Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMTI8YE)

Drug Name
Bosutinib Drug Info
Synonyms
SKI 606; SKI606; Bosutinib (USAN); PF-5208763; SKI-606; Xy]-3-quinolinecarbonitrile; 4-((2,4-dichloro-5-methoxyphenyl)amino)-6-methoxy-7-(3-(4-methyl-1-piperazinyl)propoxy)-3-quinolinecarbonitrile; 4-((2,4-dichloro-5-methoxyphenyl)amino)-6-methoxy-7-(3-(4-methylpiperazin-1-yl)propoxy)quinoline-3-carbonitrile; 4-(2,4-dichloro-5-methoxyanilino)-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile; 4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methyl-1-piperazinyl)propo; 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile; Bosutinib (BCR-ABL inhibitor 3rd gen)
Therapeutic ClassAnticancer Agents
Cross-matching ID
PubChem CID
5328940
ChEBI ID
CHEMBL288441
CAS Number
CAS 380843-75-4
TTD Drug ID
D0OB0F
VARIDT Drug ID
DR00253
INTEDE Drug ID
DR0224
ACDINA Drug ID
D00075

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Steroid biosynthesis 2.56 0.00e+0 19/20 (95%) MSMO1;SQLE;DHCR24;...
Terpenoid backbone biosynthesis 2.34 0.00e+0 18/22 (81.82%) ACAT2;IDI1;HMGCS1;...
Glycine, serine and threonine metabolism 2.20 0.00e+0 31/40 (77.5%) PSAT1;PHGDH;CBS;...
Biosynthesis of unsaturated fatty acids 2.12 2.25e-3 21/27 (77.78%) SCD;FADS1;FADS2;...
Pyruvate metabolism 2.08 1.80e-3 41/47 (87.23%) PCK2;ACAT2;ALDH2;...
PPAR signaling pathway 2.06 1.50e-3 66/74 (89.19%) PCK2;SCD;HMGCS1;...
Pantothenate and CoA biosynthesis 2.04 1.29e-3 14/21 (66.67%) ALDH2;PPCS;DPYS;...
Tyrosine metabolism 2.00 1.12e-3 30/36 (83.33%) GOT1;ADH1B;MAOA;...
Steroid hormone biosynthesis 1.95 2.00e-3 43/61 (70.49%) AKR1C2;HSD17B7;AKR1C1;...
Glyoxylate and dicarboxylate metabolism 1.95 1.80e-3 23/30 (76.67%) ACAT2;SHMT2;SHMT1;...
Ferroptosis 1.93 3.27e-3 36/41 (87.8%) SLC7A11;SLC3A2;ACSL1;...
Glycolysis / Gluconeogenesis 1.92 3.00e-3 56/67 (83.58%) PCK2;ALDH2;ADH1B;...
Arachidonic acid metabolism 1.87 6.92e-3 48/61 (78.69%) PLAAT3;PTGIS;GPX2;...
Synthesis and degradation of ketone bodies 1.83 6.43e-3 9/10 (90%) ACAT2;HMGCS1;ACAT1;...
Cysteine and methionine metabolism 1.83 6.00e-3 43/50 (86%) PSAT1;PHGDH;CBS;...
Phenylalanine metabolism 1.81 8.43e-3 14/17 (82.35%) GOT1;PAH;MAOA;...
Tryptophan metabolism 1.80 9.00e-3 35/42 (83.33%) ACAT2;ALDH2;MAOA;...
Valine, leucine and isoleucine degradation 1.78 9.50e-3 42/48 (87.5%) ACAT2;HMGCS1;ALDH2;...
alpha-Linolenic acid metabolism 1.76 1.23e-2 17/25 (68%) FADS2;PLAAT3
Arginine biosynthesis 1.75 1.30e-2 17/22 (77.27%) ASS1;GOT1;GLS2;...
Fatty acid degradation 1.74 1.24e-2 40/43 (93.02%) ACAT2;ALDH2;ADH1B;...
Cardiac muscle contraction 1.74 1.19e-2 64/87 (73.56%) TNNC1;TPM4;MYL2;...
Arginine and proline metabolism 1.73 1.41e-2 39/50 (78%) PYCR1;ALDH2;GOT1;...
Caffeine metabolism 1.72 1.69e-2 5/6 (83.33%) NAT1;NAT2;CYP2A6;...
Glutathione metabolism 1.72 1.62e-2 43/57 (75.44%) CHAC1;PGD;GPX2;...
Fatty acid elongation 1.70 2.18e-2 19/27 (70.37%) ELOVL6;HACD1;ELOVL1;...
Alanine, aspartate and glutamate metabolism 1.68 2.63e-2 27/37 (72.97%) ASNS;ASS1;GOT1;...
Citrate cycle (TCA cycle) 1.68 2.54e-2 30/30 (100%) PCK2;IDH1;SUCLA2;...
Histidine metabolism 1.67 2.79e-2 16/22 (72.73%) ALDH2;MAOA;ALDH3A1;...
Nicotinate and nicotinamide metabolism 1.65 3.48e-2 25/35 (71.43%) NNMT;NMRK1;NAMPT;...
DNA replication -1.90 2.85e-2 34/36 (94.44%) POLE;MCM2;MCM6;...
Mismatch repair -1.90 4.56e-2 22/23 (95.65%) RFC2;POLD3;RPA2;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 0.12uM - 10uM 6H, 24H, 48H
Bone marrow
Chronic myeloid leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
K-562 CVCL_0004 Homo sapiens 0.01uM - 10uM 24H
HAP1 CVCL_Y019 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 BRD4 (-) 1 CVCL_SF59 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 CDK4 (-) 1 CVCL_SI36 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 HDAC5 (-) 1 CVCL_SR11 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 ITGA4 (-) 1 CVCL_ST27 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 MAPK8 (-) 1 CVCL_SW99 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 PIK3CA (-) 1 CVCL_TD60 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 PRKACA (-) 1 CVCL_TG70 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 PRKCQ (-) CVCL_TG92 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 RELA (-) 1 CVCL_TI75 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 SRC (-) 1 CVCL_TQ36 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 TP53 (-) 1 CVCL_RJ70 Homo sapiens 0.66uM - 3.33uM 24H
Multiple myeloma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
KMS-34 CVCL_1333 Homo sapiens 0.01uM - 10uM 24H
Neuroblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SH-SY5Y CVCL_0019 Homo sapiens 0.04uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.04uM - 10uM 6H, 24H, 48H
MDA-MB-231 CVCL_0062 Homo sapiens 0.04uM - 10uM 24H
Fibrocystic breast disease
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A (Parent) CVCL_0598 Homo sapiens 1.11uM - 10uM 3H, 6H, 12H, 24H
Normal (Epithelial)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HME1 CVCL_2950 Homo sapiens 0.04uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.04uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 3H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 6H, 24H
Embryonic stem cell
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUES 3 CVCL_B062 Homo sapiens 0.04uM - 10uM 24H
Fibroblast
Nasopharyngeal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
FIBRNPC CVCL_UK07 Homo sapiens 10uM 6H, 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 0.04uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.04uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.04uM - 10uM 6H, 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 6H, 24H, 48H
A549/Asc-1 CVCL_YA87 Homo sapiens 0.04uM - 10uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 0.04uM - 10uM 6H, 24H
Lymph node
Burkitt lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BJAB CVCL_5711 Homo sapiens 0.01uM - 10uM 3H, 6H, 24H
Diffuse large B-cell lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HBL-1 CVCL_4213 Homo sapiens 0.01uM - 10uM 24H
OCI-Ly10 CVCL_8795 Homo sapiens 0.01uM - 10uM 24H
OCI-Ly19 CVCL_8797 Homo sapiens 0.01uM - 10uM 24H
OCI-Ly3 CVCL_8796 Homo sapiens 0.01uM - 10uM 24H
TMD8 CVCL_A440 Homo sapiens 0.01uM - 10uM 3H, 6H, 24H
Mantle cell lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MINO CVCL_4965 Homo sapiens 0.01uM - 10uM 3H, 6H, 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute B-lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NALM-6 CVCL_0092 Homo sapiens 0.01uM - 10uM 24H
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 3H, 6H, 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.04uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 6H, 24H
SK-L CVCL_1699 Homo sapiens 0.04uM - 10uM 24H
SK-MEL-5 CVCL_0527 Homo sapiens 0.01uM - 10uM 24H