Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMSLE03)

Drug Name
PF-562271 Drug Info
Synonyms PF-00562271
Cross-matching ID
PubChem CID
11713159
ChEBI ID
CHEMBL1084546
CAS Number
CAS 717907-75-0
TTD Drug ID
D01SJT

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Rheumatoid arthritis 2.48 0.00e+0 78/93 (83.87%) CXCL8;CCL20;ATP6V0B;...
Phagosome 2.41 0.00e+0 118/152 (77.63%) ITGAV;ATP6V0B;HLA-F;...
Oxidative phosphorylation 2.33 0.00e+0 93/133 (69.92%) ATP6V0B;ATP6V0E2;NDUFA4L2;...
Lysosome 2.15 0.00e+0 115/128 (89.84%) ATP6V0B;GNPTAB;SORT1;...
Epithelial cell signaling in Helicobacter pylori infect... 2.09 0.00e+0 62/70 (88.57%) CXCL8;CDC42;ATP6V0B;...
Vibrio cholerae infection 2.07 0.00e+0 44/50 (88%) ATP6V0B;ATP6V0E2;ATP6V1D;...
Cell adhesion molecules 2.04 0.00e+0 118/148 (79.73%) SDC2;ITGAV;HLA-F;...
Viral myocarditis 2.02 0.00e+0 53/60 (88.33%) CXADR;SGCB;HLA-F;...
IL-17 signaling pathway 1.99 0.00e+0 84/94 (89.36%) CXCL8;CCL20;FOSB;...
ECM-receptor interaction 1.87 1.43e-3 80/88 (90.91%) ITGAV;SDC4;FN1;...
Collecting duct acid secretion 1.87 1.30e-3 22/27 (81.48%) ATP6V0E2;ATP6V1D;CA2;...
Other glycan degradation 1.79 1.19e-2 13/18 (72.22%) FUCA1;MAN2B1;HEXA;...
Proximal tubule bicarbonate reclamation 1.77 1.76e-2 21/23 (91.3%) ATP1B3;AQP1;CA2;...
Amoebiasis 1.76 1.73e-2 99/102 (97.06%) CXCL8;FN1;CXCL2;...
Viral protein interaction with cytokine and cytokine re... 1.76 1.62e-2 84/100 (84%) CXCL8;CCL20;CXCL14;...
Glycosaminoglycan degradation 1.74 2.05e-2 19/19 (100%) IDS;GNS;HEXA;...
Kaposi sarcoma-associated herpesvirus infection 1.74 1.93e-2 172/193 (89.12%) CXCL8;HLA-F;CDKN1A;...
Allograft rejection 1.73 1.98e-2 32/38 (84.21%) HLA-F;HLA-C;HLA-B;...
Type I diabetes mellitus 1.72 1.95e-2 38/43 (88.37%) HLA-F;CPE;HLA-C;...
Diabetic cardiomyopathy 1.72 1.85e-2 162/203 (79.8%) MMP9;NDUFA4L2;ATP5MC3;...
Chemokine signaling pathway 1.72 1.77e-2 163/192 (84.9%) CXCL8;CCL20;CXCL14;...
Retrograde endocannabinoid signaling 1.71 2.27e-2 118/148 (79.73%) NDUFA4L2;NDUFB8;NDUFB2;...
Leukocyte transendothelial migration 1.71 2.48e-2 90/114 (78.95%) MMP9;CDC42;RHOA;...
Graft-versus-host disease 1.70 2.38e-2 32/42 (76.19%) HLA-F;HLA-C;HLA-B;...
Nitrogen metabolism 1.70 2.34e-2 16/17 (94.12%) CA2;CA12;GLUD2;...
Circadian entrainment 1.68 2.69e-2 85/97 (87.63%) GUCY1A1;ITPR3;FOS;...
Endocrine and other factor-regulated calcium reabsorpti... 1.68 2.75e-2 49/53 (92.45%) ATP1B3;ESR1;RAB11A;...
Human papillomavirus infection 1.68 2.70e-2 284/331 (85.8%) CDC42;FZD6;ITGAV;...
TNF signaling pathway 1.67 2.66e-2 103/112 (91.96%) CCL20;MMP9;TNFAIP3;...
Pertussis 1.66 2.85e-2 64/76 (84.21%) CXCL8;RHOA;C3;...
RNA transport -1.68 4.45e-2 128/186 (68.82%) GEMIN4;EIF3A;FXR1;...
Ribosome biogenesis in eukaryotes -1.69 4.86e-2 52/108 (48.15%) NXF1;NOL6;REXO2;...
Nicotinate and nicotinamide metabolism -1.90 6.18e-3 25/35 (71.43%) SIRT4;NAMPT;NMRK1;...
Ribosome -1.90 8.24e-3 113/158 (71.52%) RPL22;RPS8;RPL4;...
Base excision repair -1.95 7.42e-3 29/33 (87.88%) MUTYH;PARP2;LIG3;...
DNA replication -2.11 0.00e+0 34/36 (94.44%) PRIM1;RPA2;MCM2;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SK-ES-1 CVCL_0627 Homo sapiens 1.11uM - 10uM 24H
Brain
Glioma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
GI-1 CVCL_1230 Homo sapiens 1.11uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 3H, 6H, 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 3H, 6H, 24H
MDA-MB-468 CVCL_0419 Homo sapiens 1.11uM - 3.33uM 24H
SK-BR-3 CVCL_0033 Homo sapiens 0.04uM - 10uM 3H, 6H, 24H
Breast carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BT-20 CVCL_0178 Homo sapiens 0.04uM - 10uM 3H, 6H, 24H
Hs 578T CVCL_0332 Homo sapiens 0.04uM - 10uM 3H, 6H, 24H
Breast ductal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
T-47D CVCL_0553 Homo sapiens 1.11uM - 10uM 24H
Normal (Epithelial)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HME1 CVCL_2950 Homo sapiens 0.04uM - 10uM 3H, 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 3H, 6H, 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 6H, 24H
SNU-407 CVCL_5004 Homo sapiens 1.11uM - 3.33uM 24H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 1.11uM - 10uM 24H
HEC-1-A CVCL_0293 Homo sapiens 1.11uM - 10uM 24H
HEC-251 CVCL_2928 Homo sapiens 1.11uM - 10uM 24H
HEC-265 CVCL_2929 Homo sapiens 1.11uM - 10uM 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
CJM CVCL_U797 Homo sapiens 1.11uM - 3.33uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.04uM - 10uM 6H, 24H
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHH-5 CVCL_1320 Homo sapiens 1.11uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 6H, 24H
NCI-H1573 CVCL_1483 Homo sapiens 1.11uM - 10uM 24H
NCI-H838 CVCL_1594 Homo sapiens 1.11uM - 10uM 24H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BEN CVCL_1081 Homo sapiens 1.11uM - 10uM 24H
HCC95 CVCL_1276 Homo sapiens 1.11uM - 10uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 0.04uM - 10uM 6H, 24H
NCI-H2110 CVCL_1529 Homo sapiens 1.11uM - 3.33uM 24H
Muscle
Rhabdomyosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-204 CVCL_0134 Homo sapiens 1.11uM - 3.33uM 24H
Ovary
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
OVTOKO CVCL_3114 Homo sapiens 1.11uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 3.33uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
22Rv1 CVCL_1045 Homo sapiens 1.11uM - 10uM 24H
LNCaP CVCL_0395 Homo sapiens 0.04uM - 10uM 3H, 24H
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 6H, 24H
IGR-37 CVCL_1303 Homo sapiens 1.11uM - 10uM 24H
Mel-HO CVCL_1402 Homo sapiens 1.11uM - 10uM 24H
SH-4 CVCL_1692 Homo sapiens 1.11uM - 10uM 24H
Urinary bladder
Bladder carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BC-3C CVCL_1079 Homo sapiens 1.11uM - 3.33uM 24H
Bladder transitional cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CAL-29 CVCL_1109 Homo sapiens 1.11uM - 10uM 24H