Details of the Drug

General Information of Drug (ID: DMTKD7Q)

Drug Name
BIBW 2992
Synonyms
Afatinib; Tomtovok; Tovok; BIBW-2992; Tovok (TN); Tovok, BIBW2992; (2E)-N-{4-[(3-chloro-4-fluorophenyl)amino]-7-[(3S)-tetrahydrofuran-3-yloxy]quinazolin-6-yl}-4-(dimethylamino)but-2-enamide; EGFR inhibitor 2nd gens
Indication
Disease Entry ICD 11 Status REF
Non-small-cell lung cancer 2C25.Y Approved [1]
Affected Organisms
Humans and other mammals
ATC Code
L01EB03: BIBW 2992
L01EB: Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors
L01E: PROTEIN KINASE INHIBITORS
L01: ANTINEOPLASTIC AGENTS
L: ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 485.9
Logarithm of the Partition Coefficient (xlogp) 3.6
Rotatable Bond Count (rotbonds) 8
Hydrogen Bond Donor Count (hbonddonor) 2
Hydrogen Bond Acceptor Count (hbondacc) 8
ADMET Property
Absorption Tmax
The time to maximum plasma concentration (Tmax) is 2-5 h [2]
BDDCS Class
Biopharmaceutics Drug Disposition Classification System (BDDCS) Class 3: high solubility and low permeability [3]
Clearance
The total body clearance of drug is 1530 mL/min [4]
Elimination
Following administration of an oral solution of 15 mg afatinib, 85.4% of the dose was recovered in the feces and 4.3% in urine [2]
Half-life
The concentration or amount of drug in body reduced by one-half in 37 hours [2]
Metabolism
The drug is metabolized via the enzyme-catalyzed metabolic reactions [2]
Vd
The volume of distribution (Vd) of drug is 4500 L [4]
Chemical Identifiers
Formula
C24H25ClFN5O3
IUPAC Name
(E)-N-[4-(3-chloro-4-fluoroanilino)-7-[(3S)-oxolan-3-yl]oxyquinazolin-6-yl]-4-(dimethylamino)but-2-enamide
Canonical SMILES
CN(C)C/C=C/C(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)O[C@H]4CCOC4
InChI
InChI=1S/C24H25ClFN5O3/c1-31(2)8-3-4-23(32)30-21-11-17-20(12-22(21)34-16-7-9-33-13-16)27-14-28-24(17)29-15-5-6-19(26)18(25)10-15/h3-6,10-12,14,16H,7-9,13H2,1-2H3,(H,30,32)(H,27,28,29)/b4-3+/t16-/m0/s1
InChIKey
ULXXDDBFHOBEHA-CWDCEQMOSA-N
Cross-matching ID
PubChem CID
10184653
ChEBI ID
CHEBI:61390
CAS Number
850140-72-6
UNII
41UD74L59M
DrugBank ID
DB08916
TTD ID
D05UFG
VARIDT ID
DR00354
Combinatorial Drugs (CBD) Click to Jump to the Detailed CBD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Epidermal growth factor receptor (EGFR) TTGKNB4 EGFR_HUMAN Inhibitor [5]
Erbb2 tyrosine kinase receptor (HER2) TT6EO5L ERBB2_HUMAN Inhibitor [5]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Breast cancer resistance protein (ABCG2) DTI7UX6 ABCG2_HUMAN Substrate [6]
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [6]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Calmodulin-1 (CALM2) OTNYA92F CALM1_HUMAN Drug Response [7]
Epidermal growth factor receptor (EGFR) OTAPLO1S EGFR_HUMAN Gene/Protein Processing [8]
Inhibitor of nuclear factor kappa-B kinase subunit beta (IKBKB) OT9RDS3H IKKB_HUMAN Gene/Protein Processing [9]
POU domain, class 5, transcription factor 1 (POU5F1) OTDHHN7O PO5F1_HUMAN Gene/Protein Processing [10]
Protein SET (SET) OTGYYQJO SET_HUMAN Protein Interaction/Cellular Processes [11]
Ras GTPase-activating-like protein IQGAP1 (IQGAP1) OTZRWTGA IQGA1_HUMAN Post-Translational Modifications [12]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Non-small-cell lung cancer
ICD Disease Classification 2C25.Y
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Epidermal growth factor receptor (EGFR) DTT EGFR 5.84E-05 0.32 0.55
P-glycoprotein 1 (ABCB1) DTP P-GP 1.42E-02 -2.10E-01 -5.11E-01
Breast cancer resistance protein (ABCG2) DTP BCRP 1.07E-06 -3.94E-01 -6.94E-01
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 45 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RPMI-3460/CS1 GDSC1; GDSC2 2.6224 4.3048 2.1714 7.773
NOS-1 [Human HNSCC] GDSC1; GDSC2 1.1779 3.464 0.9418 18.4122
ES1 GDSC1; GDSC2 1.2928 3.3885 1.0889 17.339
EW-12 GDSC2 1.2949 3.2157 0.7371 10.3133
HuO9 GDSC1; GDSC2 1.37 4.2934 0.8654 18.0774
EW-22 GDSC1; GDSC2 1.6375 3.5346 1.4214 14.6016
EW-3 GDSC1; GDSC2 1.6388 4.8896 0.9059 16.9893
ES5 GDSC1; GDSC2 1.6934 4.9752 0.9255 16.7193
ES7 GDSC1; GDSC2 1.7121 3.8319 1.4035 14.4167
ES8 GDSC1; GDSC2 1.9989 4.4402 1.4711 13.1303
EW-11 GDSC1; GDSC2 2.0306 4.7002 1.3923 13.4052
SK-N-MC CTRP2 2.0554 2.6924 2.0554 26.5755
SK-ES-1 GDSC1; GDSC2; CTRP2 2.1012 3.4182 2.0996 26.2157
A-673 GDSC1; GDSC2; CTRP2 2.1093 2.8547 2.1092 26.1569
EW-18 GDSC1; GDSC2 2.1267 4.5531 1.5554 12.3144
CHSA8926 GDSC1; GDSC2 2.2105 7.1589 0.4134 17.6043
EW-1 GDSC1; GDSC2 2.3189 4.2801 1.8719 10.1786
MG-63 GDSC1; GDSC2; CTRP2 2.331 4.2351 2.3074 24.7618
MHH-ES-1 GDSC1; GDSC2; CTRP2 2.3786 4.1718 2.3605 24.4269
CAL-72 GDSC1; GDSC2 2.4264 4.6226 1.8298 10.0442
TC71 CTRP2 2.4815 3.1211 2.4815 23.7364
EW-7 GDSC1; GDSC2 2.5098 4.9803 1.7467 10.2029
SaOS-2 GDSC1; GDSC2; CTRP2 2.5505 5.3879 2.3885 23.7778
ES6 GDSC1; GDSC2 2.5774 5.1106 1.7506 9.9857
SW1353 CTRP2 2.5988 5.6594 2.3818 23.7036
SJSA-1 GDSC1; GDSC2 2.6081 4.341 2.1406 7.967
U2OS GDSC1; GDSC2; CTRP2 2.6234 4.627 2.5816 22.8797
CADO-ES1 GDSC1; GDSC2 2.6275 4.0648 2.2836 7.2127
EW-24 GDSC1; GDSC2 2.7248 3.9454 2.4358 6.1696
U-CH2 GDSC2 2.7729 8.7916 -0.7751 14.9079
EW-16 GDSC1; GDSC2 2.8196 10.9977 -0.9422 21.8084
TC-71 GDSC1; GDSC2 2.888 5.0267 2.0855 7.431
SK-PN-DW GDSC1; GDSC2 3.0023 5.0847 2.1618 6.7372
Hs 822.T CTRP2 3.0615 4.0181 3.0606 19.8754
NY GDSC1; GDSC2 3.1462 7.5918 1.0388 12.0697
CAL-78 GDSC1; GDSC2; CTRP2 3.247 5.8717 3.0369 19.3227
G-292 clone A141B1 GDSC1; GDSC2; CTRP2 3.2947 6.2292 2.9912 19.3423
Hs 888.T CTRP2 3.3258 4.7994 3.3029 18.1884
EW-13 GDSC1; GDSC2 3.481 5.4021 2.4112 4.3025
H-EMC-SS GDSC1; GDSC2 3.6655 6.4523 2.0331 5.8341
HuO-3N1 GDSC1; GDSC2 3.9257 8.7856 1.0755 10.1073
HOS GDSC1; GDSC2; CTRP2 4.453 7.3496 3.835 12.87
CHSA0011 GDSC1; GDSC2 4.5084 8.8187 1.4885 6.9218
ES4 GDSC1; GDSC2 4.9968 18.6534 -2.9966 23.5786
CHSA0108 GDSC1; GDSC2 5.5742 10.0178 1.6127 4.6479
⏷ Show the Full List of 45 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 204 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MEC1 CTRP2 2.1661 3.0769 2.166 25.8381
JM1 GDSC1; GDSC2; CTRP2 2.1211 4.2427 2.0884 26.1876
SEM CTRP2 -0.4784 2.6536 -0.5075 43.5286
F-36P CTRP2 -0.3801 4.9316 -0.6973 43.4368
CTV-1 GDSC1; GDSC2 -0.2544 1.5573 -0.2757 29.1109
HT GDSC1; GDSC2; CTRP2 -0.1447 2.6127 -0.1627 41.1918
WSU-NHL GDSC1; GDSC2 -0.0405 1.2323 -0.044 27.3023
MOLM-16 GDSC1; GDSC2 0.0399 2.6217 -0.0959 27.1984
MV4-11 GDSC1; GDSC2; CTRP2 0.05 2.5203 0.0391 39.8787
SU-DHL-6 GDSC1; GDSC2 0.0862 1.3894 0.0811 26.2805
TALL-1 [Human adult T-ALL] GDSC2 0.1139 1.9183 -0.0366 19.7166
Peer CTRP2 0.1696 1.3746 0.1696 39.139
EB1 CTRP2 0.1868 3.1039 0.1549 39.122
KY821 GDSC1; GDSC2 0.2886 1.3591 0.2867 24.6251
U-937 CTRP2 0.3607 2.2171 0.3587 37.8724
BE-13 GDSC1; GDSC2 0.3678 2.4797 0.2827 24.327
Loucy GDSC1; GDSC2 0.5632 1.6674 0.5591 22.4056
KMS-26 CTRP2 0.5821 2.7086 0.5752 36.4132
P32/ISH GDSC1; GDSC2 0.5901 1.6916 0.5858 22.1876
EoL-1 GDSC1; GDSC2; CTRP2 0.6021 2.4799 0.5992 36.1847
DEL GDSC1; GDSC2 0.6114 1.9424 0.5978 22.0533
MHH-CALL-4 GDSC2 0.6172 3.4664 -0.0621 17.7093
RPMI-8402 GDSC1; GDSC2 0.6185 2.6083 0.5313 22.3021
BONNA-12 GDSC2 0.6234 3.1818 0.0666 16.9313
ALL-PO GDSC1; GDSC2 0.6251 3.0153 0.4565 22.596
697 GDSC1; GDSC2; CTRP2 0.7316 2.0107 0.7315 35.3147
MOLT-13 GDSC1; GDSC2; CTRP2 0.7455 2.733 0.7403 35.2389
Farage GDSC1; GDSC2 0.7634 2.6915 0.6731 21.1398
SU-DHL-5 GDSC1; GDSC2 0.7833 2.8782 0.6587 21.1242
Kasumi-1 GDSC1; GDSC2; CTRP2 0.8141 2.8174 0.8082 34.7853
P12-Ichikawa GDSC1; GDSC2 0.8247 1.9868 0.8154 20.3045
DoHH2 GDSC1; GDSC2 0.8681 1.7902 0.815 10.5387
Pfeiffer CTRP2 0.8821 3.0216 0.8725 34.4236
H9 GDSC1; GDSC2 0.8925 6.406 -0.5254 25.881
IM-9 GDSC1; GDSC2 0.9055 2.9147 0.7838 20.1208
KE-37 GDSC1; GDSC2 0.9241 2.1816 0.907 19.5297
Jiyoye GDSC1; GDSC2 0.9416 4.3962 0.3682 21.8327
DB GDSC1; GDSC2; CTRP2 0.9599 3.9748 0.894 34.0119
SET-2 CTRP2 1.0169 3.0406 1.009 33.5202
CCRF-CEM GDSC1; GDSC2 1.0277 3.1827 0.8548 19.3512
RPMI-6666 GDSC1; GDSC2; CTRP2 1.0305 2.9847 1.0242 33.3483
BC-1 GDSC1; GDSC2 1.052 3.18 0.8819 19.1421
THP-1 GDSC1; GDSC2; CTRP2 1.0669 3.5229 1.0412 33.1703
Ci-1 CTRP2 1.0725 2.9196 1.068 33.1385
Mono-Mac-6 GDSC1; GDSC2 1.0791 3.8252 0.7204 19.7584
SR GDSC1; GDSC2; CTRP2 1.0877 3.4652 1.0658 33.0196
JVM-3 GDSC1; GDSC2; CTRP2 1.1168 3.5359 1.092 32.8356
CTB-1 GDSC1; GDSC2 1.1261 9.5634 -1.7755 29.6136
BL-70 CTRP2 1.1327 3.9471 1.0785 32.9015
MOLT-16 GDSC1; GDSC2 1.1437 3.2848 0.9547 18.4814
WSU-DLCL2 GDSC1; GDSC2; CTRP2 1.1642 3.0237 1.1589 32.4564
JURL-MK1 GDSC1; GDSC2 1.1838 4.0168 0.7677 19.1725
ST486 GDSC1; GDSC2; CTRP2 1.186 3.21 1.1766 32.325
GDM-1 GDSC1; GDSC2; CTRP2 1.2191 3.8834 1.1746 32.2212
OCI-AML-3 GDSC1; GDSC2; CTRP2 1.2219 3.8837 1.1775 32.2023
KE-97 CTRP2 1.2236 3.3187 1.2115 32.1571
MOLM-13 GDSC1; GDSC2; CTRP2 1.2245 3.1567 1.2172 32.0624
NALM-6 GDSC1; GDSC2; CTRP2 1.2585 3.6196 1.2338 31.8939
NK-92MI GDSC2 1.2702 4.4919 0.1036 14.2844
BC-3 GDSC2 1.2738 3.1986 0.7241 10.4714
SU-DHL-1 GDSC2 1.2752 5.9423 -0.6036 18.4469
BALL-1 GDSC1; GDSC2 1.2796 3.4993 1.0422 17.5945
JVM-2 GDSC1; GDSC2; CTRP2 1.2954 3.4976 1.278 31.6245
MOTN-1 CTRP2 1.303 4.4544 1.2015 31.9248
GR-ST GDSC1; GDSC2 1.31 4.293 0.8014 18.5784
GA-10 GDSC1; GDSC2; CTRP2 1.3103 2.9744 1.3074 31.4771
NKM-1 GDSC1; GDSC2 1.329 3.7643 1.0119 17.5512
ALL-SIL GDSC1; GDSC2; CTRP2 1.3492 2.6528 1.3488 31.2103
SUP-T1 GDSC1; GDSC2; CTRP2 1.3528 3.2586 1.3451 31.2107
LAMA-84 GDSC1; GDSC2; CTRP2 1.3542 4.4976 1.2502 31.5209
U-698-M GDSC1; GDSC2 1.3553 3.3078 1.1795 16.7088
MY-M12 GDSC1; GDSC2 1.3689 3.519 0.6667 9.4893
MOLT-3 CTRP2 1.4125 1.9584 1.4125 30.8584
OCI-Ly19 GDSC1; GDSC2; CTRP2 1.4126 4.1721 1.3513 30.9914
PF-382 GDSC1; GDSC2; CTRP2 1.434 3.0787 1.4309 30.6557
L-1236 GDSC1; GDSC2 1.4437 3.9418 1.0748 16.8599
VL51 GDSC1; GDSC2 1.4605 3.6466 1.1934 16.2628
DND-41 GDSC1; GDSC2; CTRP2 1.4621 3.5573 1.4467 30.5097
Hs 611.T CTRP2 1.4647 3.2972 1.4579 30.5333
AMO1 GDSC1; GDSC2 1.473 3.2998 1.3101 15.6984
KOPN-8 GDSC1; GDSC2 1.4803 3.3547 1.3031 15.7024
Jurkat GDSC1; GDSC2; CTRP2 1.4958 3.3144 1.489 30.257
Ku812 GDSC1; GDSC2; CTRP2 1.5119 4.9304 1.3516 30.6619
SU-DHL-10 GDSC1; GDSC2 1.5198 3.4032 1.3325 15.4708
VAL GDSC1; GDSC2 1.5253 4.1059 1.1026 16.4482
P31/FUJ GDSC1; GDSC2 1.5292 2.8733 1.4672 14.8073
ME1 CTRP2 1.5314 3.7216 1.5101 30.1372
A3/Kawakami GDSC1; GDSC2; CTRP2 1.5428 2.7256 1.5426 29.9226
HAL-01 GDSC1; GDSC2 1.5658 4.1906 1.1138 16.2573
Mino CTRP2 1.5703 3.0203 1.5688 29.8118
ML-2 GDSC1; GDSC2 1.5712 5.2845 0.6648 18.3474
TF-1 CTRP2 1.5918 3.6158 1.5773 29.7123
WIL2 NS GDSC1; GDSC2 1.6094 3.7706 1.3137 15.1877
Namalwa GDSC1; GDSC2; CTRP2 1.6187 3.6782 1.6021 29.4729
Karpas-422 GDSC1; GDSC2; CTRP2 1.6499 4.2145 1.5971 29.3868
Karpas-299 GDSC1; GDSC2; CTRP2 1.6565 3.9263 1.6273 29.2639
BL-41 GDSC1; GDSC2 1.6642 3.2806 1.5239 14.0498
Kasumi-2 CTRP2 1.6682 4.0834 1.6279 29.2897
SKM-1 GDSC1; GDSC2; CTRP2 1.6783 3.2765 1.6747 29.0333
A4/Fukuda GDSC1; GDSC2; CTRP2 1.6795 3.8293 1.6572 29.0879
NB4 GDSC1; GDSC2; CTRP2 1.6873 2.029 1.6873 28.9617
ME1 GDSC1; GDSC2 1.7024 3.333 1.5514 13.7873
MOLP-8 GDSC1; GDSC2; CTRP2 1.7139 3.4916 1.7063 28.8103
SUP-M2 GDSC1; GDSC2; CTRP2 1.7152 3.2698 1.712 28.7868
OCI-Ly3 CTRP2 1.7189 2.8426 1.7187 28.8179
AML-193 CTRP2 1.7325 2.9063 1.7322 28.7276
P30/OHK GDSC1; GDSC2 1.7373 3.2372 1.615 13.3787
PL21 CTRP2 1.7414 3.1433 1.7399 28.6722
NCI-H929 GDSC1; GDSC2; CTRP2 1.7432 4.4625 1.6689 28.8394
SCC-3 GDSC2 1.7638 3.0261 1.6922 12.9815
MLMA GDSC1; GDSC2 1.7672 4.3339 1.2716 14.8392
CA46 GDSC1; GDSC2; CTRP2 1.7704 3.4758 1.7641 28.4302
OCI-Ly10 CTRP2 1.774 6.3448 1.2985 30.0451
HuT 78 CTRP2 1.8029 3.7542 1.7881 28.3068
NOMO-1 GDSC1; GDSC2; CTRP2 1.8068 3.8555 1.7872 28.2325
Daudi GDSC1; GDSC2; CTRP2 1.8112 2.5711 1.8112 28.1381
KMS-12-BM GDSC1; GDSC2 1.814 3.6286 1.5833 13.2389
OCI-AML-2 GDSC1; GDSC2; CTRP2 1.8271 3.3029 1.8246 28.0406
MM1.S GDSC1; GDSC2; CTRP2 1.8323 3.666 1.8216 28.0333
HEL GDSC1; GDSC2; CTRP2 1.8326 4.0101 1.8047 28.0892
CMK GDSC1; CTRP2 1.852 2.4017 1.852 27.8671
L-428 GDSC1; GDSC2; CTRP2 1.8521 3.9887 1.8263 27.9525
OCI-AML-5 GDSC1; GDSC2; CTRP2 1.8595 3.545 1.853 27.8388
Karpas-45 GDSC1; GDSC2 1.8678 4.365 1.365 14.0644
HH [Human lymphoma] GDSC1; GDSC2; CTRP2 1.8725 3.4545 1.8681 27.7454
Granta-519 GDSC1; GDSC2; CTRP2 1.8753 3.2393 1.8738 27.7167
KMS-20 CTRP2 1.8788 5.1996 1.698 28.3643
HC-1 GDSC1; GDSC2 1.8981 4.435 1.3679 13.9507
CESS GDSC1; GDSC2 1.9499 3.869 1.6463 12.4735
RS4;11 GDSC1; GDSC2 1.9526 3.9441 1.6212 12.5798
SUP-HD1 GDSC1; GDSC2; CTRP2 1.9572 4.1178 1.9269 27.2688
RPMI-8866 GDSC1; GDSC2 1.9725 3.6341 1.7536 11.9036
DG-75 GDSC1; GDSC2 1.9949 3.9499 1.6643 12.2352
M-07e CTRP2 2.028 3.9622 2.0099 26.8184
OCI-Ly7 GDSC1; GDSC2 2.0346 3.5566 1.2504 4.2095
ARH-77 GDSC1; GDSC2 2.0767 3.8545 1.7877 11.3826
KMS-11 GDSC1; GDSC2; CTRP2 2.1062 4.258 2.0717 26.2929
KO52 CTRP2 2.1334 2.956 2.1334 26.0558
HEL 92.1.7 CTRP2 2.1409 3.0688 2.1409 26.0057
L-540 GDSC1; GDSC2 2.1454 4.2092 1.7208 11.4641
Karpas-1106P GDSC1; GDSC2 2.159 4.0729 1.7907 11.0895
HD-MY-Z CTRP2 2.1623 5.0235 2.0365 26.2907
KM-H2 GDSC1; GDSC2; CTRP2 2.1642 3.7854 2.1565 25.8173
KMOE-2 GDSC1; GDSC2 2.1798 3.7292 1.9445 10.3032
LC4-1 GDSC1; GDSC2 2.1835 3.6619 1.9725 10.1624
BV-173 GDSC1; GDSC2; CTRP2 2.1876 4.9265 2.0795 26.0021
JeKo-1 GDSC1; GDSC2; CTRP2 2.2034 4.2332 2.175 25.6261
HL-60 GDSC1; GDSC2; CTRP2 2.2113 3.355 2.2106 25.4809
EB2 GDSC1; GDSC2 2.2134 4.0678 1.8502 10.6276
HDLM-2 GDSC1; GDSC2; CTRP2 2.2272 4.5284 2.1738 25.5523
RC-K8 GDSC1; GDSC2 2.2693 4.4734 1.7369 10.9864
RPMI-8226 GDSC1; GDSC2; CTRP2 2.2851 4.4405 2.2435 25.1274
MEG-01 GDSC1; GDSC2 2.2862 5.7996 1.1411 13.8556
KCL-22 GDSC1; GDSC2; CTRP2 2.2912 4.1264 2.2728 25.009
ATN-1 GDSC1; GDSC2 2.2942 3.9261 1.9924 9.689
JJN-3 GDSC1; GDSC2; CTRP2 2.3258 3.98 2.3151 24.7534
Ramos.2G6.4C10 GDSC1; GDSC2 2.3414 5.0797 1.5346 11.7513
CML-T1 GDSC1; GDSC2 2.3532 4.6978 1.722 10.7962
MOLT-4 GDSC1; GDSC2 2.3569 3.6541 2.1625 8.6854
YT GDSC1; GDSC2 2.3886 4.0116 2.0577 9.0664
LP-1 GDSC1; GDSC2; CTRP2 2.4105 3.1829 2.4105 24.1543
KMS-27 CTRP2 2.4377 3.0224 2.4377 24.0284
RL GDSC1; GDSC2; CTRP2 2.4606 3.7367 2.4582 23.8292
NU-DHL-1 CTRP2 2.4971 3.1289 2.4971 23.6324
EJM GDSC1; GDSC2; CTRP2 2.503 4.697 2.447 23.7282
SUP-B15 GDSC1; GDSC2; CTRP2 2.5193 3.6194 2.5184 23.4344
U266B1 GDSC1; GDSC2; CTRP2 2.5331 3.8698 2.5293 23.3523
SIG-M5 GDSC2; CTRP2 2.5402 2.9249 2.5402 23.3452
MHH-CALL-2 GDSC1; GDSC2 2.5505 4.3622 2.0729 8.4757
SU-DHL-8 GDSC1; GDSC2 2.5789 3.7173 2.377 6.9487
L-363 GDSC1; GDSC2; CTRP2 2.5887 4.3263 2.5689 23.036
TK [Human B-cell lymphoma] GDSC1; GDSC2 2.5926 3.8478 2.3393 7.06
MHH-PREB-1 GDSC1; GDSC2 2.5972 4.2127 2.1873 7.7737
OCI-M1 GDSC1; GDSC2; CTRP2 2.6077 3.5365 2.6075 22.8445
EM-2 GDSC1; GDSC2 2.6922 3.8496 2.443 6.2405
JSC-1 GDSC1; GDSC2 2.7288 4.3865 2.2402 7.1118
Hs 445 GDSC1; GDSC2 2.7597 4.0394 2.4298 6.1059
KG-1 GDSC1; GDSC2 2.8834 4.8838 2.151 7.1133
Karpas-231 GDSC1; GDSC2 2.8976 3.8493 2.6549 4.5647
MN-60 GDSC1; GDSC2 2.9813 4.602 2.3798 5.6899
K-562 GDSC1; GDSC2; CTRP2 2.9818 3.878 2.9814 20.3582
TUR GDSC1; GDSC2 3.0019 4.9995 2.2035 6.5264
OPM-2 GDSC1; GDSC2 3.0999 4.7533 2.4137 5.2002
MOLP-2 CTRP2 3.2737 6.0772 3.0116 19.3759
MHH-CALL-3 CTRP2 3.9897 9.5202 2.3952 19.7304
SK-MM-2 GDSC1; GDSC2 4.2513 6.1601 2.5822 2.0796
Sc-1 GDSC1 4.3368 6.7049 2.3829 2.8803
PL-21 GDSC1; GDSC2 4.3751 8.8245 1.3913 7.6448
RCH-ACV GDSC1; GDSC2 4.5828 10.7421 0.603 11.0451
MC116 GDSC1; GDSC2 4.6258 6.8193 2.5032 1.942
CRO-AP2 GDSC1; GDSC2 4.7039 7.5282 2.2285 3.0626
SU-DHL-16 GDSC1; GDSC2 4.7578 6.059 2.8858 0.4076
SUP-B8 GDSC1; GDSC2 4.851 8.3941 1.9187 4.2825
SU-DHL-4 GDSC1; GDSC2 5.222 6.59 2.8758 0.2334
REC-1 CTRP2 5.3676 7.8582 4.5261 7.8209
Reh GDSC1; GDSC2; CTRP2 5.553 12.181 2.5575 15.4376
EHEB GDSC1 5.5921 7.4949 2.6907 0.4933
NU-DUL-1 GDSC1; GDSC2 5.6186 7.1794 2.8157 0.223
Raji GDSC1; GDSC2; CTRP2 5.7502 6.4697 5.5551 2.6989
ROS-50 GDSC1; GDSC2 5.8772 8.1764 2.552 0.7084
QIMR-WIL GDSC1; GDSC2 5.9022 8.6023 2.3971 1.1522
Toledo CTRP2 5.9075 7.4596 5.2197 3.7403
Karpas-620 GDSC1; GDSC2; CTRP2 6.3671 7.6569 5.4887 1.7776
KMM-1 CTRP2 8.1725 10.5833 5.2077 0.9818
⏷ Show the Full List of 204 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 27 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TE15 CTRP2 -2.3594 5.5459 -2.9957 54.655
TE-4 GDSC1; GDSC2; CTRP2 -5.9269 0.0387 -5.9922 74.748
OE19 GDSC1; GDSC2; CTRP2 -3.9474 3.0982 -4.2198 63.3325
OE21 GDSC1; GDSC2; CTRP2 -2.9801 7.2322 -4.1526 56.6502
EC-GI-10 GDSC1; GDSC2; CTRP2 -2.732 10.1135 -4.887 54.716
KYSE-140 GDSC1; GDSC2; CTRP2 -2.5849 7.5928 -3.8372 54.9224
TE-15 GDSC1; GDSC2 -2.4383 8.0746 -4.6872 48.1551
TE-14 CTRP2 -2.2811 6.7082 -3.2311 53.954
TE-6 GDSC1; GDSC2; CTRP2 -0.9003 11.5031 -4.3012 43.8178
KYSE-410 GDSC1; GDSC2; CTRP2 -0.2988 8.2307 -1.578 44.1565
TE-11 GDSC1; GDSC2; CTRP2 0.5895 5.2823 0.2808 37.1631
KYSE-450 GDSC1; GDSC2; CTRP2 0.6603 24.2549 -7.8618 45.2302
T.T GDSC1; GDSC2 1.1334 14.026 -3.9479 34.9177
KYSE-520 GDSC1; GDSC2; CTRP2 1.5358 12.9209 -1.6176 37.7825
TE-5 GDSC1; GDSC2; CTRP2 1.6685 8.5875 0.3952 33.048
OE33 GDSC1; GDSC2; CTRP2 1.7187 5.283 1.5076 29.4625
TE-10 GDSC1; GDSC2; CTRP2 1.8657 9.3406 0.2976 32.6738
TE-1 GDSC1; GDSC2; CTRP2 2.5128 10.3502 0.5307 30.0435
TE-9 GDSC1; GDSC2; CTRP2 2.5629 3.7592 2.5611 23.1475
COLO 680N GDSC1; GDSC2; CTRP2 2.569 6.5703 2.0959 24.754
KYSE-30 CTRP2 3.0279 13.5113 -0.4268 31.1688
KYSE-180 GDSC1; GDSC2; CTRP2 3.1777 21.3087 -4.0912 37.0774
KYSE-150 GDSC1; GDSC2; CTRP2 3.206 5.8273 3.0032 19.5693
KYSE-70 GDSC1; GDSC2 3.5982 5.5567 2.4256 3.9795
TE-8 GDSC1; GDSC2 3.9527 12.8315 -0.918 18.9683
KYSE-270 GDSC1; GDSC2 3.977 19.2053 -4.0807 28.3473
KYSE-510 GDSC1; GDSC2; CTRP2 5.8837 15.9996 0.9322 20.5668
⏷ Show the Full List of 27 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 39 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
N2a-PK1 CTRP2 1.2006 9.5041 -0.468 36.7838
HuP-T4 GDSC1; GDSC2; CTRP2 -0.4094 5.4627 -0.8489 43.7193
L3.3 CTRP2 -0.2775 8.9904 -1.8354 44.4116
SNU-213 CTRP2 0.5984 7.4337 -0.329 38.6643
BxPC-3 GDSC1; GDSC2; CTRP2 1.6875 9.6185 -0.0049 34.0272
Capan-2 GDSC1; GDSC2; CTRP2 1.977 8.7271 0.6662 31.2885
DAN-G GDSC1; GDSC2; CTRP2 2.0735 5.3968 1.8689 27.0907
HPAC GDSC1; GDSC2; CTRP2 2.1547 6.5989 1.6361 27.6346
KP-3 GDSC1; GDSC2; CTRP2 2.1642 5.5345 1.9373 26.5666
Panc 05.04 CTRP2 2.2365 16.8359 -2.7799 37.6367
Panc 03.27 GDSC1; GDSC2; CTRP2 2.4305 8.9365 1.057 28.7007
PaTu 8988s CTRP2 2.5227 9.1917 1.0457 28.5209
CFPAC-1 GDSC1; GDSC2; CTRP2 2.5264 10.4917 0.4815 30.1442
Hs 766T GDSC1; GDSC2; CTRP2 2.538 5.1929 2.4121 23.7357
Panc 08.13 GDSC1; GDSC2; CTRP2 2.5541 7.8676 1.6186 26.4732
PaTu 8988t GDSC1; GDSC2; CTRP2 2.6265 4.583 2.589 22.8448
PK-45H CTRP2 2.6795 5.9975 2.3849 23.4421
KP-1N GDSC1; GDSC2 2.7295 4.9458 1.9755 8.4263
Capan-1 GDSC1; GDSC2; CTRP2 2.8061 5.5894 2.6234 22.1531
PK-59 CTRP2 2.8109 6.9505 2.2323 23.5924
KP-2 GDSC1; GDSC2; CTRP2 2.8854 5.6416 2.698 21.6434
KP-4 GDSC1; GDSC2 2.9088 4.4673 2.3768 5.9068
SW1990 GDSC1; GDSC2; CTRP2 2.91 9.4906 1.3167 26.4559
MIA PaCa-2 GDSC1; GDSC2; CTRP2 2.997 4.7444 2.9633 20.3691
Panc 10.05 GDSC1; GDSC2; CTRP2 3.0075 10.6802 0.8816 27.577
PSN1 GDSC1; GDSC2; CTRP2 3.0896 4.1966 3.0868 19.6497
PL4 GDSC1; GDSC2 3.1453 5.4602 2.1023 6.6731
Panc 02.03 GDSC1; GDSC2; CTRP2 3.4239 11.8364 0.7533 26.8385
YAPC GDSC1; GDSC2; CTRP2 3.4266 10.7 1.2898 25.1194
AsPC-1 GDSC1; GDSC2; CTRP2 3.477 9.9403 1.6905 23.6115
HuP-T3 GDSC1; GDSC2; CTRP2 3.4871 6.3716 3.1577 18.1609
PaTu 8902 GDSC1; GDSC2; CTRP2 3.9737 7.1086 3.4254 15.7591
MZ-PC-1 GDSC1; GDSC2 4.1164 8.6656 1.2799 8.7004
SUIT-2 GDSC1; GDSC2; CTRP2 4.1481 6.4305 3.858 13.6359
HPAF-II GDSC1; GDSC2; CTRP2 4.3963 11.6942 1.7509 21.0652
Panc 04.03 GDSC1; GDSC2; CTRP2 4.4362 9.4309 2.8768 16.7033
QGP-1 GDSC1; GDSC2 5.0785 9.1953 1.6882 5.0164
TCC-Pan2 CTRP2 5.1013 7.8737 4.2605 9.542
SU.86.86 GDSC1; GDSC2 6.3735 14.2163 0.1596 9.8781
⏷ Show the Full List of 39 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 72 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SH4 CTRP2 1.6157 4.0791 1.5734 29.6464
CHL-1 GDSC1; GDSC2 -0.4989 9.2757 -3.2291 38.7795
A-431 GDSC1; GDSC2 0.615 15.424 -5.1105 38.222
Hs 852.T CTRP2 0.6939 5.5738 0.3267 36.7295
A-388 GDSC1; GDSC2 0.7986 10.5788 -2.5766 32.9195
COLO 792 GDSC1; GDSC2; CTRP2 1.8507 2.8371 1.8506 27.8758
Hs 940.T GDSC1; GDSC2; CTRP2 2.088 3.1517 2.0877 26.2991
HT-144 GDSC1; GDSC2; CTRP2 2.2166 4.3769 2.1773 25.5754
RVH-421 GDSC1; GDSC2; CTRP2 2.2522 3.2847 2.2519 25.2077
G-361 GDSC1; GDSC2; CTRP2 2.2993 3.9352 2.2896 24.9262
Hs 934.T CTRP2 2.3096 4.8949 2.2151 25.2023
Hs 294T CTRP2 2.3853 3.9819 2.3759 24.4091
Mel Ho GDSC1; GDSC2; CTRP2 2.5029 3.3175 2.5028 23.5405
WM1552C GDSC1; GDSC2 2.5139 4.2295 2.0947 8.4845
Hs 688(A).T CTRP2 2.5301 3.6494 2.5291 23.4161
RPMI-7951 GDSC1; GDSC2; CTRP2 2.5375 4.8868 2.4599 23.5725
WM793 GDSC1; GDSC2; CTRP2 2.5378 5.0094 2.4424 23.6318
A-375 GDSC1; GDSC2; CTRP2 2.5885 4.6789 2.5394 23.1365
WM266-4 CTRP2 2.5905 2.935 2.5905 23.01
A101D GDSC1; GDSC2; CTRP2 2.627 4.5638 2.5912 22.8354
LOX-IMVI GDSC1; GDSC2; CTRP2 2.6378 5.5677 2.4451 23.3058
MZ-MEL-2 GDSC1; GDSC2 2.6544 6.5909 1.1025 13.0164
IGR-1 GDSC1; GDSC2; CTRP2 2.709 4.4261 2.6874 22.2429
SK-MEL-24 GDSC1; GDSC2; CTRP2 2.8577 5.0874 2.7734 21.4678
IGR-37 GDSC1; GDSC2; CTRP2 2.9015 3.9104 2.9005 20.8944
UACC-62 GDSC1; GDSC2; CTRP2 2.9164 6.2813 2.5632 22.0289
GAK GDSC1; GDSC2 2.9415 3.816 2.7145 4.1382
MeWo GDSC1; GDSC2; CTRP2 3.0472 4.8108 3.0097 20.0485
Hs 895.T CTRP2 3.0642 4.8177 3.0269 19.9801
SH-4 GDSC1; GDSC2 3.0715 4.662 2.4333 5.1754
WM1799 CTRP2 3.0796 5.3199 2.974 20.1126
WM278 GDSC1; GDSC2 3.0991 6.3366 1.6251 9.2236
IST-MEL1 GDSC1; GDSC2 3.131 4.7105 2.4627 4.8701
MDA-MB-435S CTRP2 3.1748 6.2631 2.8504 20.2586
HMV-II GDSC1; GDSC2 3.1852 6.5702 1.5825 9.2291
A2058 GDSC1; GDSC2; CTRP2 3.1994 4.8348 3.1675 19.018
WM35 GDSC1; GDSC2 3.2323 31.8603 -11.022 38.7548
HMCB CTRP2 3.2728 5.0251 3.2249 18.6266
M14 GDSC1; GDSC2 3.2814 5.6941 2.1019 6.3432
SK-MEL-1 GDSC1; GDSC2; CTRP2 3.2929 4.5305 3.2845 18.3171
Mel JuSo GDSC1; GDSC2; CTRP2 3.3552 5.1189 3.3008 18.059
WM115 GDSC1; GDSC2; CTRP2 3.3693 4.1289 3.369 17.7825
COLO 679 GDSC1; GDSC2 3.3801 5.6607 2.2007 5.6059
UACC-257 GDSC1; GDSC2; CTRP2 3.4127 5.1868 3.3529 17.6953
SK-MEL-2 GDSC1; GDSC2; CTRP2 3.5264 4.2837 3.526 16.7384
WM88 CTRP2 3.571 5.2674 3.5107 16.683
COLO 800 GDSC1; GDSC2; CTRP2 3.6081 7.2354 2.9865 18.448
WM983B CTRP2 3.6749 6.3173 3.3791 16.8315
SK-MEL-5 GDSC1; GDSC2 3.7092 7.7932 1.4003 8.9499
K029AX CTRP2 3.8438 5.6833 3.7309 15.0494
IGR-39 CTRP2 3.9535 8.4657 2.8368 18.1241
DJM-1 GDSC1; GDSC2 3.993 9.484 0.7807 11.4055
WT2-iPS GDSC1; GDSC2; CTRP2 4.0318 6.3745 3.7497 14.3769
451Lu GDSC1; GDSC2 4.0396 6.4267 2.3193 3.6717
CP50-MEL-B GDSC1; GDSC2 4.4072 7.0698 2.2568 3.3674
SK-MEL-31 GDSC1; GDSC2 4.4195 8.9995 1.3377 7.8246
SK-MEL-3 GDSC1; GDSC2; CTRP2 4.4852 5.6758 4.4274 10.5613
CP66-MEL GDSC1; GDSC2 4.5101 6.4236 2.6136 1.6083
Hs 839.T CTRP2 4.5221 7.5981 3.8007 12.8503
COLO 829 GDSC1; GDSC2; CTRP2 4.5653 10.4908 2.4939 17.8897
COLO 783 GDSC1; GDSC2 4.6094 7.6002 2.1369 3.6242
G-mel GDSC1; GDSC2 4.6487 7.9065 2.0185 4.1219
MMAc-SF GDSC1; GDSC2 4.6822 10.4473 0.8195 9.832
LB373-MEL-D GDSC1; GDSC2 4.9477 6.5247 2.7881 0.5753
LB2518-MEL GDSC1; GDSC2 5.1324 6.5927 2.8398 0.3427
SK-MEL-30 GDSC1; GDSC2 5.2673 6.8745 2.7897 0.4016
SK-MEL-28 GDSC1; GDSC2; CTRP2 5.3331 5.7613 5.3232 4.7612
IPC-298 GDSC1; GDSC2 5.466 6.8968 2.8586 0.1928
VMRC-MELG GDSC1; GDSC2 5.542 7.7214 2.5829 0.8157
Hs 938.T GDSC1; GDSC2 5.544 9.4004 1.8739 3.5343
MZ-MEL-7 GDSC1; GDSC2 5.9878 7.8148 2.7289 0.268
EquiPSC Line K2 GDSC1; GDSC2 5.8702 9.2304 2.1238 2.1472
⏷ Show the Full List of 72 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 11 Cell Line(s) in Aero Dig Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KYAE-1 GDSC1; GDSC2 -2.4599 1.921 -2.6681 47.1925
KYSE-220 GDSC1; GDSC2 0.8656 14.4617 -4.4074 36.4755
TE-12 GDSC1; GDSC2 1.128 19.3393 -6.5813 38.7436
ESO-26 GDSC1; GDSC2 1.6902 16.2806 -4.5629 34.5597
FLO-1 GDSC1; GDSC2 1.8946 6.1442 0.5969 17.6605
SK-GT-4 GDSC1; GDSC2 2.7128 12.3715 -1.72 24.8838
OACP4 C GDSC1; GDSC2 3.1033 13.054 -1.7275 23.9186
ESO-51 GDSC1; GDSC2 3.4695 5.8494 2.179 5.5146
OACM5.1 C GDSC1; GDSC2 3.598 6.9419 1.7366 7.4881
HCE-4 GDSC1; GDSC2 4.2943 9.2519 1.1231 9.118
KYSE-50 GDSC1; GDSC2 5.2813 16.1042 -1.5189 18.4009
⏷ Show the Full List of 11 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 684 GDSC1; GDSC2; CTRP2 2.2065 4.2063 2.18 25.5993
Cancer Drug Sensitivity Data Curated from 36 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NB69 GDSC1; GDSC2 0.8662 11.9113 -3.1587 34.085
SK-N-BE(2) CTRP2 1.2509 5.902 0.8513 33.2163
KP-N-YS GDSC1; GDSC2 1.2577 2.4834 1.021 7.9372
SJNB-12 GDSC1; GDSC2 1.7528 4.2653 1.2837 14.831
Kelly GDSC1; GDSC2; CTRP2 1.856 3.6482 1.8464 27.8722
SK-N-DZ GDSC1; GDSC2; CTRP2 1.9134 2.9182 1.9133 27.4591
SK-N-FI GDSC1; GDSC2; CTRP2 1.9451 3.109 1.9446 27.2497
CHP-212 GDSC1; GDSC2; CTRP2 1.9914 4.1918 1.957 27.0556
SK-N-AS GDSC1; GDSC2; CTRP2 2.0056 3.6933 1.9977 26.8721
SJNB-13 GDSC1; GDSC2 2.0461 3.985 1.7055 11.8688
IMR-5 GDSC1; GDSC2 2.0573 5.0583 1.2603 13.959
NH-6 CTRP2 2.2128 3.1223 2.2127 25.5268
KP-N-SI9s CTRP2 2.214 3.9144 2.2031 25.5551
SJNB-14 GDSC1; GDSC2 2.2772 3.7452 2.0435 9.5094
NH-12 GDSC1; GDSC2 2.31 5.148 1.4717 12.155
CHP-134 GDSC2 2.3195 3.2665 2.2426 8.4852
SK-N-SH GDSC1; GDSC2; CTRP2 2.445 4.2136 2.4269 23.9857
KP-N-RT-BM-1 GDSC2 2.4506 5.9567 0.3835 8.9744
SJNB-6 GDSC1; GDSC2 2.4793 5.3525 0.7045 6.258
IMR-32 CTRP2 2.5209 2.9819 2.5209 23.4737
NB(TU)1 GDSC1; GDSC2 2.6881 4.0643 2.3459 6.7195
GOTO GDSC1; GDSC2 2.7231 4.1995 2.3206 6.7344
SiMa GDSC1; GDSC2 2.8657 4.0784 2.5188 5.328
MHH-NB-11 GDSC1; GDSC2 2.8805 8.7705 -0.6824 12.9285
SJNB-10 GDSC1; GDSC2 2.8874 4.2721 2.4494 5.6067
NB1 GDSC1; GDSC2; CTRP2 2.9468 3.8701 2.9463 20.5913
KP-N-YN GDSC1; GDSC2 2.9693 4.3062 2.512 5.0581
SJNB-7 GDSC1; GDSC2 3.0173 6.664 1.3907 10.6193
GI-ME-N GDSC1; GDSC2 3.0311 5.4269 2.0182 7.392
TGW GDSC1; GDSC2 3.0899 4.3349 2.6111 4.2248
SK-N-BE(2)-M17 GDSC1; GDSC2 3.2789 5.3632 2.2652 5.5131
SJNB-5 GDSC1; GDSC2 4.8519 18.1631 -2.8654 23.5034
CHP-126 GDSC1; GDSC2 4.8997 7.3022 2.442 1.8816
LA-N-6 GDSC1; GDSC2 5.0233 7.114 2.586 1.1944
SJNB-17 GDSC1; GDSC2 5.5247 7.871 2.516 1.0368
SK-N-MC-IXC GDSC1; GDSC2 5.5909 6.7187 2.9631 0.0498
⏷ Show the Full List of 36 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 8 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-1079 CTRP2 -4.8485 1.5518 -4.9838 68.7999
SNU-478 CTRP2 -3.2787 6.1257 -4.1526 58.472
SNU-308 CTRP2 0.161 7.0402 -0.6735 41.0593
SNU-245 CTRP2 0.6851 5.3996 0.3582 36.6765
HuCC-T1 GDSC1; GDSC2; CTRP2 1.6871 6.4517 1.172 30.6723
SNU-1196 CTRP2 2.3591 7.2079 1.6539 27.0012
HuH-28 CTRP2 2.5901 4.0761 2.582 23.0399
SNU-869 CTRP2 3.3096 10.9878 1.0402 26.3013
⏷ Show the Full List of 8 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 91 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SK-BR-3 CTRP2 -7.1165 10.5075 -9.7443 65.9128
HCC2218 GDSC1; GDSC2; CTRP2 -5.2246 0.9305 -5.3231 70.9345
MDA-MB-175-VII GDSC1; GDSC2 -4.6932 -0.3566 -4.7601 63.6094
UACC-893 GDSC1; GDSC2 -3.8666 3.3444 -4.5293 56.1029
ZR-75-30 GDSC1; GDSC2; CTRP2 -3.3125 7.5911 -4.6277 57.7507
AU565 GDSC1; GDSC2; CTRP2 -2.9576 6.5176 -3.9129 56.8754
BT-474 GDSC1; GDSC2; CTRP2 -1.8252 8.0756 -3.1734 51.5765
MDA-MB-330 GDSC1; GDSC2 -1.8133 8.1866 -4.0845 45.1064
OCUB-M GDSC1; GDSC2 -0.7017 2.5975 -0.8947 33.4142
UACC-812 GDSC2; CTRP2 -0.3785 10.8385 -2.676 45.4958
HCC2157 GDSC1; GDSC2 -0.2074 6.5659 -1.7258 34.1516
HCC202 GDSC1; CTRP2 -0.1057 6.9916 -0.948 42.5352
MDA-MB-468 GDSC1; GDSC2; CTRP2 -0.0612 7.1901 -0.9635 42.3718
EFM-192A GDSC1; GDSC2 0.2903 13.3938 -4.4199 38.1466
HCC1806 GDSC1; GDSC2; CTRP2 0.5172 6.494 -0.1161 38.4276
HDQ-P1 GDSC1; GDSC2; CTRP2 0.6633 7.7055 -0.3531 38.3926
HCC1419 GDSC1; GDSC2; CTRP2 0.8819 11.5355 -1.6614 39.9166
MDA-MB-361 GDSC1; GDSC2; CTRP2 1.0102 14.0206 -2.6474 40.8049
HCC1954 GDSC1; GDSC2; CTRP2 1.3462 6.9105 0.6569 33.3944
CAL-85-1 GDSC1; GDSC2; CTRP2 1.7584 7.146 1.0257 30.904
HCC1500 GDSC1; GDSC2; CTRP2 1.7684 3.2853 1.7656 28.4318
Hs 578T GDSC1; GDSC2; CTRP2 1.8565 4.1946 1.8158 27.9732
COLO 824 GDSC1; GDSC2 1.8913 5.9258 0.6958 17.1979
MDA-MB-453 GDSC1; GDSC2; CTRP2 2.0714 5.8048 1.7715 27.4323
MRK-nu-1 GDSC1; GDSC2 2.2119 3.5794 2.0316 9.7933
MDA-MB-231 GDSC1; GDSC2; CTRP2 2.3119 4.3662 2.278 24.9232
CAL-148 GDSC2; CTRP2 2.3245 4.4227 2.2864 24.9105
DU4475 GDSC1; GDSC2 2.3361 3.5081 2.19 8.6339
JIMT-1 GDSC1; GDSC2; CTRP2 2.4585 4.582 2.4123 23.9907
HMC-1-8 CTRP2 2.5971 4.0523 2.5898 22.9908
EFM-19 GDSC1; GDSC2 2.6049 5.2465 1.712 10.0993
HCC1143 GDSC1; GDSC2; CTRP2 2.7821 11.53 0.2659 30.0092
HCC1599 GDSC2 2.784 8.2074 0.4176 17.3916
ZR-75-1 CTRP2 2.796 7.1166 2.1579 23.9055
YMB-1-E GDSC2 2.836 4.8278 1.2073 3.0453
MDA-MB-157 GDSC1; GDSC2; CTRP2 2.8687 4.4208 2.8531 21.1607
T-47D GDSC1; GDSC2; CTRP2 2.8995 7.9576 1.9506 24.2937
CAL-51 GDSC1; GDSC2; CTRP2 2.966 4.424 2.9533 20.5047
BT-549 GDSC1; GDSC2; CTRP2 3.0072 6.5821 2.5688 21.7366
Hs 578Bst CTRP2 3.0267 5.169 2.9421 20.3922
HCC1187 GDSC1; GDSC2 3.0571 4.5661 2.4674 5.0406
KPL-1 CTRP2 3.1429 3.7433 3.1429 19.33
CAL-120 GDSC1; GDSC2 3.1453 5.2895 2.1873 6.2387
HCC1395 GDSC1; GDSC2; CTRP2 3.1711 6.19 2.8678 20.1609
MCF-7 GDSC1; GDSC2; CTRP2 3.219 4.898 3.1821 18.9045
HCC1428 GDSC1; GDSC2; CTRP2 3.2195 5.8743 3.0063 19.5164
Evsa-T GDSC1; GDSC2 3.2552 5.9329 1.9604 7.1298
MDA-MB-415 GDSC1; GDSC2 3.3362 6.3268 1.8314 7.5975
HCC38 GDSC1; GDSC2; CTRP2 3.3615 7.1807 2.7432 20.0605
MFM-223 GDSC1; GDSC2 3.3688 6.3727 1.8354 7.5009
HCC1569 GDSC1; GDSC2 3.7093 16.9967 -3.1954 26.8107
HCC1937 GDSC1; GDSC2; CTRP2 3.7424 10.6939 1.6035 23.2177
MDA-MB-436 GDSC1; GDSC2 4.5756 9.0416 1.4275 7.0982
BT-483 GDSC1; GDSC2 4.7732 8.2824 1.9217 4.3873
BT-20 GDSC1; GDSC2; CTRP2 5.1681 15.1753 0.7295 22.7166
CAMA-1 GDSC1; GDSC2; CTRP2 5.455 9.0305 4.0356 9.6313
HCC70 GDSC1; GDSC2 5.6983 15.7944 -1.0619 15.9466
BT 145 CTRP2 -2.1029 4.6748 -2.514 53.5843
BT 239 CTRP2 -0.915 4.8177 -1.2542 46.7544
BT 231 CTRP2 -0.4348 7.5345 -1.4831 44.7119
BT 159 CTRP2 -0.1989 12.9398 -3.3861 45.3351
BT 330 CTRP2 -0.1229 5.6738 -0.5887 42.1025
BT 428 CTRP2 -0.0414 5.0869 -0.3625 41.3147
BT 139 CTRP2 0.2625 9.451 -1.4382 41.848
BT164 CTRP2 0.3052 7.3018 -0.6024 40.3497
BT 172 CTRP2 0.4424 5.4881 0.0732 38.3481
BT 416 CTRP2 0.8313 3.3963 0.8048 34.8174
BT 112 CTRP2 0.8977 6.2816 0.3611 35.884
BT147 CTRP2 1.507 5.3012 1.274 31.0043
BT 333 CTRP2 1.6599 6.438 1.1464 30.9125
BT 187 CTRP2 1.827 8.1636 0.729 31.6504
BT 232 CTRP2 2.1496 12.6714 -0.8905 34.6682
BT 248 CTRP2 2.3054 3.3753 2.3049 24.9114
BT 228 CTRP2 2.368 4.2233 2.3466 24.5645
BT 245 CTRP2 2.4065 4.4797 2.3674 24.368
BT 504 CTRP2 2.4282 3.9754 2.42 24.1189
BT 179 CTRP2 2.4393 16.0485 -2.2075 36.2594
BT 271 CTRP2 2.4904 3.2032 2.4904 23.6773
BT 359 CTRP2 2.5207 3.7586 2.5185 23.4828
BT 422 CTRP2 2.5725 4.1369 2.5617 23.1662
BT 440 CTRP2 2.5838 3.7498 2.5823 23.0599
BT 131 CTRP2 2.6159 3.2282 2.6159 22.8408
BT 286 CTRP2 2.7218 3.2865 2.7218 22.1354
BT 340 CTRP2 2.7547 3.7458 2.7541 21.9186
BT 224 CTRP2 2.9162 9.4488 1.3414 26.412
BT 444 CTRP2 2.9789 3.8331 2.9786 20.4236
BT 216 CTRP2 3.0313 3.8981 3.0309 20.0748
BT 482 CTRP2 3.3088 4.1944 3.3079 18.2281
BT 498 CTRP2 3.575 5.4609 3.4834 16.7646
BT 320 CTRP2 5.3452 11.7302 2.5996 15.748
BT 328 CTRP2 5.4261 5.962 5.3902 4.2431
⏷ Show the Full List of 91 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Tongue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
YD-38 CTRP2 -3.8588 1.7537 -3.9624 64.1639
Cancer Drug Sensitivity Data Curated from 68 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-626 CTRP2 1.6495 3.7056 1.6326 29.336
D-245MG GDSC2 2.0964 6.9277 -0.384 14.5904
A-172 GDSC1; GDSC2; CTRP2 2.1565 5.4067 1.957 26.5229
GaMG GDSC1; GDSC2; CTRP2 2.2067 4.6783 2.1348 25.7517
SNU-466 CTRP2 2.249 3.8701 2.2405 25.3139
H4 GDSC1; GDSC2 2.3188 4.3313 1.8497 10.2857
SF539 GDSC1; GDSC2; CTRP2 2.3286 3.8393 2.3224 24.7197
GMS-10 CTRP2 2.3336 4.1805 2.3135 24.7893
PFSK-1 GDSC1; GDSC2 2.3923 4.9348 1.6523 11.019
Hs 683 GDSC1; GDSC2; CTRP2 2.3984 2.9765 2.3984 24.2349
KNS-81 CTRP2 2.4533 5.2252 2.3147 24.3979
D283 Med GDSC1; GDSC2; CTRP2 2.4954 4.9735 2.4024 23.9054
MOG-G-UVW GDSC1; GDSC2 2.5304 4.1563 2.1437 8.1957
SF268 GDSC1; GDSC2; CTRP2 2.5533 4.1415 2.5419 23.2433
LN-18 GDSC1; GDSC2; CTRP2 2.5723 3.0582 2.5723 23.0789
SNU-201 CTRP2 2.5771 5.5493 2.3832 23.7667
42-MG-BA GDSC1; GDSC2; CTRP2 2.5955 4.7122 2.5433 23.1005
M059K CTRP2 2.6393 5.5971 2.4402 23.3712
GI-1 GDSC1; GDSC2 2.6486 4.9079 1.9159 8.9563
SK-MG-1 GDSC1; GDSC2 2.693 5.1996 1.8185 9.3165
DK-MG GDSC1; GDSC2; CTRP2 2.7699 5.4575 2.6123 22.3056
YH-13 GDSC1; GDSC2; CTRP2 2.8219 4.9692 2.7522 21.6558
GOS-3 CTRP2 2.8299 5.7583 2.6102 22.1762
Becker GDSC1; GDSC2; CTRP2 2.8575 4.8723 2.8024 21.3691
M059J GDSC1; GDSC2 2.8676 4.786 2.1837 6.9922
Daoy GDSC1; GDSC2; CTRP2 2.8737 4.2352 2.8663 21.1003
U-251MG GDSC1; GDSC2; CTRP2 2.9021 4.4348 2.8868 20.9378
SNB-75 GDSC1; GDSC2; CTRP2 2.9156 6.046 2.6294 21.7936
ONS-76 GDSC1; GDSC2 2.9672 4.9222 2.2098 6.5872
KG-1-C CTRP2 2.9684 4.8715 2.9201 20.6556
LNZTA3WT4 GDSC1; GDSC2 2.9966 4.8232 2.2855 6.1246
SNU-1105 CTRP2 3.0242 5.3498 2.9088 20.5158
CAS-1 GDSC1; GDSC2; CTRP2 3.1113 4.8955 3.0686 19.6398
LN-229 GDSC1; GDSC2; CTRP2 3.123 9.8593 1.3703 25.6781
MOG-G-CCM GDSC1; GDSC2 3.2076 5.3141 2.229 5.871
U-118MG GDSC1; GDSC2; CTRP2 3.2527 5.2614 3.1702 18.8368
SW1088 GDSC1; GDSC2; CTRP2 3.342 6.178 3.0576 18.9592
D-263MG GDSC1; GDSC2 3.3949 4.7886 2.6485 3.2806
SNU-489 CTRP2 3.4089 7.3248 2.7396 19.9841
AM-38 GDSC1; GDSC2 3.4133 5.102 2.5068 3.9637
GB-1 GDSC1; GDSC2; CTRP2 3.4877 6.0875 3.2423 17.8517
KNS-42 GDSC1; GDSC2; CTRP2 3.5228 6.0151 3.3004 17.5362
KINGS-1 GDSC1; GDSC2 3.5358 8.979 0.6696 12.9595
TM-31 CTRP2 3.6263 5.6205 3.508 16.5165
KS-1 [Human Krukenberg tumour] GDSC1; GDSC2 3.6304 11.0039 -0.2651 17.0302
SNU-738 CTRP2 3.6845 7.2316 3.0695 17.9603
SF295 GDSC1; GDSC2; CTRP2 3.7667 6.6208 3.3804 16.5182
KALS-1 GDSC1; GDSC2; CTRP2 3.7798 7.6112 3.0203 17.8419
T98G GDSC1; GDSC2; CTRP2 3.8165 9.4631 2.2488 20.6853
SF126 GDSC1; GDSC2; CTRP2 3.8893 5.0474 3.8719 14.3831
YKG-1 GDSC1; GDSC2; CTRP2 3.9667 5.9998 3.789 14.4294
D-566MG GDSC1; GDSC2 3.9754 7.1936 1.9 5.8795
D-392MG GDSC1; GDSC2 4.0283 8.3179 1.3854 8.354
LN-405 GDSC1; GDSC2 4.1977 7.2813 2.0161 4.8855
D-423MG GDSC1; GDSC2 4.3194 9.451 1.0437 9.4564
D-336MG GDSC1; GDSC2 4.3279 8.8551 1.3423 7.9761
DBTRG-05MG GDSC1; GDSC2; CTRP2 4.5666 8.8917 3.2581 14.8682
Onda 10 GDSC1; GDSC2 4.5999 9.7185 1.116 8.5665
Onda 11 GDSC1; GDSC2 5.0012 7.1476 2.561 1.3071
NMC-G1 GDSC1; GDSC2; CTRP2 5.139 6.5177 4.8963 6.9024
CCF-STTG1 CTRP2 5.223 8.3163 4.1678 9.6306
D-502MG GDSC1; GDSC2 5.245 15.8712 -1.4311 18.1614
D-247MG GDSC1; GDSC2 5.3235 7.7508 2.4695 1.3563
U-87MG ATCC GDSC1; GDSC2; CTRP2 5.3945 6.9895 4.961 5.9726
D-542MG GDSC1; GDSC2 5.4841 7.2736 2.7292 0.4492
KNS-81-FD GDSC1; GDSC2 5.7686 11.7105 0.9492 7.3643
SW1783 GDSC1; GDSC2; CTRP2 6.1099 11.0571 3.5924 10.1395
8-MG-BA GDSC1; GDSC2; CTRP2 6.5909 12.4669 3.2765 10.5455
⏷ Show the Full List of 68 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Digestive System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TGBC24TKB GDSC1; GDSC2 1.3817 9.796 -1.6465 28.4021
ETK-1 GDSC1; GDSC2 2.2079 12.9069 -2.4279 28.4006
TGBC1TKB GDSC1; GDSC2 3.2201 5.8396 1.9772 7.1285
Cancer Drug Sensitivity Data Curated from 23 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JHUEM-3 CTRP2 -0.773 6.5671 -1.5447 46.2995
HEC-251 CTRP2 -0.0535 5.5179 -0.4744 41.5899
HEC-1-B CTRP2 0.0235 8.4304 -1.3035 42.5906
HEC-1-A CTRP2 0.9743 6.1087 0.4936 35.2415
RL95-2 GDSC1; GDSC2; CTRP2 1.1785 7.8596 0.1474 35.3606
JHUEM-7 CTRP2 1.3442 3.3185 1.3347 31.345
HEC-108 CTRP2 1.3757 3.7072 1.35 31.1894
HEC-151 CTRP2 1.5164 5.7562 1.1785 31.2848
JHUEM-2 CTRP2 1.5275 3.5053 1.5157 30.1316
KLE GDSC1; GDSC2; CTRP2 1.7938 8.0854 0.7235 31.7073
JHUEM-1 CTRP2 2.2628 2.8737 2.2628 25.1933
HEC-59 CTRP2 2.2769 3.6358 2.2741 25.109
MFE-280 GDSC1; GDSC2 2.3084 5.8384 1.144 13.7768
MFE-319 GDSC1; GDSC2; CTRP2 2.5498 7.3383 1.8129 25.8115
HEC-6 CTRP2 2.7335 5.1729 2.6263 22.4234
AN3-CA GDSC1; GDSC2; CTRP2 2.8245 4.827 2.7727 21.577
EN GDSC1; GDSC2; CTRP2 3.1659 4.9451 3.1209 19.285
ESS-1 GDSC1; GDSC2; CTRP2 3.383 6.2935 3.0683 18.7973
HEC-265 CTRP2 3.4116 5.1175 3.3609 17.7117
MFE-296 GDSC1; GDSC2; CTRP2 3.4817 5.3308 3.4052 17.2942
HEC-50B CTRP2 4.283 6.8126 3.8687 13.2382
EFE-184 CTRP2 4.7827 19.5641 -1.7937 30.0053
Ishikawa (Heraklio) 02 ER- CTRP2 2.9008 4.3516 2.8896 20.9803
⏷ Show the Full List of 23 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 39 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SW13 GDSC1; GDSC2 -1.7028 3.0466 -2.089 41.8262
LB2241-RCC GDSC1; GDSC2 -1.433 9.4224 -4.2369 43.7125
CAL-54 GDSC1; GDSC2; CTRP2 -0.396 10.9373 -2.7352 45.5336
769-P GDSC1; GDSC2; CTRP2 0.1325 7.8269 -0.9692 41.5895
TK-10 GDSC1; GDSC2 0.1626 14.715 -5.1825 39.5666
ACHN GDSC1; GDSC2; CTRP2 0.8372 9.7129 -0.9359 38.8927
KTCTL-140 GDSC1; GDSC2 1.0571 15.7934 -4.8891 36.7229
TUHR14TKB CTRP2 1.5949 4.783 1.4656 30.0768
UO-31 GDSC1; GDSC2; CTRP2 1.651 6.375 1.1555 30.8439
LB996-RCC GDSC1; GDSC2 1.6622 14.7838 -3.8449 33.3339
KMRC-3 CTRP2 2.2653 3.6085 2.2627 25.1855
BFTC-909 GDSC1; GDSC2; CTRP2 2.2795 5.341 2.1041 25.6239
A-704 GDSC1; GDSC2 2.3579 5.7241 1.2462 13.1283
KMRC-20 GDSC1; GDSC2; CTRP2 2.412 6.1154 2.0606 25.3603
TUHR4TKB CTRP2 2.4205 5.6299 2.1945 24.9208
A-498 GDSC1; GDSC2; CTRP2 2.4368 7.4408 1.6539 26.7046
786-O GDSC1; GDSC2; CTRP2 2.502 6.0717 2.171 24.6931
VMRC-RCW GDSC1; GDSC2; CTRP2 2.5055 5.5314 2.3093 24.1962
KTCTL-21 GDSC1; GDSC2 2.5101 19.5244 -5.4654 34.1263
LB1047-RCC GDSC1; GDSC2 2.6703 17.6494 -4.3918 31.8747
RCC10RGB GDSC1; GDSC2; CTRP2 2.6822 9.2931 1.1678 27.6005
KMRC-1 GDSC1; GDSC2; CTRP2 2.8908 6.7125 2.3997 22.6964
Caki-2 CTRP2 2.9536 12.2462 0.101 30.0323
SW156 GDSC1; GDSC2 3.5093 15.3393 -2.5313 25.4504
OS-RC-2 GDSC1; GDSC2; CTRP2 3.5537 7.7094 2.742 19.5241
KTCTL-26A GDSC1; GDSC2 3.824 9.2812 0.7497 11.922
Caki-1 GDSC1; GDSC2; CTRP2 3.9043 16.9769 -1.2939 30.8809
KMRC-2 CTRP2 3.9247 12.277 1.0235 24.7479
KTCTL-1M GDSC1; GDSC2 3.9546 14.6765 -1.8371 22.275
SNU-1272 CTRP2 4.2782 5.7387 4.191 12.0666
KTCTL-13 GDSC1; GDSC2 4.4248 7.5675 2.033 4.4116
RXF 393L GDSC1; GDSC2 4.4657 9.7147 1.0214 9.2788
HA7-RCC GDSC1; GDSC2 4.5918 10.421 0.767 10.254
KTCTL-195 GDSC1; GDSC2 4.821 13.9178 -0.7845 16.5823
NCC021 GDSC1; GDSC2 5.136 7.8043 2.3509 1.9962
NCC010 GDSC1; GDSC2 5.211 12.3927 0.2482 11.4725
VMRC-RCZ GDSC1; GDSC2; CTRP2 5.8172 14.6423 1.5547 18.6119
BB65-RCC GDSC1; GDSC2 6.0904 24.8419 -5.2269 26.769
SN12C GDSC1; GDSC2 8.3991 22.7815 -2.5714 16.52
⏷ Show the Full List of 39 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 58 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
DiFi GDSC1; GDSC2 -7.8661 2.4297 -8.6563 72.1035
NCI-H508 GDSC1; GDSC2; CTRP2 -3.9108 5.2935 -4.6245 61.4094
CCK-81 GDSC1; GDSC2; CTRP2 -3.687 4.5247 -4.2027 61.0872
GP2d CTRP2 -1.1247 4.7359 -1.4649 48.0153
SW48 GDSC1; GDSC2; CTRP2 -0.9708 12.1433 -3.8406 48.1198
SNU-C4 CTRP2 -0.9294 4.1985 -1.1534 46.7356
CW-2 GDSC1; GDSC2; CTRP2 -0.6927 6.7591 -1.5149 45.8124
SW1463 GDSC1; GDSC2; CTRP2 -0.2517 7.1809 -1.1676 43.467
SNU-C2A CTRP2 -0.2458 6.1832 -0.8587 43.0891
SNU-175 GDSC2; CTRP2 -0.0136 15.1509 -4.1897 45.2333
HT-55 GDSC1; GDSC2; CTRP2 0.0854 9.5063 -1.6481 42.7151
SNU-503 CTRP2 0.1684 10.2342 -1.8529 42.7205
LS513 GDSC1; GDSC2; CTRP2 0.3279 5.1275 0.0302 38.819
SNU-1033 CTRP2 0.609 7.966 -0.5044 38.9842
LoVo GDSC1; GDSC2; CTRP2 0.7873 6.9095 0.0495 37.0137
HT115 GDSC1; GDSC2 0.8482 8.1356 -1.3645 29.1777
SW1116 GDSC1; GDSC2 0.9129 9.3782 -1.8905 30.6525
SK-CO-1 GDSC1; GDSC2 0.9791 4.9134 0.2054 22.4343
NCI-H747 GDSC1; GDSC2; CTRP2 1.0583 7.9872 -0.0286 36.2184
COLO 678 GDSC1; GDSC2; CTRP2 1.1636 10.4935 -0.9205 37.7444
HCT 15 GDSC1; GDSC2; CTRP2 1.2263 3.7988 1.1887 32.1507
SNU-407 GDSC1; GDSC2; CTRP2 1.3381 7.3839 0.4888 33.9003
GP5d GDSC1; GDSC2 1.5107 7.2915 -0.3192 23.0012
SNU-61 GDSC1; GDSC2; CTRP2 1.5885 6.6077 1.0168 31.4902
LS180 GDSC1; GDSC2; CTRP2 1.7209 6.9698 1.0443 30.968
HCC2998 GDSC1; GDSC2 1.7265 4.4416 1.185 15.3825
LS123 GDSC1; GDSC2; CTRP2 1.7289 7.6798 0.8051 31.6763
SW948 GDSC1; GDSC2; CTRP2 1.731 4.3068 1.6733 28.8642
LS411N GDSC1; GDSC2 1.7554 5.4599 0.7741 17.2436
SNU-1040 GDSC1; GDSC2 1.8382 8.8551 -0.7612 23.8811
KM12 GDSC1; GDSC2; CTRP2 1.9472 4.854 1.8327 27.6207
HCC-56 CTRP2 2.1166 5.5054 1.8921 26.9346
SNU-C5 GDSC1; GDSC2; CTRP2 2.2061 5.492 1.9925 26.2429
COLO 320 CTRP2 2.2841 4.1248 2.2654 25.1142
T84 GDSC1; GDSC2; CTRP2 2.2886 6.1603 1.9133 26.2589
COLO 320HSR GDSC1; GDSC2 2.336 4.3006 1.8807 10.0816
C2BBe1 GDSC1; GDSC2; CTRP2 2.3745 11.045 0.079 31.6879
RKO GDSC1; GDSC2; CTRP2 2.4618 4.1349 2.4482 23.8589
HCT 116 GDSC1; GDSC2; CTRP2 2.5156 5.3199 2.3642 23.9731
SW837 GDSC1; GDSC2 2.5165 5.2867 1.6079 10.8728
SW620 GDSC1; GDSC2; CTRP2 2.5714 4.0459 2.5638 23.1103
SNU-C1 GDSC1; GDSC2; CTRP2 2.5794 4.7046 2.5271 23.2079
RCM-1 [Human ESC] GDSC1; GDSC2; CTRP2 2.6265 10.0008 0.8018 28.9101
OUMS-23 CTRP2 2.6838 4.4703 2.6582 22.4748
MDST8 GDSC1; GDSC2 2.7082 5.1001 1.881 8.96
SNU-C2B GDSC1; GDSC2 2.8153 11.4917 -1.1925 22.7659
CL-11 GDSC1; GDSC2; CTRP2 2.8836 6.0241 2.6005 21.9948
LS1034 GDSC1; GDSC2; CTRP2 2.887 5.8412 2.652 21.801
COLO201 CTRP2 3.3105 6.6024 2.8917 19.7034
HCT 8 CTRP2 3.3662 5.1601 3.3069 18.0437
NCI-H716 GDSC1; GDSC2; CTRP2 3.396 5.1214 3.3439 17.7802
COLO205 GDSC1; GDSC2; CTRP2 3.5637 5.3488 3.4904 16.7385
SNU-81 GDSC1; GDSC2 3.6458 6.2568 2.1149 5.4594
HT-29 GDSC1; GDSC2; CTRP2 4.1268 10.3101 2.1596 20.2289
SW626 GDSC1; GDSC2 4.1775 9.3195 1.0029 9.9403
CaR-1 GDSC1; GDSC2 4.3029 18.2191 -3.3257 25.8659
SW1417 GDSC1; GDSC2 4.8063 13.5126 -0.5954 15.8559
SNU-283 GDSC2 4.9723 18.6532 -3.9982 22.7887
⏷ Show the Full List of 58 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Leukemia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MO-T GDSC1; GDSC2 2.2629 4.1152 1.883 10.3085
Cancer Drug Sensitivity Data Curated from 23 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JHH-5 CTRP2 -3.3902 5.1634 -4.0254 59.5034
SNU-182 CTRP2 -0.5705 3.5593 -0.6787 44.2921
SNU-878 CTRP2 0.7873 3.127 0.7722 35.0733
SNU-398 GDSC1; GDSC2; CTRP2 2.1494 4.7876 2.0592 26.1944
SNU-761 CTRP2 2.2472 4.0798 2.0813 16.0375
JHH-2 GDSC1; GDSC2; CTRP2 2.391 4.9949 2.2871 24.6364
HLF CTRP2 2.4117 4.3086 2.3864 24.2862
Hep-G2 CTRP2 2.4153 4.0385 2.4046 24.2133
JHH-4 GDSC1; GDSC2; CTRP2 2.6166 5.4255 2.4526 23.3462
SNU-423 GDSC1; GDSC2 2.741 5.1017 1.9113 8.7155
PLC/PRF/5 CTRP2 2.7829 6.1036 2.4687 22.8254
SNU-449 GDSC1; GDSC2; CTRP2 2.9394 7.5539 2.1504 23.4588
JHH-1 GDSC1; GDSC2; CTRP2 3.1079 14.1146 -0.6394 31.405
SNU-387 GDSC1; GDSC2; CTRP2 3.2706 7.1397 2.6607 20.6279
Hep 3B2.1-7 GDSC1; GDSC2; CTRP2 3.3319 5.4588 3.221 18.4091
HuH-1 GDSC1; GDSC2; CTRP2 3.3908 5.476 3.2815 18.0124
HLE GDSC1; GDSC2 3.521 10.1729 0.0609 15.8459
Hep-G2/C3A GDSC1; GDSC2 3.6063 5.3147 2.5514 3.3251
JHH-7 GDSC1; GDSC2 3.6132 5.9871 2.2236 4.9749
SK-HEP-1 GDSC1; GDSC2; CTRP2 3.8792 5.8079 3.7416 14.8674
SNU-475 CTRP2 4.2495 8.2864 3.2183 15.8594
Huh-7 GDSC1; GDSC2 4.9028 7.2614 2.4614 1.7984
JHH-6 GDSC1; GDSC2; CTRP2 5.3594 5.7956 5.3472 4.5945
⏷ Show the Full List of 23 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 217 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HCC827 GDSC1; GDSC2; CTRP2 -15.7123 6.775 -17.9028 79.2298
HCC4006 CTRP2 -12.8031 -1.7029 -13.0397 87.8797
NCI-H3255 GDSC1; GDSC2 -8.247 10.9638 -11.9799 64.4473
PC-14 GDSC1; GDSC2; CTRP2 -8.1333 12.2585 -11.4793 66.4102
HCC2935 CTRP2 -7.749 5.5312 -8.8717 71.7458
PaCa-3 GDSC1; GDSC2 -5.4718 14.7599 -10.7272 56.8511
COR-L105 GDSC1; GDSC2; CTRP2 -4.4501 7.1386 -5.7251 61.9062
NCI-H2170 GDSC1; GDSC2; CTRP2 -4.1021 7.5391 -5.4703 60.5162
NCI-H322 CTRP2 -3.4599 9.4348 -5.4177 57.4693
EMC-BAC-1 GDSC1; GDSC2 -3.2514 3.1878 -3.8156 52.6165
NCI-H1666 GDSC1; GDSC2; CTRP2 -3.1978 8.4255 -4.7797 56.9505
NCI-H1623 GDSC1; GDSC2; CTRP2 -2.4872 8.8725 -4.1674 54.162
NCI-H292 GDSC1; GDSC2; CTRP2 -1.9638 9.3469 -3.7764 52.0129
NCI-H1975 GDSC1; GDSC2; CTRP2 -1.6522 2.2826 -1.7002 51.1248
Calu-3 GDSC1; GDSC2; CTRP2 -1.4725 5.5238 -2.023 49.971
NCI-H1781 GDSC1; GDSC2 -1.3586 3.825 -1.9318 39.7161
DV-90 CTRP2 -1.2436 5.0356 -1.6582 48.7489
NCI-H322M GDSC1; GDSC2 -1.237 9.8798 -4.2453 42.9773
HCC1588 CTRP2 -0.4361 4.4797 -0.6704 43.6494
RERF-LC-Sq1 GDSC1; GDSC2 -0.4053 13.3972 -5.0808 41.1109
NCI-H358 GDSC1; GDSC2; CTRP2 -0.2549 6.6017 -0.9901 43.2369
NCI-H1648 GDSC1; GDSC2 -0.1586 7.9639 -2.2903 35.5009
LUDLU-1 CTRP2 -0.1556 10.2421 -2.1974 44.2809
Sq-1 CTRP2 -0.087 6.4331 -0.7571 42.238
EPLC-272H GDSC1; GDSC2; CTRP2 0.049 12.0837 -2.7577 43.9781
LC-1F CTRP2 0.1966 12.3352 -2.7152 43.5061
CAL-12T GDSC1; GDSC2; CTRP2 0.573 6.3635 -0.0168 37.9806
NCI-H1568 GDSC1; GDSC2; CTRP2 0.5925 14.0145 -3.0631 42.5072
NCI-H1184 CTRP2 0.5935 2.4815 0.5905 36.3245
NCI-H2126 CTRP2 0.6328 3.4065 0.5986 36.1634
HCC2279 CTRP2 0.6454 7.7243 -0.3789 38.5909
IST-SL2 GDSC1; GDSC2 0.6967 3.5197 0.4006 22.5704
SK-MES-1 GDSC1; GDSC2; CTRP2 0.8567 8.9512 -0.6104 38.2098
EKVX GDSC1; GDSC2; CTRP2 0.8688 16.1553 -3.7791 42.358
NCI-H1573 GDSC1; GDSC2; CTRP2 0.938 6.2182 0.4232 35.4909
NCI-H209 GDSC1; GDSC2 0.9545 3.3293 0.7362 20.1427
COLO 699 CTRP2 1.0042 5.2435 0.7401 34.4154
HARA [Human squamous cell lung carcinoma] GDSC1; GDSC2; CTRP2 1.0292 8.3014 -0.1765 36.668
NCI-H524 GDSC1; GDSC2; CTRP2 1.0673 3.1443 1.0576 33.1151
COR-L303 GDSC2 1.1652 2.5584 0.893 9.8885
NCI-H1869 GDSC1; GDSC2; CTRP2 1.2276 7.5601 0.3077 34.7742
NCI-H1838 GDSC1; GDSC2; CTRP2 1.2454 5.9153 0.8417 33.1907
NCI-H1693 GDSC1; GDSC2; CTRP2 1.2768 9.6216 -0.4363 36.3877
NCI-H1734 GDSC1; GDSC2; CTRP2 1.2769 5.4007 1.0021 32.5843
CPC-N GDSC1; GDSC2 1.4028 4.2106 0.9319 17.6577
HCC33 GDSC2 1.4614 4.5504 0.2522 12.7211
NCI-H2171 GDSC2; CTRP2 1.4879 3.0783 1.4852 30.3651
NCI-H1703 GDSC1; GDSC2; CTRP2 1.5429 3.8641 1.5135 30.0194
NCI-H1105 GDSC1; GDSC2; CTRP2 1.5996 3.2738 1.5952 29.559
LOU-NH91 GDSC1; GDSC2; CTRP2 1.6121 22.8883 -6.3065 42.456
Ms-1 GDSC1; GDSC2 1.6669 3.4079 1.4915 14.1827
NCI-H2122 GDSC1; GDSC2; CTRP2 1.6842 5.0907 1.5084 29.5725
NCI-H211 GDSC1; GDSC2; CTRP2 1.6937 3.3628 1.6888 28.9352
NCI-H82 GDSC1; GDSC2 1.7049 3.9579 1.3502 14.686
COR-L279 GDSC1; GDSC2 1.713 3.5981 1.4835 14.0507
NCI-H847 GDSC1; GDSC2 1.7179 3.4282 1.5413 13.7746
NCI-H835 GDSC1; GDSC2 1.7381 4.0144 1.365 14.5032
HCC2108 CTRP2 1.7565 4.9979 1.6035 29.0828
NCI-H1435 GDSC1; GDSC2; CTRP2 1.7748 4.619 1.6826 28.6899
SHP-77 GDSC1; GDSC2 1.7808 3.6932 1.5258 13.6178
NCI-H69 GDSC1; GDSC2; CTRP2 1.7855 3.9843 1.7575 28.4026
HCC78 GDSC1; GDSC2; CTRP2 1.8118 6.3428 1.3404 29.7178
NCI-H1341 GDSC1; GDSC2; CTRP2 1.8246 3.4923 1.8188 28.0681
NCI-H2085 GDSC1; GDSC2; CTRP2 1.8261 6.2572 1.381 29.5375
NCI-H64 GDSC1; GDSC2 1.843 3.6359 1.6124 13.0041
NCI-H1755 GDSC1; GDSC2; CTRP2 1.8456 4.932 1.7109 28.3638
DMS 273 GDSC1; GDSC2; CTRP2 1.8502 4.0053 1.8233 27.9688
NCI-H2141 GDSC1; GDSC2; CTRP2 1.8589 4.0271 1.8309 27.9143
NCI-H1694 GDSC1; GDSC2; CTRP2 1.8679 3.1085 1.8672 27.7632
NCI-H661 GDSC1; GDSC2; CTRP2 1.8711 6.1622 1.4572 29.1386
LCLC-97TM1 GDSC1; GDSC2; CTRP2 1.8837 6.8796 1.251 29.7792
A-549 GDSC1; GDSC2; CTRP2 1.8989 7.1931 1.1616 30.0195
NCI-H446 GDSC1; GDSC2 1.9069 3.7208 1.6529 12.5931
NCI-H522 GDSC1; GDSC2; CTRP2 1.9337 8.7455 0.6131 31.6449
NCI-H1963 GDSC1; GDSC2 1.9558 3.4459 1.7954 11.7761
COR-L311 GDSC2 1.9756 3.32 1.8532 11.4802
HCC1438 CTRP2 1.978 6.5605 1.4557 28.8665
NCI-H2795 GDSC1; GDSC2 2.0053 5.69 0.9182 15.78
NCI-H2110 GDSC1; GDSC2; CTRP2 2.0455 9.8524 0.2684 32.1857
COLO 668 GDSC1; GDSC2; CTRP2 2.0498 3.1782 2.0494 26.5536
COR-L32 GDSC1; GDSC2 2.0973 4.7887 1.4217 14.2474
DMS 454 CTRP2 2.1058 4.299 2.068 26.3666
LXF 289 GDSC1; GDSC2; CTRP2 2.1531 5.0726 2.0182 26.3232
NCI-H810 GDSC1; GDSC2; CTRP2 2.1643 2.9595 2.1643 25.7912
EBC-1 GDSC1; GDSC2; CTRP2 2.1824 3.8265 2.1739 25.699
NCI-H841 GDSC1; GDSC2; CTRP2 2.2029 6.1941 1.8102 26.8847
NCI-H510A GDSC1; GDSC2 2.2335 4.5848 0.8967 5.7392
COR-L95 GDSC1; GDSC2; CTRP2 2.2368 3.6058 2.2341 25.318
NCI-H2029 GDSC1; GDSC2; CTRP2 2.2462 3.1022 2.2461 25.2468
NCI-H1092 GDSC1; GDSC2; CTRP2 2.2604 3.8293 2.2533 25.1756
DMS 79 GDSC1; GDSC2; CTRP2 2.2633 3.527 2.2617 25.1385
NCI-H2009 GDSC1; GDSC2; CTRP2 2.269 5.413 2.0779 25.7477
NCI-H1944 GDSC1; GDSC2; CTRP2 2.2694 8.5614 1.0419 29.2378
NCI-H1915 GDSC1; GDSC2; CTRP2 2.2716 5.2948 2.1048 25.6461
NCI-H526 GDSC1; GDSC2; CTRP2 2.2727 3.6942 2.2689 25.083
NCI-H1993 GDSC1; GDSC2 2.2746 5.0224 1.4947 12.1488
NCI-H2196 GDSC2; CTRP2 2.2792 4.097 2.2619 25.1424
NCI-H513 GDSC1; GDSC2 2.2814 7.8977 0.118 18.778
NCI-H1563 GDSC1; GDSC2; CTRP2 2.2929 5.544 2.0753 25.6813
HCC44 GDSC1; GDSC2; CTRP2 2.3043 4.4671 2.2612 25.0054
DMS 53 GDSC1; GDSC2; CTRP2 2.34 3.6417 2.3378 24.6303
NCI-H748 GDSC2 2.3465 5.9486 0.3065 9.7263
NCI-H1385 CTRP2 2.3521 4.0393 2.3397 24.6401
NCI-H1155 GDSC1; GDSC2 2.3685 4.617 1.774 10.4954
HCC366 GDSC1; GDSC2; CTRP2 2.3778 6.52 1.9036 26.0169
Lu-139 GDSC1; GDSC2 2.4272 4.9916 1.6604 10.8746
NCI-H2081 GDSC1; GDSC2; CTRP2 2.493 5.0297 2.3911 23.9522
NCI-H2087 GDSC1; GDSC2; CTRP2 2.5083 5.2702 2.3658 23.9907
DMS 114 GDSC1; GDSC2; CTRP2 2.5349 3.9061 2.5304 23.3427
NCI-H2023 GDSC1; GDSC2; CTRP2 2.5563 6.5705 2.0821 24.8414
COR-L88 GDSC1; GDSC2; CTRP2 2.5896 4.8366 2.5221 23.1921
LK2 CTRP2 2.5923 2.9798 2.5923 22.9981
NCI-H290 GDSC1; GDSC2 2.5929 10.9385 -1.1097 23.0428
NCI-H1299 GDSC1; GDSC2; CTRP2 2.5962 5.2967 2.4558 23.3994
HCC1833 CTRP2 2.62 6.5712 2.1512 24.4579
RERF-LC-A1 CTRP2 2.6282 4.8712 2.5588 22.9942
NCI-H720 GDSC1; GDSC2 2.6325 4.2557 2.2038 7.5835
Lu-165 GDSC1; GDSC2 2.6777 4.739 2.0244 8.3313
NCI-H23 GDSC1; GDSC2; CTRP2 2.6987 5.3872 2.5493 22.7501
SBC-3 GDSC1; GDSC2 2.702 5.0283 1.9097 8.834
NCI-H250 GDSC2 2.71 8.851 -0.8532 14.2469
Lu-135 GDSC1; GDSC2 2.7114 4.5847 2.1302 7.7074
NCI-H596 GDSC1; GDSC2 2.7164 5.0438 1.9159 8.7619
NCI-H1581 GDSC1; GDSC2 2.7697 3.8352 2.5297 5.5748
NCI-H727 GDSC1; GDSC2; CTRP2 2.8202 8.0044 1.8478 24.8893
NCI-H2373 GDSC1; GDSC2 2.8287 4.9854 2.0504 7.7713
HCC95 CTRP2 2.8327 10.6151 0.7358 28.5717
NCI-H1373 CTRP2 2.8335 6.1764 2.5033 22.5464
NCI-H520 GDSC1; GDSC2; CTRP2 2.8415 4.2264 2.8338 21.3153
NCI-H3122 GDSC1; GDSC2 2.8514 7.3401 0.9084 13.4611
NCI-H1688 GDSC1; GDSC2 2.8634 4.8078 2.1692 7.0768
NCI-H2731 GDSC1; GDSC2 2.8731 4.7772 2.1932 6.9292
NCI-H1876 GDSC1; GDSC2 2.8824 4.4442 2.3626 6.0536
NCI-H2291 GDSC1; GDSC2; CTRP2 2.9025 8.4756 1.743 25.0207
RERF-LC-Ad2 CTRP2 2.9148 7.663 2.0822 23.8299
Calu-6 GDSC1; GDSC2; CTRP2 2.9197 4.8964 2.8656 20.9524
HOP-92 GDSC1; GDSC2; CTRP2 2.9291 6.2239 2.5939 21.8803
VMRC-LCD GDSC1; GDSC2; CTRP2 2.9303 4.7366 2.8939 20.8214
COR-L23 GDSC1; GDSC2 2.9511 4.8722 2.2196 6.5814
NCI-H196 GDSC1; GDSC2; CTRP2 2.9603 4.9809 2.8982 20.7098
HCC1171 CTRP2 3.0087 10.8116 0.8227 27.811
HCC15 GDSC1; GDSC2; CTRP2 3.029 5.4417 2.8964 20.4974
LC-1/sq GDSC1; GDSC2 3.0716 16.6537 -3.5537 29.1435
NCI-H740 GDSC2 3.0729 5.7999 0.9025 4.3767
Lu-99A GDSC1; GDSC2 3.0969 5.2439 2.1675 6.4625
LK-2 GDSC1; GDSC2 3.099 4.4733 2.5513 4.5034
NCI-H1792 GDSC1; GDSC2; CTRP2 3.1001 6.0903 2.8186 20.5534
NCI-H1355 GDSC1; GDSC2; CTRP2 3.1334 7.2428 2.4753 21.709
NCI-H1048 GDSC1; GDSC2 3.1576 5.3951 2.1454 6.4223
T3M-10 CTRP2 3.1928 7.2791 2.5255 21.4009
NCI-H2228 GDSC1; GDSC2; CTRP2 3.1996 6.9165 2.6645 20.8194
Lu-65 GDSC1; GDSC2; CTRP2 3.2146 8.3447 2.1243 22.7697
SBC-5 GDSC1; GDSC2; CTRP2 3.2247 4.6562 3.2077 18.7992
NCI-H2461 GDSC1; GDSC2 3.226 6.5017 1.6514 8.7784
Calu-1 CTRP2 3.2319 5.596 3.0848 19.2439
NCI-H2342 GDSC1; GDSC2; CTRP2 3.2499 8.9936 1.8834 23.544
NCI-H650 GDSC1; GDSC2; CTRP2 3.2516 4.6738 3.2345 18.6211
NCI-H441 GDSC1; GDSC2; CTRP2 3.257 11.6954 0.6572 27.5752
HOP-62 GDSC1; GDSC2; CTRP2 3.2884 5.5549 3.1548 18.7772
NCI-H2066 GDSC1; GDSC2 3.3617 6.1315 1.9501 6.9309
LC-1/sq-SF CTRP2 3.4302 14.5315 -0.5353 30.3768
NCI-H2818 GDSC1; GDSC2 3.4308 6.4155 1.865 7.2069
KNS-62 GDSC1; GDSC2; CTRP2 3.4338 7.5153 2.6923 20.046
NCI-H1793 GDSC1; GDSC2; CTRP2 3.4391 5.9605 3.2237 18.0667
SW1271 GDSC1; GDSC2; CTRP2 3.4625 6.6367 3.0452 18.6468
NCI-H647 GDSC1; GDSC2; CTRP2 3.5479 6.7198 3.1095 18.1599
MOR/CPR CTRP2 3.5714 5.464 3.479 16.7914
RERF-LC-Ad1 CTRP2 3.6184 5.1993 3.5706 16.3242
NCI-H345 GDSC1; GDSC2 3.6642 6.7249 1.8966 6.531
NCI-H1651 GDSC1; GDSC2; CTRP2 3.7358 8.1462 2.7511 18.9918
NCI-H2405 GDSC1; GDSC2; CTRP2 3.7888 5.6386 3.6805 15.3646
NCI-H2722 GDSC1; GDSC2 3.7915 6.9347 1.8904 6.2957
LCLC-103H GDSC1; GDSC2; CTRP2 3.8235 5.7697 3.6898 15.2231
NCI-H838 GDSC1; GDSC2; CTRP2 3.845 5.7334 3.7214 15.045
RERF-LC-MS GDSC1; GDSC2; CTRP2 3.857 6.1912 3.6155 15.3877
NCI-H2030 GDSC1; GDSC2; CTRP2 3.8608 17.7805 -1.7299 31.8719
NCI-H1339 CTRP2 3.8929 6.2518 3.6366 15.238
NCI-H1436 GDSC1; GDSC2 3.9542 6.5865 2.1818 4.5081
NCI-H2595 GDSC1; GDSC2 3.9829 8.4349 1.2932 8.9068
NCI-H2347 GDSC1; GDSC2 4.0125 7.0105 2.0167 5.2235
NCI-H226 GDSC1; GDSC2 4.0538 7.8697 1.6254 7.1024
EMC-BAC-2 GDSC1; GDSC2 4.0864 16.9721 -2.877 25.1345
NCI-H2444 GDSC1; GDSC2; CTRP2 4.1134 7.453 2.4263 7.9491
NCI-H2369 GDSC1; GDSC2 4.1235 7.0097 2.0958 4.6246
ABC-1 GDSC1; GDSC2 4.165 9.1513 1.0765 9.6052
IA-LM GDSC1; GDSC2; CTRP2 4.1894 6.6032 3.8439 13.5685
NCI-H1304 GDSC1 4.3287 7.129 2.1779 3.8704
UMC-11 GDSC1; GDSC2 4.3579 8.8808 1.3515 7.8736
RERF-LC-KJ GDSC1; GDSC2 4.4634 13.8271 -1.0124 18.2122
ChaGo-K-1 GDSC1; GDSC2; CTRP2 4.493 7.0615 3.9955 12.1403
NCI-H1770 GDSC1; GDSC2 4.55 8.7988 1.5271 6.6583
NCI-H1836 GDSC1; GDSC2 4.5588 9.0546 1.4095 7.2162
SK-LU-1 GDSC1; GDSC2; CTRP2 4.5741 7.7111 3.8047 12.6699
BEN GDSC1; GDSC2; CTRP2 4.6131 5.0044 4.613 9.5142
NCI-H2803 GDSC1; GDSC2 4.6531 7.4723 2.2233 3.1581
NCI-H2227 GDSC1; GDSC2 4.6537 7.7056 2.1156 3.6574
NCI-H146 GDSC1; GDSC2 4.6823 7.5752 2.1937 3.2525
NCI-H2591 GDSC1; GDSC2 4.7143 14.6674 -1.2363 18.5257
LC-2/ad GDSC1; GDSC2 4.7978 8.6662 1.757 5.1293
HCC1195 CTRP2 4.9957 11.6663 2.3179 17.6104
IST-SL1 GDSC1; GDSC2 5.0465 7.3226 2.5103 1.4569
NCI-H187 GDSC1 5.0874 6.4842 2.8618 0.3114
SW1573 GDSC1; GDSC2 5.158 9.9027 1.407 6.2103
NCI-H460 GDSC1; GDSC2; CTRP2 5.1596 6.0495 5.0774 6.1685
SBC-1 GDSC1; GDSC2 5.2129 11.418 0.7208 9.3253
NCI-H2172 GDSC1; GDSC2; CTRP2 5.2718 6.759 4.9375 6.3822
NCI-H1650 GDSC1; GDSC2; CTRP2 5.3487 23.004 -3.0219 31.104
LB647-SCLC GDSC1; GDSC2 5.5735 7.9067 2.524 0.9764
NCI-H2810 GDSC1; GDSC2 5.6716 7.8998 2.5702 0.7736
A-427 GDSC1; GDSC2 5.6845 9.4768 1.919 3.1718
NCI-H2135 GDSC1; GDSC2 5.7912 7.0962 2.9056 0.0748
NCI-H2804 GDSC1; GDSC2 6.0525 8.7169 2.4192 0.9844
COR-L321 GDSC1; GDSC2 6.086 7.8846 2.7407 0.2232
NCI-H2869 GDSC1; GDSC2 6.3198 8.8867 2.4681 0.7019
NCI-H1437 GDSC1; GDSC2 6.342 8.3844 2.6598 0.2873
Lu-134-A GDSC1; GDSC2 6.699 10.1019 2.1633 1.345
NCI-H2286 CTRP2 8.3482 20.3458 0.7111 16.8488
⏷ Show the Full List of 217 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Lymphoma Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CBTCi002-A GDSC1; GDSC2 1.8944 3.8958 1.5768 12.9857
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Clivus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
U-CH1 CTRP2 1.1049 6.1594 0.6219 34.4095
Cancer Drug Sensitivity Data Curated from 45 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
2004 CTRP2 1.47 4.9806 1.2972 31.0508
SNU-840 CTRP2 -1.9184 15.012 -6.0595 51.3776
IGROV-1 GDSC1; GDSC2; CTRP2 -0.7668 6.2726 -1.4524 46.1036
ONCO-DG-1 CTRP2 -0.2022 3.7033 -0.3049 41.8776
SNU-119 CTRP2 0.0405 4.4471 -0.151 40.5032
RMG-I GDSC1; GDSC2; CTRP2 0.1423 8.9416 -1.3681 42.1362
COV644 CTRP2 0.4514 10.9329 -1.8476 41.7002
JHOC-5 CTRP2 0.9059 10.544 -1.2098 39.1957
OC 314 GDSC1; GDSC2; CTRP2 1.139 4.8405 0.9651 33.1715
COV434 CTRP2 1.6873 4.2173 1.6361 29.1991
SNU-8 CTRP2 1.7461 4.6363 1.6495 28.9609
Caov-3 GDSC2; CTRP2 1.8355 8.2317 0.7119 31.6733
COV362 CTRP2 2.0081 4.7453 1.9142 27.2079
JHOS-2 GDSC1; GDSC2; CTRP2 2.0456 9.9071 0.245 32.2483
A2780 GDSC1; GDSC2; CTRP2 2.1425 4.3997 2.0974 26.0873
DOV13 GDSC1; GDSC2; CTRP2 2.1436 6.7241 1.584 27.8469
JHOS-4 GDSC1; GDSC2 2.181 13.4723 -2.7328 29.3095
OVCAR-4 GDSC1; GDSC2; CTRP2 2.4646 6.7474 1.9253 25.6746
OVCAR-5 GDSC1; GDSC2; CTRP2 2.4715 8.512 1.2751 27.8748
Kuramochi GDSC1; GDSC2; CTRP2 2.6711 6.4194 2.2541 23.8806
OVSAHO CTRP2 2.6872 6.3457 2.2941 23.7427
OVCAR-3 GDSC1; GDSC2 2.7433 6.3278 1.3132 11.7223
Caov-4 GDSC1; GDSC2 2.9393 6.3368 1.4849 10.3407
OV7 CTRP2 2.9394 5.22 2.8401 21.0243
ES-2 GDSC1; GDSC2 2.9648 4.8302 2.2528 6.3765
TOV-21G GDSC1; GDSC2; CTRP2 2.9995 7.38 2.2805 22.8112
OVCAR-8 GDSC1; GDSC2; CTRP2 3.0301 7.1731 2.3898 22.3229
TYK-nu GDSC1; GDSC2; CTRP2 3.0882 5.4434 2.9602 20.0881
OAW28 GDSC1; GDSC2; CTRP2 3.1584 8.6419 1.9403 23.5941
EFO-27 GDSC1; GDSC2; CTRP2 3.2463 14.7259 -0.803 31.4198
OVTOKO GDSC1; GDSC2; CTRP2 3.2672 15.9101 -1.3586 32.557
SK-OV-3 GDSC1; GDSC2; CTRP2 3.4272 14.0943 -0.3262 29.821
TOV-112D GDSC1; GDSC2; CTRP2 3.5191 9.8797 1.7603 23.2523
OAW42 GDSC1; GDSC2; CTRP2 3.5536 7.8742 2.6747 19.779
OV-90 GDSC1; GDSC2; CTRP2 3.6196 5.0186 3.592 16.2105
OVISE GDSC1; GDSC2; CTRP2 3.7682 15.1879 -0.5397 29.4915
JHOM-1 CTRP2 3.86 6.4125 3.5507 15.6516
OVKATE GDSC1; GDSC2 3.9028 8.97 0.9662 10.6944
OV56 GDSC1; GDSC2; CTRP2 4.0281 5.4659 3.9706 13.5976
FU-OV-1 GDSC1; GDSC2; CTRP2 4.1149 16.4841 -0.8594 29.4213
MCAS CTRP2 4.3629 6.6259 4.0231 12.4274
ES2 CTRP2 4.4817 7.7522 3.6919 13.3854
OVK18 GDSC1; GDSC2 4.5131 6.7383 2.4747 2.2095
EFO-21 GDSC1; GDSC2; CTRP2 5.4161 12.2499 2.4037 16.3235
HEY A8 CTRP2 5.465 10.6623 3.2365 12.9356
⏷ Show the Full List of 45 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Thigh Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
P-STS CTRP2 2.3608 3.8836 2.354 24.5633
SYO-1 CTRP2 2.544 3.0787 2.544 23.3201
H-STS CTRP2 2.558 2.8963 2.558 23.2268
Cancer Drug Sensitivity Data Curated from 31 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Yamato-SS CTRP2 2.4621 3.1461 2.4621 23.8658
Aska-SS CTRP2 2.6321 3.321 2.6321 22.7331
TE 617.T CTRP2 -6.2338 -0.6966 -6.2721 77.036
BT-16 CTRP2 1.2497 4.3155 1.1626 32.2316
Rh41 GDSC1; GDSC2; CTRP2 1.3993 3.5536 1.3823 30.9324
A-204 GDSC1; GDSC2; CTRP2 1.8412 3.7833 1.8261 27.9888
TE 441.T GDSC2; CTRP2 2.0478 2.9037 2.0478 26.6259
G-401 GDSC1; GDSC2 2.21 9.0485 -0.5137 21.7411
G-402 GDSC1; GDSC2; CTRP2 2.2589 5.4983 2.0485 25.8816
Rh30 GDSC1; GDSC2 2.347 4.2586 1.9102 9.9048
KYM-1 GDSC1; GDSC2; CTRP2 2.4058 3.9821 2.3968 24.2157
Tm87-16 CTRP2 2.4768 3.8334 2.473 23.7802
TTC-709 CTRP2 2.5531 3.3056 2.5531 23.2595
Rh18 GDSC1; CTRP2 2.5683 4.9911 2.4779 23.4119
RD GDSC1; GDSC2; CTRP2 2.6401 4.8749 2.5709 22.8623
SW982 GDSC1; GDSC2; CTRP2 2.6486 4.6516 2.6056 22.7165
EW-8 GDSC1; GDSC2 2.7258 4.2272 2.3107 6.7744
GCT GDSC1; GDSC2; CTRP2 2.7353 4.6691 2.6952 22.1305
Hs 633.T GDSC1; GDSC2 2.7616 4.895 2.0306 8.0591
BT-12 CTRP2 2.82 3.1846 2.82 21.4815
MES-SA GDSC1; GDSC2; CTRP2 2.8895 5.1396 2.7995 21.276
SK-UT-1 GDSC1; GDSC2; CTRP2 3.009 5.2901 2.903 20.5373
Hs 729.T CTRP2 3.0506 5.0738 2.982 20.1779
SK-LMS-1 GDSC1; GDSC2; CTRP2 3.1575 6.0889 2.8815 20.1529
VA-ES-BJ GDSC1; GDSC2 3.1632 5.1569 2.2691 5.7762
SW684 GDSC1; GDSC2 3.3608 5.0833 2.4734 4.2542
SW872 GDSC1; GDSC2 3.5827 5.2706 2.5555 3.3526
HT-1080 GDSC1; GDSC2; CTRP2 3.826 4.9745 3.8112 14.7953
MFH-ino GDSC1; GDSC2 3.9355 7.8889 1.5274 7.8321
RKN GDSC1; GDSC2; CTRP2 4.0607 5.3761 4.0187 13.3276
STS-0421 GDSC1; GDSC2 5.0725 9.6794 1.4569 6.1119
⏷ Show the Full List of 31 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 8 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H2452 GDSC1; GDSC2; CTRP2 2.1755 4.8722 2.0748 26.0572
IST-Mes1 GDSC1; GDSC2; CTRP2 2.2962 3.8369 2.2896 24.9362
MPP 89 GDSC1; GDSC2; CTRP2 2.6131 4.4088 2.589 22.8884
NCI-H2052 GDSC1; GDSC2; CTRP2 3.1553 7.2494 2.4963 21.5687
JL-1 CTRP2 3.2383 6.6386 2.8013 20.2488
ACC-MESO-1 CTRP2 3.2547 4.6708 3.2379 18.6416
NCI-H28 GDSC1; GDSC2 4.3064 18.3031 -3.3649 25.9586
MSTO-211H GDSC1; GDSC2 4.759 8.391 1.8616 4.6932
⏷ Show the Full List of 8 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 7 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
LNCaP clone FGC GDSC1; GDSC2; CTRP2 2.0341 5.4529 1.814 27.405
NCI-H660 GDSC2 2.5713 5.4106 0.7443 6.4322
22Rv1 GDSC1; GDSC2; CTRP2 2.803 6.0594 2.5029 22.5898
VCaP GDSC1; GDSC2 3.3698 5.989 2.0281 6.5128
PC-3 GDSC1; GDSC2 3.8776 5.7646 2.5269 2.9349
DU145 GDSC1; GDSC2; CTRP2 4.025 10.7873 1.8343 21.6779
PaCa-3 CTRP2 4.0581 6.3524 3.7854 14.2006
⏷ Show the Full List of 7 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
YD-15 CTRP2 -2.8134 4.3179 -3.2116 57.3528
A-253 GDSC1; GDSC2; CTRP2 2.4506 10.1445 0.5584 30.1482
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Small Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuTu 80 GDSC1; GDSC2 2.1631 9.8814 -0.9674 23.6846
Cancer Drug Sensitivity Data Curated from 43 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-N87 GDSC1; GDSC2; CTRP2 -7.1304 0.5446 -7.2876 77.3994
SK-GT-2 GDSC1; GDSC2 -6.7881 -1.9903 -6.8303 76.7312
SNU-216 CTRP2 -3.3121 4.0451 -3.6985 59.8757
NCC-StC-K140 CTRP2 -3.1074 5.8753 -3.8975 57.9017
NUGC-4 GDSC1; GDSC2; CTRP2 -1.6277 5.4557 -2.1753 50.8204
KE-39 CTRP2 -0.9765 8.4169 -2.3753 47.726
GSS CTRP2 0.2361 2.2549 0.2328 38.7067
NUGC-3 GDSC1; GDSC2 0.3039 16.2242 -5.7896 39.8979
GCIY GDSC1; GDSC2 0.5494 13.9534 -4.4504 37.4377
IM95 GDSC1; GDSC2; CTRP2 0.6757 5.3602 0.3571 36.6334
SNU-668 CTRP2 1.1218 3.8862 1.0724 32.9585
HuG1-N CTRP2 1.2225 10.3415 -0.7945 37.3735
SNU-719 CTRP2 1.2632 9.5399 -0.4169 36.4606
23132/87 GDSC1; GDSC2; CTRP2 1.5445 3.6542 1.527 29.969
MKN74 CTRP2 1.5986 8.0542 0.5264 32.984
HSC-39 GDSC1; GDSC2 1.8382 3.8597 1.5295 13.3984
SCH GDSC1; GDSC2 1.945 6.4272 0.5124 17.911
ECC10 GDSC1; GDSC2 1.9643 4.4208 1.4431 13.3765
MKN1 GDSC1; GDSC2 2.0351 8.6496 -0.4779 22.0926
HGC-27 GDSC1; GDSC2; CTRP2 2.0748 3.6185 2.0699 26.4023
SNU-16 GDSC1; GDSC2; CTRP2 2.0846 3.0466 2.0845 26.3211
GSU CTRP2 2.1235 4.6158 2.0541 26.356
SNU-1 GDSC1; GDSC2; CTRP2 2.1411 4.2177 2.1111 26.0456
MKN7 GDSC1; GDSC2; CTRP2 2.3521 8.7588 1.0485 28.9647
SNU-5 GDSC1; GDSC2; CTRP2 2.3855 3.5448 2.3845 24.3239
SNU-601 CTRP2 2.4268 8.2766 1.3227 27.9135
MKN28 GDSC1; GDSC2 2.5465 7.3192 0.6453 15.5582
Hs 746.T GDSC1; GDSC2; CTRP2 2.5983 4.5071 2.566 23.0145
TGBC11TKB GDSC1; GDSC2 2.6343 4.8889 1.9112 9.0213
RF-48 GDSC1; GDSC2 2.8949 4.4825 2.3562 6.0497
Fu97 GDSC1; GDSC2 3.2507 4.7799 2.5328 4.2113
ECC12 GDSC2; CTRP2 3.3066 6.9872 2.7548 20.2211
AGS GDSC1; GDSC2; CTRP2 3.3904 5.6685 3.2413 18.1544
RERF-GC-1B GDSC1; GDSC2 3.7767 13.3749 -1.3308 20.9225
KATO III GDSC1; GDSC2; CTRP2 4.1069 6.699 3.7209 14.2658
LMSU CTRP2 4.1519 7.2527 3.5581 14.7916
SH-10-TC CTRP2 4.2121 6.0455 4.0444 12.7937
TMK-1 GDSC1; GDSC2 4.5163 15.6631 -1.8837 21.2037
OCUM-1 GDSC1; GDSC2 4.6128 7.9656 1.9676 4.4204
MKN45 GDSC1; GDSC2; CTRP2 5.1331 6.0749 5.0414 6.3785
SNG-M GDSC1; GDSC2; CTRP2 2.2811 5.8786 1.9814 26.0452
SNU-1077 CTRP2 3.2995 8.6215 2.0954 22.6896
SNU-685 CTRP2 3.514 5.5936 3.3917 17.2783
⏷ Show the Full List of 43 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 18 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SW579 CTRP2 2.0195 3.3185 2.0182 26.819
8305C GDSC1; GDSC2; CTRP2 2.083 3.8989 2.0694 26.3767
FTC-238 CTRP2 2.2525 3.5345 2.2507 25.2681
ML-1 [Human leukemia] GDSC1; GDSC2; CTRP2 2.3427 4.6012 2.2881 24.7888
CAL-62 GDSC1; GDSC2; CTRP2 2.52 4.0594 2.5109 23.4567
TT GDSC1; GDSC2; CTRP2 2.6356 4.0795 2.6283 22.6824
B-CPAP GDSC1; GDSC2; CTRP2 2.7029 4.694 2.6587 22.3596
IHH-4 GDSC1; GDSC2 2.7802 4.6445 2.1686 7.3161
BHT-101 GDSC1; GDSC2; CTRP2 2.8897 3.9929 2.8878 20.9754
8505C GDSC1; GDSC2; CTRP2 3.0324 5.9016 2.7952 20.8441
K5 GDSC1; GDSC2 3.2154 6.7446 1.521 9.4683
TT2609-C02 GDSC1; GDSC2; CTRP2 3.3605 6.6735 2.9222 19.3993
CGTH-W-1 GDSC1; GDSC2; CTRP2 3.3699 4.6653 3.3574 17.8194
ASH-3 GDSC1; GDSC2 3.4196 4.7325 2.6963 2.9809
FTC-133 GDSC1; GDSC2; CTRP2 3.8315 10.8884 1.5986 23.0054
HTC-C3 GDSC1; GDSC2 4.034 7.3624 1.86 5.966
WRO GDSC1; GDSC2 4.6965 10.2081 0.9463 9.2013
KMH-2 GDSC1; GDSC2 5.2372 7.2675 2.6251 0.8888
⏷ Show the Full List of 18 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 53 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
YD-10B CTRP2 -5.2616 1.8533 -5.453 70.0035
PE/CA-PJ34 (clone C12) CTRP2 -4.32 5.7672 -5.1921 62.6086
CAL-27 GDSC1; GDSC2; CTRP2 -3.9938 6.5132 -5.0421 60.8352
BICR 56 CTRP2 -3.6984 5.9316 -4.5576 60.235
DOK GDSC1; GDSC2 -3.5829 11.8159 -7.4916 52.4928
SAT [Human HNSCC] GDSC1; GDSC2 -3.5456 13.6546 -8.2841 52.1456
JHU-029 GDSC1; GDSC2 -2.8867 7.1547 -4.7823 50.2273
SNU-1076 CTRP2 -2.7983 2.6317 -2.9326 58.0603
NCI-H3118 GDSC1; GDSC2 -2.3534 32.3405 -16.1516 49.2407
JHU-022 GDSC1; GDSC2 -2.1759 13.3464 -6.7785 47.7929
JHU-011 GDSC1; GDSC2 -1.731 14.5857 -7.6203 44.3263
BB30-HNC GDSC1; GDSC2 -1.6211 7.5826 -3.6277 43.8354
Ca9-22 GDSC1; GDSC2 -1.5451 9.1112 -4.2123 44.1264
SCC-9 GDSC1; GDSC2; CTRP2 -1.4038 5.9118 -2.0482 49.6013
BICR 31 GDSC2; CTRP2 -1.2563 7.7534 -2.4476 49.015
SCC-25 GDSC1; GDSC2; CTRP2 -1.1567 6.333 -1.8951 48.2896
PE/CA-PJ41 (clone D2) CTRP2 -1.1543 13.9257 -4.7988 48.9835
BHY GDSC1; GDSC2; CTRP2 -0.6152 5.4776 -1.0769 44.9894
PE/CA-PJ49 CTRP2 -0.5538 12.2346 -3.4462 46.5722
HSC-2 GDSC1; GDSC2; CTRP2 -0.5454 11.1391 -2.9754 46.232
UPCI-SCC-090 GDSC1; GDSC2 -0.4888 14.9767 -5.9219 42.2076
FaDu GDSC1; GDSC2; CTRP2 -0.4142 11.8798 -3.1498 45.8623
PCI-06A GDSC1; GDSC2 -0.3895 28.9927 -12.724 45.5118
PCI-04B GDSC1; GDSC2 -0.2291 9.3447 -2.992 37.344
HO-1-u-1 GDSC1; GDSC2 -0.2057 8.58 -2.6171 36.4553
CAL-33 GDSC1; GDSC2; CTRP2 -0.1653 9.724 -2.0001 44.0594
SCC-15 GDSC1; GDSC2 0.1119 11.8595 -3.8477 37.7762
PCI-15A GDSC1; GDSC2 0.1478 3.9293 -0.3251 27.742
HO-1-N-1 GDSC1; GDSC2 0.357 8.1696 -1.8662 32.4662
HSC-3 GDSC1; GDSC2; CTRP2 0.4775 6.418 -0.1369 38.6291
SAS GDSC1; GDSC2 0.6029 11.4121 -3.1646 34.9115
PE/CA-PJ15 GDSC1; GDSC2; CTRP2 0.6578 11.7491 -1.985 41.1052
SCC-4 GDSC1; GDSC2; CTRP2 0.6848 7.4302 -0.2342 38.0551
HSC-4 GDSC1; GDSC2; CTRP2 0.6987 20.2372 -5.8834 44.2457
BICR 6 CTRP2 0.7783 4.0335 0.6959 35.3481
BICR 16 CTRP2 0.9319 6.7142 0.2686 36.0055
Detroit 562 GDSC1; GDSC2; CTRP2 1.0013 5.6871 0.634 34.6649
OSC-19 GDSC1; GDSC2 1.3179 13.2523 -3.3985 33.286
BICR 22 GDSC1; GDSC2 1.6587 10.526 -1.7454 27.8866
SNU-46 CTRP2 2.0282 5.0096 1.8943 27.2107
SNU-1041 CTRP2 2.1479 14.8108 -1.8962 36.5348
KOSC-2 GDSC1; GDSC2 2.428 14.1852 -2.8715 29.0292
BB49-HNC GDSC1; GDSC2 2.7337 5.3654 1.7764 9.4141
SNU-899 CTRP2 2.7788 5.5344 2.6057 22.3517
SNU-1066 CTRP2 2.9509 10.2589 1.0163 27.3704
PCI-30 GDSC1; GDSC2 2.9688 6.9211 1.2202 11.6032
BICR 10 GDSC1; GDSC2 3.1136 6.3342 1.6389 9.1175
BICR 78 GDSC1; GDSC2 4.2173 21.6463 -5.1052 29.9491
LB771-HNC GDSC1; GDSC2 4.6945 8.7288 1.6591 5.7679
SKN-3 GDSC1; GDSC2 4.6965 16.4494 -2.1344 21.6387
OSC-20 GDSC1; GDSC2 4.7265 15.1052 -1.444 19.2526
KON GDSC1; GDSC2 5.155 18.3113 -2.7053 22.4441
PCI-38 GDSC1 7.5041 23.8903 -3.7196 21.0482
⏷ Show the Full List of 53 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 25 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
U-BLC1 CTRP2 -6.7761 -2.1836 -6.7851 81.2552
SCaBER CTRP2 -3.7759 5.0929 -4.4287 61.1234
VM-CUB-1 CTRP2 -1.0803 4.899 -1.4508 47.7687
5637 GDSC1; GDSC2; CTRP2 -0.0827 5.9204 -0.6088 41.8778
KMBC-2 CTRP2 0.2084 4.5593 0.0107 39.4277
253J CTRP2 0.2853 4.1141 0.1618 38.7293
CAL-29 GDSC1; GDSC2; CTRP2 1.1165 9.4218 -0.5231 37.1193
JMSU-1 CTRP2 1.1538 3.8227 1.1112 32.7231
253J-BV CTRP2 1.4463 3.9125 1.4096 30.7558
647V GDSC1; GDSC2; CTRP2 1.8535 4.4521 1.787 28.0803
RT-4 GDSC1; GDSC2; CTRP2 2.2049 3.0424 2.2049 25.521
BFTC-905 GDSC1; GDSC2 2.2762 3.641 2.08 9.3454
BC-3C CTRP2 2.4477 6.7959 1.891 25.9046
639V GDSC1; GDSC2 2.5199 5.3564 1.5778 11.0128
HT-1376 GDSC1; GDSC2; CTRP2 2.9086 8.6264 1.6866 25.2004
TCCSUP GDSC1; GDSC2; CTRP2 2.9888 4.9303 2.9349 20.4924
RT-112 GDSC1; GDSC2; CTRP2 3.0456 4.0117 3.0447 19.9359
KU-19-19 GDSC1; GDSC2 3.1177 6.1773 1.7207 8.6901
UM-UC-1 CTRP2 3.3907 5.0014 3.3524 17.8086
HT-1197 GDSC1; GDSC2; CTRP2 3.5527 5.6227 2.3578 4.4204
J82 GDSC1; GDSC2; CTRP2 3.5611 8.1675 2.5603 20.1911
SW1710 GDSC1; GDSC2; CTRP2 3.6761 7.7221 2.8659 18.7161
T24 GDSC1; GDSC2; CTRP2 4.1882 6.9527 3.7143 14.0606
UM-UC-3 GDSC1; GDSC2; CTRP2 4.3688 6.1822 4.1764 11.8142
SW780 GDSC1; GDSC2 4.4959 11.5372 0.1469 13.3145
⏷ Show the Full List of 25 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 39 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
OVMIU GDSC1; GDSC2 -4.5028 7.6041 -6.6756 56.8112
DSH1 GDSC1; GDSC2 -3.6824 4.8858 -4.7999 54.4964
BPH-1 GDSC1; GDSC2 -3.5004 14.9428 -8.8315 51.8849
CAL-39 GDSC1; GDSC2 -3.1909 4.2878 -4.0712 52.0515
OVCA420 GDSC1; GDSC2 -2.8819 6.3927 -4.4792 50.2167
C-33 A GDSC1; GDSC2 0.1986 5.9035 -1.0227 30.2799
OMC-1 [Human cervical carcinoma] GDSC1; GDSC2 1.1675 5.6978 0.0693 22.4067
ME-180 GDSC1; GDSC2 1.277 14.5455 -4.0735 34.7579
DoTc2 4510 GDSC1; GDSC2 1.4388 12.6284 -2.9808 31.9852
C-4-I GDSC1; GDSC2 1.9202 9.0141 -0.7628 23.5873
PA-1 GDSC1; GDSC2 2.009 4.4276 1.487 13.0217
TC-YIK GDSC1; GDSC2 2.1369 3.9351 1.8215 11.0196
NT2-D1 GDSC1; GDSC2 2.2154 4.82 1.5276 12.1694
Ca Ski GDSC1; GDSC2 2.4106 13.4194 -2.505 28.081
NCC-IT GDSC2 2.4597 4.4346 1.9484 11.5778
SW954 GDSC1; GDSC2 2.5534 15.1344 -3.2364 29.6325
NEC8 GDSC1; GDSC2 2.555 3.9414 2.2612 7.554
HeLa GDSC1; GDSC2; CTRP2 2.5604 2.9308 2.5604 23.1584
PWR-1E GDSC1; GDSC2 3.015 4.3311 2.5432 4.7728
ACC-OV7 GDSC1; GDSC2 3.1024 8.8974 0.3492 15.529
SKN GDSC1; GDSC2 3.1669 6.5783 1.5628 9.374
UWB1.289 GDSC1; GDSC2 3.2264 19.8345 -5.0141 31.8071
KGN GDSC1; GDSC2 3.2316 8.6221 0.5962 14.0351
LB831-BLC GDSC1; GDSC2 3.3118 6.1098 1.9196 7.2038
HEY GDSC1; GDSC2 3.4079 6.2921 1.9078 7.0404
HEC-1 GDSC1; GDSC2 3.6074 5.998 2.2137 5.0378
SiSo GDSC1; GDSC2 3.787 8.2995 1.2093 9.7393
SKG-IIIa GDSC1; GDSC2 4.0798 16.1035 -2.4488 23.9215
SiHa GDSC1; GDSC2 4.1805 8.4549 1.4311 7.8225
HT-3 GDSC1; GDSC2 4.2227 13.63 -1.102 19.0729
JHOS-3 GDSC1; GDSC2 4.2629 11.631 -0.0769 14.7963
JEG-3 GDSC1; GDSC2 4.4702 6.3071 2.6428 1.5315
JAR GDSC1; GDSC2 4.6832 7.0741 2.4221 2.2229
SW962 GDSC1; GDSC2 4.6963 8.3257 1.8518 4.8398
MS751 GDSC1; GDSC2 4.7246 12.0988 0.0406 13.3254
OVCA433 GDSC1; GDSC2 5.2265 15.7042 -1.3625 17.9521
SW756 GDSC1; GDSC2 5.6805 11.5198 0.9824 7.3505
OV17R GDSC1; GDSC2 6.692 15.6464 -0.3089 11.304
PEO1 GDSC1; GDSC2 6.818 23.636 -4.0893 23.0713
⏷ Show the Full List of 39 Cancer Drug Sensitivity Data of This Drug

Drug-Drug Interaction (DDI) Information of This Drug

Coadministration of a Drug Treating the Same Disease as BIBW 2992
DDI Drug Name DDI Drug ID Severity Mechanism Disease REF
PF-06463922 DMKM7EW Moderate Accelerated clearance of BIBW 2992 due to the transporter induction by PF-06463922. Lung cancer [2C25] [13]
Coadministration of a Drug Treating the Disease Different from BIBW 2992 (Comorbidity)
DDI Drug Name DDI Drug ID Severity Mechanism Comorbidity REF
Remdesivir DMBFZ6L Moderate Increased risk of hepatotoxicity by the combination of BIBW 2992 and Remdesivir. 1D6YCoronavirus Disease 2019 [1D6YCoronavirus Disease 2019] [14]
Arn-509 DMT81LZ Moderate Accelerated clearance of BIBW 2992 due to the transporter induction by Arn-509. Acute myeloid leukaemia [2A60] [13]
Ag-221 DMS0ZBI Moderate Decreased clearance of BIBW 2992 due to the transporter inhibition by Ag-221. BCR-ABL1-negative chronic myeloid leukaemia [2A41] [14]
Erdafitinib DMI782S Moderate Decreased clearance of BIBW 2992 due to the transporter inhibition by Erdafitinib. Bladder cancer [2C94] [15]
Pexidartinib DMS2J0Z Major Increased risk of hepatotoxicity by the combination of BIBW 2992 and Pexidartinib. Bone/articular cartilage neoplasm [2F7B] [16]
Talazoparib DM1KS78 Moderate Decreased clearance of BIBW 2992 due to the transporter inhibition by Talazoparib. Breast cancer [2C60-2C6Y] [17]
Cannabidiol DM0659E Moderate Increased risk of hepatotoxicity by the combination of BIBW 2992 and Cannabidiol. Epileptic encephalopathy [8A62] [18]
Ripretinib DM958QB Moderate Decreased clearance of BIBW 2992 due to the transporter inhibition by Ripretinib. Gastrointestinal stromal tumour [2B5B] [14]
Fostemsavir DM50ILT Moderate Decreased clearance of BIBW 2992 due to the transporter inhibition by Fostemsavir. Human immunodeficiency virus disease [1C60-1C62] [19]
Calaspargase pegol DMQZBXI Moderate Increased risk of hepatotoxicity by the combination of BIBW 2992 and Calaspargase pegol. Malignant haematopoietic neoplasm [2B33] [20]
Idelalisib DM602WT Moderate Increased risk of hepatotoxicity by the combination of BIBW 2992 and Idelalisib. Mature B-cell leukaemia [2A82] [21]
Ibrutinib DMHZCPO Moderate Decreased clearance of BIBW 2992 due to the transporter inhibition by Ibrutinib. Mature B-cell lymphoma [2A85] [18]
Arry-162 DM1P6FR Moderate Decreased clearance of BIBW 2992 due to the transporter inhibition by Arry-162. Melanoma [2C30] [14]
Ubrogepant DM749I3 Moderate Decreased clearance of BIBW 2992 due to the transporter inhibition by Ubrogepant. Migraine [8A80] [22]
Rimegepant DMHOAUG Moderate Decreased clearance of BIBW 2992 due to the transporter inhibition by Rimegepant. Migraine [8A80] [23]
Lasmiditan DMXLVDT Moderate Decreased clearance of BIBW 2992 due to the transporter inhibition by Lasmiditan. Migraine [8A80] [24]
Rucaparib DM9PVX8 Moderate Decreased clearance of BIBW 2992 due to the transporter inhibition by Rucaparib. Ovarian cancer [2C73] [25]
Darolutamide DMV7YFT Moderate Decreased clearance of BIBW 2992 due to the transporter inhibition by Darolutamide. Prostate cancer [2C82] [26]
Tedizolid DMG2SKR Moderate Decreased clearance of BIBW 2992 due to the transporter inhibition by Tedizolid. Skin and skin-structure infection [1F28-1G0Z] [18]
Pitolisant DM8RFNJ Moderate Increased metabolism of BIBW 2992 caused by Pitolisant mediated induction of UGT. Somnolence [MG42] [18]
Fostamatinib DM6AUHV Moderate Decreased clearance of BIBW 2992 due to the transporter inhibition by Fostamatinib. Thrombocytopenia [3B64] [27]
Lusutrombopag DMH6IKO Moderate Decreased clearance of BIBW 2992 due to the transporter inhibition by Lusutrombopag. Thrombocytopenia [3B64] [25]
⏷ Show the Full List of 22 DDI Information of This Drug

References

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21 Product Information. Zydelig (idelalisib). Gilead Sciences, Foster City, CA.
22 Product Information. Ubrelvy (ubrogepant). Allergan Inc, Irvine, CA.
23 Product Information. Nurtec ODT (rimegepant). Biohaven Pharmaceuticals, New Haven, CT.
24 Product Information. Reyvow (lasmiditan). Lilly, Eli and Company, Indianapolis, IN.
25 EMA. European Medicines Agency. European Union "EMA - List of medicines under additional monitoring.".
26 Product Information. Nubeqa (darolutamide). Bayer HealthCare Pharmaceuticals Inc., Whippany, NJ.
27 Product Information. Tavalisse (fostamatinib). Rigel Pharmaceuticals, South San Francisco, CA.