011
SCH GDSC1; GDSC2 2.6556 6.2113 1.2902 14.8897
MKN45 GDSC1 2.6581 3.9536 1.7664 3.3034
MKN28 GDSC1 2.737 4.9448 1.3383 6.3751
TGBC11TKB GDSC1 2.7981 5.3921 1.1634 7.5395
SNU-5 GDSC1 2.7984 4.3294 1.6822 3.5583
NUGC-4 GDSC1 3.1139 5.5457 1.3128 5.5016
RF-48 GDSC1 3.2387 5.997 1.1809 6.1575
NUGC-3 GDSC1 3.2473 5.1962 1.5632 3.3456
ECC12 GDSC2 3.9491 10.5797 0.2015 17.115
MKN74 CTRP1 4.0271 7.1588 3.0609 22.4806
RERF-GC-1B GDSC1 4.2252 7.7091 1.0005 5.1783
IM95 GDSC1 4.3766 6.8813 1.4415 2.1728
NCI-N87 GDSC1 4.5883 6.7149 1.6056 1.1106
MKN7 GDSC1; GDSC2 4.9403 14.2548 -0.8614 19.4557
SNG-M GDSC1; CTRP1 3.3841 5.5733 3.0687 17.1816
⏷ Show the Full List of 30 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CGTH-W-1 GDSC1 -0.609 1.7562 -0.7419 37.3722
IHH-4 GDSC1 0.5728 2.1344 0.4607 22.5909
BHT-101 GDSC1 0.7149 2.7788 0.4251 22.0256
TT2609-C02 GDSC1 0.819 3.402 0.2985 22.3387
B-CPAP GDSC1 0.978 2.6318 0.7603 18.2563
CAL-62 GDSC1 1.2759 2.5295 1.1177 14.1323
KMH-2 GDSC1; GDSC2 1.4035 3.9597 1.025 21.2928
FTC-133 GDSC1 1.5337 3.4211 1.0293 13.4592
K5 GDSC1 1.6615 2.8132 1.426 9.8909
8305C GDSC1 1.8513 5.3366 0.4064 16.7311
WRO GDSC1 1.944 4.744 0.7831 13.5374
8505C GDSC1 1.964 4.0623 1.138 10.7163
ASH-3 GDSC1 2.0487 3.4659 1.5089 7.4752
HTC-C3 GDSC1 2.3199 3.6461 1.6582 5.2424
ML-1 [Human leukemia] GDSC1; GDSC2 2.3652 8.0054 0.1418 22.3412
TT GDSC1 3.3945 7.3673 0.6276 9.7932
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 40 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
BICR 22 GDSC1 0.1286 2.8326 -0.2284 29.6728
HO-1-N-1 GDSC1 0.1828 4.8687 -0.9905 33.4131
PCI-06A GDSC1; GDSC2 0.2687 1.3115 0.2671 30.6474
HSC-3 GDSC1 0.7153 2.9725 0.3561 22.4978
PCI-04B GDSC1; GDSC2 0.9713 4.255 0.4526 26.3241
Ca9-22 GDSC1 1.1282 3.1107 0.7429 17.5788
OSC-20 GDSC1 1.1311 4.3824 0.1857 21.5378
Detroit 562 GDSC1 1.2176 3.196 0.802 16.6934
BICR 78 GDSC1 1.2499 3.1773 0.8435 16.2275
OSC-19 GDSC1; GDSC2 1.3667 5.1069 0.5307 24.1718
JHU-011 GDSC1; GDSC2 1.4258 5.0432 0.6192 23.4433
JHU-022 GDSC1 1.4457 5.0841 0.1565 20.2618
PCI-38 GDSC1 1.5113 6.1729 -0.3148 23.0493
KOSC-2 GDSC1; GDSC2 1.6258 3.9823 1.2562 19.0294
DOK GDSC1 1.7467 3.7566 1.0827 12.074
CAL-33 GDSC1 1.935 3.6201 1.3277 9.3644
KON GDSC1; GDSC2 1.9447 5.4205 0.9823 19.3033
PCI-30 GDSC1 1.9741 5.6336 0.368 16.5087
BICR 10 GDSC1 2.079 4.2402 1.1535 10.1292
NCI-H3118 GDSC1 2.1881 3.9953 1.3713 7.996
FaDu GDSC1 2.226 3.5725 1.615 5.9328
SAT [Human HNSCC] GDSC1 2.2297 9.1632 -1.1759 24.8278
CAL-27 GDSC1 2.2554 4.2123 1.3208 8.1382
BB49-HNC GDSC1 2.3058 6.4008 0.269 15.9298
SKN-3 GDSC1 2.3675 4.9932 1.0241 10.054
SCC-9 GDSC1; CTRP1 2.8017 6.1458 2.2321 23.8676
HO-1-u-1 GDSC1 2.8237 5.488 1.1351 7.6783
HSC-2 GDSC1 2.8313 5.9428 0.9165 9.3275
SCC-15 GDSC1 2.8586 22.9634 -7.555 38.0315
SCC-4 GDSC1 2.8624 6.0225 0.9005 9.3516
BICR 31 GDSC2 3.0009 4.9543 2.2249 7.9391
BHY GDSC1; GDSC2 3.0487 7.7858 0.8584 16.1707
BB30-HNC GDSC1; GDSC2 3.1636 5.262 2.217 7.4697
UPCI-SCC-090 GDSC1 3.3814 5.9149 1.313 4.8333
PCI-15A GDSC1; GDSC2 3.8137 5.5661 2.5786 3.4542
PE/CA-PJ15 GDSC1; GDSC2 3.9464 8.3 1.3322 10.8004
JHU-029 GDSC1; GDSC2 4.0417 6.6799 2.1984 5.272
LB771-HNC GDSC1 4.0665 6.4276 1.476 2.4163
SCC-25 GDSC1; GDSC2 4.6487 8.173 1.893 5.8245
SAS GDSC1 5.2518 7.249 1.674 0.4436
⏷ Show the Full List of 40 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
BFTC-905 GDSC1 0.295 1.5125 0.2671 25.5131
CAL-29 GDSC1 1.0262 3.9035 0.2982 21.2731
5637 GDSC1 1.0493 4.7107 -0.048 23.511
SW1710 GDSC1 1.2336 2.7586 0.9917 15.2463
SW780 GDSC1 1.2876 3.1894 0.8778 15.7871
UM-UC-3 GDSC1 1.7131 3.0781 1.3652 10.0853
RT-112 GDSC1 1.7964 5.1752 0.4367 16.7396
KU-19-19 GDSC1 2.3177 3.9459 1.5064 6.447
639V GDSC1 2.4437 4.758 1.2038 8.3815
TCCSUP GDSC1 2.4827 4.5354 1.3462 7.1308
HT-1376 GDSC1 2.8771 5.8883 0.9776 8.7206
J82 GDSC1 3.0225 4.7268 1.6412 3.2982
647V GDSC1 3.3119 5.5824 1.4243 4.1924
T24 GDSC1; GDSC2 3.7498 5.9554 2.3425 5.0621
HT-1197 GDSC1 4.0498 5.5366 1.8271 0.6338
RT-4 GDSC1 4.0523 5.672 1.7765 0.8416
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 38 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
PA-1 GDSC1 0.0117 1.4526 -0.0259 29.1145
SKN GDSC1 0.0293 2.754 -0.3101 30.769
NT2-D1 GDSC1 0.1711 1.8179 0.0905 27.3988
HEY GDSC1 0.3714 3.0012 -0.0244 26.9641
TC-YIK GDSC1 0.8247 2.4997 0.6362 19.9642
ACC-OV7 GDSC1; GDSC2 1.028 6.1455 -0.2713 29.5849
PWR-1E GDSC1 1.0931 2.4219 0.9523 16.2914
KGN GDSC1 1.1126 3.0061 0.768 17.4803
BPH-1 GDSC1 1.2413 3.2818 0.7906 16.6566
SW962 GDSC1; GDSC2 1.588 6.2208 0.2583 24.6845
JAR GDSC1; GDSC2 1.7006 3.5688 1.4795 17.4511
HEC-1 GDSC1 1.707 5.535 0.178 18.9634
DoTc2 4510 GDSC1 1.8154 3.9938 1.0338 12.1488
ME-180 GDSC1 1.8493 4.4255 0.8543 13.3847
OVCA433 GDSC1; GDSC2 1.9454 5.7184 0.8458 20.0842
JEG-3 GDSC1; GDSC2 1.9469 5.8969 0.7642 20.5409
CAL-39 GDSC1 2.0699 4.075 1.2274 9.5876
SW954 GDSC1; GDSC2 2.2166 4.5561 1.6465 14.3287
SiSo GDSC1 2.2622 4.8592 1.0032 10.601
HeLa GDSC1 2.3172 4.5767 1.1906 8.9345
NEC8 GDSC1 2.3838 6.4523 0.3081 15.364
LB831-BLC GDSC1 2.4152 5.3434 0.8882 10.9359
PEO1 GDSC1 2.4249 4.777 1.1791 8.6399
Ca Ski GDSC1 2.5685 5.4561 0.9553 9.8867
SKG-IIIa GDSC1 2.6075 4.4183 1.5012 5.5086
DSH1 GDSC1 2.6102 5.513 0.9598 9.7119
HT-3 GDSC1 2.6645 4.7603 1.3751 6.3125
SW756 GDSC1 2.7259 4.7606 1.4206 5.771
MS751 GDSC1 2.7571 5.8069 0.9274 9.4795
SiHa GDSC1 2.8064 4.349 1.6782 3.5673
C-4-I GDSC1 2.9703 4.8755 1.5367 4.2002
OVCA420 GDSC1 3.0607 4.6873 1.6836 2.9038
OV17R GDSC1; GDSC2 3.1767 6.2084 1.756 10.334
OVMIU GDSC1 3.7117 5.7446 1.5829 2.3247
UWB1.289 GDSC1; GDSC2 3.7516 6.8595 1.8973 7.8366
C-33 A GDSC1 3.9293 5.8439 1.6517 1.5984
OMC-1 [Human cervical carcinoma] GDSC1; GDSC2 4.1171 7.2185 1.99 6.376
JHOS-3 GDSC1; GDSC2 6.1334 7.8057 2.785 0.1877
⏷ Show the Full List of 38 Cancer Drug Sensitivity Data of This Drug

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8006).
2 Novel small molecule inhibitors of 3-phosphoinositide-dependent kinase-1. J Biol Chem. 2005 May 20;280(20):19867-74.
3 Expression of endogenous retroviruses reflects increased usage of atypical enhancers in T cells. EMBO J. 2019 Jun 17;38(12):e101107. doi: 10.15252/embj.2018101107. Epub 2019 May 8.
4 Hydroxychloroquine-inhibited dengue virus is associated with host defense machinery. J Interferon Cytokine Res. 2015 Mar;35(3):143-56. doi: 10.1089/jir.2014.0038. Epub 2014 Oct 16.