Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMU6L4I)

Drug Name
AZD-7545 Drug Info
Synonyms
AZD7545; 252017-04-2; 4-[(3-Chloro-4-{[(2r)-3,3,3-Trifluoro-2-Hydroxy-2-Methylpropanoyl]amino}phenyl)sulfonyl]-N,N-Dimethylbenzamide; 4-{3-chloro-4-[(2R)-3,3,3-trifluoro-2-hydroxy-2-methylpropanamido]benzenesulfonyl}-N,N-dimethylbenzamide; DTDZLJHKVNTQGZ-GOSISDBHSA-N; AZD-7545; AZD 7545; 2q8g; C19H18ClF3N2O5S; GTPL9362; SCHEMBL6350247; AOB6866; MolPort-035-395-876; ZINC1547088; EX-A1208; AZD-7547; BCP07524; KS-00000RM2; s7517; 2244AH; AZD 7545;AZD-7545; AKOS027326647; DB07403; CS-1740; NCGC00250391-07; NCGC00250391-01; HY-16082
Cross-matching ID
PubChem CID
16741245
ChEBI ID
CHEMBL1231132
TTD Drug ID
D03GFC

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
ECM-receptor interaction 2.19 0.00e+0 80/88 (90.91%) COL6A1;COL6A3;THBS1;...
Ribosome 2.16 0.00e+0 113/158 (71.52%) MRPS16;RPL10;MRPL15;...
Focal adhesion 1.80 3.17e-2 180/201 (89.55%) COL6A1;JUN;COL6A3;...
PPAR signaling pathway 1.77 3.46e-2 66/74 (89.19%) FABP4;FABP1;PCK1;...
Caffeine metabolism 1.75 3.81e-2 5/6 (83.33%) CYP1A2;CYP2A6;NAT2;...
Retinol metabolism 1.74 3.75e-2 41/68 (60.29%) CYP3A5;CYP1A1;CYP1A2;...
Carbohydrate digestion and absorption -1.79 2.59e-2 37/47 (78.72%) AKT1;HK2;HK3;...
Autophagy -1.80 2.83e-2 113/169 (66.86%) GABARAPL2;CTSL;SQSTM1;...
Sphingolipid metabolism -1.80 3.39e-2 32/49 (65.31%) SMPD2;GALC;CERS2;...
Other glycan degradation -1.83 2.83e-2 13/18 (72.22%) NEU1;FUCA1;GLB1;...
Collecting duct acid secretion -1.94 7.54e-3 22/27 (81.48%) ATP4B;TCIRG1;ATP6V1E1;...
Lysosome -2.07 5.66e-3 115/128 (89.84%) CTSO;CLTCL1;LAMP1;...
Protein processing in endoplasmic reticulum -2.11 1.13e-2 127/171 (74.27%) PLAA;DERL2;BAX;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-673 CVCL_0080 Homo sapiens 20uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 20uM 6H, 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 2.22uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CL-34 CVCL_1123 Homo sapiens 20uM 6H
HT-29 CVCL_0320 Homo sapiens 0.01uM - 20uM 6H, 24H
LoVo CVCL_0399 Homo sapiens 20uM 6H
MDST8 CVCL_1400 Homo sapiens 20uM 6H
NCI-H508 CVCL_1561 Homo sapiens 20uM 6H
SNU-1040 CVCL_5001 Homo sapiens 20uM 6H
SNU-C4 CVCL_5008 Homo sapiens 20uM 6H
SNU-C5 CVCL_5009 Homo sapiens 20uM 6H
SW480 CVCL_0546 Homo sapiens 20uM 6H
SW620 CVCL_0547 Homo sapiens 20uM 6H
SW948 CVCL_0550 Homo sapiens 20uM 6H
Colorectal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCT 116 CVCL_0291 Homo sapiens 20uM 6H
HT115 CVCL_1294 Homo sapiens 20uM 6H
RKO CVCL_0504 Homo sapiens 20uM 6H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 20uM 6H
SNG-M CVCL_1707 Homo sapiens 20uM 6H
Endometrial carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHUEM-2 CVCL_1327 Homo sapiens 20uM 6H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 20uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.04uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.05uM - 20uM 6H, 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 20uM 6H, 24H
DV-90 CVCL_1184 Homo sapiens 20uM 6H
SK-LU-1 CVCL_0624 Homo sapiens 20uM 6H
Lung adenosquamous carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H596 CVCL_1571 Homo sapiens 20uM 6H
Lung large cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COR-L23 CVCL_1133 Homo sapiens 20uM 6H
T3M-10 CVCL_1729 Homo sapiens 20uM 6H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC15 CVCL_1253 Homo sapiens 20uM 6H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1299 CVCL_0060 Homo sapiens 20uM 6H
HCC515 CVCL_5134 Homo sapiens 0.05uM - 20uM 6H, 24H
NCI-H2073 CVCL_1523 Homo sapiens 20uM 6H
Small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1694 CVCL_1495 Homo sapiens 20uM 6H
NCI-H1836 CVCL_1502 Homo sapiens 20uM 6H
Lymph node
Diffuse large B-cell lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
WSU-DLCL2 CVCL_1787 Homo sapiens 20uM 6H
Ovary
Ovarian carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
EFO-27 CVCL_1194 Homo sapiens 20uM 6H
OV7 CVCL_1623 Homo sapiens 20uM 6H
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
RMG-I CVCL_1663 Homo sapiens 20uM 6H
Ovarian mucinous cystadenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COV644 CVCL_2011 Homo sapiens 20uM 6H
RMUG-S CVCL_1666 Homo sapiens 20uM 6H
Ovarian undifferentiated carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
TYK-nu CVCL_1774 Homo sapiens 20uM 6H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 20uM 6H, 24H
Acute myeloid leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NOMO-1 CVCL_1609 Homo sapiens 20uM 6H
PL-21 CVCL_2161 Homo sapiens 20uM 6H
SKM-1 CVCL_0010 Homo sapiens 20uM 6H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Pleural effusion
Histiocytic lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-937 CVCL_0007 Homo sapiens 20uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 20uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 20uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 20uM 6H, 24H
SK-MEL-1 CVCL_0523 Homo sapiens 20uM 6H
SK-MEL-28 CVCL_0526 Homo sapiens 20uM 6H
Stomach
Gastric adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
AGS CVCL_0139 Homo sapiens 20uM 6H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.04uM - 10uM 24H