Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMTLRGZ)

• Drug Name: SGC-CBP30 Drug Info
• Synonyms: SGC-CBP30; 1613695-14-9; (s)-4-(1-(2-(3-chloro-4-methoxyphenethyl)-5-(3,5-dimethylisoxazol-4-yl)-1h-benzo[d]imidazol-1-yl)propan-2-yl)morpholine; 2-[2-(3-chloro-4-methoxyphenyl)ethyl]-5-(dimethyl-1,2-oxazol-4-yl)-1-[(2S)-2-(morpholin-4-yl)propyl]-1H-1,3-benzodiazole; 2-[2-(3-Chloro-4-Methoxyphenyl)ethyl]-5-(3,5-Dimethyl-1,2-Oxazol-4-Yl)-1-[(2s)-2-(Morpholin-4-Yl)propyl]-1h-Benzimidazole; 2LO; C28H33ClN4O3; GTPL7529; SCHEMBL17512896; CHEMBL3622373; AOB4800; MolPort-035-395-859; BDBM188519; EX-A2159; ZINC96170456; s7256
• Cross-matching ID:
  PubChem CID: 72201027
  ChEBI ID: CHEMBL3622373
  TTD Drug ID: D03XXT

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
DNA replication	2.04	6.68e-3	34/36 (94.44%)	DNA2;POLE2;RFC5;...
N-Glycan biosynthesis	1.98	6.68e-3	38/50 (76%)	ST6GAL1;ALG6;MGAT4A;...
Oxidative phosphorylation	1.96	4.45e-3	93/133 (69.92%)	ATP6V0E2;COX6C;COX8A;...
Viral protein interaction with cytokine and cytokine re...	-1.83	2.92e-2	84/100 (84%)	CCL8;TNFRSF14;CCL20;...
Th17 cell differentiation	-1.90	1.49e-2	95/107 (88.79%)	IL2RA;IL12RB1;SMAD3;...
TNF signaling pathway	-1.91	1.53e-2	103/112 (91.96%)	CCL20;AKT3;CASP10;...
Osteoclast differentiation	-1.93	1.60e-2	117/127 (92.13%)	TGFB2;CSF1R;AKT3;...
Hematopoietic cell lineage	-1.95	1.71e-2	90/99 (90.91%)	FLT3LG;IL1R2;HLA-DOB;...
Steroid biosynthesis	-2.01	6.39e-3	19/20 (95%)	SOAT2;FDFT1;CYP51A1;...
Cytokine-cytokine receptor interaction	-2.03	1.28e-2	246/295 (83.39%)	IL9R;TNFRSF4;CD40;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	0.04uM - 10uM	24H	Hide ▲

Fibrocystic breast disease

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF-10A (Parent)	CVCL_0598	Homo sapiens	1.11uM - 10uM	3H, 6H, 12H, 24H	Hide ▲

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	0.04uM - 10uM	24H	Show ▼

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	0.04uM - 10uM	24H	Show ▼

Liver

Hepatoblastoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Hep G2	CVCL_0027	Homo sapiens	0.04uM - 10uM	24H	Show ▼

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	0.04uM - 10uM	24H	Show ▼

Non-small cell lung carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HCC515	CVCL_5134	Homo sapiens	0.04uM - 10uM	24H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	0.04uM - 10uM	24H	Show ▼

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	0.04uM - 10uM	24H	Show ▼