Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMTOI7S)

• Drug Name: ARRY-520 Drug Info
• Synonyms: Filanesib; ARRY-520; 885060-09-3; UNII-8A49OSO368; Arry520; CHEMBL2347655; ARRY 520 trifluoroacetate; 8A49OSO368; ARRY 520; (2S)-2-(3-aminopropyl)-5-(2,5-difluorophenyl)-N-methoxy-N-methyl-2-phenyl-1,3,4-thiadiazole-3(2H)-carboxamide; Filanesib [INN]; Filanesib [USAN:INN]; C20H22F2N4O2S; ARRY-520; Filanesib; 1385020-40-5; Filanesib(ARRY-520); SCHEMBL368043; DTXSID50237086; EX-A678; BCP07442; ZINC43204022; 3452AH; BDBM50431893; AKOS030526964; SB19209; RL05514; CS-0867; NCGC00381751-02; NCGC00381751-04
• Therapeutic Class: Anticancer Agents
• Cross-matching ID:
  PubChem CID: 44224257
  ChEBI ID: CHEMBL2347655
  CAS Number: CAS 885060-09-3
  TTD Drug ID: D04VWJ

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
One carbon pool by folate	-1.64	4.54e-2	15/20 (75%)	FTCD;ALDH1L1;MTHFR;...
Steroid hormone biosynthesis	-1.65	4.39e-2	43/61 (70.49%)	CYP3A5;AKR1C4;UGT2B4;...
DNA replication	-1.65	4.61e-2	34/36 (94.44%)	MCM4;MCM7;RFC2;...
Starch and sucrose metabolism	-1.67	3.98e-2	25/36 (69.44%)	MGAM;GBE1;PGM1;...
Mitophagy	-1.68	4.02e-2	56/68 (82.35%)	RPS27A;HIF1A;EIF2AK3;...
Mismatch repair	-1.68	4.26e-2	22/23 (95.65%)	RFC2;RFC5;POLD4;...
Fructose and mannose metabolism	-1.68	3.91e-2	30/33 (90.91%)	HK1;KHK;PFKL;...
Nitrogen metabolism	-1.71	2.56e-2	16/17 (94.12%)	GLUL;CA4;CPS1;...
Tryptophan metabolism	-1.73	2.27e-2	35/42 (83.33%)	ECHS1;DDC;ALDH9A1;...
Ascorbate and aldarate metabolism	-1.79	1.18e-2	15/30 (50%)	UGDH;UGT2B15;ALDH9A1;...
Glycerolipid metabolism	-1.79	1.19e-2	44/61 (72.13%)	DGKA;DGKB;ALDH9A1;...
Proximal tubule bicarbonate reclamation	-1.81	8.97e-3	21/23 (91.3%)	CA4;ATP1B2;FXYD2;...
Pentose and glucuronate interconversions	-1.82	9.87e-3	17/34 (50%)	UGT2B4;KL;UGT2A3;...
Glyoxylate and dicarboxylate metabolism	-1.83	1.10e-2	23/30 (76.67%)	GLUL;MMUT;PCCB;...
Arginine and proline metabolism	-1.88	8.22e-3	39/50 (78%)	CNDP2;SMS;P4HA1;...
Collecting duct acid secretion	-1.92	0.00e+0	22/27 (81.48%)	ATP6V1B2;ATP6V1F;SLC4A1;...
Histidine metabolism	-1.97	0.00e+0	16/22 (72.73%)	HAL;FTCD;ALDH9A1;...
Galactose metabolism	-1.99	0.00e+0	26/31 (83.87%)	PFKM;MGAM;PGM1;...
Drug metabolism	-2.04	0.00e+0	78/151 (51.66%)	CYP2D6;FMO4;CYP3A5;...
Metabolism of xenobiotics by cytochrome P450	-2.09	0.00e+0	49/77 (63.64%)	CYP2D6;CYP2A13;CYP3A5;...
Glutathione metabolism	-2.14	0.00e+0	43/57 (75.44%)	GSTA1;GSS;SMS;...
Glycolysis / Gluconeogenesis	-2.16	0.00e+0	56/67 (83.58%)	HK3;GCK;PGAM1;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	1.11uM - 10uM	24H	Hide ▲

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	1.11uM - 10uM	24H	Hide ▲