Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMSVOCZ)

Drug Name
Pantoprazole Drug Info
Synonyms
Astropan; Pantoprazol; Pantoprazolum; Pantoprozole; Pantor; Pantozol; Protium; Protonix; Somac; Pantoprazole Na; Pantoprazole Sodium; Protonix IV; BY 1023; Astropan (TN); BY-1023; Controloc (TN); Inipomp (TN); Pantecta (TN); Pantoloc (TN); Pantopan (TN); Pantoprazol [INN-Spanish]; Pantoprazolum [INN-Latin]; Pantor (TN); Pantotab (TN); Pantozol (TN); Protium (TN); Protonix (TN); SK&F 96022; SK-96022; SKF-96022; Somac (TN); Ulcepraz (TN); Pantoprazole (USAN/INN); Pantoprazole [USAN:BAN:INN]; SK&F-96022; 5-(Difluoromethoxy)-2-(((3,4-dimethoxy-2-pyridyl)methyl)sulfinyl)benzimidazole; 5-(difluoromethoxy)-2-{[(3,4-dimethoxypyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole; 6-(difluoromethoxy)-2-[(3,4-dimethoxypyridin-2-yl)methylsulfinyl]-1H-benzimidazole
Therapeutic ClassAntiulcer Agents
Cross-matching ID
PubChem CID
4679
ChEBI ID
CHEMBL1502
CAS Number
CAS 102625-70-7
TTD Drug ID
D0T6XX
VARIDT Drug ID
DR00458
INTEDE Drug ID
DR1236
ACDINA Drug ID
D00508

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
DNA replication 2.66 0.00e+0 34/36 (94.44%) PCNA;RFC4;MCM5;...
Spliceosome 2.18 0.00e+0 101/150 (67.33%) LSM5;HSPA1A;SNRPG;...
Proteasome 2.09 3.11e-3 44/46 (95.65%) PSMD14;IFNG;PSMB2;...
Mismatch repair 2.08 2.33e-3 22/23 (95.65%) PCNA;RFC4;POLD3;...
Viral protein interaction with cytokine and cytokine re... 2.07 1.87e-3 84/100 (84%) CXCL8;CXCL6;CXCL5;...
Mineral absorption 2.06 1.56e-3 48/60 (80%) STEAP1;FTH1;MT1E;...
Cell cycle 1.94 4.00e-3 110/124 (88.71%) E2F2;CCNB1;CDC45;...
NF-kappa B signaling pathway 1.89 7.00e-3 90/104 (86.54%) CD40;CXCL8;CXCL2;...
TNF signaling pathway 1.86 8.30e-3 103/112 (91.96%) CXCL6;CXCL5;CXCL2;...
Nucleotide excision repair 1.83 1.03e-2 40/47 (85.11%) RAD23B;PCNA;RFC4;...
Prion disease 1.76 2.21e-2 209/273 (76.56%) NOTCH1;TUBB2A;HSPA1A;...
IL-17 signaling pathway 1.74 2.64e-2 84/94 (89.36%) CXCL8;CXCL6;CXCL5;...
Homologous recombination 1.73 2.44e-2 35/41 (85.37%) RBBP8;POLD3;TOPBP1;...
Parkinson disease 1.69 3.20e-2 176/249 (70.68%) GNAI1;TUBB2A;PSMD14;...
Cytokine-cytokine receptor interaction 1.67 3.67e-2 246/295 (83.39%) CD40;CXCL8;CXCL6;...
Rheumatoid arthritis 1.66 3.73e-2 78/93 (83.87%) CXCL8;CXCL6;CXCL5;...
Protein export 1.63 4.39e-2 17/23 (73.91%) SPCS3;SEC61G;SEC11A;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 0.12uM - 10uM 6H, 24H, 48H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 6H, 24H, 48H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 6H, 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HuH-7 CVCL_0336 Homo sapiens 8uM 72H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.12uM - 10uM 6H, 24H, 48H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 6H, 24H