General Information of Drug (ID: DMTM4QA)

Drug Name
LCL161 Drug Info
Cross-matching ID
PubChem CID
24737642
ChEBI ID
CHEMBL2431768
CAS Number
CAS 1005342-46-0
TTD Drug ID
D09MIN

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name NES FDR q-val Tag % Leading Edge Genes
TNF signaling pathway 2.27 0.00e+0 103/112 (91.96%) CXCL1;CXCL5;CXCL10;...
NOD-like receptor signaling pathway 2.27 0.00e+0 145/181 (80.11%) CXCL8;OAS3;GBP1;...
Measles 2.15 0.00e+0 133/139 (95.68%) MX1;OAS3;OAS1;...
Legionellosis 2.09 0.00e+0 51/57 (89.47%) CXCL8;CXCL1;C3;...
Influenza A 2.05 0.00e+0 156/172 (90.7%) CXCL8;MX1;RSAD2;...
Cytokine-cytokine receptor interaction 2.05 0.00e+0 246/295 (83.39%) CXCL8;TGFBR2;CXCL1;...
DNA replication 2.00 1.57e-3 34/36 (94.44%) PCNA;MCM7;FEN1;...
Herpes simplex virus 1 infection 1.99 1.38e-3 165/498 (33.13%) OAS3;BST2;OAS1;...
IL-17 signaling pathway 1.96 2.44e-3 84/94 (89.36%) CXCL8;CXCL1;CXCL5;...
Hepatitis B 1.95 2.20e-3 151/162 (93.21%) PCNA;CXCL8;TGFBR2;...
Cell cycle 1.95 2.00e-3 110/124 (88.71%) PCNA;CCNB1;CDC20;...
NF-kappa B signaling pathway 1.95 1.83e-3 90/104 (86.54%) RELB;CXCL8;CXCL1;...
Chagas disease 1.94 3.38e-3 93/102 (91.18%) CXCL8;TGFBR2;C3;...
Toll-like receptor signaling pathway 1.94 3.14e-3 94/104 (90.38%) CXCL8;CXCL10;NFKBIA;...
Viral protein interaction with cytokine and cytokine re... 1.92 3.67e-3 84/100 (84%) CXCL8;CXCL1;CXCL5;...
RIG-I-like receptor signaling pathway 1.91 3.44e-3 64/70 (91.43%) ISG15;CXCL8;CXCL10;...
Hepatitis C 1.90 3.24e-3 139/157 (88.54%) IFIT1;MX1;RSAD2;...
Mineral absorption 1.88 3.67e-3 48/60 (80%) MT1E;ATP1A2;MT1H;...
AGE-RAGE signaling pathway in diabetic complications 1.88 4.05e-3 97/100 (97%) CXCL8;TGFBR2;F3;...
Cytosolic DNA-sensing pathway 1.86 5.50e-3 52/63 (82.54%) CXCL10;NFKBIA;DDX58;...
Small cell lung cancer 1.85 6.81e-3 90/92 (97.83%) NFKBIA;BIRC3;PIK3CD;...
Proteasome 1.83 8.00e-3 44/46 (95.65%) PSMB9;PSMD11;PSMC2;...
Ribosome biogenesis in eukaryotes 1.81 9.57e-3 52/108 (48.15%) NOP56;NXT1;DKC1;...
Lipid and atherosclerosis 1.80 1.01e-2 190/215 (88.37%) CXCL8;CXCL1;NFKBIA;...
TGF-beta signaling pathway 1.79 1.01e-2 81/94 (86.17%) ID1;TGFBR2;THBS1;...
Osteoclast differentiation 1.78 1.27e-2 117/127 (92.13%) RELB;TGFBR2;NFKBIA;...
Kaposi sarcoma-associated herpesvirus infection 1.78 1.26e-2 172/193 (89.12%) CXCL8;CXCL1;C3;...
Epstein-Barr virus infection 1.77 1.53e-2 189/202 (93.56%) RELB;ISG15;OAS3;...
Epithelial cell signaling in Helicobacter pylori infect... 1.76 1.52e-2 62/70 (88.57%) CXCL8;CXCL1;NFKBIA;...
Rheumatoid arthritis 1.73 1.65e-2 78/93 (83.87%) CXCL8;CXCL1;CXCL5;...
Other glycan degradation -1.72 4.71e-2 13/18 (72.22%) NEU3;HEXA;GLB1;...
Metabolism of xenobiotics by cytochrome P450 -1.79 2.21e-2 49/77 (63.64%) CYP2C9;CYP1A1;UGT2B17;...
Glycine, serine and threonine metabolism -1.89 8.82e-3 31/40 (77.5%) PSPH;GCAT;AOC3;...
Retinol metabolism -1.89 1.32e-2 41/68 (60.29%) CYP2C9;CYP1A1;RDH16;...
Oxidative phosphorylation -1.98 1.76e-2 93/133 (69.92%) ATP6V1A;ATP6V0A1;ATP5F1A;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
Fibrocystic breast disease
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A (Parent) CVCL_0598 Homo sapiens 1.11uM - 10uM 3H, 6H, 12H, 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 3H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H