Details of the Drug

General Information of Drug (ID: DMTI8YE)

Drug Name
Bosutinib
Synonyms
SKI 606; SKI606; Bosutinib (USAN); PF-5208763; SKI-606; Xy]-3-quinolinecarbonitrile; 4-((2,4-dichloro-5-methoxyphenyl)amino)-6-methoxy-7-(3-(4-methyl-1-piperazinyl)propoxy)-3-quinolinecarbonitrile; 4-((2,4-dichloro-5-methoxyphenyl)amino)-6-methoxy-7-(3-(4-methylpiperazin-1-yl)propoxy)quinoline-3-carbonitrile; 4-(2,4-dichloro-5-methoxyanilino)-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile; 4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methyl-1-piperazinyl)propo; 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile; Bosutinib (BCR-ABL inhibitor 3rd gen)
Indication
Disease Entry ICD 11 Status REF
Blast phase chronic myelogenous leukemia, BCR-ABL1 positive N.A. Approved [1]
Breast cancer 2C60-2C65 Approved [2]
Therapeutic Class
Anticancer Agents
Affected Organisms
Humans and other mammals
ATC Code
L01EA04: Bosutinib
L01EA: BCR-ABL tyrosine kinase inhibitors
L01E: PROTEIN KINASE INHIBITORS
L01: ANTINEOPLASTIC AGENTS
L: ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 2 Molecular Weight (mw) 530.4
Logarithm of the Partition Coefficient (xlogp) 5.4
Rotatable Bond Count (rotbonds) 9
Hydrogen Bond Donor Count (hbonddonor) 1
Hydrogen Bond Acceptor Count (hbondacc) 8
ADMET Property
Absorption AUC
The area under the plot of plasma concentration (AUC) of drug is 3650 mcgh/L []
Absorption Cmax
The maximum plasma concentration (Cmax) of drug is 200 mcg/L []
Absorption Tmax
The time to maximum plasma concentration (Tmax) is 4-6 h []
Half-life
The concentration or amount of drug in body reduced by one-half in 22.5 hours [3]
Metabolism
The drug is metabolized via the CYP3A4 []
Vd
The volume of distribution (Vd) of drug is 6080 +/- 1230 L []
Chemical Identifiers
Formula
C26H29Cl2N5O3
IUPAC Name
4-(2,4-dichloro-5-methoxyanilino)-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile
Canonical SMILES
CN1CCN(CC1)CCCOC2=C(C=C3C(=C2)N=CC(=C3NC4=CC(=C(C=C4Cl)Cl)OC)C#N)OC
InChI
InChI=1S/C26H29Cl2N5O3/c1-32-6-8-33(9-7-32)5-4-10-36-25-13-21-18(11-24(25)35-3)26(17(15-29)16-30-21)31-22-14-23(34-2)20(28)12-19(22)27/h11-14,16H,4-10H2,1-3H3,(H,30,31)
InChIKey
UBPYILGKFZZVDX-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
5328940
ChEBI ID
CHEBI:39112
CAS Number
380843-75-4
UNII
5018V4AEZ0
DrugBank ID
DB06616
TTD ID
D0OB0F
VARIDT ID
DR00253
INTEDE ID
DR0224
ACDINA ID
D00075
Combinatorial Drugs (CBD) Click to Jump to the Detailed CBD Information of This Drug
Repurposed Drugs (RPD) Click to Jump to the Detailed RPD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Proto-oncogene c-Src (SRC) TT6PKBN SRC_HUMAN Inhibitor [4]
Tyrosine-protein kinase ABL1 (ABL) TT3PJMV ABL1_HUMAN Inhibitor [4]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [5]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4)
Main DME 		DE4LYSA CP3A4_HUMAN Substrate [6]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Alanine aminotransferase 1 (GPT) OTOXOA0Q ALAT1_HUMAN Protein Interaction/Cellular Processes [7]
Catenin beta-1 (CTNNB1) OTZ932A3 CTNB1_HUMAN Post-Translational Modifications [8]
Cellular tumor antigen p53 (TP53) OTIE1VH3 P53_HUMAN Gene/Protein Processing [9]
G1/S-specific cyclin-D1 (CCND1) OT8HPTKJ CCND1_HUMAN Gene/Protein Processing [8]
Proto-oncogene tyrosine-protein kinase Src (SRC) OTETYX40 SRC_HUMAN Post-Translational Modifications [8]
Tyrosine-protein kinase ABL1 (ABL1) OT09YVXH ABL1_HUMAN Gene/Protein Processing [10]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Blast phase chronic myelogenous leukemia, BCR-ABL1 positive
ICD Disease Classification
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Tyrosine-protein kinase ABL1 (ABL) DTT ABL1 9.65E-34 0.48 1.49
P-glycoprotein 1 (ABCB1) DTP P-GP 4.70E-06 -5.80E-02 -1.98E-01
Cytochrome P450 3A4 (CYP3A4) DME CYP3A4 7.29E-03 -3.47E-02 -1.80E-01
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 45 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RPMI-3460/CS1 GDSC1; GDSC2 1.827 5.3261 -0.5186 7.4422
ES1 GDSC1; GDSC2 0.801 4.2377 -0.7875 11.8793
EW-3 GDSC1; GDSC2 0.8968 7.6081 -2.3904 20.5774
ES5 GDSC1; GDSC2 1.274 4.9263 -0.7398 10.2089
SK-ES-1 GDSC1; GDSC2; CTRP2 1.3797 4.3164 1.3006 31.3404
EW-16 GDSC1; GDSC2 1.485 4.3755 -0.3026 6.9354
A-673 GDSC1; GDSC2; CTRP2 1.4918 3.2809 1.4858 30.3502
EW-12 GDSC2 1.5569 3.6873 0.0874 4.3458
ES7 GDSC1; GDSC2 1.6115 4.2317 -0.1389 5.614
TC71 CTRP2 1.6931 6.1681 1.2613 30.4311
NOS-1 [Human HNSCC] GDSC1; GDSC2 1.7332 4.6569 -0.2593 6.0727
ES8 GDSC1; GDSC2 1.751 4.7834 -0.3082 6.3319
EW-24 GDSC1; GDSC2 1.7547 3.2249 0.4358 1.8831
HuO-3N1 GDSC1; GDSC2 1.7954 3.8703 0.1613 3.3941
EW-11 GDSC1; GDSC2 1.7987 4.5723 -0.1722 5.3937
CAL-72 GDSC1; GDSC2 1.8213 3.9838 0.1245 3.5609
ES4 GDSC1; GDSC2 1.8604 5.9298 -0.7898 9.009
SK-PN-DW GDSC1; GDSC2 1.9012 4.9382 -0.278 5.8114
U2OS GDSC1; GDSC2; CTRP2 1.9067 4.4414 1.8445 27.7755
CHSA0108 GDSC1; GDSC2 1.9783 4.3818 0.0383 3.7626
HuO9 GDSC1; GDSC2 1.9936 4.2955 0.0884 3.4415
EW-7 GDSC1; GDSC2 2.0241 4.9722 -0.2111 5.1484
ES6 GDSC1; GDSC2 2.0314 4.1355 0.1857 2.8165
H-EMC-SS GDSC1; GDSC2 2.061 6.2001 -0.7776 8.4653
EW-22 GDSC1; GDSC2 2.0868 4.3123 0.1381 2.9893
Hs 888.T CTRP2 2.1787 4.1913 2.1521 25.843
MHH-ES-1 GDSC1; GDSC2; CTRP2 2.2045 4.1538 2.1814 25.6592
EW-18 GDSC1; GDSC2 2.2618 4.5656 0.1266 2.7614
CHSA8926 GDSC1; GDSC2 2.3134 5.0803 -0.0772 3.8132
NY GDSC1; GDSC2 2.3748 5.4804 -0.2244 4.544
Hs 822.T CTRP2 2.4685 2.8918 2.4685 23.8231
TC-71 GDSC1; GDSC2 2.509 5.2425 -0.0348 3.2485
CADO-ES1 GDSC1; GDSC2 2.5898 4.4285 0.3596 1.1708
SK-N-MC CTRP2 2.6164 2.9821 2.6164 22.8375
SaOS-2 GDSC1; GDSC2; CTRP2 2.7057 4.0021 2.7016 22.2568
G-292 clone A141B1 GDSC1; GDSC2; CTRP2 2.9039 4.1524 2.8994 20.9371
EW-1 GDSC1; GDSC2 2.9564 4.9902 0.3041 1.0594
CHSA0011 GDSC1; GDSC2 2.964 5.8273 -0.0401 2.6154
MG-63 GDSC1; GDSC2; CTRP2 2.9676 4.5797 2.9458 20.571
HOS GDSC1; GDSC2; CTRP2 3.0235 5.5261 2.8733 20.6422
EW-13 GDSC1; GDSC2 3.1378 5.5121 0.1787 1.4045
SJSA-1 GDSC1; GDSC2; CTRP2 3.3182 5.3601 3.2242 18.4834
U-CH2 GDSC2 3.707 5.425 0.4459 0.2423
CAL-78 GDSC1; GDSC2; CTRP2 3.8113 5.7207 3.6875 15.3043
SW1353 CTRP2 7.8563 11.4452 4.6629 3.1012
⏷ Show the Full List of 45 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 220 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JK1 CTRP2 -2.2509 1.1317 -2.2649 55.1813
MEC1 CTRP2 0.7566 3.8734 0.69 35.4425
JM1 GDSC1; GDSC2; CTRP2 1.2512 2.6699 1.2505 31.9353
CTV-1 GDSC1; GDSC2 -2.7947 -1.0925 -2.8062 38.135
Mono-Mac-1 CTRP2 -2.452 2.4731 -2.551 56.1425
LAMA-84 GDSC1; GDSC2 -2.0035 -0.472 -2.022 30.2338
NCO2 CTRP2 -1.9557 -0.2791 -1.9558 53.2976
Ku812 GDSC1; GDSC2; CTRP2 -1.9454 -0.1462 -1.9455 53.2286
Pfeiffer CTRP2 -1.9337 0.9993 -1.9405 53.1281
MEG-01 GDSC1; GDSC2 -1.8431 -0.0641 -1.89 28.7681
MOLM-6 CTRP2 -1.7831 1.5952 -1.8019 52.1153
EM-2 GDSC1; GDSC2; CTRP2 -1.7198 0.2252 -1.7201 51.7253
697 GDSC1; GDSC2; CTRP2 -1.6997 1.3267 -1.7096 51.5785
BV-173 GDSC1; GDSC2; CTRP2 -1.6694 1.0241 -1.6739 51.3841
OCI-Ly7 GDSC1; GDSC2 -1.6653 -0.0251 -1.7061 26.9536
ALL-SIL GDSC1; GDSC2; CTRP2 -1.4265 0.3437 -1.4267 49.7724
SEM CTRP2 -1.3722 0.817 -1.3734 49.4112
JURL-MK1 GDSC1; GDSC2; CTRP2 -1.2014 -0.0979 -1.2014 48.2724
BE-13 GDSC1; GDSC2 -1.1518 1.8582 -1.6281 24.1446
SU-DHL-16 GDSC1; GDSC2 -1.0733 0.1838 -1.103 20.957
Farage GDSC1; GDSC2 -1.0613 1.8433 -1.5254 23.184
SU-DHL-5 GDSC1; GDSC2 -1.0325 1.7921 -1.4756 22.7835
CTB-1 GDSC1; GDSC2 -1.0061 2.7946 -1.8482 24.6922
RPMI-8866 GDSC1; GDSC2 -0.8954 2.4739 -1.5978 22.8654
CML-T1 GDSC1; GDSC2; CTRP2 -0.8322 1.2119 -0.8333 45.8156
Karpas-231 GDSC1; GDSC2 -0.6339 1.8539 -1.072 18.7983
MY-M12 GDSC1; GDSC2 -0.6122 2.8047 -1.4458 20.8426
KYO-1 CTRP2 -0.5607 1.4512 -0.562 44.0076
MOLM-16 GDSC1; GDSC2; CTRP2 -0.537 3.3824 -0.624 44.0349
Hs 611.T CTRP2 -0.4837 3.2852 -0.5584 43.6616
BONNA-12 GDSC2 -0.4327 4.0884 -1.8557 22.4036
KE-37 GDSC1; GDSC2; CTRP2 -0.348 1.8256 -0.351 42.596
KE-97 CTRP2 -0.2793 2.8868 -0.3146 42.2244
Peer CTRP2 -0.2676 2.0426 -0.2728 42.0671
ATN-1 GDSC1; GDSC2 -0.2498 0.8776 -0.3326 12.9741
SUP-B8 GDSC1; GDSC2 -0.2428 4.5526 -1.8947 21.8934
Ri-1 CTRP2 -0.2342 4.6633 -0.4859 42.3985
A4/Fukuda GDSC1; GDSC2; CTRP2 -0.2284 3.0177 -0.2701 41.9038
JVM-3 GDSC1; GDSC2; CTRP2 -0.2169 3.4047 -0.2892 41.903
EB1 CTRP2 -0.1622 3.2495 -0.2183 41.5022
MLMA GDSC1; GDSC2 -0.1485 3.2703 -1.1924 17.572
WSU-NHL GDSC1 -0.0923 1.6939 -0.4337 16.0078
MV4-11 GDSC1; GDSC2; CTRP2 -0.0432 2.3788 -0.052 40.5837
EoL-1 GDSC1; GDSC2; CTRP2 -0.0335 1.8785 -0.0351 40.4967
NB4 GDSC1; GDSC2 0.0125 1.5185 -0.2532 11.3714
RS4;11 GDSC1; GDSC2; CTRP2 0.0182 3.7209 -0.0736 40.4033
KCL-22 GDSC1; GDSC2 0.1111 1.1349 -0.01 9.5668
GA-10 GDSC1; GDSC2; CTRP2 0.1257 2.8563 0.1046 39.4961
MOLT-16 GDSC1; GDSC2; CTRP2 0.2123 2.9746 0.1883 38.929
NU-DUL-1 GDSC1; GDSC2; CTRP2 0.2986 1.4357 0.2986 38.2792
Kasumi-2 CTRP2 0.3204 3.7978 0.2376 38.3838
Karpas-1106P GDSC1; GDSC2 0.3539 2.1995 -0.197 9.6934
Mino CTRP2 0.3704 2.4156 0.3662 37.8145
VAL GDSC1; GDSC2 0.3765 4.3541 -1.2214 15.8848
SKM-1 GDSC1; GDSC2; CTRP2 0.4452 3.9195 0.3561 37.5762
NKM-1 GDSC1; GDSC2 0.488 3.5276 -0.7123 12.4131
MOLM-13 GDSC1; GDSC2; CTRP2 0.5323 3.181 0.5076 36.8018
KMS-20 CTRP2 0.5344 4.8003 0.3194 37.348
JeKo-1 GDSC1; GDSC2; CTRP2 0.5404 2.3303 0.5385 36.6746
P31/FUJ GDSC1; GDSC2; CTRP2 0.5474 3.0321 0.53 36.6784
RCH-ACV GDSC1; GDSC2; CTRP2 0.5781 3.5956 0.5277 36.5777
HAL-01 GDSC1; GDSC2 0.579 2.4697 -0.1096 8.3532
Karpas-45 GDSC1; GDSC2 0.5918 4.042 -0.8733 13.068
QIMR-WIL GDSC1; GDSC2 0.6121 5.6178 -1.6396 17.5369
P32/ISH GDSC1; GDSC2 0.6179 2.307 0.006 7.5005
NALM-6 GDSC1; GDSC2; CTRP2 0.6329 2.693 0.6271 36.0715
SUP-B15 GDSC1; GDSC2; CTRP2 0.6465 3.2503 0.6218 36.0417
MOTN-1 CTRP2 0.6536 3.4657 0.6162 36.035
PL21 CTRP2 0.691 2.748 0.6849 35.6854
P30/OHK GDSC1; GDSC2 0.7486 3.1601 -0.2961 8.9663
KMS-12-BM GDSC1; GDSC2; CTRP2 0.7526 3.5203 0.7154 35.3758
ST486 GDSC1; CTRP2 0.7609 2.6175 0.7577 35.2099
TALL-1 [Human adult T-ALL] GDSC2; CTRP2 0.799 4.3673 0.6753 35.339
KY821 GDSC1; GDSC2 0.8107 3.2795 -0.3011 8.8035
A3/Kawakami GDSC1; GDSC2; CTRP2 0.8331 3.6667 0.7886 34.8637
OCI-Ly19 GDSC1; GDSC2; CTRP2 0.8333 4.3372 0.7162 35.0913
L-540 GDSC1; GDSC2; CTRP2 0.8495 2.9196 0.842 34.6339
KMS-26 CTRP2 0.8569 1.6561 0.8569 34.5595
KG-1 GDSC1; GDSC2 0.8822 3.3311 -0.2651 8.3574
PF-382 GDSC1; GDSC2; CTRP2 0.8827 2.3705 0.8821 34.3899
RPMI-8402 GDSC1; GDSC2; CTRP2 0.9156 2.5788 0.9139 34.1743
SU-DHL-6 GDSC1; GDSC2; CTRP2 0.9229 3.9351 0.859 34.329
PL-21 GDSC1; GDSC2 0.9407 3.342 -0.2208 7.9021
BC-3 GDSC2 0.9407 2.1548 0.3725 4.1489
K-562 GDSC1; GDSC2; CTRP2 0.9635 2.5905 0.9619 33.855
GDM-1 GDSC1; GDSC2; CTRP2 1.0027 4.532 0.8692 34.0209
KOPN-8 GDSC1; GDSC2 1.0332 3.6063 -0.2756 7.978
L-363 GDSC1; GDSC2; CTRP2 1.0753 4.3116 0.9777 33.4248
DoHH2 GDSC1; GDSC2; CTRP2 1.1077 2.4988 1.1072 32.8906
RPMI-6666 GDSC1; GDSC2; CTRP2 1.1402 4.3614 1.0403 33.0008
DB GDSC1; GDSC2; CTRP2 1.1499 3.9591 1.0955 32.788
KHM-1B CTRP2 1.1714 3.9507 1.1188 32.639
L-1236 GDSC1; GDSC2 1.1878 3.3244 -0.0096 5.8666
OCI-AML-2 GDSC1; GDSC2; CTRP2 1.1899 2.2988 1.1898 32.3418
BL-41 GDSC1; GDSC2 1.2048 2.9725 0.1788 4.6333
Ki-JK CTRP2 1.2067 3.7409 1.1725 32.343
Karpas-299 GDSC1; GDSC2; CTRP2 1.2098 3.2933 1.1983 32.247
Daudi GDSC1; GDSC2; CTRP2 1.2323 2.5846 1.2318 32.0606
EJM GDSC1; GDSC2; CTRP2 1.2356 3.235 1.2264 32.0678
DEL GDSC1; GDSC2; CTRP2 1.2418 3.0219 1.2375 32.0101
HC-1 GDSC1; GDSC2 1.255 3.4475 -0.0183 5.7425
IM-9 GDSC1; GDSC2 1.2872 3.1877 0.1353 4.6947
SCC-3 GDSC2 1.2901 2.9341 0.2628 3.8889
JVM-2 GDSC1; GDSC2 1.2969 4.1835 -0.3516 7.7273
Ramos.2G6.4C10 GDSC1; GDSC2 1.3131 6.0426 -1.2653 13.2766
OCI-AML-3 GDSC1; GDSC2; CTRP2 1.3248 2.8889 1.3229 31.4489
SU-DHL-8 GDSC2; CTRP2 1.3324 3.0373 1.3288 31.4039
HDLM-2 GDSC1; GDSC2; CTRP2 1.3356 5.0929 1.1305 32.0467
GR-ST GDSC1; GDSC2 1.3418 5.6347 -1.039 11.8502
WIL2 NS GDSC1; GDSC2 1.3431 4.0239 -0.2364 6.8831
KMOE-2 GDSC1; GDSC2 1.3444 4.9642 -0.7029 9.7897
SUP-T1 GDSC1; GDSC2; CTRP2 1.3624 2.9382 1.3603 31.1989
KMS-34 CTRP2 1.3646 2.3549 1.3646 31.1773
U-698-M GDSC1; GDSC2 1.3765 4.0342 -0.2159 6.6685
CESS GDSC1; GDSC2 1.3933 3.4168 0.1017 4.6411
KMS-11 GDSC1; GDSC2; CTRP2 1.3973 3.4144 1.3858 30.998
MOLT-4 GDSC1; GDSC2 1.4143 4.8309 -0.5821 8.8559
SIG-M5 GDSC2; CTRP2 1.4173 2.9809 1.4151 30.8338
Granta-519 GDSC1; GDSC2; CTRP2 1.4201 3.7339 1.3944 30.8935
KMS-18 CTRP2 1.4237 3.5164 1.4089 30.833
MOLT-3 CTRP2 1.4437 3.7721 1.4165 30.7414
WSU-DLCL2 GDSC1; GDSC2; CTRP2 1.4476 3.6375 1.428 30.6896
SUP-M2 GDSC1; GDSC2; CTRP2 1.462 2.3068 1.462 30.5285
HPB-ALL CTRP2 1.4695 2.5658 1.4694 30.4789
KMS-21-BM CTRP2 1.472 4.3808 1.3908 30.7331
BALL-1 GDSC1; GDSC2 1.4834 5.0312 -0.6283 8.9616
NK-92MI GDSC2 1.4838 3.171 0.2864 3.29
RPMI-8226 GDSC1; GDSC2 1.4908 4.685 -0.4512 7.8452
L-428 GDSC1; GDSC2; CTRP2 1.5036 3.0719 1.5012 30.2595
CCRF-CEM GDSC1; GDSC2 1.5174 4.8328 -0.5041 8.1065
HD-MY-Z CTRP2 1.5192 3.5408 1.5058 30.1921
H9 GDSC1; GDSC2 1.5312 7.1378 -1.6382 14.8065
Jurkat GDSC1; GDSC2 1.5324 5.7724 -0.9583 10.8509
ALL-PO GDSC1; GDSC2 1.5335 5.1717 -0.6597 9.0263
MHH-CALL-3 CTRP2 1.5373 11.0298 -0.7668 36.2879
DND-41 GDSC1; GDSC2; CTRP2 1.5407 2.9868 1.5393 30.0088
MHH-PREB-1 GDSC1; GDSC2 1.5477 3.9172 -0.0311 5.0974
Namalwa GDSC1; GDSC2; CTRP2 1.5495 4.144 1.4981 30.1178
HT GDSC1; GDSC2; CTRP2 1.5662 2.1731 1.5662 29.8341
DG-75 GDSC1; GDSC2 1.5662 4.1321 -0.1229 5.6215
JJN-3 GDSC1; GDSC2; CTRP2 1.5736 2.2785 1.5736 29.7852
AML-193 CTRP2 1.6062 2.4983 1.6062 29.5679
THP-1 GDSC1; GDSC2; CTRP2 1.6085 2.772 1.6082 29.5535
Reh GDSC1; GDSC2; CTRP2 1.6133 2.6626 1.6132 29.5208
M-07e CTRP2 1.647 3.0898 1.6454 29.3017
NU-DHL-1 CTRP2 1.6779 3.9352 1.649 29.1869
MM1.S GDSC1; GDSC2; CTRP2 1.6923 4.0293 1.6573 29.1115
F-36P CTRP2 1.6927 3.7466 1.6751 29.0505
SET-2 CTRP2 1.6973 3.9435 1.6686 29.0572
OPM-2 GDSC1; GDSC2; CTRP2 1.6998 3.165 1.6978 28.9511
NOMO-1 GDSC1; GDSC2 1.7141 5.1561 -0.5171 7.7008
LC4-1 GDSC1; GDSC2 1.7147 4.9506 -0.416 7.0785
TK [Human B-cell lymphoma] GDSC1; GDSC2 1.7372 3.7656 0.1728 3.4421
NCI-H929 GDSC1; GDSC2; CTRP2 1.7455 4.4918 1.6678 28.901
MHH-CALL-4 GDSC2; CTRP2 1.7505 7.3335 0.9523 31.2257
CA46 GDSC1; GDSC2; CTRP2 1.7689 3.8615 1.7478 28.5545
ME1 GDSC1; GDSC2 1.7864 4.466 -0.1295 5.1606
SUP-T11 CTRP2 1.8014 3.5682 1.7932 28.2946
Mono-Mac-6 GDSC1; GDSC2; CTRP2 1.8098 9.1481 0.3186 32.8627
U266B1 GDSC1; GDSC2; CTRP2 1.8238 3.7834 1.8082 28.1703
JSC-1 GDSC1; GDSC2 1.8314 3.6454 0.2893 2.5795
U-937 CTRP2 1.8342 3.1461 1.8332 28.0524
CRO-AP2 GDSC1; GDSC2 1.8346 4.9796 -0.3445 6.363
SU-DHL-4 GDSC1; GDSC2; CTRP2 1.8544 3.4813 1.8492 27.9316
Hs 445 GDSC2 1.8705 7.4233 -1.5182 13.2391
SU-DHL-1 GDSC2; CTRP2 1.879 3.5087 1.8736 27.7687
KMS-28BM CTRP2 1.881 3.3513 1.8783 27.7462
HuT 78 CTRP2 1.8914 4.0031 1.8662 27.752
KO52 CTRP2 1.901 4.4343 1.8393 27.8117
HuNS1 CTRP2 1.9024 3.5097 1.8973 27.6118
MOLP-8 GDSC1; GDSC2; CTRP2 1.9299 4.1847 1.8933 27.534
MOLT-13 GDSC1; GDSC2 1.93 7.6969 -1.6085 13.5899
VL51 GDSC1; GDSC2 1.9465 4.5436 -0.0587 4.3981
EHEB GDSC1; CTRP2 2.0099 5.9943 1.655 28.0899
HH [Human lymphoma] GDSC1; GDSC2; CTRP2 2.0243 3.4876 2.0211 26.7933
ROS-50 GDSC1; GDSC2 2.0243 4.9686 -0.2092 5.1365
EB2 GDSC1; GDSC2 2.0268 3.7132 0.3733 1.795
Loucy GDSC1; GDSC2 2.0322 4.137 0.1854 2.8164
Ci-1 CTRP2 2.1028 2.9779 2.1028 26.2597
MN-60 GDSC1; GDSC2 2.1142 7.7404 -1.4928 12.4869
P12-Ichikawa GDSC1; CTRP2 2.1641 3.89 2.1529 25.8887
OCI-Ly3 CTRP2 2.1662 4.1715 2.1405 25.9234
ARH-77 GDSC1; GDSC2 2.2195 10.2991 -2.6764 18.2421
TUR GDSC1; GDSC2 2.2291 6.4035 -0.7587 7.9758
OCI-AML-5 GDSC1; GDSC2; CTRP2 2.2307 3.2416 2.2305 25.4083
HL-60 GDSC1; GDSC2; CTRP2 2.2457 5.2001 2.095 25.8211
BC-1 GDSC1; GDSC2 2.2856 4.7004 0.0796 2.9815
RL GDSC1; GDSC2; CTRP2 2.2951 3.4698 2.2942 24.9813
Jiyoye GDSC1; GDSC2 2.3282 7.3756 -1.1602 10.0962
KM-H2 GDSC1; GDSC2 2.3309 5.0695 -0.0616 3.6942
OCI-M1 GDSC1; GDSC2; CTRP2 2.3792 4.0781 2.3658 24.4631
ML-2 GDSC1; GDSC2 2.3882 6.764 -0.8232 8.0105
LP-1 GDSC1; GDSC2; CTRP2 2.4122 3.6021 2.4109 24.2026
Kasumi-1 GDSC1; GDSC2; CTRP2 2.415 4.6492 2.3593 24.3676
SU-DHL-10 GDSC2; CTRP2 2.4237 6.9722 1.8057 26.2772
MOLP-2 CTRP2 2.4809 5.1935 2.3503 24.1865
ME1 CTRP2 2.4943 4.1735 2.4798 23.6997
MHH-CALL-2 GDSC1 2.5206 4.215 0.4136 1.2563
MC116 GDSC1; GDSC2; CTRP2 2.5283 4.1864 2.5141 23.4723
Toledo CTRP2 2.5486 5.5948 2.342 24.0008
SR GDSC1; GDSC2; CTRP2 2.5488 4.5297 2.5122 23.4115
BL-70 CTRP2 2.5703 3.1343 2.5703 23.1451
KMS-27 CTRP2 2.5872 4.8317 2.5201 23.2594
SUP-HD1 GDSC1; GDSC2; CTRP2 2.5902 4.3524 2.5689 23.084
Raji GDSC1; GDSC2; CTRP2 2.7377 3.9575 2.7348 22.0394
AMO1 GDSC1; GDSC2; CTRP2 2.7678 4.4795 2.7449 21.9062
OCI-Ly10 CTRP2 2.8225 5.8029 2.5912 22.2666
Karpas-422 GDSC1; GDSC2; CTRP2 2.8266 3.8911 2.8253 21.4417
YT GDSC1; GDSC2 2.8463 4.1652 0.5702 0.2718
TF-1 CTRP2 2.9311 4.9701 2.8685 20.9534
SK-MM-2 GDSC1; GDSC2; CTRP2 2.955 4.7325 2.9202 20.6991
HEL 92.1.7 CTRP2 2.9646 5.7128 2.7677 21.1991
RC-K8 GDSC1 3.0854 4.6153 0.5002 0.425
Sc-1 GDSC1 3.4631 4.9009 0.5389 0.1875
P3HR-1 CTRP2 3.6124 7.9648 2.699 19.5695
Karpas-620 GDSC1; GDSC2; CTRP2 4.3604 6.1477 4.1774 11.863
REC-1 CTRP2 4.4588 7.5659 3.7492 13.2198
CMK GDSC1; CTRP2 5.2953 9.924 3.4497 12.4276
HEL GDSC1; GDSC2; CTRP2 6.225 12.7875 2.8221 13.0774
KMM-1 CTRP2 7.7091 15.143 2.7968 10.5911
⏷ Show the Full List of 220 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 28 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TE15 CTRP2 0.5156 7.0589 -0.2941 38.9081
TE8 CTRP2 1.5977 3.2428 1.5937 29.6378
OE21 GDSC1; GDSC2; CTRP2 -0.5606 4.0223 -0.7294 44.3324
TE-15 GDSC1; GDSC2 0.2128 3.171 -0.7954 13.869
KYSE-140 GDSC1; GDSC2; CTRP2 1.0311 4.9752 0.8237 34.0648
T.T GDSC1; GDSC2 1.1815 3.8165 -0.26 7.4633
TE-11 GDSC1; GDSC2; CTRP2 1.4043 3.8991 1.3667 31.0385
TE-5 GDSC1; GDSC2; CTRP2 1.4083 3.1406 1.4039 30.9008
KYSE-410 GDSC1; GDSC2; CTRP2 1.445 5.7533 1.1013 31.7724
EC-GI-10 GDSC1; GDSC2; CTRP2 1.4484 4.5925 1.3376 30.9888
TE-8 GDSC1; GDSC2 1.6156 3.3474 0.2912 2.982
KYSE-270 GDSC1; GDSC2 1.6978 4.8552 -0.3815 6.9062
KYSE-520 GDSC1; GDSC2; CTRP2 1.8769 6.2468 1.4394 29.2449
KYSE-180 GDSC1; GDSC2; CTRP2 1.9774 5.3936 1.7652 27.8168
TE-6 GDSC1; GDSC2; CTRP2 2.0587 3.9451 2.0423 26.6079
TE-4 GDSC1; GDSC2; CTRP2 2.0996 5.1695 1.9427 26.8148
TE-10 GDSC1; GDSC2; CTRP2 2.1881 4.0917 2.1682 25.7578
KYSE-30 CTRP2 2.3127 3.5972 2.3107 24.8678
KYSE-450 GDSC1; GDSC2; CTRP2 2.3534 5.8777 2.0606 25.6003
TE-1 GDSC1; GDSC2; CTRP2 2.4346 6.468 1.9815 25.6266
TE-14 CTRP2 2.4911 4.6554 2.439 23.8484
KYSE-510 GDSC1; GDSC2; CTRP2 2.6788 3.2348 2.6788 22.422
OE33 GDSC1; GDSC2; CTRP2 2.704 4.3997 2.6839 22.3216
COLO 680N GDSC1; GDSC2; CTRP2 2.7972 5.9848 2.5167 22.6099
TE-9 GDSC1; GDSC2; CTRP2 2.9082 5.6514 2.7206 21.5415
KYSE-150 GDSC1; GDSC2; CTRP2 3.1684 5.3653 3.0617 19.5251
OE19 GDSC1; GDSC2; CTRP2 3.4876 6.2789 3.1867 18.0947
KYSE-70 GDSC1; GDSC2; CTRP2 4.7487 11.1028 2.3682 17.9823
⏷ Show the Full List of 28 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 40 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
N2a-PK1 CTRP2 3.1179 7.7729 2.2554 22.6131
PaTu 8988s CTRP2 0.6575 3.0487 0.6422 35.9385
SNU-410 CTRP2 0.9171 11.2318 -1.4929 39.611
Panc 03.27 GDSC1; GDSC2; CTRP2 1.4476 2.6609 1.4473 30.6255
Hs 766T GDSC1; GDSC2; CTRP2 1.6467 4.4666 1.5659 29.5693
HPAC GDSC1; GDSC2; CTRP2 1.681 3.6985 1.6653 29.1222
HuP-T4 GDSC1; GDSC2; CTRP2 1.7464 4.6588 1.6467 28.9695
MIA PaCa-2 GDSC1; GDSC2; CTRP2 1.8613 3.7268 1.8491 27.9091
BxPC-3 GDSC1; GDSC2; CTRP2 1.9391 4.5257 1.8692 27.5857
PaTu 8988t GDSC1; GDSC2; CTRP2 1.9497 2.9577 1.9495 27.2801
KP-1N GDSC1; GDSC2 2.0103 4.483 0.0113 3.8595
KP-3 GDSC1; GDSC2; CTRP2 2.2195 5.9699 1.8903 26.6149
PK-45H CTRP2 2.2875 5.195 2.1412 25.5281
Panc 10.05 GDSC1; GDSC2; CTRP2 2.3745 4.2688 2.3504 24.5302
SW1990 GDSC1; GDSC2; CTRP2 2.4415 5.0889 2.326 24.3965
TCC-Pan2 CTRP2 2.5491 6.4787 2.103 24.8458
DAN-G GDSC1; GDSC2; CTRP2 2.5941 4.364 2.5722 23.0598
Panc 08.13 GDSC1; GDSC2; CTRP2 2.6157 3.4065 2.6156 22.8429
CFPAC-1 GDSC1; GDSC2; CTRP2 2.636 4.2282 2.623 22.7507
SU.86.86 GDSC1; GDSC2; CTRP2 2.6859 4.9169 2.6142 22.6178
AsPC-1 GDSC1; GDSC2; CTRP2 2.7042 5.8505 2.4502 23.1337
KP-4 GDSC1; GDSC2; CTRP2 2.8904 4.2477 2.883 21.0371
PK-59 CTRP2 2.8932 8.9839 1.519 25.8784
PL4 GDSC1; GDSC2 3.0642 4.6881 0.4654 0.4407
SNU-213 CTRP2 3.0729 7.554 2.2929 22.6047
SUIT-2 GDSC1; GDSC2; CTRP2 3.1113 7.3128 2.4255 22.0059
PaTu 8902 GDSC1; GDSC2; CTRP2 3.123 5.1031 3.0552 19.6928
L3.3 CTRP2 3.2077 4.5764 3.1947 18.9418
HPAF-II GDSC1; CTRP2 3.2441 5.8597 3.0367 19.3765
YAPC GDSC1; GDSC2; CTRP2 3.3135 4.3743 3.3101 18.205
HuP-T3 GDSC1; GDSC2; CTRP2 3.3523 5.5461 3.2259 18.3696
KP-2 GDSC1; GDSC2; CTRP2 3.4151 5.0635 3.3713 17.6646
Capan-2 GDSC1; CTRP2 3.4984 5.127 3.4521 17.1186
Capan-1 GDSC1; GDSC2; CTRP2 3.6298 6.2981 3.3358 17.1247
Panc 02.03 GDSC1; GDSC2; CTRP2 3.8916 5.6169 3.7964 14.6688
Panc 04.03 GDSC1; GDSC2; CTRP2 3.9602 5.7728 3.8379 14.3076
MZ-PC-1 GDSC1; GDSC2 3.9765 5.8964 0.38 0.286
PSN1 GDSC1; GDSC2; CTRP2 4.2861 6.3506 4.0339 12.6105
Panc 05.04 CTRP2 5.4552 13.3429 1.8932 18.1939
QGP-1 GDSC1; GDSC2; CTRP2 8.0515 13.3864 3.8811 5.8558
⏷ Show the Full List of 40 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 75 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SH4 CTRP2 0.5233 5.1689 0.2336 37.623
WM35 GDSC1; GDSC2 -1.0502 1.1783 -1.2885 21.8356
CHL-1 GDSC1; GDSC2 -0.6353 3.0505 -1.5784 21.6818
MZ-MEL-2 GDSC1; GDSC2 0.9585 4.5949 -0.8321 11.6801
A-431 GDSC1; GDSC2 0.9744 2.9338 0.0117 6.3322
451Lu GDSC1; GDSC2 1.1705 4.5432 -0.6316 9.8243
M14 GDSC1 1.1727 3.3205 -0.0197 7.4348
G-mel GDSC1; GDSC2 1.2126 3.6254 -0.14 6.6224
IPC-298 GDSC1; GDSC2; CTRP2 1.4217 5.7543 1.0756 31.9329
WM278 GDSC1; GDSC2 1.6229 3.9006 0.0303 4.5473
Hs 938.T GDSC1; GDSC2 1.6388 3.0979 0.4236 2.1568
Hs 940.T GDSC1; GDSC2 1.6407 3.302 0.3291 2.7058
UACC-257 GDSC1; GDSC2; CTRP2 1.677 2.377 1.677 29.096
A-388 GDSC1; GDSC2 1.7458 4.3583 -0.1056 5.1044
SH-4 GDSC1; GDSC2 1.8034 4.5399 -0.1534 5.2692
Malme-3M CTRP2 1.84 5.3196 1.6316 28.7157
IST-MEL1 GDSC1; GDSC2 1.9829 5.7542 -0.6161 7.6742
LOX-IMVI GDSC1; GDSC2; CTRP2 2.0326 4.994 1.9018 27.1707
DJM-1 GDSC1; GDSC2 2.039 5.4332 -0.4219 6.3803
RPMI-7951 GDSC1; GDSC2; CTRP2 2.0688 3.375 2.0673 26.4912
G-361 GDSC1; GDSC2 2.1119 4.5398 0.0486 3.4545
Mel JuSo GDSC1; GDSC2; CTRP2 2.1321 4.0456 2.1128 26.1291
Mel Ho GDSC1; GDSC2; CTRP2 2.1411 5.3024 1.9619 26.6157
MMAc-SF GDSC1; GDSC2 2.2458 4.4235 0.1812 2.49
WM1552C GDSC1; GDSC2 2.2695 3.6165 0.5376 0.7305
WM983B CTRP2 2.29 6.3351 1.8642 26.4852
MZ-MEL-7 GDSC1; GDSC2 2.3471 4.2795 0.3002 1.727
Hs 934.T CTRP2 2.4043 2.9471 2.4043 24.2505
IGR-37 GDSC1; GDSC2; CTRP2 2.4439 2.9526 2.4439 23.9873
WM88 CTRP2 2.4542 5.4922 2.2621 24.5781
COLO 800 GDSC1; GDSC2; CTRP2 2.4828 5.0244 2.381 24.0743
A2058 GDSC1; GDSC2; CTRP2 2.5141 3.7453 2.512 23.5265
A-375 GDSC1; GDSC2; CTRP2 2.5151 4.951 2.4268 23.8124
IGR-1 GDSC1; GDSC2; CTRP2 2.6046 3.2747 2.6046 22.9161
Hs 688(A).T CTRP2 2.6061 3.005 2.6061 22.9061
MeWo GDSC1; GDSC2; CTRP2 2.6683 4.55 2.6357 22.6018
CP50-MEL-B GDSC1; GDSC2 2.6786 4.0979 0.5287 0.4651
SK-MEL-3 GDSC1; GDSC2; CTRP2 2.687 3.9818 2.6831 22.3804
SK-MEL-24 GDSC1; GDSC2; CTRP2 2.7091 3.3536 2.7091 22.2201
K029AX CTRP2 2.7222 4.193 2.7129 22.1642
CP66-MEL GDSC1; GDSC2 2.7666 4.3017 0.4884 0.5381
LB2518-MEL GDSC1; GDSC2 2.7877 3.9845 0.6123 0.2015
LB373-MEL-D GDSC1; GDSC2 2.8134 3.8643 0.6631 0.1071
Hs 294T CTRP2 2.848 4.1473 2.8427 21.3127
WM115 GDSC1; GDSC2; CTRP2 2.8943 3.5011 2.8943 20.9867
COLO 792 GDSC1; GDSC2; CTRP2 2.943 3.8836 2.9423 20.6643
HMCB CTRP2 2.9574 4.9131 2.9035 20.7483
A101D GDSC1; GDSC2; CTRP2 3.0023 3.952 3.0015 20.2694
HT-144 GDSC1; GDSC2; CTRP2 3.0049 4.388 2.9949 20.2832
IGR-39 CTRP2 3.0419 4.7546 3.0095 20.1123
RVH-421 GDSC1; GDSC2; CTRP2 3.0481 6.3971 2.6717 21.2888
UACC-62 GDSC1; GDSC2; CTRP2 3.0482 5.3367 2.937 20.3412
Hs 944.T CTRP2 3.0546 5.4492 2.9227 20.371
MDA-MB-435S CTRP2 3.0716 4.868 3.0296 19.9468
GAK GDSC1; GDSC2 3.1185 4.6255 0.5091 0.3067
SK-MEL-1 GDSC1; GDSC2; CTRP2 3.1275 6.0126 2.8697 20.3328
COLO 783 GDSC1; GDSC2 3.129 4.7787 0.4579 0.4296
SK-MEL-30 GDSC1; GDSC2; CTRP2 3.3309 4.1202 3.3306 18.0786
VMRC-MELG GDSC1; GDSC2 3.3503 4.7276 0.5582 0.1463
WM793 GDSC1; GDSC2; CTRP2 3.4813 4.221 3.481 17.0766
SK-MEL-5 GDSC1; GDSC2; CTRP2 3.5108 4.2904 3.5103 16.8807
COLO 679 GDSC1; GDSC2 3.5462 5.157 0.4806 0.2247
Hs 895.T CTRP2 3.5669 6.2985 3.2672 17.5632
WM266-4 CTRP2 3.6611 9.245 2.1915 21.3542
WT2-iPS GDSC1; GDSC2; CTRP2 3.7692 5.7648 3.6318 15.6326
WM1799 CTRP2 3.8422 4.4944 3.8419 14.6725
CJM [Human melanoma] CTRP2 3.8498 5.7582 3.721 15.0658
HMV-II GDSC1; GDSC2 3.8939 6.2264 0.23 0.6756
COLO 829 GDSC1; GDSC2; CTRP2 4.2045 6.0692 4.0296 12.8702
SK-MEL-28 GDSC1; GDSC2; CTRP2 4.2236 4.9396 4.2211 12.1387
SK-MEL-31 GDSC1; GDSC2; CTRP2 4.5882 5.1785 4.5858 9.7094
SK-MEL-2 GDSC1; GDSC2; CTRP2 4.6105 8.303 3.5748 13.5229
Hs 839.T CTRP2 5.3744 5.9188 5.3433 4.5705
Hs 936.T CTRP2 6.1578 12.6093 2.856 13.0715
EquiPSC Line K2 GDSC1; GDSC2 3.3586 14.9097 -4.1005 21.2172
⏷ Show the Full List of 75 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 11 Cell Line(s) in Aero Dig Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TE-12 GDSC1; GDSC2 0.7738 6.1403 -1.761 17.6995
KYSE-220 GDSC1; GDSC2 0.8952 3.9636 -0.57 10.2371
SK-GT-4 GDSC1; GDSC2 0.9186 4.2295 -0.683 10.8736
KYAE-1 GDSC1; GDSC2 1.0095 3.7053 -0.3448 8.4834
OACP4 C GDSC1; GDSC2 1.3458 6.3481 -1.3916 13.9216
ESO-26 GDSC1; GDSC2 1.4228 4.8138 -0.567 8.7397
KYSE-50 GDSC1; GDSC2 1.5327 3.5317 0.1459 4.0411
FLO-1 GDSC1; GDSC2 1.7204 6.1013 -0.978 10.4847
ESO-51 GDSC1; GDSC2 2.7446 5.7598 -0.1313 3.4017
OACM5.1 C GDSC1; GDSC2 2.7685 5.2121 0.1212 2.0705
HCE-4 GDSC1; GDSC2 3.357 12.2694 -2.8117 16.1759
⏷ Show the Full List of 11 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 684 GDSC1; GDSC2; CTRP2 2.8198 4.5881 2.791 21.5794
Cancer Drug Sensitivity Data Curated from 34 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MHH-NB-11 GDSC1; GDSC2; CTRP2 0.837 5.3897 0.5259 35.6464
SJNB-6 GDSC1; GDSC2 1.29 3.3602 0.052 5.2097
Kelly GDSC1; GDSC2 1.4986 3.1298 0.3165 3.0747
SK-N-DZ GDSC1; GDSC2; CTRP2 1.5438 2.6844 1.5436 29.9841
SJNB-7 GDSC1; GDSC2 1.6203 7.4238 -1.7108 14.9651
GI-ME-N GDSC1; GDSC2 1.6294 4.7034 -0.3569 6.9184
SJNB-13 GDSC1; GDSC2 1.8178 5.1321 -0.4305 6.926
NB(TU)1 GDSC1; GDSC2 1.8586 4.8511 -0.2654 5.8283
SK-N-MC-IXC GDSC1; GDSC2 1.9225 3.2383 0.524 1.1667
KP-N-YS GDSC1; GDSC2 1.951 3.7241 0.3251 2.1728
SJNB-14 GDSC1; GDSC2 1.9846 3.7345 0.34 2.038
SJNB-5 GDSC1; GDSC2 2.0129 3.5609 0.4327 1.5062
NH-12 GDSC1; GDSC2 2.0425 4.3239 0.1056 3.2525
CHP-212 GDSC1; GDSC2; CTRP2 2.1655 3.8834 2.1546 25.8781
SK-N-BE(2) CTRP2 2.2691 4.487 2.2223 25.3092
IMR-5 GDSC1; GDSC2 2.3553 4.9834 -0.0076 3.3499
SK-N-AS GDSC1; GDSC2; CTRP2 2.3853 3.4778 2.3846 24.3797
SK-N-FI GDSC1; GDSC2; CTRP2 2.4919 3.4363 2.4917 23.6678
SK-N-BE(2)-M17 GDSC1; GDSC2 2.5042 3.9176 0.5238 0.5947
SJNB-17 GDSC1; GDSC2 2.5799 4.4114 0.3618 1.171
SK-N-SH GDSC1; GDSC2; CTRP2 2.6084 3.2154 2.6084 22.8913
SJNB-12 GDSC1; GDSC2 2.6993 4.7523 0.2795 1.4096
TGW GDSC1; GDSC2 2.7557 4.4015 0.4457 0.6887
NH-6 CTRP2 2.7938 3.5419 2.7938 21.6561
NB69 GDSC1; GDSC2 3.0133 4.7518 0.4211 0.6001
SJNB-10 GDSC1; GDSC2 3.0475 4.7974 0.4181 0.5888
NB1 GDSC1; GDSC2; CTRP2 3.1383 5.2942 3.0417 19.6906
KP-N-SI9s CTRP2 3.207 7.3682 2.5071 21.4284
KP-N-RT-BM-1 GDSC2 3.3261 5.3499 0.3255 0.7114
GOTO GDSC1; GDSC2 3.3346 5.5835 0.2396 0.9992
CHP-126 GDSC1; GDSC2; CTRP2 3.3564 4.7815 3.3361 17.9761
LA-N-6 GDSC1; GDSC2 3.4521 5.1814 0.4372 0.3428
SiMa GDSC1; GDSC2 4.3559 6.2032 0.4095 0.1545
KP-N-YN GDSC1; GDSC2; CTRP2 4.8469 6.3805 4.6325 8.7467
⏷ Show the Full List of 34 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 6 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-478 CTRP2 0.8805 4.1095 0.7955 34.678
SNU-1079 CTRP2 1.7328 3.928 1.7065 28.8126
SNU-1196 CTRP2 1.9411 5.5378 1.6939 28.1773
SNU-308 CTRP2 2.099 4.9153 1.986 26.668
HuCC-T1 GDSC1; GDSC2; CTRP2 2.1275 4.4013 2.0815 26.2498
SNU-869 CTRP2 4.0995 5.6904 4.007 13.2749
⏷ Show the Full List of 6 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 89 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HDQ-P1 GDSC1; GDSC2; CTRP2 0.9695 4.4078 0.8519 34.1905
BT-474 GDSC1; GDSC2; CTRP2 1.1771 3.1969 1.1679 32.4574
HCC1954 GDSC1; GDSC2; CTRP2 1.3272 3.5534 1.3081 31.4902
HCC2157 GDSC1; GDSC2 1.4476 2.9934 0.3472 2.9991
CAL-148 GDSC2; CTRP2 1.6761 2.7264 1.676 29.1027
HCC1569 GDSC1; GDSC2 1.7211 3.9182 0.0893 3.9754
HCC1806 GDSC1; GDSC2; CTRP2 1.8262 3.8651 1.8067 28.1677
MDA-MB-468 GDSC1; GDSC2; CTRP2 1.8636 3.9643 1.8397 27.9331
MDA-MB-175-VII GDSC1; GDSC2 1.9684 3.6754 0.3571 1.9702
AU565 GDSC1; GDSC2; CTRP2 1.9865 3.3852 1.9844 27.0412
HCC1395 GDSC1; GDSC2; CTRP2 2.0181 3.927 2.0014 26.8796
MFM-223 GDSC1; GDSC2 2.019 3.892 0.289 2.2616
CAL-85-1 GDSC1; GDSC2; CTRP2 2.0962 4.2744 2.0599 26.4254
HCC2218 GDSC1; GDSC2; CTRP2 2.203 5.1488 2.0584 26.0843
BT-483 GDSC1; GDSC2 2.2647 3.8739 0.4299 1.2032
Hs 578T GDSC1; GDSC2; CTRP2 2.2691 3.7049 2.265 25.1652
HCC1599 GDSC2 2.2734 4.444 0.1877 2.4126
SK-BR-3 CTRP2 2.3211 3.4908 2.3201 24.8085
DU4475 GDSC1; GDSC2; CTRP2 2.3715 3.4778 2.3708 24.4718
MDA-MB-453 GDSC1; GDSC2; CTRP2 2.3742 3.5218 2.3733 24.4544
ZR-75-30 GDSC1; GDSC2; CTRP2 2.3873 4.808 2.3104 24.6245
Hs 578Bst CTRP2 2.395 3.3102 2.3949 24.313
MDA-MB-436 GDSC1; GDSC2 2.4111 4.6143 0.1892 2.2034
UACC-812 GDSC2 2.4445 4.7151 0.1633 2.2899
Evsa-T GDSC1; GDSC2 2.4461 4.1574 0.4016 1.1342
CAL-51 GDSC1; GDSC2; CTRP2 2.449 3.9836 2.4409 23.9803
MDA-MB-157 GDSC1; GDSC2; CTRP2 2.4717 9.6749 0.7854 29.4764
JIMT-1 GDSC1; GDSC2; CTRP2 2.4768 5.7933 2.2166 24.6666
EFM-19 GDSC1; GDSC2 2.5279 5.1454 0.0196 2.9254
HCC1143 GDSC1; GDSC2; CTRP2 2.5343 4.6293 2.4875 23.5425
HCC1937 GDSC1; GDSC2; CTRP2 2.5393 5.1267 2.425 23.7411
BT-549 GDSC1; GDSC2; CTRP2 2.6314 5.6838 2.4116 23.4968
OCUB-M GDSC1; GDSC2 2.6459 4.6332 0.3026 1.3631
MRK-nu-1 GDSC1; GDSC2 2.6496 4.601 0.3177 1.2924
T-47D GDSC1; GDSC2; CTRP2 2.6702 4.1098 2.6627 22.5045
HCC202 GDSC1; CTRP2 2.6714 5.3749 2.5221 22.9832
HCC1187 GDSC1; GDSC2 2.6883 5.3428 0.0218 2.6777
HCC38 GDSC1; GDSC2; CTRP2 2.7515 4.52 2.7251 22.0265
HCC1500 GDSC1; GDSC2; CTRP2 2.8409 4.8608 2.7862 21.527
HCC70 GDSC1; GDSC2 3.0429 4.7287 0.4419 0.5192
KPL-1 CTRP2 3.1296 4.5809 3.1138 19.4717
HCC1419 GDSC1; GDSC2; CTRP2 3.1305 6.457 2.7428 20.7832
CAL-120 GDSC1; GDSC2; CTRP2 3.1383 4.9349 3.0928 19.5147
HCC1428 GDSC1; GDSC2; CTRP2 3.2173 5.0391 3.1642 19.0142
EFM-192A GDSC1; GDSC2; CTRP2 3.2199 5.6342 3.0634 19.3568
MDA-MB-231 GDSC1; GDSC2; CTRP2 3.2211 5.5903 3.0743 19.315
HMC-1-8 CTRP2 3.2743 3.8723 3.2742 18.4551
UACC-893 GDSC1; GDSC2 3.3239 5.8457 0.1311 1.4279
MDA-MB-415 GDSC1; GDSC2; CTRP2 3.5205 5.2423 3.4603 17.0188
BT-20 GDSC1; GDSC2; CTRP2 3.5466 6.224 3.2674 17.6237
YMB-1-E GDSC2 3.8326 5.9983 0.2893 0.5435
MDA-MB-330 GDSC1; GDSC2 3.9141 6.093 0.2867 0.5133
MDA-MB-361 GDSC1; GDSC2; CTRP2 3.9382 6.0164 3.7534 14.6775
COLO 824 GDSC1; GDSC2 4.045 5.8451 0.4223 0.1975
ZR-75-1 CTRP2 6.749 11.1511 4.0518 7.1049
MCF-7 GDSC1; GDSC2; CTRP2 7.0125 11.4055 4.1216 6.39
CAMA-1 GDSC1; GDSC2; CTRP2 7.4901 15.1008 2.6573 11.4798
BT 139 CTRP2 0.9596 3.4706 0.9332 33.9626
BT 159 CTRP2 1.5965 3.2967 1.5916 29.649
BT 428 CTRP2 2.1305 3.7699 2.1227 26.101
BT 416 CTRP2 2.3355 3.7239 2.332 24.7209
BT 145 CTRP2 2.3701 5.0036 2.2633 24.8419
BT 172 CTRP2 2.3793 3.9875 2.3696 24.4499
BT 245 CTRP2 2.3889 5.2571 2.2392 24.865
BT 231 CTRP2 2.4373 3.2395 2.4372 24.0313
BT 228 CTRP2 2.6202 2.9933 2.6202 22.8128
BT 239 CTRP2 2.668 3.0869 2.668 22.4939
BT 504 CTRP2 2.6692 3.0621 2.6692 22.4859
BT 286 CTRP2 2.6902 3.1636 2.6902 22.3464
BT 187 CTRP2 2.7254 3.9357 2.7227 22.1205
BT 216 CTRP2 2.7304 3.9941 2.7268 22.0904
BT 440 CTRP2 2.764 3.9159 2.762 21.8614
BT 232 CTRP2 2.7944 3.6282 2.7942 21.6526
BT147 CTRP2 2.8173 5.1006 2.7281 21.803
BT 112 CTRP2 2.8756 4.395 2.8616 21.1577
BT 330 CTRP2 3.0892 5.1066 3.0185 19.9282
BT 444 CTRP2 3.139 4.3847 3.1323 19.3789
BT164 CTRP2 3.1392 5.0442 3.0805 19.5537
BT 179 CTRP2 3.1635 4.9309 3.12 19.3398
BT 359 CTRP2 3.2323 5.5465 3.0956 19.2046
BT 271 CTRP2 3.6068 7.2512 2.9791 18.5214
BT 224 CTRP2 3.6951 5.5451 3.5976 15.9853
BT 482 CTRP2 3.7158 5.4016 3.6454 15.7534
BT 340 CTRP2 4.0195 5.6741 3.9236 13.8197
BT 333 CTRP2 4.0267 5.662 3.9339 13.761
BT 248 CTRP2 4.0471 5.3337 4.0096 13.4332
BT 328 CTRP2 4.4673 8.1574 3.497 14.1956
BT 422 CTRP2 4.658 6.3516 4.4376 10.0226
BT 320 CTRP2 5.0763 6.5405 4.8205 7.3828
⏷ Show the Full List of 89 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Tongue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
YD-38 CTRP2 0.1614 3.4337 0.1051 39.3609
Cancer Drug Sensitivity Data Curated from 68 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
H4 GDSC1; GDSC2 0.2768 4.1559 -1.2148 16.1836
SF539 GDSC1; GDSC2; CTRP2 1.0967 2.3877 1.0964 32.9631
MOG-G-UVW GDSC1; GDSC2 1.1204 3.9392 -0.3705 8.3289
Daoy GDSC1; GDSC2; CTRP2 1.3102 4.3283 1.2254 31.8218
KNS-60 CTRP2 1.4036 2.3523 1.4036 30.9175
MOG-G-CCM GDSC1; GDSC2 1.595 5.3007 -0.6769 8.9759
D-336MG GDSC1; GDSC2 1.6426 4.4984 -0.2469 6.2072
D-423MG GDSC1; GDSC2 1.6655 4.4712 -0.2171 5.9701
D-566MG GDSC1; GDSC2 1.8219 4.3692 -0.0587 4.6553
LNZTA3WT4 GDSC1; GDSC2 1.8226 4.3486 -0.0483 4.5913
SK-MG-1 GDSC1; GDSC2 1.8321 4.7599 -0.2398 5.7309
KS-1 [Human Krukenberg tumour] GDSC1; GDSC2 1.8819 4.2092 0.0574 3.8381
SF268 GDSC1; GDSC2; CTRP2 1.8974 4.6321 1.8115 27.9179
D-502MG GDSC1; GDSC2 1.9198 5.3918 -0.4846 7.0224
ONS-76 GDSC1; GDSC2; CTRP2 2.1154 5.2184 1.9506 26.7368
LN-18 GDSC1; GDSC2 2.1344 3.7185 0.4292 1.3631
LN-229 GDSC1; GDSC2 2.146 5.5157 -0.389 5.9563
Hs 683 GDSC1; GDSC2; CTRP2 2.1789 2.9027 2.1789 25.7524
GaMG GDSC1; GDSC2; CTRP2 2.195 4.1237 2.1734 25.7179
D-263MG GDSC1; GDSC2 2.1988 3.7131 0.4643 1.119
Onda 11 GDSC1; GDSC2 2.2753 4.7635 0.0449 3.191
AM-38 GDSC1; GDSC2; CTRP2 2.3735 4.1284 2.3575 24.5095
GB-1 GDSC1; GDSC2; CTRP2 2.4295 4.3669 2.4007 24.1797
M059J GDSC1; GDSC2 2.4785 4.2998 0.3586 1.2918
KG-1-C CTRP2 2.5311 2.956 2.5311 23.4058
42-MG-BA GDSC1; GDSC2; CTRP2 2.5451 2.9892 2.5451 23.3128
KINGS-1 GDSC1; GDSC2 2.5811 4.8821 0.1644 2.0976
D283 Med GDSC1; GDSC2; CTRP2 2.5992 3.0549 2.5992 22.9521
SW1088 GDSC1; GDSC2; CTRP2 2.6962 4.1973 2.6861 22.3402
SF126 GDSC1; GDSC2; CTRP2 2.7208 4.4015 2.7012 22.2079
CAS-1 GDSC1; GDSC2; CTRP2 2.7587 4.1968 2.7501 21.9186
D-392MG GDSC1; GDSC2 2.8836 5.4339 0.0862 2.0975
M059K CTRP2 2.9099 3.6296 2.9098 20.8829
DBTRG-05MG GDSC1; GDSC2; CTRP2 2.9172 6.0031 2.6428 21.7904
SF295 GDSC1; GDSC2; CTRP2 2.9577 5.4951 2.8083 21.0776
Becker GDSC1; GDSC2; CTRP2 3.0762 4.7451 3.0463 19.8754
A-172 GDSC1; GDSC2; CTRP2 3.1175 4.9318 3.0711 19.6563
LN-405 GDSC1; GDSC2 3.1317 4.617 0.5171 0.2837
KNS-81-FD GDSC1; GDSC2 3.1613 5.9608 0.0051 2.1517
T98G GDSC1; GDSC2; CTRP2 3.207 5.0396 3.1532 19.0854
GMS-10 CTRP2 3.2148 4.2949 3.2117 18.8616
SNB-75 GDSC1; GDSC2; CTRP2 3.2316 4.6922 3.2125 18.8033
D-542MG GDSC1; GDSC2 3.2768 4.7448 0.5259 0.2185
Onda 10 GDSC1; GDSC2 3.3057 5.0703 0.4209 0.444
SNU-626 CTRP2 3.3415 4.132 3.3411 18.0081
TM-31 CTRP2 3.3438 5.1867 3.2793 18.2105
KALS-1 GDSC1; GDSC2; CTRP2 3.4019 4.7398 3.3862 17.6575
SNU-489 CTRP2 3.4659 4.2548 3.4653 17.1802
8-MG-BA GDSC1; GDSC2; CTRP2 3.6478 5.2265 3.5984 16.1338
SNU-738 CTRP2 3.7152 4.4699 3.7145 15.5198
U-251MG GDSC1; GDSC2; CTRP2 3.7425 5.0468 3.7184 15.4169
KNS-81 CTRP2 3.7852 4.496 3.7846 15.0529
PFSK-1 GDSC1 3.8511 5.5146 0.4665 0.2166
DK-MG GDSC1; GDSC2; CTRP2 3.8725 5.2364 3.8361 14.5924
GOS-3 CTRP2 3.9306 5.4114 3.8744 14.2736
GI-1 GDSC1; GDSC2 3.9521 5.627 0.4638 0.1575
YH-13 GDSC1; GDSC2; CTRP2 3.9737 4.8591 3.969 13.811
NMC-G1 GDSC1; GDSC2; CTRP2 4.0099 5.2497 3.98 13.655
SW1783 GDSC1; GDSC2; CTRP2 4.2693 6.4525 3.9822 12.8512
U-118MG GDSC1; GDSC2; CTRP2 4.2746 6.1665 4.0783 12.4817
YKG-1 GDSC1; GDSC2; CTRP2 4.2969 6.3275 4.0531 12.5078
D-247MG GDSC1; GDSC2 4.3192 6.4762 0.303 0.3295
CCF-STTG1 CTRP2 4.3689 5.3649 4.3469 11.2366
KNS-42 GDSC1; GDSC2; CTRP2 4.4235 5.7244 4.3514 11.0462
D-245MG GDSC2 4.7964 7.5407 0.1047 0.5857
U-87MG ATCC GDSC1; CTRP2 6.6228 12.523 3.2736 10.5233
SNU-201 CTRP2 7.8123 9.725 5.3857 0.715
SNU-1105 CTRP2 7.9159 9.1454 5.6468 0.1292
⏷ Show the Full List of 68 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Digestive System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ETK-1 GDSC1; GDSC2 1.8076 4.8174 -0.2848 6.0599
TGBC1TKB GDSC1; GDSC2 2.3961 3.9346 0.4685 0.8972
TGBC24TKB GDSC1; GDSC2 3.438 5.7466 0.2213 0.9881
Cancer Drug Sensitivity Data Curated from 23 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JHUEM-7 CTRP2 1.035 2.6537 1.0334 33.3786
HEC-151 CTRP2 1.8045 4.7313 1.6983 28.6048
JHUEM-3 CTRP2 1.8709 3.8409 1.854 27.8609
KLE GDSC1; GDSC2 1.8849 3.725 0.2853 2.507
JHUEM-1 CTRP2 1.888 2.8633 1.888 27.6905
HEC-50B CTRP2 2.1395 5.2594 1.9686 26.5976
EN GDSC1; GDSC2; CTRP2 2.2173 3.3564 2.2166 25.499
HEC-1-A CTRP2 2.3239 3.7335 2.32 24.7993
ESS-1 GDSC1; GDSC2; CTRP2 2.4037 3.8021 2.3995 24.2688
HEC-6 CTRP2 2.4502 5.3746 2.2824 24.5198
MFE-296 GDSC1; GDSC2; CTRP2 2.6183 4.5432 2.5839 22.9411
MFE-319 GDSC1; GDSC2; CTRP2 3.1497 5.8605 2.9336 20.0356
AN3-CA GDSC1; GDSC2; CTRP2 3.392 5.0329 3.3503 17.8117
EFE-184 CTRP2 3.4025 6.623 2.9848 19.0889
HEC-1-B CTRP2 3.5283 10.2211 1.6127 23.7979
MFE-280 GDSC1; GDSC2 4.4805 6.717 0.278 0.3289
HEC-59 CTRP2 5.5341 11.7164 2.7727 14.6618
RL95-2 GDSC1; GDSC2; CTRP2 6.4958 12.055 3.4065 10.2095
HEC-251 CTRP2 6.9249 16.8737 1.3449 17.2293
HEC-265 CTRP2 7.3355 9.7894 5.1071 2.0359
JHUEM-2 CTRP2 7.5748 10.2534 5.037 2.0364
HEC-108 CTRP2 7.5824 17.1498 1.7156 14.7929
Ishikawa (Heraklio) 02 ER- CTRP2 3.2616 5.6655 3.1019 19.0905
⏷ Show the Full List of 23 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 39 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SW13 GDSC1; GDSC2 -0.4971 1.5625 -0.8158 16.7565
KTCTL-140 GDSC1; GDSC2 -0.329 3.772 -1.6051 20.6312
LB996-RCC GDSC2 0.6861 3.5518 -0.5461 10.7334
SW156 GDSC1; GDSC2 0.6879 4.4703 -1.0016 13.5477
CAL-54 GDSC1; GDSC2; CTRP2 0.8558 6.3169 0.3052 36.1874
LB2241-RCC GDSC1; GDSC2 1.0154 3.329 -0.1517 7.2467
TK-10 GDSC1; GDSC2 1.159 3.2598 -0.0003 5.8859
LB1047-RCC GDSC1; GDSC2 1.1809 4.4311 -0.5672 9.3936
KTCTL-26A GDSC1; GDSC2 1.1912 3.7231 -0.2057 7.0939
BB65-RCC GDSC1; GDSC2 1.2249 4.4764 -0.5545 9.1926
KTCTL-13 GDSC1; GDSC2 1.266 3.6006 -0.0858 6.1388
UO-31 GDSC1; GDSC2; CTRP2 1.3017 3.6159 1.2786 31.6735
NCC010 GDSC1; GDSC2 1.4871 3.8487 -0.0416 5.3061
KTCTL-1M GDSC1; GDSC2 1.4894 5.0992 -0.6574 9.1258
TUHR4TKB CTRP2 1.4937 4.1164 1.4421 30.4901
769-P GDSC1; GDSC2; CTRP2 1.5215 5.144 1.3218 30.7985
KTCTL-195 GDSC1; GDSC2 1.5314 5.0562 -0.6041 8.689
A-704 GDSC1; GDSC2 1.6035 4.9918 -0.518 7.9765
HA7-RCC GDSC1; GDSC2 1.6816 3.5209 0.2523 3.0802
VMRC-RCZ GDSC1; GDSC2; CTRP2 2.0534 3.4713 2.0508 26.5973
VMRC-RCW GDSC1; GDSC2; CTRP2 2.0644 4.8 1.9665 26.8465
A-498 GDSC1; GDSC2; CTRP2 2.1646 5.3312 1.9815 26.473
RXF 393L GDSC1; GDSC2 2.1846 7.4645 -1.306 11.2642
BFTC-909 GDSC1; GDSC2; CTRP2 2.2221 4.0531 2.2053 25.5206
KMRC-20 GDSC1; GDSC2; CTRP2 2.4595 5.8796 2.1758 24.8643
SN12C GDSC1; GDSC2 2.5044 5.5139 -0.1606 3.952
786-O GDSC1; GDSC2; CTRP2 2.5318 5.0865 2.4237 23.7694
NCC021 GDSC1; GDSC2 2.6212 4.7769 0.2302 1.7259
KTCTL-21 GDSC1; GDSC2 2.6776 8.5013 -1.4613 11.0022
KMRC-1 GDSC1; GDSC2; CTRP2 3.1908 5.0333 3.1368 19.1937
RCC10RGB GDSC1; GDSC2; CTRP2 3.3268 5.22 3.2562 18.345
KMRC-2 CTRP2 3.3684 5.2077 3.3025 18.0517
SNU-1272 CTRP2 3.4599 5.4487 3.3613 17.5557
TUHR10TKB CTRP2 3.4834 4.3684 3.482 17.0661
TUHR14TKB CTRP2 3.9629 6.3127 3.6943 14.818
ACHN GDSC1; GDSC2; CTRP2 3.9886 9.7859 2.2708 20.2045
Caki-2 CTRP2 4.4879 10.7267 2.3065 18.8338
OS-RC-2 GDSC1; GDSC2; CTRP2 4.8626 11.9701 2.047 18.9343
Caki-1 GDSC1; GDSC2; CTRP2 6.4025 14.7555 1.9836 15.9496
⏷ Show the Full List of 39 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 57 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
DiFi GDSC1; GDSC2 0.501 4.1221 -0.9942 14.1028
SW48 GDSC1; GDSC2; CTRP2 0.5154 4.1222 0.406 37.1718
CCK-81 GDSC1; GDSC2; CTRP2 0.8024 3.937 0.7318 35.1506
LoVo GDSC1; GDSC2; CTRP2 0.987 4.4401 0.866 34.0852
SNU-81 GDSC1; GDSC2 1.0898 7.5528 -2.2018 19.0609
NCI-H508 GDSC1; GDSC2; CTRP2 1.099 3.6148 1.0689 33.0469
GP2d CTRP2 1.3012 5.0687 1.098 32.2684
SNU-C5 GDSC1; GDSC2; CTRP2 1.3708 5.804 1.0075 32.3207
GP5d GDSC1; GDSC2 1.3839 3.583 0.0128 5.2188
HCT 15 GDSC1; GDSC2; CTRP2 1.4754 4.2719 1.407 30.6678
C2BBe1 GDSC1; GDSC2; CTRP2 1.5206 4.6373 1.4083 30.5139
SNU-C4 CTRP2 1.5398 4.6444 1.4277 30.3855
NCI-H747 GDSC1; GDSC2; CTRP2 1.6856 3.3682 1.6804 29.0563
NCI-H716 GDSC1; GDSC2; CTRP2 1.7842 4.1773 1.7414 28.5257
SNU-283 GDSC2 1.8126 3.4732 0.3571 2.2268
SW1116 GDSC1; GDSC2 1.8249 4.413 -0.0776 4.7631
HT115 GDSC1; GDSC2; CTRP2 1.8523 3.2334 1.8507 27.9337
SNU-175 GDSC2; CTRP2 1.88 5.773 1.5708 28.7926
T84 GDSC1; GDSC2; CTRP2 1.8815 3.1977 1.8803 27.7378
SNU-C1 GDSC1; GDSC2; CTRP2 1.8851 3.5055 1.8799 27.727
SNU-407 GDSC1; GDSC2; CTRP2 1.8986 5.4218 1.6735 28.384
SNU-C2A CTRP2 1.9085 5.8242 1.589 28.6393
SW948 GDSC1; GDSC2; CTRP2 1.9295 3.2869 1.9279 27.4196
SNU-61 GDSC1; GDSC2; CTRP2 1.9518 4.4631 1.8899 27.4738
HT-55 GDSC1; GDSC2; CTRP2 1.9932 3.8554 1.9791 27.0367
COLO 320 CTRP2 2.0364 5.1527 1.8776 27.2416
OUMS-23 CTRP2 2.1128 3.0463 2.1128 26.1929
LS513 GDSC1; GDSC2; CTRP2 2.2916 3.3476 2.2912 25.0029
SW1417 GDSC1; GDSC2; CTRP2 2.3418 4.624 2.2846 24.8603
SW626 GDSC1; GDSC2 2.3858 5.2475 -0.1101 3.8723
CL-11 GDSC1; GDSC2; CTRP2 2.4574 4.3296 2.4324 23.981
RKO GDSC1; GDSC2; CTRP2 2.5883 4.7364 2.5329 23.2121
SW1463 GDSC1; GDSC2 2.6528 4.9692 0.1647 2.0032
HCC-56 CTRP2 2.6558 4.3326 2.638 22.6349
LS180 GDSC1; GDSC2; CTRP2 2.6677 4.5649 2.6338 22.6101
SNU-503 CTRP2 2.7001 7.8762 1.7708 25.5685
LS123 GDSC1; GDSC2; CTRP2 2.7911 4.2939 2.7794 21.7131
RCM-1 [Human ESC] GDSC1; GDSC2; CTRP2 2.8182 5.6377 2.6257 22.1575
COLO 320HSR GDSC1; GDSC2 2.822 7.2673 -0.7765 6.863
KM12 GDSC1; GDSC2; CTRP2 2.8634 4.9625 2.7973 21.4163
HCT 8 CTRP2 2.9049 3.9586 2.9035 20.9203
LS1034 GDSC1; GDSC2; CTRP2 2.9127 3.8824 2.912 20.8659
SW620 GDSC1; GDSC2; CTRP2 3.0936 5.5603 2.9422 20.1796
LS411N GDSC1; GDSC2; CTRP2 3.1261 4.137 3.1245 19.4477
SW837 GDSC1; GDSC2 3.1447 5.9951 -0.0177 2.2788
CW-2 GDSC1; GDSC2; CTRP2 3.2117 6.5822 2.791 20.3655
MDST8 GDSC1; GDSC2; CTRP2 3.2607 7.1536 2.645 20.7619
COLO 678 GDSC1; GDSC2; CTRP2 3.2766 9.7128 1.5918 24.5515
SNU-C2B GDSC1; GDSC2 3.3079 6.0239 0.0512 1.7822
SK-CO-1 GDSC1; GDSC2; CTRP2 3.3179 4.44 3.313 18.1807
CaR-1 GDSC1; GDSC2 3.4067 11.1146 -2.2193 13.3367
HT-29 GDSC1; GDSC2; CTRP2 3.9696 8.3837 2.8894 17.8771
DLD-1 CTRP2 4.1269 5.1073 4.115 12.8145
HCC2998 GDSC1; GDSC2 4.2625 5.9068 0.4765 0.0954
COLO201 CTRP2 5.2875 13.3574 1.7394 19.1115
HCT 116 GDSC1; GDSC2; CTRP2 7.9759 14.809 3.1487 8.8213
COLO205 GDSC1; GDSC2; CTRP2 8.757 18.1492 2.0764 11.6664
⏷ Show the Full List of 57 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Leukemia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MO-T GDSC1; GDSC2 1.8961 5.7841 -0.6926 8.3371
Cancer Drug Sensitivity Data Curated from 26 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuH-6 CTRP2 1.1396 3.9275 1.0875 32.849
JHH-5 CTRP2 1.1929 5.0131 0.9915 32.9783
SNU-182 CTRP2 1.2707 2.9411 1.2679 31.8122
Li-7 CTRP2 1.5433 5.1154 1.3511 30.6291
HLF CTRP2 1.6552 3.3588 1.6499 29.2591
SNU-761 CTRP2 1.6753 4.6829 1.5672 29.4711
HLE GDSC1; GDSC2 1.8184 3.687 0.2619 2.7611
JHH-1 GDSC1; GDSC2; CTRP2 2.2705 3.9945 2.2578 25.1845
HuH-1 GDSC1; GDSC2; CTRP2 2.4507 4.8723 2.3692 24.218
Huh-7 GDSC1; GDSC2 2.5773 4.8177 0.1901 1.9749
Hep-G2 CTRP2 2.659 4.7784 2.603 22.7433
SNU-449 GDSC1; GDSC2; CTRP2 2.6814 4.6995 2.6354 22.56
JHH-7 GDSC1; GDSC2 2.8071 4.7889 0.316 1.145
PLC/PRF/5 CTRP2 2.8331 4.558 2.8073 21.4807
JHH-4 GDSC1; GDSC2; CTRP2 2.8612 5.6855 2.6615 21.8968
SNU-387 GDSC1; GDSC2; CTRP2 2.9594 5.008 2.8936 20.7758
Hep-G2/C3A GDSC1; GDSC2 3.0921 4.511 0.5399 0.249
SNU-878 CTRP2 3.096 4.0209 3.0952 19.6454
JHH-2 GDSC1; GDSC2; CTRP2 3.1838 6.5968 2.7559 20.5768
SNU-423 GDSC1; GDSC2; CTRP2 3.3639 5.193 3.2999 18.0752
SNU-886 CTRP2 3.7336 5.2952 3.6806 15.5745
SNU-398 GDSC1; GDSC2; CTRP2 3.7677 7.344 3.1145 17.5561
SK-HEP-1 GDSC1; GDSC2; CTRP2 4.2001 7.3507 3.5693 14.6167
SNU-475 CTRP2 4.3461 5.6671 4.2787 11.5452
JHH-6 GDSC1; GDSC2; CTRP2 4.6977 5.9041 4.6105 9.2742
Hep 3B2.1-7 GDSC1; GDSC2; CTRP2 7.4719 16.85 1.7802 14.7524
⏷ Show the Full List of 26 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 220 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HCC827 GDSC1; GDSC2; CTRP2 -4.0017 -0.8395 -4.0044 66.6376
HCC4006 CTRP2 -1.4761 4.2591 -1.7535 50.0918
PC-14 GDSC1; GDSC2; CTRP2 -1.1699 3.7111 -1.3362 48.1907
HCC2935 CTRP2 -0.5203 5.0556 -0.8761 44.3661
NCI-H3255 GDSC1; GDSC2 -0.2873 3.8177 -1.5861 20.3661
NCI-H2369 GDSC1; GDSC2 0.0586 6.4635 -2.5511 24.0848
NCI-H209 GDSC1; GDSC2 0.1652 5.1426 -1.8024 19.9289
PaCa-3 GDSC1; GDSC2 0.193 5.5847 -1.9954 20.867
LUDLU-1 CTRP2 0.3923 3.9008 0.3022 37.929
NCI-H1666 GDSC1; GDSC2; CTRP2 0.5084 4.1221 0.3986 37.2191
NCI-H292 GDSC1; GDSC2; CTRP2 0.5275 4.6647 0.3365 37.326
EMC-BAC-1 GDSC1; GDSC2 0.6906 3.6354 -0.5837 10.9542
CAL-12T GDSC1; GDSC2; CTRP2 0.7639 5.1525 0.4984 35.9918
LOU-NH91 GDSC1; GDSC2; CTRP2 0.8878 11.6316 -1.6973 40.0138
NCI-H1568 GDSC1; GDSC2; CTRP2 0.941 5.4202 0.6321 34.9627
DV-90 CTRP2 0.9626 3.6909 0.9218 33.9897
NCI-H322M GDSC1; GDSC2 0.9815 5.7175 -1.3742 14.8724
NCI-H2795 GDSC1; GDSC2 1.1279 3.7746 -0.2822 7.7508
NCI-H290 GDSC1; GDSC2 1.2097 4.4317 -0.5444 9.1713
HARA [Human squamous cell lung carcinoma] GDSC1; GDSC2; CTRP2 1.2098 4.1024 1.1446 32.4248
SK-MES-1 GDSC1; GDSC2; CTRP2 1.2436 3.693 1.214 32.0821
NCI-H1975 GDSC1; GDSC2 1.2743 3.4271 0.0068 5.5348
NCI-H1703 GDSC1; GDSC2; CTRP2 1.2926 3.7136 1.2634 31.7544
RERF-LC-Sq1 GDSC1; GDSC2 1.3123 7.8098 -2.1483 18.139
NCI-H2803 GDSC1; GDSC2 1.3286 4.0708 -0.2709 7.137
NCI-H1648 GDSC1; GDSC2 1.3539 3.2974 0.1312 4.5532
EMC-BAC-2 GDSC1; GDSC2 1.3658 3.8941 -0.1547 6.3123
A-427 GDSC1; GDSC2 1.4864 5.9081 -1.0614 11.5926
NCI-H64 GDSC1; GDSC2 1.491 2.8893 0.4266 2.4268
COR-L23 GDSC1; GDSC2 1.5176 3.7947 0.007 4.9321
NCI-H2373 GDSC1; GDSC2 1.5303 4.6629 -0.4105 7.493
EBC-1 GDSC1; GDSC2; CTRP2 1.5521 3.03 1.5505 29.9336
NCI-H810 GDSC1; GDSC2; CTRP2 1.5688 2.2453 1.5688 29.817
NCI-H322 CTRP2 1.5721 5.4576 1.3104 30.6687
NCI-H1693 GDSC1; GDSC2; CTRP2 1.6572 4.8618 1.5198 29.6897
NCI-H661 GDSC1; GDSC2; CTRP2 1.6585 5.0674 1.4849 29.8032
COR-L105 GDSC1; GDSC2; CTRP2 1.678 5.967 1.3002 30.3533
LC-1/sq GDSC1; GDSC2 1.6873 7.8917 -1.8911 15.7577
NCI-H2170 GDSC1; GDSC2; CTRP2 1.7323 4.6607 1.6313 29.0679
EKVX GDSC1; GDSC2; CTRP2 1.7532 4.7621 1.6388 28.974
ChaGo-K-1 GDSC1; GDSC2; CTRP2 1.7572 2.5499 1.7572 28.5617
NCI-H647 GDSC1; GDSC2; CTRP2 1.758 4.076 1.7224 28.6758
LK-2 GDSC1; GDSC2 1.7746 3.5876 0.2807 2.7333
RERF-LC-KJ GDSC1; GDSC2 1.7777 4.5605 -0.1812 5.4945
RERF-LC-A1 CTRP2 1.7886 4.6458 1.6936 28.6729
NCI-H1915 GDSC1; GDSC2; CTRP2 1.8136 3.0001 1.8132 28.1875
HOP-92 GDSC1; GDSC2; CTRP2 1.8278 4.1007 1.7933 28.2071
NCI-H23 GDSC1; GDSC2; CTRP2 1.8461 3.6051 1.8376 27.998
ABC-1 GDSC1; GDSC2 1.8546 10.958 -3.286 21.8058
Lu-99 CTRP2 1.861 5.4901 1.6175 28.6957
NCI-H1573 GDSC1; GDSC2; CTRP2 1.8613 4.9957 1.7168 28.3571
NCI-H2286 CTRP2 1.8636 6.8462 1.2401 29.9453
NCI-H1563 GDSC1; GDSC2; CTRP2 1.8866 4.6065 1.8034 27.9803
SK-LU-1 GDSC1; CTRP2 1.9245 6.7396 1.3408 29.4197
HCC1171 CTRP2 1.9398 7.2253 1.1947 29.8474
NCI-H82 GDSC1; GDSC2 1.9456 6.2333 -0.8766 9.3255
NCI-H720 GDSC1; GDSC2 1.9501 4.0013 0.1979 2.8899
NCI-H524 GDSC1; GDSC2 1.9568 6.4263 -0.963 9.8134
NCI-H522 GDSC2; CTRP2 1.9723 3.8982 1.9556 27.1848
NCI-H1781 GDSC1; GDSC2 2.0111 4.0948 0.192 2.8159
Calu-3 GDSC1; GDSC2; CTRP2 2.0249 3.5015 2.0215 26.7896
EPLC-272H GDSC1; GDSC2; CTRP2 2.0306 6.7789 1.4435 28.74
NCI-H1944 GDSC1; GDSC2; CTRP2 2.0526 3.8615 2.0398 26.6368
NCI-H2461 GDSC1; GDSC2 2.0775 4.2275 0.1713 2.8186
NCI-H1650 GDSC1; GDSC2; CTRP2 2.0838 6.7461 1.5119 28.342
HCC1588 CTRP2 2.0972 3.4139 2.0955 26.3024
NCI-H2081 GDSC1; GDSC2 2.0977 4.6759 -0.0236 3.897
NCI-H1048 GDSC1; GDSC2 2.1088 6.7229 -0.9982 9.6614
LC-1/sq-SF CTRP2 2.1186 3.835 2.1084 26.1881
HCC95 CTRP2 2.1375 4.7472 2.0521 26.317
NCI-H847 GDSC1; GDSC2 2.1386 4.391 0.1332 2.9282
NCI-H513 GDSC1; GDSC2 2.154 4.7863 -0.0396 3.8855
NCI-H2066 GDSC1; GDSC2 2.1586 3.8783 0.3731 1.6104
NCI-H1623 GDSC1; GDSC2; CTRP2 2.1663 4.6651 2.0936 26.0821
HCC44 GDSC1; GDSC2; CTRP2 2.174 3.6789 2.1692 25.8014
NCI-H2110 GDSC1; GDSC2; CTRP2 2.2012 5.0489 2.074 26.0365
IST-SL2 GDSC1; GDSC2 2.2127 5.7649 -0.4633 6.2597
LCLC-97TM1 GDSC1; GDSC2; CTRP2 2.2249 4.1704 2.2015 25.5244
NCI-H2291 GDSC1; GDSC2 2.2411 4.2342 0.2626 2.0644
NCI-H358 GDSC1; GDSC2; CTRP2 2.2443 5.4813 2.0364 26.0289
NCI-H2722 GDSC1; GDSC2 2.2445 4.8787 -0.0265 3.6464
HCC33 GDSC2 2.2462 3.7971 0.4528 1.1186
NCI-H1304 GDSC1 2.2549 3.973 0.3831 1.7896
NCI-H1755 GDSC1; GDSC2; CTRP2 2.2557 5.153 2.1145 25.722
Lu-65 GDSC1; GDSC2; CTRP2 2.2663 3.885 2.2577 25.199
NCI-H2087 GDSC1; GDSC2; CTRP2 2.2721 3.9299 2.262 25.1654
COR-L51 CTRP2 2.2724 3.3067 2.2721 25.1307
NCI-H520 GDSC1; GDSC2; CTRP2 2.2741 3.322 2.2737 25.1195
NCI-H2405 GDSC1; GDSC2; CTRP2 2.2907 4.3462 2.2574 25.1195
COLO 699 CTRP2 2.303 4.7519 2.2279 25.1796
NCI-H1355 GDSC1; GDSC2; CTRP2 2.3084 5.2731 2.1489 25.4349
DMS 454 CTRP2 2.3429 4.1508 2.3247 24.7209
NCI-H1838 GDSC1; GDSC2; CTRP2 2.3474 4.8178 2.2664 24.9042
NCI-H2731 GDSC1; GDSC2 2.3528 4.5084 0.2036 2.2113
NCI-H345 GDSC1; GDSC2 2.3739 3.2704 0.7102 0.1388
NCI-H727 GDSC1; GDSC2; CTRP2 2.3856 4.9835 2.2831 24.7236
NCI-H841 GDSC1; GDSC2; CTRP2 2.4056 4.5763 2.3571 24.4057
NCI-H2818 GDSC1; GDSC2 2.4057 10.0142 -2.396 16.4654
Calu-6 GDSC1; GDSC2; CTRP2 2.4074 3.9966 2.398 24.2614
NCI-H2869 GDSC1; GDSC2 2.441 4.9207 0.0704 2.7859
NCI-H146 GDSC1; GDSC2; CTRP2 2.454 3.3741 2.4539 23.9202
COR-L279 GDSC1; GDSC2 2.4548 3.8781 0.5176 0.6538
NCI-H1373 CTRP2 2.4556 4.2644 2.4348 23.9786
NCI-H187 GDSC1 2.4684 3.4616 0.678 0.2153
DMS 53 GDSC1; GDSC2; CTRP2 2.4939 3.3638 2.4938 23.6545
NCI-H1869 GDSC1; CTRP2 2.4969 8.3887 1.3519 27.6054
CPC-N GDSC1; GDSC2 2.5034 5.2409 -0.0373 3.2714
NCI-H1435 GDSC1; GDSC2 2.5204 3.9996 0.4991 0.6715
IST-SL1 GDSC1; GDSC2 2.5461 4.8008 0.1809 2.0614
Lu-139 GDSC1; GDSC2 2.552 4.3931 0.3559 1.2256
LC-2/ad GDSC1; GDSC2 2.5596 5.5546 -0.1462 3.7787
NCI-H1694 GDSC1; GDSC2; CTRP2 2.5604 3.168 2.5604 23.211
HCC2279 CTRP2 2.5645 7.214 1.8734 25.6121
COLO 668 GDSC1; GDSC2; CTRP2 2.5769 4.8155 2.5113 23.3228
RERF-LC-Ad2 CTRP2 2.5778 6.847 2.0151 25.0705
NCI-H2009 GDSC1; GDSC2; CTRP2 2.5903 4.5862 2.5506 23.1454
NCI-H1651 GDSC1; GDSC2; CTRP2 2.5924 3.6306 2.5918 22.9998
NCI-H1341 GDSC1; GDSC2; CTRP2 2.5928 3.1926 2.5928 22.9951
SW1271 GDSC1; GDSC2; CTRP2 2.6043 4.7326 2.5502 23.1012
NCI-H1793 GDSC1; GDSC2; CTRP2 2.6264 5.7222 2.397 23.5639
Lu-134-A GDSC1; GDSC2 2.6452 4.7765 0.2426 1.6389
MOR/CPR CTRP2 2.6506 3.1393 2.6506 22.6099
LXF 289 GDSC1; GDSC2; CTRP2 2.6524 5.7362 2.422 23.3946
VMRC-LCD GDSC1; GDSC2; CTRP2 2.6774 4.6552 2.6356 22.5723
Sq-1 CTRP2 2.6866 4.6488 2.646 22.5068
Lu-165 GDSC1; GDSC2 2.7168 4.1499 0.5249 0.4545
SHP-77 GDSC1; GDSC2; CTRP2 2.7468 3.7766 2.746 21.9715
NCI-H2591 GDSC1; GDSC2 2.7678 5.9009 -0.1811 3.6339
COR-L311 GDSC2 2.7758 11.6813 -2.9427 18.0651
Lu-135 GDSC1; GDSC2 2.7848 4.6323 0.3683 0.9541
NCI-H2023 GDSC1; GDSC2; CTRP2 2.8031 4.5424 2.7772 21.681
SBC-1 GDSC1; GDSC2 2.8151 5.0829 0.1993 1.6462
SBC-3 GDSC1; GDSC2 2.8215 4.7839 0.3246 1.0962
DMS 273 GDSC1; GDSC2; CTRP2 2.843 3.8684 2.8421 21.3312
DMS 114 GDSC1; GDSC2; CTRP2 2.8665 4.0882 2.8628 21.1839
NCI-H2228 GDSC1; GDSC2; CTRP2 2.871 5.3382 2.7453 21.572
NCI-H1770 GDSC1; GDSC2 2.8718 4.1701 0.5781 0.2445
HOP-62 GDSC1; GDSC2; CTRP2 2.8757 5.162 2.7811 21.4322
NCI-H211 GDSC1; GDSC2; CTRP2 2.903 3.7937 2.9026 20.9299
HCC1833 CTRP2 2.9044 8.7688 1.6222 25.4911
NCI-H2135 GDSC1; GDSC2 2.9134 4.5391 0.4598 0.539
NCI-H446 GDSC1; GDSC2; CTRP2 2.9161 3.9026 2.9152 20.8441
NCI-H2171 GDSC2 2.9505 4.4951 0.4912 0.4268
A-549 GDSC1; GDSC2; CTRP2 2.9942 5.6135 2.8226 20.9125
Ms-1 GDSC1; GDSC2 3.0055 4.7804 0.407 0.6502
NCI-H1105 GDSC1; GDSC2; CTRP2 3.0126 4.3396 3.0047 20.2247
NCI-H650 GDSC1; GDSC2; CTRP2 3.0258 5.6417 2.8507 20.715
LK2 CTRP2 3.0434 4.2052 3.0398 20.0053
NCI-H2444 GDSC1; GDSC2; CTRP2 3.0467 4.5201 3.0316 20.0217
NCI-H1963 GDSC1; GDSC2 3.0534 4.8635 0.3956 0.6569
COR-L95 GDSC1; GDSC2; CTRP2 3.0567 4.665 3.0324 19.9862
NCI-H838 GDSC1; GDSC2; CTRP2 3.0637 4.5548 3.0471 19.9132
UMC-11 GDSC1; GDSC2 3.0639 4.6716 0.4714 0.4248
NCI-H1184 CTRP2 3.074 4.5898 3.0556 19.8507
Lu-99A GDSC1; GDSC2 3.0745 5.7438 0.0525 2.0306
NCI-H510A GDSC1; GDSC2 3.1097 5.169 0.3023 0.9416
HCC15 GDSC1; GDSC2; CTRP2 3.1149 4.7846 3.0833 19.623
NCI-H1155 GDSC1; GDSC2; CTRP2 3.1181 4.5936 3.1011 19.5527
T3M-10 CTRP2 3.1224 4.4604 3.1124 19.5
NCI-H2227 GDSC1; GDSC2 3.1638 4.6462 0.5188 0.2686
COR-L321 GDSC1; GDSC2 3.1706 8.3117 -1.044 7.6934
Calu-1 CTRP2 3.171 5.4198 3.0544 19.5424
LB647-SCLC GDSC1; GDSC2 3.1844 4.909 0.432 0.4727
COR-L303 GDSC2 3.195 4.6288 0.5365 0.2228
NCI-H1792 GDSC1; GDSC2; CTRP2 3.2044 6.621 2.7703 20.4628
NCI-H889 CTRP2 3.2093 5.9283 2.9813 19.6818
DMS 79 GDSC1; GDSC2 3.2104 4.7319 0.506 0.2798
NCI-H1437 GDSC1; GDSC2 3.23 5.2454 0.3247 0.7758
NCI-H596 GDSC1; GDSC2 3.2449 4.7417 0.5153 0.2487
HCC366 GDSC1; GDSC2; CTRP2 3.2469 5.1777 3.1769 18.8749
NCI-H1092 GDSC1; GDSC2; CTRP2 3.2475 4.7656 3.2238 18.7127
NCI-H2141 GDSC1; GDSC2; CTRP2 3.257 5.439 3.1437 18.9582
NCI-H2029 GDSC1; GDSC2; CTRP2 3.2625 5.2117 3.1885 18.7849
NCI-H1993 GDSC1; GDSC2 3.2625 4.9347 0.4533 0.381
NCI-H69 GDSC1; GDSC2 3.2654 5.2769 0.3277 0.7428
NCI-H2106 CTRP2 3.2888 4.9285 3.2525 18.4806
NCI-H2347 GDSC1; GDSC2 3.2911 5.551 0.2331 1.0567
NCI-H2810 GDSC1; GDSC2 3.3051 11.7028 -2.5734 15.2202
NCI-H748 GDSC2 3.3143 5.1138 0.4084 0.4731
NCI-H1436 GDSC1; GDSC2 3.3506 4.7494 0.5509 0.1572
NCI-H2122 GDSC1; GDSC2; CTRP2 3.3845 4.4812 3.3797 17.7369
NCI-H835 GDSC1; GDSC2 3.3875 5.16 0.4202 0.4092
NCI-H1688 GDSC1; GDSC2 3.4092 5.1517 0.4315 0.3726
NCI-H196 GDSC1; GDSC2; CTRP2 3.4435 5.266 3.3744 17.5623
NCI-H2804 GDSC1; GDSC2 3.4473 5.751 0.2236 0.973
COR-L32 GDSC2 3.4596 5.4635 0.3376 0.5971
NCI-H1581 GDSC1; GDSC2; CTRP2 3.4825 4.4001 3.4807 17.0738
HCC78 GDSC1; GDSC2; CTRP2 3.548 4.9382 3.524 16.7122
NCI-H526 GDSC1; GDSC2; CTRP2 3.5555 4.36 3.5547 16.5841
NCI-H1836 GDSC1; GDSC2 3.5656 5.0862 0.5119 0.1684
NCI-H1395 CTRP2 3.5953 8.2914 2.5433 20.2075
NCI-H2196 GDSC2; CTRP2 3.6273 4.5082 3.6253 16.1097
RERF-LC-Ad1 CTRP2 3.7363 4.9252 3.7213 15.4273
NCI-H1299 GDSC1; GDSC2; CTRP2 3.7481 7.399 3.072 17.7724
COR-L88 GDSC1; GDSC2; CTRP2 3.7756 7.4558 3.0786 17.6708
NCI-H1339 CTRP2 3.7898 5.1373 3.7596 15.1223
RERF-LC-MS GDSC1; GDSC2; CTRP2 3.8593 5.2716 3.8178 14.6979
NCI-H1734 GDSC1; GDSC2 3.8924 5.7238 0.4094 0.2562
HCC1195 CTRP2 3.9219 7.5038 3.2138 16.7494
NCI-H250 GDSC2 3.9504 5.6387 0.4592 0.1641
NCI-H1876 GDSC1; GDSC2 3.9615 5.5739 0.4849 0.129
NCI-H3122 GDSC1; GDSC2 3.9664 6.2645 0.2448 0.5982
SW1573 GDSC1; GDSC2; CTRP2 3.9716 7.8278 3.1316 16.9318
BEN GDSC1; GDSC2; CTRP2 4.0368 4.9895 4.0285 13.4026
IA-LM GDSC1; GDSC2; CTRP2 4.0757 5.7999 3.9574 13.5247
NCI-H740 GDSC2 4.234 6.2228 0.36 0.2515
NCI-H2595 GDSC1; GDSC2 4.2876 5.8775 0.4946 0.0768
SBC-5 GDSC1; GDSC2; CTRP2 4.321 5.0097 4.3184 11.4903
NCI-H2342 GDSC1; GDSC2; CTRP2 4.4518 7.6272 3.7155 13.371
KNS-62 GDSC1; GDSC2; CTRP2 4.5054 6.161 4.3316 10.8654
NCI-H226 GDSC1; GDSC2; CTRP2 4.5465 6.2369 4.3534 10.6625
NCI-H2030 GDSC1; GDSC2; CTRP2 4.6853 16.2267 -0.2195 26.5657
NCI-H460 GDSC1; GDSC2; CTRP2 5.3072 12.3716 2.2473 17.1915
NCI-H2085 GDSC1; GDSC2; CTRP2 5.4281 11.9409 2.568 15.6942
NCI-H2126 CTRP2 6.3046 12.906 2.828 12.9021
LCLC-103H GDSC1; GDSC2; CTRP2 7.6129 11.6843 4.4 4.4044
HCC2108 CTRP2 7.8848 18.3309 1.3593 15.5114
NCI-H2172 GDSC1; GDSC2; CTRP2 7.9275 9.4465 5.5429 0.2927
NCI-H441 GDSC1; GDSC2; CTRP2 8.9437 10.4796 5.5544 0.073
Hs 888.Lu CTRP2 3.4422 9.3283 1.9322 22.8927
⏷ Show the Full List of 220 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Lymphoma Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CBTCi002-A GDSC1; GDSC2 3.4388 5.5154 0.3098 0.6924
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Clivus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
U-CH1 CTRP2 1.08 7.9626 0.0038 36.1367
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Thigh Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SYO-1 CTRP2 1.7312 2.9431 1.7307 28.7367
H-STS CTRP2 1.896 2.5357 1.896 27.6371
P-STS CTRP2 3.502 6.5036 3.1321 18.2523
Cancer Drug Sensitivity Data Curated from 31 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Yamato-SS CTRP2 2.2607 3.4042 2.2599 25.2103
Aska-SS CTRP2 2.4657 3.6707 2.4641 23.8471
TE 617.T CTRP2 -0.5284 3.2148 -0.5989 43.9462
BT-16 CTRP2 0.6736 4.243 0.5586 36.1422
Hs 729.T CTRP2 1.4953 3.7942 1.4686 30.3958
Hs 633.T GDSC1; GDSC2 1.7283 4.3315 -0.1048 5.1382
EW-8 GDSC1; GDSC2 1.7631 3.7844 0.1808 3.3422
VA-ES-BJ GDSC1; GDSC2 1.8581 5.2837 -0.4756 7.1087
A-204 GDSC1; GDSC2; CTRP2 1.9408 3.6997 1.9313 27.3706
Rh41 GDSC1; GDSC2; CTRP2 2.0491 3.4331 2.0469 26.6245
MFH-ino GDSC1; GDSC2 2.0544 4.8018 -0.1104 4.4891
GCT GDSC1; GDSC2; CTRP2 2.2517 3.2742 2.2515 25.2682
Tm87-16 CTRP2 2.3219 3.0175 2.3219 24.7998
SW684 GDSC1; GDSC2 2.3526 3.2441 0.7116 0.1427
BT-12 CTRP2 2.3768 2.7803 2.3768 24.4342
TTC-709 CTRP2 2.3793 3.7476 2.3758 24.429
G-401 GDSC1; GDSC2; CTRP2 2.4291 3.6356 2.4276 24.0905
STS-0421 GDSC1; GDSC2 2.4958 4.7978 0.1551 2.2602
KYM-1 GDSC1; GDSC2; CTRP2 2.5804 3.0138 2.5804 23.0773
TE 441.T GDSC2; CTRP2 2.6072 3.0776 2.6072 22.8992
SK-UT-1 GDSC1; GDSC2; CTRP2 2.6531 5.1441 2.5446 22.9629
RKN GDSC1; GDSC2; CTRP2 2.6657 5.0335 2.5758 22.8149
Rh30 GDSC1; GDSC2 2.6691 4.958 0.1779 1.9186
RD GDSC1; GDSC2; CTRP2 2.7504 4.6436 2.7135 22.0694
SW982 GDSC1; GDSC2; CTRP2 2.7539 4.5815 2.7227 22.0268
HT-1080 GDSC1; GDSC2; CTRP2 2.8073 4.0827 2.8029 21.5809
G-402 GDSC1; GDSC2; CTRP2 3.134 5.3159 3.0333 19.7334
SW872 GDSC1; GDSC2 3.2006 4.9965 0.4062 0.5375
Rh18 GDSC1 3.4124 4.9442 0.5059 0.2695
SK-LMS-1 GDSC1; GDSC2; CTRP2 3.6905 7.932 2.7943 18.9925
MES-SA GDSC1; GDSC2; CTRP2 7.4735 8.4997 5.7098 0.1426
⏷ Show the Full List of 31 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 45 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
2004 CTRP2 2.6115 3.2912 2.6115 22.8706
IGROV-1 GDSC1; GDSC2; CTRP2 0.2313 5.6524 -0.197 39.8255
SNU-119 CTRP2 0.6521 3.1904 0.6306 35.9944
COV434 CTRP2 0.8398 3.7387 0.7897 34.837
OVTOKO GDSC1; GDSC2; CTRP2 0.903 4.6439 0.7444 34.7591
ES-2 GDSC1; GDSC2 0.9166 4.8223 -0.9811 12.7193
OC 314 GDSC1; GDSC2; CTRP2 1.0343 3.1872 1.0226 33.4168
Caov-3 GDSC2; CTRP2 1.1309 4.9538 0.9357 33.3681
SNU-8 CTRP2 1.3053 5.6211 0.9816 32.6255
COV362 CTRP2 1.4055 3.3528 1.3961 30.9364
TYK-nu GDSC1; GDSC2; CTRP2 1.4382 4.0723 1.3878 30.8556
JHOS-4 GDSC1; GDSC2 1.5127 3.1729 0.3055 3.1113
DOV13 GDSC1; GDSC2; CTRP2 1.53 4.7494 1.4013 30.5064
OVCAR-5 GDSC1; GDSC2; CTRP2 1.6028 4.0772 1.56 29.7337
ES2 CTRP2 1.6921 6.2309 1.2424 30.4962
OVCAR-4 GDSC1; GDSC2; CTRP2 1.8481 4.3691 1.7903 28.1507
RMG-I GDSC1; GDSC2; CTRP2 2.0272 7.4786 1.1992 29.5547
OVCAR-8 GDSC1; GDSC2; CTRP2 2.1178 3.6466 2.1129 26.1758
OVKATE GDSC1; GDSC2 2.1832 4.8473 -0.0498 3.8903
COV644 CTRP2 2.2912 4.2338 2.2662 25.0883
EFO-27 GDSC1; GDSC2; CTRP2 2.4337 6.8738 1.8498 26.0922
A2780 GDSC1; GDSC2; CTRP2 2.4788 4.4932 2.442 23.8781
ONCO-DG-1 CTRP2 2.4966 4.6008 2.4506 23.7908
JHOC-5 CTRP2 2.579 8.9122 1.2224 27.7861
OAW42 GDSC1; CTRP2 2.6324 4.4765 2.6041 22.8264
OV7 CTRP2 2.6394 5 2.5527 22.9791
OAW28 GDSC1; GDSC2; CTRP2 2.713 4.3326 2.6971 22.2474
HEY A8 CTRP2 2.8224 5.0876 2.7356 21.7607
MCAS CTRP2 2.8605 5.5127 2.6991 21.7666
OVCAR-3 GDSC1; GDSC2 2.8629 4.699 0.377 0.8569
FU-OV-1 GDSC1; GDSC2; CTRP2 2.9999 6.0842 2.7109 21.2935
SNU-840 CTRP2 3.061 7.2386 2.399 22.2492
TOV-21G GDSC1; GDSC2; CTRP2 3.185 5.2744 3.0953 19.3554
OVK18 GDSC1; GDSC2; CTRP2 3.2645 4.1217 3.2638 18.5224
JHOS-2 GDSC1; GDSC2; CTRP2 3.2794 5.5761 3.1406 18.8985
EFO-21 GDSC1; GDSC2; CTRP2 3.3179 5.9287 3.0996 18.9246
OVSAHO CTRP2 3.3352 6.6452 2.9043 19.5839
TOV-112D GDSC1; GDSC2; CTRP2 3.4478 6.2109 3.1635 18.2991
OV56 GDSC1; GDSC2; CTRP2 3.4516 5.3169 3.3751 17.5339
OVISE GDSC1; GDSC2; CTRP2 3.4922 6.0473 3.2583 17.8212
Caov-4 GDSC1; GDSC2 3.5706 5.5368 0.3548 0.494
Kuramochi GDSC1; GDSC2; CTRP2 3.6489 5.2853 3.5914 16.1544
JHOM-1 CTRP2 3.7525 5.4302 3.6801 15.5157
SK-OV-3 GDSC1; GDSC2; CTRP2 4.0664 10.007 2.2438 20.1084
OV-90 GDSC1; GDSC2; CTRP2 4.1672 5.8894 4.0359 12.9619
⏷ Show the Full List of 45 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 8 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MSTO-211H GDSC1; GDSC2; CTRP2 0.0549 5.6171 -0.3805 40.9442
NCI-H28 GDSC1; GDSC2; CTRP2 1.4199 3.2052 1.4144 30.8273
NCI-H2052 GDSC1; GDSC2; CTRP2 2.5208 7.4067 1.7566 26.1535
MPP 89 GDSC1; GDSC2; CTRP2 2.5795 4.0078 2.5732 23.1044
ACC-MESO-1 CTRP2 2.8483 5.2295 2.7404 21.6611
NCI-H2452 GDSC1; GDSC2; CTRP2 2.9301 5.0031 2.863 20.9756
IST-Mes1 GDSC1; GDSC2; CTRP2 4.1613 5.778 4.0555 12.9105
JL-1 CTRP2 5.1447 8.1602 4.1674 9.8168
⏷ Show the Full List of 8 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 7 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H660 GDSC2 2.4989 4.0427 0.4726 0.7893
LNCaP clone FGC GDSC1; GDSC2; CTRP2 3.0131 5.8989 2.7748 21.0238
22Rv1 GDSC1; GDSC2; CTRP2 3.3116 5.5479 3.1815 18.6534
DU145 GDSC1; GDSC2; CTRP2 3.3362 6.9556 2.7981 19.9743
VCaP GDSC1; GDSC2; CTRP2 3.6987 5.1734 3.6591 15.7613
PC-3 GDSC1; GDSC2 3.7529 5.7585 0.3452 0.4381
PaCa-3 CTRP2 5.2804 5.8919 5.2467 5.2056
⏷ Show the Full List of 7 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
YD-15 CTRP2 -0.1396 3.4632 -0.2134 41.3974
A-253 GDSC1; GDSC2 1.939 3.811 0.2785 2.4522
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Small Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuTu 80 GDSC1; GDSC2 3.0033 10.9283 -2.4099 15.1272
Cancer Drug Sensitivity Data Curated from 44 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCC-StC-K140 CTRP2 -0.1672 4.3766 -0.3628 41.8553
NUGC-4 GDSC1; GDSC2; CTRP2 0.7342 4.0948 0.6421 35.6708
NCI-N87 GDSC1 0.9025 2.8407 -0.0028 8.268
SNU-216 CTRP2 0.9263 4.75 0.7515 34.6551
HSC-39 GDSC1; GDSC2 1.09 2.8428 0.1525 5.1101
HGC-27 GDSC1; GDSC2; CTRP2 1.1585 3.6845 1.1261 32.6581
SK-GT-2 GDSC1; GDSC2 1.2295 3.9441 -0.2854 7.4922
SCH GDSC1; GDSC2 1.2752 5.575 -1.0624 12.1752
SNU-16 GDSC1; GDSC2; CTRP2 1.4027 3.5154 1.3875 30.9743
GCIY GDSC1; GDSC2 1.4856 3.028 0.3566 2.8594
RF-48 GDSC1; GDSC2 1.573 4.2173 -0.1597 5.8334
HuG1-N CTRP2 1.657 4.3782 1.5873 29.4633
SNU-5 GDSC1; GDSC2; CTRP2 1.7069 3.5188 1.6984 28.9253
SNU-601 CTRP2 1.7435 3.1974 1.7415 28.6599
TMK-1 GDSC1; GDSC2 1.7914 4.6058 -0.1935 5.5396
RERF-GC-1B GDSC1; GDSC2 1.8599 9.6741 -2.643 19.0221
ECC10 GDSC1; GDSC2; CTRP2 1.8899 5.2285 1.7043 28.3069
GSS CTRP2 1.9335 4.0244 1.9085 27.4713
OCUM-1 GDSC1; GDSC2 1.9506 4.3522 0.0344 3.8387
SNU-1 GDSC1; GDSC2; CTRP2 1.9624 3.8396 1.9481 27.2427
IM95 GDSC1; GDSC2; CTRP2 2.0711 4.5327 2.0083 26.6827
KE-39 CTRP2 2.0882 8.0053 1.0686 29.7792
NUGC-3 GDSC1; GDSC2; CTRP2 2.2507 7.1265 1.5653 27.6389
MKN1 GDSC1; GDSC2; CTRP2 2.2563 5.4635 2.0532 25.9326
Hs 746.T GDSC1; GDSC2; CTRP2 2.312 3.7381 2.3079 24.8793
MKN28 GDSC1; GDSC2 2.3442 6.2537 -0.6088 6.8459
Fu97 GDSC1; GDSC2; CTRP2 2.4747 4.7578 2.4098 24.0014
SNU-719 CTRP2 2.5573 6.3337 2.156 24.6322
SH-10-TC CTRP2 2.5653 5.857 2.297 24.1074
MKN74 CTRP2 2.6164 8.0039 1.6319 26.2999
SNU-668 CTRP2 2.6898 5.0518 2.5988 22.6582
TGBC11TKB GDSC1; GDSC2 2.6976 5.0509 0.1531 2.0037
SNU-620 CTRP2 2.9533 4.6258 2.9275 20.6797
MKN7 GDSC1; GDSC2; CTRP2 2.9658 5.9168 2.7186 21.3702
GSU CTRP2 3.0477 3.7225 3.0477 19.9642
23132/87 GDSC1; GDSC2; CTRP2 3.1135 4.1795 3.1112 19.5338
ECC12 GDSC2; CTRP2 3.3886 3.9718 3.3885 17.6937
LMSU CTRP2 3.5919 5.113 3.5529 16.4705
KATO III GDSC1; GDSC2; CTRP2 3.9678 7.0225 3.4522 15.7096
MKN45 GDSC1; GDSC2; CTRP2 7.5499 13.2342 3.6138 7.6221
AGS GDSC1; GDSC2; CTRP2 9.7285 19.5843 2.0435 10.4344
SNU-1077 CTRP2 2.2613 4.7726 2.1807 25.4765
SNG-M GDSC1; GDSC2; CTRP2 2.3853 5.6144 2.1598 25.153
SNU-685 CTRP2 3.1697 5.6472 3.006 19.7168
⏷ Show the Full List of 44 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 18 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
IHH-4 GDSC1; GDSC2 0.9874 4.5791 -0.8 11.3963
K5 GDSC1; GDSC2 1.1746 3.1213 0.0811 5.3298
HTC-C3 GDSC1; GDSC2 1.5046 4.2049 -0.2039 6.2726
WRO GDSC1; GDSC2 1.7944 5.3864 -0.5715 7.8422
FTC-238 CTRP2 1.9309 3.2326 1.9298 27.4085
ML-1 [Human leukemia] GDSC1; GDSC2; CTRP2 2.0545 5.6042 1.8019 27.4438
8505C GDSC1; GDSC2; CTRP2 2.1031 5.6146 1.8525 27.1146
KMH-2 GDSC1; GDSC2 2.2073 3.6776 0.4832 1.0233
TT GDSC1; GDSC2; CTRP2 2.4365 4.8019 2.3636 24.2829
BHT-101 GDSC1; GDSC2; CTRP2 2.5141 3.4067 2.514 23.5199
SW579 CTRP2 2.5144 2.9068 2.5144 23.5171
ASH-3 GDSC1; GDSC2 2.5569 4.2148 0.4305 0.9054
CAL-62 GDSC1; GDSC2; CTRP2 2.585 4.4012 2.5602 23.13
8305C GDSC1; GDSC2; CTRP2 3.1097 5.1539 3.0335 19.8104
B-CPAP GDSC1; GDSC2; CTRP2 3.1772 4.8316 3.1445 19.2117
TT2609-C02 GDSC1; GDSC2; CTRP2 3.3581 8.1571 2.3527 21.5762
CGTH-W-1 GDSC1; GDSC2; CTRP2 3.5331 4.104 3.5331 16.7304
FTC-133 GDSC1; GDSC2; CTRP2 5.0912 9.1974 3.6169 12.199
⏷ Show the Full List of 18 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 56 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
YD-10B CTRP2 -2.6828 5.0029 -3.217 56.4117
NCI-H3118 GDSC1; GDSC2 -2.1121 1.7515 -2.6277 33.6518
BICR 78 GDSC1; GDSC2 -1.4399 2.5106 -2.1866 28.3448
PCI-06A GDSC1; GDSC2 -1.2371 2.6042 -2.0103 26.545
PCI-04B GDSC1; GDSC2 -1.0968 1.9097 -1.5881 23.6834
JHU-029 GDSC1; GDSC2 -1.0866 1.7979 -1.5358 23.3525
PCI-38 GDSC1 -0.7386 3.5207 -1.8949 29.0815
DOK GDSC1; GDSC2 -0.7385 5.1523 -2.6575 27.5393
JHU-011 GDSC1; GDSC2 -0.6702 3.4388 -1.7888 22.9797
SNU-1076 CTRP2 -0.579 4.2944 -0.7923 44.5208
JHU-022 GDSC1; GDSC2 -0.4686 6.4968 -3.0512 28.1557
HSC-4 GDSC1; GDSC2; CTRP2 -0.3975 4.8066 -0.6907 43.5058
BB30-HNC GDSC1; GDSC2 -0.2384 2.6543 -0.998 16.7639
KON GDSC1; GDSC2 -0.2193 5.4921 -2.3285 24.0227
CAL-33 GDSC1; GDSC2; CTRP2 0.0394 3.0616 0.0049 40.1085
BICR 6 CTRP2 0.2989 4.0464 0.1853 38.6124
PE/CA-PJ34 (clone C12) CTRP2 0.3205 4.4541 0.1491 38.6278
CAL-27 GDSC1; GDSC2; CTRP2 0.4088 4.2963 0.2682 37.9641
SAT [Human HNSCC] GDSC1; GDSC2 0.4778 7.8122 -2.8505 24.0184
PE/CA-PJ15 GDSC1; GDSC2; CTRP2 0.5719 6.4262 -0.0363 38.1118
BICR 10 GDSC1 0.6005 3.7501 -0.7207 15.0014
LB771-HNC GDSC1; GDSC2 0.6236 7.7499 -2.6935 22.8531
SNU-1214 CTRP2 0.6521 4.4711 0.5025 36.3879
KOSC-2 GDSC1; GDSC2 0.6653 2.7323 -0.1587 8.371
HO-1-N-1 GDSC1; GDSC2 0.6686 3.1692 -0.3718 9.6969
FaDu GDSC1; GDSC2; CTRP2 0.757 4.4008 0.6256 35.6402
SKN-3 GDSC1; GDSC2 0.8531 6.3633 -1.8051 17.695
HO-1-u-1 GDSC1; GDSC2 1.0369 2.2957 0.3827 3.8027
SCC-15 GDSC1; GDSC2 1.048 3.4375 -0.179 7.3251
SAS GDSC1; GDSC2 1.1329 4.2724 -0.5268 9.2747
Ca9-22 GDSC1; GDSC2 1.2636 3.6296 -0.1021 6.2476
PE/CA-PJ49 CTRP2 1.3359 4.0802 1.2796 31.5558
PCI-15A GDSC1; GDSC2 1.4263 4.559 -0.4379 7.9279
BICR 56 CTRP2 1.5736 6.5001 1.0336 31.5565
PE/CA-PJ41 (clone D2) CTRP2 1.5769 6.8701 0.9208 31.8965
BHY GDSC1; GDSC2; CTRP2 1.6743 7.0955 0.9517 31.4782
OSC-20 GDSC1; GDSC2 1.8367 4.7028 -0.209 5.5339
BICR 22 GDSC1; GDSC2; CTRP2 1.8605 3.8104 1.8448 27.9262
SCC-25 GDSC1; GDSC2; CTRP2 1.929 4.5488 1.8557 27.6642
OSC-19 GDSC1; GDSC2 1.9299 7.4862 -1.5045 13.0111
UPCI-SCC-090 GDSC1; GDSC2 2.0276 6.3012 -0.8507 8.9777
SCC-9 GDSC1; GDSC2; CTRP2 2.0989 4.8256 1.9997 26.6215
BICR 31 GDSC2; CTRP2 2.1924 6.7973 1.6133 27.6565
YD-8 CTRP2 2.3005 3.8695 2.293 24.9673
SCC-4 GDSC1; GDSC2; CTRP2 2.5493 5.0606 2.4467 23.6339
HSC-2 GDSC1; GDSC2; CTRP2 2.6414 5.7065 2.4171 23.4463
BICR 16 CTRP2 2.7919 5.5141 2.6244 22.2448
PCI-30 GDSC1; GDSC2 2.8126 6.3183 -0.3435 4.4485
SNU-1066 CTRP2 2.9274 8.6084 1.7137 25.1064
SNU-46 CTRP2 3.2365 13.1109 -0.0347 29.6248
SNU-899 CTRP2 3.3874 6.9874 2.8418 19.6638
BICR 18 CTRP2 3.4052 5.4206 3.3074 17.9172
BB49-HNC GDSC1 3.4094 5.6807 0.2344 1.1984
Detroit 562 GDSC1; GDSC2; CTRP2 4.3206 9.2083 2.8678 17.0623
SNU-1041 CTRP2 4.3485 12.5289 1.2993 22.7947
HSC-3 GDSC1; GDSC2; CTRP2 5.6654 13.9858 1.7536 18.2568
⏷ Show the Full List of 56 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 25 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
U-BLC1 CTRP2 -0.6825 1.9491 -0.6912 44.8368
253J CTRP2 0.596 2.4351 0.5935 36.3066
JMSU-1 CTRP2 0.6697 3.0658 0.654 35.8582
SCaBER CTRP2 0.7465 5.7448 0.3416 36.4937
VM-CUB-1 CTRP2 0.8171 4.8983 0.6067 35.4819
5637 GDSC1; GDSC2; CTRP2 0.9696 4.6312 0.8181 34.2965
CAL-29 GDSC1; GDSC2; CTRP2 1.3147 4.0203 1.2629 31.6823
253J-BV CTRP2 1.4809 4.3764 1.4008 30.6705
HT-1376 GDSC1; GDSC2; CTRP2 1.5138 5.8944 1.1402 31.4171
BC-3C CTRP2 1.6644 5.3302 1.4387 29.9383
TCCSUP GDSC1; GDSC2; CTRP2 2.0263 4.049 2.0032 26.8467
647V GDSC1; GDSC2; CTRP2 2.1941 3.5948 2.1911 25.6613
T24 GDSC1; GDSC2; CTRP2 2.2549 6.2598 1.848 26.6515
BFTC-905 GDSC1; GDSC2; CTRP2 2.3573 3.3325 2.3571 24.5646
SW780 GDSC1; GDSC2 2.448 8.1672 -1.4603 11.514
RT-112 GDSC1; GDSC2; CTRP2 2.5387 4.248 2.5217 23.4125
639V GDSC1; GDSC2; CTRP2 2.5931 4.1388 2.5827 23.0279
KMBC-2 CTRP2 2.6052 4.8227 2.5404 23.1317
J82 GDSC1; GDSC2; CTRP2 2.8342 5.3567 2.702 21.8396
SW1710 GDSC1; GDSC2; CTRP2 3.2834 7.4354 2.5632 21.001
HT-1197 GDSC1; GDSC2; CTRP2 3.4037 5.6294 3.2643 18.0728
KU-19-19 GDSC1; GDSC2; CTRP2 3.4424 9.2229 1.9794 22.7209
UM-UC-3 GDSC1; GDSC2; CTRP2 3.5742 5.8148 3.4076 17.0342
RT-4 GDSC1; GDSC2; CTRP2 3.9078 7.4349 3.2268 16.7379
UM-UC-1 CTRP2 5.0338 7.7811 4.237 9.8028
⏷ Show the Full List of 25 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 39 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SW756 GDSC1; GDSC2 -1.7383 23.7772 -12.744 45.2555
HEY GDSC1; GDSC2 -0.077 6.4665 -2.6756 25.1302
BPH-1 GDSC1; GDSC2 0.0136 3.4919 -1.1401 16.6646
C-33 A GDSC1; GDSC2 0.3237 2.6262 -0.428 11.219
OVMIU GDSC1; GDSC2 0.4672 2.9194 -0.4333 10.75
CAL-39 GDSC1; GDSC2 0.4896 3.1449 -0.5227 11.2301
Ca Ski GDSC1; GDSC2 0.9643 4.3976 -0.7286 11.0219
OVCA420 GDSC1; GDSC2 1.0025 3.3 -0.1479 7.2601
ME-180 GDSC1; GDSC2 1.0417 7.2106 -2.0706 18.5336
OMC-1 [Human cervical carcinoma] GDSC1; GDSC2 1.1042 3.3873 -0.1079 6.717
DSH1 GDSC1; GDSC2 1.1157 3.942 -0.3757 8.3743
JAR GDSC1; GDSC2 1.276 3.1377 0.1516 4.621
C-4-I GDSC1; GDSC2 1.2786 4.607 -0.5769 9.1856
SW954 GDSC1; GDSC2 1.3384 4.6166 -0.5346 8.7614
KGN GDSC1; GDSC2 1.4585 4.1708 -0.2214 6.4953
SKN GDSC1; GDSC2 1.4887 4.7091 -0.4647 7.9347
DoTc2 4510 GDSC1; GDSC2 1.5165 3.7538 0.0262 4.8158
PEO1 GDSC1; GDSC2 1.5385 3.8674 -0.0135 5.01
HeLa GDSC1; GDSC2; CTRP2 1.6979 2.3187 1.6979 28.9569
PWR-1E GDSC1; GDSC2 1.7455 4.8195 -0.3297 6.4767
PA-1 GDSC1; GDSC2 1.746 4.5482 -0.1974 5.6646
OV17R GDSC1; GDSC2 1.7886 3.6998 0.2371 2.9612
OVCA433 GDSC1; GDSC2 2.0774 6.3774 -0.8523 8.8722
JEG-3 GDSC1; GDSC2 2.0994 3.9026 0.3301 1.916
SiSo GDSC1; GDSC2 2.1741 4.4075 0.1468 2.7932
SW962 GDSC1; GDSC2 2.2383 3.7625 0.4633 1.0796
HEC-1 GDSC1; GDSC2 2.2771 5.5816 -0.334 5.3662
UWB1.289 GDSC1; GDSC2 2.2912 5.6476 -0.356 5.4674
MS751 GDSC1; GDSC2 2.2917 4.0891 0.3527 1.5388
SKG-IIIa GDSC1; GDSC2 2.436 4.2936 0.34 1.4252
ACC-OV7 GDSC1; GDSC2 2.4608 5.1019 0.0006 3.1324
NT2-D1 GDSC1; GDSC2 2.5234 4.6614 0.2288 1.853
HT-3 GDSC1; GDSC2 2.893 5.5387 0.0464 2.2788
LB831-BLC GDSC1; GDSC2 3.0131 5.0217 0.3172 0.9619
SiHa GDSC1; GDSC2 3.133 4.6752 0.4969 0.3294
NEC8 GDSC1; GDSC2 3.2071 4.6416 0.5365 0.2192
NCC-IT GDSC2 3.3759 5.1447 0.4212 0.4116
JHOS-3 GDSC1; GDSC2 3.5003 5.4826 0.3469 0.5495
TC-YIK GDSC1; GDSC2 3.5021 5.5579 0.3197 0.6262
⏷ Show the Full List of 39 Cancer Drug Sensitivity Data of This Drug

Drug-Drug Interaction (DDI) Information of This Drug

Coadministration of a Drug Treating the Same Disease as Bosutinib
DDI Drug Name DDI Drug ID Severity Mechanism Disease REF
Eribulin DM1DX4Q Moderate Increased risk of prolong QT interval by the combination of Bosutinib and Eribulin. Breast cancer [2C60-2C6Y] [11]
HKI-272 DM6QOVN Moderate Decreased clearance of Bosutinib due to the transporter inhibition by HKI-272. Breast cancer [2C60-2C6Y] [11]
Tucatinib DMBESUA Major Decreased metabolism of Bosutinib caused by Tucatinib mediated inhibition of CYP450 enzyme. Breast cancer [2C60-2C6Y] [12]
Alpelisib DMEXMYK Moderate Decreased clearance of Bosutinib due to the transporter inhibition by Alpelisib. Breast cancer [2C60-2C6Y] [11]
Coadministration of a Drug Treating the Disease Different from Bosutinib (Comorbidity)
DDI Drug Name DDI Drug ID Severity Mechanism Comorbidity REF
Remdesivir DMBFZ6L Moderate Increased risk of hepatotoxicity by the combination of Bosutinib and Remdesivir. 1D6YCoronavirus Disease 2019 [1D6YCoronavirus Disease 2019] [12]
Sarecycline DMLZNIQ Moderate Decreased clearance of Bosutinib due to the transporter inhibition by Sarecycline . Acne vulgaris [ED80] [11]
Ivosidenib DM8S6T7 Major Increased risk of prolong QT interval by the combination of Bosutinib and Ivosidenib. Acute myeloid leukaemia [2A60] [13]
Arn-509 DMT81LZ Major Increased metabolism of Bosutinib caused by Arn-509 mediated induction of CYP450 enzyme. Acute myeloid leukaemia [2A60] [14]
Gilteritinib DMTI0ZO Moderate Increased risk of prolong QT interval by the combination of Bosutinib and Gilteritinib. Acute myeloid leukaemia [2A60] [15]
Ivabradine DM0L594 Major Increased risk of ventricular arrhythmias by the combination of Bosutinib and Ivabradine. Angina pectoris [BA40] [11]
Bedaquiline DM3906J Major Increased risk of prolong QT interval by the combination of Bosutinib and Bedaquiline. Antimicrobial drug resistance [MG50-MG52] [16]
Levalbuterol DM5YBO1 Moderate Increased risk of ventricular arrhythmias by the combination of Bosutinib and Levalbuterol. Asthma [CA23] [17]
Troleandomycin DMUZNIG Major Decreased metabolism of Bosutinib caused by Troleandomycin mediated inhibition of CYP450 enzyme. Bacterial infection [1A00-1C4Z] [12]
Pexidartinib DMS2J0Z Major Increased risk of hepatotoxicity by the combination of Bosutinib and Pexidartinib. Bone/articular cartilage neoplasm [2F7B] [18]
PF-04449913 DMSB068 Moderate Increased risk of prolong QT interval by the combination of Bosutinib and PF-04449913. Chronic myelomonocytic leukaemia [2A40] [19]
Olodaterol DM62B78 Moderate Increased risk of prolong QT interval by the combination of Bosutinib and Olodaterol. Chronic obstructive pulmonary disease [CA22] [20]
Vilanterol DMF5EK1 Moderate Increased risk of prolong QT interval by the combination of Bosutinib and Vilanterol. Chronic obstructive pulmonary disease [CA22] [17]
Pasireotide DMHM7JS Major Increased risk of prolong QT interval by the combination of Bosutinib and Pasireotide. Cushing syndrome [5A70] [21]
Osilodrostat DMIJC9X Moderate Increased risk of prolong QT interval by the combination of Bosutinib and Osilodrostat. Cushing syndrome [5A70] [11]
Lumacaftor DMCLWDJ Major Increased metabolism of Bosutinib caused by Lumacaftor mediated induction of CYP450 enzyme. Cystic fibrosis [CA25] [11]
Ivacaftor DMZC1HS Moderate Decreased clearance of Bosutinib due to the transporter inhibition by Ivacaftor. Cystic fibrosis [CA25] [11]
MK-8228 DMOB58Q Major Decreased metabolism of Bosutinib caused by MK-8228 mediated inhibition of CYP450 enzyme. Cytomegaloviral disease [1D82] [12]
SODIUM CITRATE DMHPD2Y Moderate Decreased absorption of Bosutinib due to altered gastric pH caused by SODIUM CITRATE. Discovery agent [N.A.] [11]
Deutetrabenazine DMUPFLI Moderate Additive CNS depression effects by the combination of Bosutinib and Deutetrabenazine. Dystonic disorder [8A02] [22]
Ingrezza DMVPLNC Moderate Additive CNS depression effects by the combination of Bosutinib and Ingrezza. Dystonic disorder [8A02] [23]
Stiripentol DMMSDOY Major Decreased metabolism of Bosutinib caused by Stiripentol mediated inhibition of CYP450 enzyme. Epilepsy/seizure [8A61-8A6Z] [12]
Eslicarbazepine DMZREFQ Moderate Increased metabolism of Bosutinib caused by Eslicarbazepine mediated induction of CYP450 enzyme. Epilepsy/seizure [8A61-8A6Z] [14]
Cannabidiol DM0659E Moderate Increased risk of hepatotoxicity by the combination of Bosutinib and Cannabidiol. Epileptic encephalopathy [8A62] [11]
Tazemetostat DMWP1BH Moderate Increased metabolism of Bosutinib caused by Tazemetostat mediated induction of CYP450 enzyme. Follicular lymphoma [2A80] [24]
Boceprevir DMBSHMF Major Decreased metabolism of Bosutinib caused by Boceprevir mediated inhibition of CYP450 enzyme. Hepatitis virus infection [1E50-1E51] [12]
Daclatasvir DMSFK9V Moderate Decreased clearance of Bosutinib due to the transporter inhibition by Daclatasvir. Hepatitis virus infection [1E50-1E51] [11]
GS-5885 DMSL3DX Moderate Decreased clearance of Bosutinib due to the transporter inhibition by GS-5885. Hepatitis virus infection [1E50-1E51] [11]
GS-9857 DMYU6P5 Moderate Decreased clearance of Bosutinib due to the transporter inhibition by GS-9857. Hepatitis virus infection [1E50-1E51] [11]
Brentuximab vedotin DMWLC57 Moderate Increased risk of hepatotoxicity by the combination of Bosutinib and Brentuximab vedotin. Hodgkin lymphoma [2B30] [25]
Cobicistat DM6L4H2 Major Decreased metabolism of Bosutinib caused by Cobicistat mediated inhibition of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [12]
Rilpivirine DMJ0QOW Moderate Increased risk of prolong QT interval by the combination of Bosutinib and Rilpivirine. Human immunodeficiency virus disease [1C60-1C62] [11]
Teriflunomide DMQ2FKJ Major Increased risk of hepatotoxicity by the combination of Bosutinib and Teriflunomide. Hyper-lipoproteinaemia [5C80] [26]
BMS-201038 DMQTAGO Major Increased risk of hepatotoxicity by the combination of Bosutinib and BMS-201038. Hyper-lipoproteinaemia [5C80] [27]
Levamlodipine DM92S6N Moderate Decreased metabolism of Bosutinib caused by Levamlodipine mediated inhibition of CYP450 enzyme. Hypertension [BA00-BA04] [11]
Berotralstat DMWA2DZ Major Decreased metabolism of Bosutinib caused by Berotralstat mediated inhibition of CYP450 enzyme. Innate/adaptive immunodeficiency [4A00] [12]
Suvorexant DM0E6S3 Moderate Decreased clearance of Bosutinib due to the transporter inhibition by Suvorexant. Insomnia [7A00-7A0Z] [11]
Polyethylene glycol DM4I1JP Moderate Increased risk of ventricular arrhythmias by the combination of Bosutinib and Polyethylene glycol. Irritable bowel syndrome [DD91] [11]
Denosumab DMNI0KO Moderate Additive myelosuppressive effects by the combination of Bosutinib and Denosumab. Low bone mass disorder [FB83] [28]
Crizotinib DM4F29C Major Decreased metabolism of Bosutinib caused by Crizotinib mediated inhibition of CYP450 enzyme. Lung cancer [2C25] [12]
Brigatinib DM7W94S Moderate Decreased clearance of Bosutinib due to the transporter inhibition by Brigatinib. Lung cancer [2C25] [11]
Ceritinib DMB920Z Major Decreased metabolism of Bosutinib caused by Ceritinib mediated inhibition of CYP450 enzyme. Lung cancer [2C25] [12]
PF-06463922 DMKM7EW Major Increased metabolism of Bosutinib caused by PF-06463922 mediated induction of CYP450 enzyme. Lung cancer [2C25] [14]
Osimertinib DMRJLAT Major Increased risk of prolong QT interval by the combination of Bosutinib and Osimertinib. Lung cancer [2C25] [29]
Capmatinib DMYCXKL Moderate Decreased clearance of Bosutinib due to the transporter inhibition by Capmatinib. Lung cancer [2C25] [11]
Selpercatinib DMZR15V Major Increased risk of prolong QT interval by the combination of Bosutinib and Selpercatinib. Lung cancer [2C25] [11]
Lumefantrine DM29GAD Major Increased risk of prolong QT interval by the combination of Bosutinib and Lumefantrine. Malaria [1F40-1F45] [12]
Calaspargase pegol DMQZBXI Moderate Increased risk of hepatotoxicity by the combination of Bosutinib and Calaspargase pegol. Malignant haematopoietic neoplasm [2B33] [30]
Idelalisib DM602WT Major Decreased metabolism of Bosutinib caused by Idelalisib mediated inhibition of CYP450 enzyme. Mature B-cell leukaemia [2A82] [12]
IPI-145 DMWA24P Major Decreased metabolism of Bosutinib caused by IPI-145 mediated inhibition of CYP450 enzyme. Mature B-cell leukaemia [2A82] [12]
Ibrutinib DMHZCPO Moderate Decreased clearance of Bosutinib due to the transporter inhibition by Ibrutinib. Mature B-cell lymphoma [2A85] [11]
Ponatinib DMYGJQO Moderate Decreased clearance of Bosutinib due to the transporter inhibition by Ponatinib. Mature B-cell lymphoma [2A85] [11]
Vemurafenib DM62UG5 Major Increased risk of prolong QT interval by the combination of Bosutinib and Vemurafenib. Melanoma [2C30] [21]
LGX818 DMNQXV8 Moderate Increased risk of prolong QT interval by the combination of Bosutinib and LGX818. Melanoma [2C30] [31]
Dabrafenib DMX6OE3 Moderate Increased metabolism of Bosutinib caused by Dabrafenib mediated induction of CYP450 enzyme. Melanoma [2C30] [11]
Lasmiditan DMXLVDT Moderate Decreased clearance of Bosutinib due to the transporter inhibition by Lasmiditan. Migraine [8A80] [32]
Tecfidera DM2OVDT Moderate Additive immunosuppressive effects by the combination of Bosutinib and Tecfidera. Multiple sclerosis [8A40] [33]
Siponimod DM2R86O Major Increased risk of ventricular arrhythmias by the combination of Bosutinib and Siponimod. Multiple sclerosis [8A40] [12]
Fingolimod DM5JVAN Major Additive immunosuppressive effects by the combination of Bosutinib and Fingolimod. Multiple sclerosis [8A40] [34]
Ocrelizumab DMEZ2KH Moderate Additive immunosuppressive effects by the combination of Bosutinib and Ocrelizumab. Multiple sclerosis [8A40] [35]
Ozanimod DMT6AM2 Major Increased risk of ventricular arrhythmias by the combination of Bosutinib and Ozanimod. Multiple sclerosis [8A40] [11]
Fedratinib DM4ZBK6 Major Decreased metabolism of Bosutinib caused by Fedratinib mediated inhibition of CYP450 enzyme. Myeloproliferative neoplasm [2A20] [12]
Rolapitant DM8XP26 Moderate Decreased clearance of Bosutinib due to the transporter inhibition by Rolapitant. Nausea/vomiting [MD90] [36]
Netupitant DMEKAYI Major Decreased metabolism of Bosutinib caused by Netupitant mediated inhibition of CYP450 enzyme. Nausea/vomiting [MD90] [12]
Entrectinib DMMPTLH Moderate Increased risk of prolong QT interval by the combination of Bosutinib and Entrectinib. Non-small cell lung cancer [2C25] [12]
Rucaparib DM9PVX8 Moderate Increased risk of prolong QT interval by the combination of Bosutinib and Rucaparib. Ovarian cancer [2C73] [11]
Triclabendazole DMPWGBR Moderate Increased risk of prolong QT interval by the combination of Bosutinib and Triclabendazole. Parasitic worm infestation [1F90] [11]
Istradefylline DM20VSK Moderate Decreased metabolism of Bosutinib caused by Istradefylline mediated inhibition of CYP450 enzyme. Parkinsonism [8A00] [11]
Abametapir DM2RX0I Moderate Decreased metabolism of Bosutinib caused by Abametapir mediated inhibition of CYP450 enzyme. Pediculosis [1G00] [37]
Macimorelin DMQYJIR Major Increased risk of prolong QT interval by the combination of Bosutinib and Macimorelin. Pituitary gland disorder [5A60-5A61] [38]
Degarelix DM3O8QY Moderate Increased risk of prolong QT interval by the combination of Bosutinib and Degarelix. Prostate cancer [2C82] [11]
Enzalutamide DMGL19D Major Increased metabolism of Bosutinib caused by Enzalutamide mediated induction of CYP450 enzyme. Prostate cancer [2C82] [14]
Golimumab DMHZV7X Major Additive immunosuppressive effects by the combination of Bosutinib and Golimumab. Rheumatoid arthritis [FA20] [39]
Anthrax vaccine DM9GSWY Moderate Antagonize the effect of Bosutinib when combined with Anthrax vaccine. Sepsis [1G40-1G41] [40]
Voxelotor DMCS6M5 Major Decreased metabolism of Bosutinib caused by Voxelotor mediated inhibition of CYP450 enzyme. Sickle-cell disorder [3A51] [12]
Telotristat ethyl DMDIYFZ Moderate Increased metabolism of Bosutinib caused by Telotristat ethyl mediated induction of CYP450 enzyme. Small intestine developmental anomaly [DA90] [11]
Larotrectinib DM26CQR Moderate Decreased metabolism of Bosutinib caused by Larotrectinib mediated inhibition of CYP450 enzyme. Solid tumour/cancer [2A00-2F9Z] [11]
LEE011 DMMX75K Major Increased risk of prolong QT interval by the combination of Bosutinib and LEE011. Solid tumour/cancer [2A00-2F9Z] [21]
Triptorelin DMTK4LS Moderate Increased risk of prolong QT interval by the combination of Bosutinib and Triptorelin. Solid tumour/cancer [2A00-2F9Z] [11]
Fostamatinib DM6AUHV Moderate Decreased clearance of Bosutinib due to the transporter inhibition by Fostamatinib. Thrombocytopenia [3B64] [41]
Lenvatinib DMB1IU4 Moderate Increased risk of prolong QT interval by the combination of Bosutinib and Lenvatinib. Thyroid cancer [2D10] [11]
Cabozantinib DMIYDT4 Major Increased risk of prolong QT interval by the combination of Bosutinib and Cabozantinib. Thyroid cancer [2D10] [11]
⏷ Show the Full List of 82 DDI Information of This Drug

Drug Inactive Ingredient(s) (DIG) and Formulation(s) of This Drug

DIG
DIG Name DIG ID PubChem CID Functional Classification
Carmellose sodium E00625 Not Available Disintegrant
Eisenoxyd E00585 56841934 Colorant
Ferric hydroxide oxide yellow E00539 23320441 Colorant
Magnesium stearate E00208 11177 lubricant
Poloxamer 188 E00645 Not Available Emulsifying agent; Solubilizing agent; Surfactant
Polyethylene glycol 3350 E00652 Not Available Coating agent; Diluent; Ointment base; Plasticizing agent; Solvent; Suppository base; lubricant
Polyethylene glycol 4000 E00654 Not Available Coating agent; Diluent; Ointment base; Plasticizing agent; Solvent; Suppository base; lubricant
Polyvinyl alcohol E00666 Not Available Coating agent; Emulsion stabilizing agent; Film/Membrane-forming agent
Povidone E00667 Not Available Binding agent; Coating agent; Disintegrant; Film/membrane-forming agent; Solubilizing agent; Suspending agent
Talc E00520 16211421 Anticaking agent; Diluent; Glidant; lubricant
Titanium dioxide E00322 26042 Coating agent; Colorant; Opacifying agent
Haematite red E00236 14833 Colorant
Cellulose microcrystalline E00698 Not Available Adsorbent; Suspending agent; Diluent
⏷ Show the Full List of 13 Pharmaceutical Excipients of This Drug
Pharmaceutical Formulation
Formulation Name Drug Dosage Dosage Form Route
Bosutinib Monohydrate eq 400mg base tablet eq 400mg base Tablet Oral
Bosutinib Monohydrate eq 500mg base tablet eq 500mg base Tablet Oral
Bosutinib Monohydrate eq 100mg base tablet eq 100mg base Tablet Oral
Bosutinib 100 mg tablet 100 mg Oral Tablet Oral
Bosutinib 400 mg tablet 400 mg Oral Tablet Oral
Bosutinib 500 mg tablet 500 mg Oral Tablet Oral
Jump to Detail Pharmaceutical Formulation Page of This Drug

References

1 Bosutinib FDA Label
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5710).
3 Trend Analysis of a Database of Intravenous Pharmacokinetic Parameters in Humans for 1352 Drug Compounds
4 A comparison of physicochemical property profiles of marketed oral drugs and orally bioavailable anti-cancer protein kinase inhibitors in clinical development. Curr Top Med Chem. 2007;7(14):1408-22.
5 In vitro and in vivo identification of ABCB1 as an efflux transporter of bosutinib. J Hematol Oncol. 2015 Jul 7;8:81.
6 In vitro assessment of time-dependent inhibitory effects on CYP2C8 and CYP3A activity by fourteen protein kinase inhibitors. Drug Metab Dispos. 2014 Jul;42(7):1202-9.
7 Cytotoxicity of 34 FDA approved small-molecule kinase inhibitors in primary rat and human hepatocytes. Toxicol Lett. 2018 Jul;291:138-148. doi: 10.1016/j.toxlet.2018.04.010. Epub 2018 Apr 12.
8 SKI-606 decreases growth and motility of colorectal cancer cells by preventing pp60(c-Src)-dependent tyrosine phosphorylation of beta-catenin and its nuclear signaling. Cancer Res. 2006 Feb 15;66(4):2279-86. doi: 10.1158/0008-5472.CAN-05-2057.
9 Identification of environmental chemicals that activate p53 signaling after in vitro metabolic activation. Arch Toxicol. 2022 Jul;96(7):1975-1987. doi: 10.1007/s00204-022-03291-5. Epub 2022 Apr 18.
10 In vitro and in vivo activity of SKI-606, a novel Src-Abl inhibitor, against imatinib-resistant Bcr-Abl+ neoplastic cells. Cancer Res. 2006 Dec 1;66(23):11314-22. doi: 10.1158/0008-5472.CAN-06-1199. Epub 2006 Nov 17.
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14 Product Information. Bosulif (bosutinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
15 Product Information. Xospata (gilteritinib). Astellas Pharma US, Inc, Deerfield, IL.
16 Product Information. Sirturo (bedaquiline). Janssen Pharmaceuticals, Titusville, NJ.
17 Product Information. Arcapta Neohaler (indacaterol). Novartis Pharmaceuticals, East Hanover, NJ.
18 Product Information. Turalio (pexidartinib). Daiichi Sankyo, Inc., Parsippany, NJ.
19 Product Information. Daurismo (glasdegib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
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24 Product Information. Tazverik (tazemetostat). Epizyme, Inc, Cambridge, MA.
25 Product Information. Adcetris (brentuximab vedotin). Seattle Genetics Inc, Bothell, WA.
26 Product Information. Arava (leflunomide). Hoechst Marion-Roussel Inc, Kansas City, MO.
27 Product Information. Juxtapid (lomitapide). Aegerion Pharmaceuticals Inc, Cambridge, MA.
28 Product Information. Prolia (denosumab). Amgen USA, Thousand Oaks, CA.
29 Product Information. Tagrisso (osimertinib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
30 Al-Nawakil C, Willems L, Mauprivez C, et.al "Successful treatment of l-asparaginase-induced severe acute hepatotoxicity using mitochondrial cofactors." Leuk Lymphoma 55 (2014): 1670-4. [PMID: 24090500]
31 Product Information. Braftovi (encorafenib). Array BioPharma Inc., Boulder, CO.
32 Product Information. Reyvow (lasmiditan). Lilly, Eli and Company, Indianapolis, IN.
33 Product Information. Vumerity (diroximel fumarate). Alkermes, Inc, Cambridge, MA.
34 Product Information. Gilenya (fingolimod). Novartis Pharmaceuticals, East Hanover, NJ.
35 Product Information. Ocrevus (ocrelizumab). Genentech, South San Francisco, CA.
36 Product Information. Varubi (rolapitant). Tesaro Inc., Waltham, MA.
37 Product Information. Xeglyze (abametapir topical). Dr. Reddy's Laboratories Inc, Upper Saddle River, NJ.
38 Product Information. Macrilen (macimorelin). Aeterna Zentaris, Charleston, SC.
39 Product Information. Cimzia (certolizumab). UCB Pharma Inc, Smyrna, GA.
40 CDC. Centers for Disease Control and Prevention/ "Recommendations of the advisory committtee on immunization practices (ACIP): use of vaccines and immune globulins in persons with altered immunocompetence." MMWR Morb Mortal Wkly Rep 42(RR-04) (1993): 1-18. [PMID: 20300058]
41 Product Information. Tavalisse (fostamatinib). Rigel Pharmaceuticals, South San Francisco, CA.