Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMUKC5L)

Drug Name
Tivozanib Drug Info
Synonyms ASP4130/AV-951
Cross-matching ID
PubChem CID
9911830
ChEBI ID
CHEMBL1289494
CAS Number
CAS 475108-18-0
TTD Drug ID
D0W7JZ

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Steroid biosynthesis 2.14 0.00e+0 19/20 (95%) MSMO1;NSDHL;DHCR7;...
Glyoxylate and dicarboxylate metabolism 2.00 0.00e+0 23/30 (76.67%) GLUL;CAT;PCCB;...
Biosynthesis of unsaturated fatty acids 1.96 0.00e+0 21/27 (77.78%) SCD;TECR;FADS1;...
Glycine, serine and threonine metabolism 1.92 0.00e+0 31/40 (77.5%) PSAT1;MAOB;PHGDH;...
Tryptophan metabolism 1.85 9.47e-3 35/42 (83.33%) MAOB;CYP1B1;CAT;...
Valine, leucine and isoleucine degradation 1.84 1.05e-2 42/48 (87.5%) HMGCS1;ALDH6A1;PCCB;...
Propanoate metabolism 1.84 1.01e-2 30/34 (88.24%) ALDH6A1;PCCB;ACAT1;...
Terpenoid backbone biosynthesis 1.79 2.07e-2 18/22 (81.82%) HMGCS1;HMGCR;FDPS;...
PPAR signaling pathway 1.78 2.02e-2 66/74 (89.19%) SCD;HMGCS1;SORBS1;...
Citrate cycle (TCA cycle) 1.74 3.08e-2 30/30 (100%) PCK2;IDH1;IDH2;...
Sulfur metabolism 1.73 3.16e-2 9/10 (90%) SELENBP1;TST;MPST;...
Pyruvate metabolism 1.71 3.42e-2 41/47 (87.23%) PCK2;ADH1B;ACAT1;...
Fatty acid biosynthesis 1.71 3.16e-2 16/18 (88.89%) ACSL1;FASN;ACSL3;...
Hepatitis B -1.62 4.84e-2 151/162 (93.21%) CCNE1;SMAD3;MAP2K1;...
Sphingolipid signaling pathway -1.64 4.48e-2 106/119 (89.08%) GAB2;NSMAF;MAP2K1;...
TNF signaling pathway -1.64 4.72e-2 103/112 (91.96%) CASP7;MAP2K1;VCAM1;...
PD-L1 expression and PD-1 checkpoint pathway in cancer -1.65 4.26e-2 79/89 (88.76%) NFKB1;CD3D;CD4;...
Coronavirus disease -1.67 4.20e-2 215/232 (92.67%) RPS29;IFNA17;FGB;...
JAK-STAT signaling pathway -1.67 4.14e-2 146/162 (90.12%) IFNB1;IL2RG;IFNAR2;...
C-type lectin receptor signaling pathway -1.70 3.64e-2 93/104 (89.42%) NFKB1;CBLB;CLEC7A;...
RNA polymerase -1.70 3.90e-2 23/31 (74.19%) POLR3G;POLR1C;POLR3D;...
Endocytosis -1.72 3.50e-2 198/252 (78.57%) STAM2;SPG21;CCR5;...
Hepatitis C -1.74 2.81e-2 139/157 (88.54%) CLDN16;IFNAR1;IRF3;...
Salmonella infection -1.75 2.83e-2 198/249 (79.52%) DNM2;RAB5A;ARPC2;...
Shigellosis -1.75 3.12e-2 180/246 (73.17%) RBX1;BECN1;ARPC2;...
Bacterial invasion of epithelial cells -1.76 3.18e-2 59/77 (76.62%) CAV3;HCLS1;CTNNA3;...
NOD-like receptor signaling pathway -1.80 1.62e-2 145/181 (80.11%) NFKB1;FADD;IFNB1;...
Epithelial cell signaling in Helicobacter pylori infect... -1.81 1.30e-2 62/70 (88.57%) ATP6V1G1;TJP1;ATP6V1A;...
Mitophagy -1.86 8.66e-3 56/68 (82.35%) BCL2L1;NRAS;HRAS;...
Pathogenic Escherichia coli infection -1.87 1.04e-2 152/197 (77.16%) PAK1;MYO10;LPAR1;...
Bladder cancer -1.89 1.30e-2 40/41 (97.56%) MAP2K1;NRAS;HRAS;...
Hematopoietic cell lineage -1.96 8.66e-3 90/99 (90.91%) ITGA2;CD3D;CD22;...
Yersinia infection -1.99 6.49e-3 120/137 (87.59%) SKAP2;ARPC2;PIP5K1A;...
Ribosome -1.99 1.30e-2 113/158 (71.52%) RPL30;RPL3L;RPL26L1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-673 CVCL_0080 Homo sapiens 10uM 6H
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 0.12uM - 10uM 6H, 24H, 48H
Bone marrow
Neuroblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SH-SY5Y CVCL_0019 Homo sapiens 0.04uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 6H, 24H, 48H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 6H, 24H
SK-BR-3 CVCL_0033 Homo sapiens 0.08uM - 10uM 6H, 24H
Breast carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BT-20 CVCL_0178 Homo sapiens 0.08uM - 10uM 6H, 24H
Hs 578T CVCL_0332 Homo sapiens 0.08uM - 10uM 6H, 24H
Normal (Epithelial)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HME1 CVCL_2950 Homo sapiens 0.04uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 6H, 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colon carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCT 116 TP53(-/-) CVCL_HD97 Homo sapiens 0.04uM - 10uM 24H
HCT 116 CVCL_0291 Homo sapiens 0.04uM - 10uM 24H
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CL-34 CVCL_1123 Homo sapiens 10uM 6H
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 6H, 24H
LoVo CVCL_0399 Homo sapiens 10uM 6H
MDST8 CVCL_1400 Homo sapiens 10uM 6H
NCI-H508 CVCL_1561 Homo sapiens 10uM 6H
SNU-1040 CVCL_5001 Homo sapiens 10uM 6H
SNU-C4 CVCL_5008 Homo sapiens 10uM 6H
SNU-C5 CVCL_5009 Homo sapiens 10uM 6H
SW480 CVCL_0546 Homo sapiens 10uM 6H
SW620 CVCL_0547 Homo sapiens 10uM 6H
SW948 CVCL_0550 Homo sapiens 10uM 6H
Colorectal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCT 116 CVCL_0291 Homo sapiens 10uM 6H
HCT 116 (Parent) CVCL_0291 Homo sapiens 0.04uM - 10uM 24H
HT115 CVCL_1294 Homo sapiens 10uM 6H
RKO CVCL_0504 Homo sapiens 10uM 6H
Embryonic stem cell
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUES 3 CVCL_B062 Homo sapiens 0.04uM - 10uM 24H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 10uM 6H
SNG-M CVCL_1707 Homo sapiens 10uM 6H
Endometrial carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHUEM-2 CVCL_1327 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 0.04uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.04uM - 10uM 6H, 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 6H, 24H, 48H
A549/Asc-1 CVCL_YA87 Homo sapiens 0.04uM - 10uM 24H
DV-90 CVCL_1184 Homo sapiens 10uM 6H
SK-LU-1 CVCL_0624 Homo sapiens 10uM 6H
Lung adenosquamous carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H596 CVCL_1571 Homo sapiens 10uM 6H
Lung large cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COR-L23 CVCL_1133 Homo sapiens 10uM 6H
T3M-10 CVCL_1729 Homo sapiens 10uM 6H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC15 CVCL_1253 Homo sapiens 10uM 6H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1299 CVCL_0060 Homo sapiens 10uM 6H
HCC515 CVCL_5134 Homo sapiens 0.04uM - 10uM 6H, 24H
NCI-H2073 CVCL_1523 Homo sapiens 10uM 6H
Small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1694 CVCL_1495 Homo sapiens 10uM 6H
NCI-H1836 CVCL_1502 Homo sapiens 10uM 6H
Lymph node
Diffuse large B-cell lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
WSU-DLCL2 CVCL_1787 Homo sapiens 10uM 6H
Ovary
Ovarian carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
EFO-27 CVCL_1194 Homo sapiens 10uM 6H
OV7 CVCL_1623 Homo sapiens 10uM 6H
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
RMG-I CVCL_1663 Homo sapiens 10uM 6H
Ovarian mucinous cystadenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COV644 CVCL_2011 Homo sapiens 10uM 6H
RMUG-S CVCL_1666 Homo sapiens 10uM 6H
Ovarian undifferentiated carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
TYK-nu CVCL_1774 Homo sapiens 10uM 6H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 6H, 24H
Acute myeloid leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NOMO-1 CVCL_1609 Homo sapiens 10uM 6H
PL-21 CVCL_2161 Homo sapiens 10uM 6H
SKM-1 CVCL_0010 Homo sapiens 10uM 6H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Pleural effusion
Histiocytic lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-937 CVCL_0007 Homo sapiens 10uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 6H, 24H
SK-L CVCL_1699 Homo sapiens 0.04uM - 10uM 24H
SK-MEL-1 CVCL_0523 Homo sapiens 10uM 6H
SK-MEL-28 CVCL_0526 Homo sapiens 10uM 6H
Stomach
Gastric adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
AGS CVCL_0139 Homo sapiens 10uM 6H