Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMTYXQF)

Drug Name
NVP-AUY922 Drug Info
Synonyms
Luminespib; 747412-49-3; AUY922; VER-52296; AUY-922; UNII-C6V1DAR5EB; AUY922 (NVP-AUY922); Luminespib (NVP-AUY922); NVP-AUY 922; 5-(2,4-dihydroxy-5-isopropylphenyl)-N-ethyl-4-(4-(morpholinomethyl)phenyl)isoxazole-3-carboxamide; C6V1DAR5EB; Luminespib (AUY-922, NVP-AUY922); CHEBI:83656; 5-[2,4-DIHYDROXY-5-ISOPROPYLPHENYL]-N-ETHYL-4-[4-(4-MORPHOLINYLMETHYL)PHENYL]-3-ISOXAZOLECARBOXAMIDE; AK174786; 5-[2,4-Dihydroxy-5-(1-Methylethyl)phenyl]-N-Ethyl-4-[4-(Morpholin-4-Ylmethyl)phenyl]isoxazole-3-Carboxamide
Therapeutic ClassAnticancer Agents
Cross-matching ID
PubChem CID
135539077
ChEBI ID
CHEMBL83656
CAS Number
CAS 747412-49-3
TTD Drug ID
D05BYA
VARIDT Drug ID
DR00742

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Protein processing in endoplasmic reticulum 2.77 0.00e+0 127/171 (74.27%) HSPA1A;HSPH1;HSPA8;...
Spliceosome 2.09 3.23e-3 101/150 (67.33%) HSPA1A;HSPA8;HSPA6;...
Antigen processing and presentation 1.95 6.47e-3 60/78 (76.92%) HSPA1A;HSPA8;HSPA6;...
Nitrogen metabolism 1.87 1.46e-2 16/17 (94.12%) GLUL;GLUD1;CPS1;...
Longevity regulating pathway 1.86 1.29e-2 90/151 (59.6%) HSPA1A;HSPA8;HSPA6;...
Propanoate metabolism 1.79 2.26e-2 30/34 (88.24%) ALDH6A1;MMUT;LDHB;...
Phenylalanine metabolism 1.73 3.51e-2 14/17 (82.35%) MAOA;MAOB;GOT1;...
Progesterone-mediated oocyte maturation 1.71 3.88e-2 75/100 (75%) AURKA;HSP90AA1;HSP90AB1;...
Th1 and Th2 cell differentiation -1.71 1.61e-2 80/92 (86.96%) MAPK3;IL2RG;HLA-DOB;...
Th17 cell differentiation -1.72 1.49e-2 95/107 (88.79%) MAPK3;SMAD2;IL2RG;...
Tuberculosis -1.72 1.50e-2 159/180 (88.33%) HLA-DOB;FCGR2C;CD74;...
Fluid shear stress and atherosclerosis -1.73 1.41e-2 123/139 (88.49%) ARHGEF2;RHOA;ACTB;...
RIG-I-like receptor signaling pathway -1.73 1.46e-2 64/70 (91.43%) TRAF3;DDX58;RIPK1;...
Phototransduction -1.76 1.26e-2 21/29 (72.41%) CALML3;CALML5
Maturity onset diabetes of the young -1.76 1.31e-2 21/26 (80.77%) IAPP;INS;NEUROD1;...
Chagas disease -1.78 1.25e-2 93/102 (91.18%) GNAS;PPP2R2D;CD247;...
Epithelial cell signaling in Helicobacter pylori infect... -1.78 1.19e-2 62/70 (88.57%) NFKB1;CXCL1;ATP6V0B;...
Human cytomegalovirus infection -1.79 1.18e-2 201/225 (89.33%) GNAS;CCND1;ITPR3;...
AGE-RAGE signaling pathway in diabetic complications -1.79 1.18e-2 97/100 (97%) AGT;NOX4;AKT1;...
Base excision repair -1.82 9.65e-3 29/33 (87.88%) POLE3;POLD3;POLD1;...
Pantothenate and CoA biosynthesis -1.83 8.73e-3 14/21 (66.67%) ALDH1B1;PANK3;ENPP1;...
Homologous recombination -1.84 8.47e-3 35/41 (85.37%) RAD54L;POLD2;RPA2;...
Kaposi sarcoma-associated herpesvirus infection -1.85 8.18e-3 172/193 (89.12%) CLEC2B;MAPK3;LEF1;...
Influenza A -1.85 7.86e-3 156/172 (90.7%) OAS2;TRAF3;CASP1;...
Rheumatoid arthritis -1.91 4.68e-3 78/93 (83.87%) ATP6V0A2;CCL20;HLA-DPB1;...
NOD-like receptor signaling pathway -1.94 1.01e-3 145/181 (80.11%) PKN1;IFNAR2;ITPR3;...
TGF-beta signaling pathway -1.95 1.09e-3 81/94 (86.17%) RHOA;TFDP1;SMAD3;...
Malaria -1.98 0.00e+0 44/50 (88%) THBS2;MYD88;IL6;...
Osteoclast differentiation -1.99 0.00e+0 117/127 (92.13%) FHL2;LILRB1;AKT1;...
Cytosolic DNA-sensing pathway -2.00 0.00e+0 52/63 (82.54%) POLR2E;CASP1;DDX58;...
Mismatch repair -2.01 0.00e+0 22/23 (95.65%) MSH2;POLD2;RPA2;...
C-type lectin receptor signaling pathway -2.03 0.00e+0 93/104 (89.42%) ITPR1;HRAS;PAK1;...
Fanconi anemia pathway -2.12 0.00e+0 36/54 (66.67%) RPA3;REV3L;BRIP1;...
Leishmaniasis -2.12 0.00e+0 67/77 (87.01%) MYD88;HLA-DPB1;HLA-DPA1;...
TNF signaling pathway -2.19 0.00e+0 103/112 (91.96%) TRAF3;MMP14;MAP3K8;...
DNA replication -2.20 0.00e+0 34/36 (94.44%) POLD2;RPA2;POLE3;...
NF-kappa B signaling pathway -2.20 0.00e+0 90/104 (86.54%) TRAF3;DDX58;GADD45A;...
IL-17 signaling pathway -2.26 0.00e+0 84/94 (89.36%) TRAF3;TRAF4;CCL20;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-673 CVCL_0080 Homo sapiens 10uM 6H
SK-ES-1 CVCL_0627 Homo sapiens 0.08uM - 10uM 24H
TC-32 CVCL_7141 Homo sapiens 0.08uM - 10uM 24H
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 0.08uM - 10uM 6H, 24H, 48H
Brain
Glioblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-251 MG CVCL_0021 Homo sapiens 0.08uM - 10uM 24H
YH-13 CVCL_1800 Homo sapiens 0.08uM - 10uM 24H
Glioma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
GI-1 CVCL_1230 Homo sapiens 0.08uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.002uM - 10uM 3H, 6H, 24H, 48H
MDA-MB-231 CVCL_0062 Homo sapiens 0.04uM - 10uM 3H, 6H, 24H
MDA-MB-468 CVCL_0419 Homo sapiens 0.08uM - 10uM 24H
SK-BR-3 CVCL_0033 Homo sapiens 0.04uM - 10uM 3H, 6H, 24H
Breast carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BT-20 CVCL_0178 Homo sapiens 0.04uM - 10uM 3H, 6H, 24H
Hs 578T CVCL_0332 Homo sapiens 0.04uM - 10uM 3H, 6H, 24H
Breast ductal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BT-474 CVCL_0179 Homo sapiens 0.08uM - 10uM 24H
T-47D CVCL_0553 Homo sapiens 0.08uM - 10uM 24H
ZR-75-1 CVCL_0588 Homo sapiens 0.08uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.04uM - 10uM 3H, 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CL-34 CVCL_1123 Homo sapiens 10uM 6H
GP2d CVCL_1234 Homo sapiens 0.08uM - 10uM 24H
HT-29 CVCL_0320 Homo sapiens 0.04uM - 10uM 6H, 24H
LoVo CVCL_0399 Homo sapiens 10uM 6H
MDST8 CVCL_1400 Homo sapiens 10uM 6H
NCI-H508 CVCL_1561 Homo sapiens 10uM 6H
SNU-1040 CVCL_5001 Homo sapiens 10uM 6H
SNU-407 CVCL_5004 Homo sapiens 0.08uM - 10uM 24H
SNU-C4 CVCL_5008 Homo sapiens 10uM 6H
SNU-C5 CVCL_5009 Homo sapiens 10uM 6H
SW480 CVCL_0546 Homo sapiens 10uM 6H
SW620 CVCL_0547 Homo sapiens 10uM 6H
SW948 CVCL_0550 Homo sapiens 10uM 6H
Colorectal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCT 116 CVCL_0291 Homo sapiens 10uM 6H
HT115 CVCL_1294 Homo sapiens 10uM 6H
RKO CVCL_0504 Homo sapiens 10uM 6H
Embryonic stem cell
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
WA09 (H9) Derived CVCL_9773 (WA09) Homo sapiens 0.08uM - 10uM 24H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 0.08uM - 10uM 6H, 24H
HEC-151 CVCL_2927 Homo sapiens 0.08uM - 10uM 24H
HEC-1-A CVCL_0293 Homo sapiens 0.08uM - 10uM 24H
HEC-251 CVCL_2928 Homo sapiens 0.08uM - 10uM 24H
HEC-265 CVCL_2929 Homo sapiens 0.08uM - 10uM 24H
SNG-M CVCL_1707 Homo sapiens 10uM 6H
Endometrial carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHUEM-2 CVCL_1327 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CJM CVCL_U797 Homo sapiens 0.08uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.04uM - 10uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
1HAEo- CVCL_0128 Homo sapiens 10uM 24H
NL20 CVCL_0461 Homo sapiens 10uM 24H
Renal cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
RCC10RGB CVCL_1656 Homo sapiens 0.08uM - 10uM 24H
Rhabdoid tumor
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
G-401 CVCL_0270 Homo sapiens 0.08uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.04uM - 10uM 6H, 24H
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHH-5 CVCL_1320 Homo sapiens 0.08uM - 10uM 24H
JHH-7 CVCL_1322 Homo sapiens 0.08uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.002uM - 10uM 6H, 24H, 48H
DV-90 CVCL_1184 Homo sapiens 10uM 6H
NCI-H1437 CVCL_1472 Homo sapiens 0.08uM - 1.11uM 24H
NCI-H1573 CVCL_1483 Homo sapiens 0.08uM - 10uM 24H
NCI-H838 CVCL_1594 Homo sapiens 0.08uM - 10uM 24H
SK-LU-1 CVCL_0624 Homo sapiens 10uM 6H
Lung adenosquamous carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H596 CVCL_1571 Homo sapiens 10uM 6H
Lung large cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COR-L23 CVCL_1133 Homo sapiens 10uM 6H
T3M-10 CVCL_1729 Homo sapiens 10uM 6H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BEN CVCL_1081 Homo sapiens 0.08uM - 10uM 24H
HCC15 CVCL_1253 Homo sapiens 10uM 6H
HCC1588 CVCL_1263 Homo sapiens 0.08uM - 10uM 24H
HCC95 CVCL_1276 Homo sapiens 0.08uM - 10uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1299 CVCL_0060 Homo sapiens 10uM 6H
HCC515 CVCL_5134 Homo sapiens 0.04uM - 10uM 6H, 24H
NCI-H2073 CVCL_1523 Homo sapiens 10uM 6H
NCI-H2110 CVCL_1529 Homo sapiens 0.08uM - 10uM 24H
NCI-H2172 CVCL_1534 Homo sapiens 0.08uM - 10uM 24H
Normal (Fibroblast)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HFL1 CVCL_4295 Homo sapiens 10uM 24H
IMR-90 CVCL_0347 Homo sapiens 10uM 24H
WI-38 CVCL_0579 Homo sapiens 10uM 24H
Small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1694 CVCL_1495 Homo sapiens 10uM 6H
NCI-H1836 CVCL_1502 Homo sapiens 10uM 6H
NCI-H841 CVCL_1595 Homo sapiens 0.08uM - 10uM 24H
Lymph node
Diffuse large B-cell lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
WSU-DLCL2 CVCL_1787 Homo sapiens 10uM 6H
Muscle
Rhabdomyosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-204 CVCL_0134 Homo sapiens 0.08uM - 10uM 24H
Oral cavity
Oral squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BICR 6 CVCL_1086 Homo sapiens 0.08uM - 10uM 24H
Ovary
Ovarian carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
EFO-27 CVCL_1194 Homo sapiens 10uM 6H
OV7 CVCL_1623 Homo sapiens 10uM 6H
OVK18 CVCL_1629 Homo sapiens 0.08uM - 10uM 24H
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ES-2 CVCL_3509 Homo sapiens 0.08uM - 10uM 24H
OVTOKO CVCL_3114 Homo sapiens 0.08uM - 10uM 24H
RMG-I CVCL_1663 Homo sapiens 10uM 6H
Ovarian cystadenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
OAW 28 CVCL_1611 Homo sapiens 1.11uM - 10uM 24H
OC 316 CVCL_1615 Homo sapiens 0.08uM - 10uM 24H
Ovarian endometrioid carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
TOV-112D CVCL_3612 Homo sapiens 0.08uM - 10uM 24H
Ovarian granulosa cell tumor
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COV434 CVCL_2010 Homo sapiens 0.08uM - 10uM 24H
Ovarian mucinous cystadenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COV644 CVCL_2011 Homo sapiens 10uM 6H
RMUG-S CVCL_1666 Homo sapiens 10uM 6H
Ovarian undifferentiated carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
TYK-nu CVCL_1774 Homo sapiens 10uM 6H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.08uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 10uM 6H
Acute myeloid leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NOMO-1 CVCL_1609 Homo sapiens 10uM 6H
PL-21 CVCL_2161 Homo sapiens 10uM 6H
SKM-1 CVCL_0010 Homo sapiens 10uM 6H
Pleural effusion
Histiocytic lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-937 CVCL_0007 Homo sapiens 10uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
22Rv1 CVCL_1045 Homo sapiens 0.08uM - 10uM 24H
LNCaP clone FGC CVCL_1379 Homo sapiens 0.08uM - 10uM 24H
PC-3 CVCL_0035 Homo sapiens 0.04uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.04uM - 10uM 6H, 24H
IGR-37 CVCL_1303 Homo sapiens 0.08uM - 10uM 24H
Mel-HO CVCL_1402 Homo sapiens 0.08uM - 10uM 24H
SH-4 CVCL_1692 Homo sapiens 0.08uM - 10uM 24H
SK-MEL-1 CVCL_0523 Homo sapiens 10uM 6H
SK-MEL-28 CVCL_0526 Homo sapiens 10uM 6H
SK-MEL-3 CVCL_0525 Homo sapiens 0.08uM - 10uM 24H
Stomach
Gastric adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
AGS CVCL_0139 Homo sapiens 0.08uM - 10uM 6H, 24H
MKN45 CVCL_0434 Homo sapiens 0.08uM - 10uM 24H
Gastric carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
IM95 CVCL_1305 Homo sapiens 0.08uM - 10uM 24H
Urinary bladder
Bladder carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BC-3C CVCL_1079 Homo sapiens 0.08uM - 10uM 24H
Bladder transitional cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CAL-29 CVCL_1109 Homo sapiens 0.08uM - 10uM 24H