Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMTKD7Q)

Drug Name
BIBW 2992 Drug Info
Synonyms
Afatinib; Tomtovok; Tovok; BIBW-2992; Tovok (TN); Tovok, BIBW2992; (2E)-N-{4-[(3-chloro-4-fluorophenyl)amino]-7-[(3S)-tetrahydrofuran-3-yloxy]quinazolin-6-yl}-4-(dimethylamino)but-2-enamide; EGFR inhibitor 2nd gens
Cross-matching ID
PubChem CID
10184653
ChEBI ID
CHEMBL1173655
CAS Number
CAS 850140-72-6
TTD Drug ID
D05UFG
VARIDT Drug ID
DR00354

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Cysteine and methionine metabolism 2.21 0.00e+0 43/50 (86%) PHGDH;CBS;PSAT1;...
Lysosome 2.11 0.00e+0 115/128 (89.84%) HEXB;TPP1;ASAH1;...
Porphyrin and chlorophyll metabolism 2.02 0.00e+0 23/43 (53.49%) HMOX1;BLVRB;GUSB;...
Glycine, serine and threonine metabolism 2.01 2.56e-3 31/40 (77.5%) PHGDH;CBS;PSAT1;...
Ferroptosis 1.98 6.14e-3 36/41 (87.8%) HMOX1;SLC3A2;SLC7A11;...
Folate biosynthesis 1.94 5.12e-3 23/26 (88.46%) AKR1C3;AKR1B10;SPR;...
Pentose and glucuronate interconversions 1.92 5.85e-3 17/34 (50%) AKR1B10;GUSB;AKR1B1;...
Collecting duct acid secretion 1.89 6.40e-3 22/27 (81.48%) ATP6V1B2;ATP6V1C1;ATP6V0E2;...
Homologous recombination 1.84 1.59e-2 35/41 (85.37%) BARD1;RBBP8;BLM;...
mTOR signaling pathway 1.81 1.95e-2 114/154 (74.03%) DDIT4;SLC3A2;RRAGD;...
One carbon pool by folate 1.81 1.95e-2 15/20 (75%) MTHFD2;SHMT2;SHMT1;...
Glutathione metabolism 1.81 1.88e-2 43/57 (75.44%) CHAC1;IDH1;GSTA1;...
Steroid hormone biosynthesis 1.77 2.36e-2 43/61 (70.49%) AKR1C3;AKR1C1;CYP1B1;...
Riboflavin metabolism 1.76 2.19e-2 7/8 (87.5%) BLVRB;ENPP1;ACP5;...
Other glycan degradation 1.75 2.53e-2 13/18 (72.22%) HEXB;NEU1;GLB1;...
Mineral absorption 1.73 2.62e-2 48/60 (80%) HMOX1;FTH1;FXYD2;...
Amino sugar and nucleotide sugar metabolism 1.73 2.53e-2 38/48 (79.17%) GNPDA1;HEXB;AMDHD2;...
Alanine, aspartate and glutamate metabolism 1.71 2.96e-2 27/37 (72.97%) ASNS;ASS1;GOT1;...
Autophagy 1.71 2.96e-2 113/169 (66.86%) DDIT4;RRAGD;SQSTM1;...
Glycosaminoglycan degradation 1.70 2.97e-2 19/19 (100%) HEXB;GLB1;HEXA;...
Longevity regulating pathway 1.67 3.85e-2 90/151 (59.6%) ATF4;EIF4EBP1;HSPA1A;...
Selenocompound metabolism 1.65 4.19e-2 11/17 (64.71%) CTH;TXNRD1;SEPHS2;...
Pentose phosphate pathway 1.63 4.58e-2 25/30 (83.33%) G6PD;ALDOC;PGD;...
Biosynthesis of unsaturated fatty acids 1.63 4.48e-2 21/27 (77.78%) SCD;FADS1;TECR;...
PI3K-Akt signaling pathway -1.65 4.36e-2 317/354 (89.55%) PDPK1;LAMB4;IGF1;...
IL-17 signaling pathway -1.72 1.95e-2 84/94 (89.36%) ELAVL1;CXCL6;IL6;...
Proteoglycans in cancer -1.81 5.33e-3 172/205 (83.9%) ITGB5;HSPG2;DDX5;...
Small cell lung cancer -1.83 5.86e-3 90/92 (97.83%) IKBKB;TRAF1;CDK2;...
Arrhythmogenic right ventricular cardiomyopathy -1.92 1.09e-3 70/77 (90.91%) SGCA;ITGA4;TCF7L2;...
Complement and coagulation cascades -1.99 0.00e+0 76/85 (89.41%) C4BPA;SERPINA5;C5AR1;...
Malaria -1.99 0.00e+0 44/50 (88%) ICAM1;TGFB1;IL6;...
AGE-RAGE signaling pathway in diabetic complications -2.03 0.00e+0 97/100 (97%) TGFB1;TGFBR1;EGR1;...
Focal adhesion -2.09 0.00e+0 180/201 (89.55%) PDPK1;LAMB4;IGF1;...
Dilated cardiomyopathy -2.13 0.00e+0 86/96 (89.58%) ITGA9;CACNA1S;ADCY9;...
Hypertrophic cardiomyopathy -2.14 0.00e+0 81/90 (90%) SGCA;ITGA4;CACNA2D3;...
Amoebiasis -2.27 0.00e+0 99/102 (97.06%) SERPINB10;TGFB1;LAMA5;...
ECM-receptor interaction -2.28 0.00e+0 80/88 (90.91%) LAMA2;ITGB5;HSPG2;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SK-ES-1 CVCL_0627 Homo sapiens 0.12uM - 10uM 24H
TC-32 CVCL_7141 Homo sapiens 0.12uM - 10uM 24H
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 0.12uM - 10uM 6H, 24H, 48H
Bone marrow
Chronic myeloid leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
K-562 CVCL_0004 Homo sapiens 0.01uM - 10uM 4H, 24H
Multiple myeloma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
KMS-34 CVCL_1333 Homo sapiens 0.01uM - 10uM 24H
Brain
Glioblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
LN-229 CVCL_0393 Homo sapiens 0.01uM - 10uM 24H
U-251 MG CVCL_0021 Homo sapiens 0.12uM - 10uM 24H
YH-13 CVCL_1800 Homo sapiens 0.12uM - 10uM 24H
Glioma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
GI-1 CVCL_1230 Homo sapiens 0.12uM - 1.11uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 3H, 6H, 24H, 48H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 3H, 6H, 24H
MDA-MB-468 CVCL_0419 Homo sapiens 0.12uM - 10uM 24H
SK-BR-3 CVCL_0033 Homo sapiens 0.04uM - 10uM 3H, 6H, 24H, XH
Breast carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BT-20 CVCL_0178 Homo sapiens 0.04uM - 10uM 3H, 6H, 24H
Hs 578T CVCL_0332 Homo sapiens 0.04uM - 10uM 3H, 6H, 24H
Breast ductal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BT-474 CVCL_0179 Homo sapiens 0.01uM - 10uM 24H
T-47D CVCL_0553 Homo sapiens 0.12uM - 10uM 24H
ZR-75-1 CVCL_0588 Homo sapiens 0.12uM - 10uM 24H
Fibrocystic breast disease
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A (Parent) CVCL_0598 Homo sapiens 1.11uM - 10uM 3H, 6H, 12H, 24H
Normal (Epithelial)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HME1 CVCL_2950 Homo sapiens 0.04uM - 10uM 3H, 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 3H, 6H, 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CW-2 CVCL_1155 Homo sapiens 0.01uM - 10uM 24H
GP2d CVCL_1234 Homo sapiens 0.12uM - 10uM 24H
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 6H, 24H, XH
NCI-H508 CVCL_1561 Homo sapiens 0.66uM - 10uM XH
SNU-1040 CVCL_5001 Homo sapiens 0.01uM - 10uM 24H
SNU-407 CVCL_5004 Homo sapiens 0.12uM - 10uM 24H
Embryonic stem cell
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
WA09 (H9) Derived CVCL_9773 (WA09) Homo sapiens 0.12uM - 10uM 24H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
AN3 CA CVCL_0146 Homo sapiens 0.01uM - 10uM 24H
HEC-108 CVCL_2926 Homo sapiens 0.12uM - 10uM 24H
HEC-151 CVCL_2927 Homo sapiens 0.12uM - 10uM 24H
HEC-1-A CVCL_0293 Homo sapiens 0.12uM - 10uM 24H
HEC-251 CVCL_2928 Homo sapiens 0.12uM - 10uM 24H
HEC-265 CVCL_2929 Homo sapiens 0.12uM - 1.11uM 24H
MFE-319 CVCL_1409 Homo sapiens 0.01uM - 10uM 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
CJM CVCL_U797 Homo sapiens 0.12uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
1HAEo- CVCL_0128 Homo sapiens 10uM 24H
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
NL20 CVCL_0461 Homo sapiens 10uM 24H
Renal cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
RCC10RGB CVCL_1656 Homo sapiens 0.12uM - 10uM 24H
Rhabdoid tumor
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
G-401 CVCL_0270 Homo sapiens 0.12uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.04uM - 10uM 6H, 24H, XH
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHH-5 CVCL_1320 Homo sapiens 0.12uM - 10uM 24H
JHH-7 CVCL_1322 Homo sapiens 0.12uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 6H, 24H, 48H, XH
DV-90 CVCL_1184 Homo sapiens 0.01uM - 10uM 24H
NCI-H1563 CVCL_1478 Homo sapiens 0.01uM - 10uM 24H
NCI-H1781 CVCL_1499 Homo sapiens 0.01uM - 10uM 24H
NCI-H1975 CVCL_1511 Homo sapiens 0.66uM - 10uM XH
HCC827 CVCL_2063 Homo sapiens 0.01uM - 10uM 24H
NCI-H1437 CVCL_1472 Homo sapiens 0.12uM - 10uM 24H
NCI-H1573 CVCL_1483 Homo sapiens 0.12uM - 10uM 24H
NCI-H1975 CVCL_1511 Homo sapiens 0.66uM - 10uM XH
NCI-H838 CVCL_1594 Homo sapiens 0.12uM - 10uM 24H
Lung adenosquamous carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H596 CVCL_1571 Homo sapiens 0.66uM - 10uM XH
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BEN CVCL_1081 Homo sapiens 0.12uM - 10uM 24H
HCC1588 CVCL_1263 Homo sapiens 0.12uM - 1.11uM 24H
HCC95 CVCL_1276 Homo sapiens 0.12uM - 10uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H2110 CVCL_1529 Homo sapiens 0.01uM - 10uM 24H
HCC515 CVCL_5134 Homo sapiens 0.04uM - 10uM 6H, 24H
NCI-H2073 CVCL_1523 Homo sapiens 0.66uM - 10uM XH
NCI-H2110 CVCL_1529 Homo sapiens 0.12uM - 10uM 24H
NCI-H2172 CVCL_1534 Homo sapiens 0.12uM - 10uM 24H
Normal (Fibroblast)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HFL1 CVCL_4295 Homo sapiens 10uM 24H
IMR-90 CVCL_0347 Homo sapiens 10uM 24H
WI-38 CVCL_0579 Homo sapiens 10uM 24H
Small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H841 CVCL_1595 Homo sapiens 0.12uM - 10uM 24H
Lymph node
Burkitt lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BJAB CVCL_5711 Homo sapiens 0.01uM - 10uM 4H
Diffuse large B-cell lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HBL-1 CVCL_4213 Homo sapiens 0.01uM - 10uM 4H, 24H
OCI-Ly10 CVCL_8795 Homo sapiens 0.01uM - 10uM 24H
OCI-Ly19 CVCL_8797 Homo sapiens 0.01uM - 10uM 4H, 24H
OCI-Ly3 CVCL_8796 Homo sapiens 0.01uM - 10uM 4H, 24H
SU-DHL-4 CVCL_0539 Homo sapiens 0.66uM - 10uM XH
TMD8 CVCL_A440 Homo sapiens 0.01uM - 10uM 4H, 24H
Muscle
Rhabdomyosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-204 CVCL_0134 Homo sapiens 0.12uM - 10uM 24H
Oral cavity
Oral squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BICR 6 CVCL_1086 Homo sapiens 0.12uM - 10uM 24H
Ovary
Ovarian carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
OC 314 CVCL_1614 Homo sapiens 0.01uM - 10uM 24H
OVCAR-8 CVCL_1625 Homo sapiens 0.01uM - 10uM 24H
OVK18 CVCL_1629 Homo sapiens 0.12uM - 10uM 24H
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ES-2 CVCL_3509 Homo sapiens 0.12uM - 10uM 24H
OVTOKO CVCL_3114 Homo sapiens 0.12uM - 10uM 24H
Ovarian cystadenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
OAW 28 CVCL_1611 Homo sapiens 0.12uM - 10uM 24H
OC 316 CVCL_1615 Homo sapiens 0.12uM - 10uM 24H
Ovarian endometrioid carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
TOV-112D CVCL_3612 Homo sapiens 0.12uM - 10uM 24H
Ovarian granulosa cell tumor
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COV434 CVCL_2010 Homo sapiens 0.12uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute B-lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NALM-6 CVCL_0092 Homo sapiens 0.01uM - 10uM 24H
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 4H, 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
22Rv1 CVCL_1045 Homo sapiens 0.12uM - 10uM 24H
LNCaP CVCL_0395 Homo sapiens 0.04uM - 10uM 3H, 24H
LNCaP clone FGC CVCL_1379 Homo sapiens 0.12uM - 10uM 24H
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 6H, 24H, XH
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 6H, 24H, XH
IGR-37 CVCL_1303 Homo sapiens 0.12uM - 10uM 24H
Mel-HO CVCL_1402 Homo sapiens 0.12uM - 10uM 24H
SH-4 CVCL_1692 Homo sapiens 0.12uM - 10uM 24H
SK-MEL-3 CVCL_0525 Homo sapiens 0.12uM - 10uM 24H
SK-MEL-5 CVCL_0527 Homo sapiens 0.01uM - 10uM 24H
Stomach
Gastric adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
AGS CVCL_0139 Homo sapiens 0.12uM - 10uM 24H
MKN45 CVCL_0434 Homo sapiens 0.12uM - 10uM 24H
Gastric carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
IM95 CVCL_1305 Homo sapiens 0.12uM - 10uM 24H
Unclear
Rat sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
XC CVCL_1891 Rattus norvegicus (Rat) 0.01uM - 10uM 24H
Urinary bladder
Bladder carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
5637 CVCL_0126 Homo sapiens 0.01uM - 10uM 24H
BC-3C CVCL_1079 Homo sapiens 0.12uM - 10uM 24H
Bladder transitional cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CAL-29 CVCL_1109 Homo sapiens 0.12uM - 10uM 24H
J82 CVCL_0359 Homo sapiens 0.01uM - 10uM 24H
VM-CUB-1 CVCL_1786 Homo sapiens 0.01uM - 10uM 24H