Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMURMY1)

Drug Name
Isoxsuprine Drug Info
Cross-matching ID
PubChem CID
3783
ChEBI ID
CHEMBL91855
CAS Number
CAS 395-28-8
TTD Drug ID
D0O8OB

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
DNA replication 2.22 0.00e+0 34/36 (94.44%) RFC2;FEN1;MCM5;...
Ribosome biogenesis in eukaryotes 2.00 6.50e-3 52/108 (48.15%) RPP30;NOP56;RPP38;...
Non-homologous end-joining 1.82 3.03e-2 11/13 (84.62%) FEN1;MRE11;DNTT;...
Spliceosome 1.78 2.92e-2 101/150 (67.33%) HSPA8;HSPA6;SRSF7;...
Legionellosis 1.77 2.73e-2 51/57 (89.47%) HSPA8;C3;CXCL1;...
RNA transport 1.76 2.49e-2 128/186 (68.82%) EIF5;NUP107;TARDBP;...
Glutathione metabolism 1.75 2.32e-2 43/57 (75.44%) GPX3;ODC1;GSTA1;...
Citrate cycle (TCA cycle) 1.74 2.03e-2 30/30 (100%) DLAT;CS;PDHA1;...
Primary immunodeficiency 1.70 3.03e-2 33/38 (86.84%) IL7R;IGLL1;ADA;...
Glyoxylate and dicarboxylate metabolism 1.69 2.79e-2 23/30 (76.67%) CS;SHMT1;DLD;...
Homologous recombination 1.68 2.89e-2 35/41 (85.37%) BLM;MRE11;RAD51;...
Arachidonic acid metabolism 1.66 3.41e-2 48/61 (78.69%) GPX3;PTGIS;PLA2G2A;...
Base excision repair 1.65 3.55e-2 29/33 (87.88%) FEN1;POLD3;TDG;...
Endometrial cancer -1.65 4.81e-2 56/58 (96.55%) GSK3B;CTNNA1;HRAS;...
C-type lectin receptor signaling pathway -1.66 4.87e-2 93/104 (89.42%) CLEC1B;PPP3CA;PIK3R1;...
Focal adhesion -1.66 4.91e-2 180/201 (89.55%) MAPK1;PDPK1;BIRC3;...
Apelin signaling pathway -1.68 3.94e-2 117/137 (85.4%) GNG7;PRKAA1;GNB2;...
Porphyrin and chlorophyll metabolism -1.69 3.85e-2 23/43 (53.49%) UGT2B4;UGT2B15;UGT2B17;...
Breast cancer -1.70 4.00e-2 119/147 (80.95%) HRAS;RPS6KB1;DDB2;...
Leukocyte transendothelial migration -1.72 3.15e-2 90/114 (78.95%) TXK;AFDN;CLDN9;...
Thyroid cancer -1.74 2.78e-2 36/37 (97.3%) PAX8;HRAS;DDB2;...
Collecting duct acid secretion -1.74 2.89e-2 22/27 (81.48%) ATP6V1B2;ATP6V0C;ATP6V0A1;...
Glioma -1.75 2.90e-2 67/75 (89.33%) PIK3R1;TGFA;IGF1R;...
Bile secretion -1.76 2.91e-2 68/90 (75.56%) KCNN2;CYP7A1;SLCO1A2;...
Melanogenesis -1.78 2.23e-2 74/101 (73.27%) PRKCB;CREB3L1;HRAS;...
GnRH signaling pathway -1.79 1.70e-2 80/93 (86.02%) MAP2K3;MAP3K3;PRKCB;...
Proteoglycans in cancer -1.80 1.74e-2 172/205 (83.9%) PDCD4;TLR4;PIK3R1;...
Mitophagy -1.82 1.99e-2 56/68 (82.35%) ULK1;ATF4;CSNK2A1;...
MicroRNAs in cancer -1.82 2.09e-2 146/310 (47.1%) BMPR2;HDAC1;PRKCB;...
Mineral absorption -1.84 2.23e-2 48/60 (80%) ATP7A;TRPV6;MT1X;...
Gastric cancer -1.90 1.74e-2 122/149 (81.88%) HRAS;RPS6KB1;CDKN2B;...
Prolactin signaling pathway -1.98 9.27e-3 66/70 (94.29%) GSK3B;ELF5;SLC2A2;...
Hepatitis C -1.99 1.39e-2 139/157 (88.54%) HRAS;CLDN6;PPP2R2B;...
Bladder cancer -2.11 2.78e-2 40/41 (97.56%) MDM2;MMP1;DAPK1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 6.66uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H, 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H, 24H