Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMUZNF0)

Drug Name
Tridolgosir Drug Info
Synonyms
Swainsonine; Swainsonine hydrochloride; Tridolgosir hydrochloride; Carbohydrate processing inhibitors, GLYCODesign; GD-0039; Transforming growth factor beta inhibitors, GLYCODesign; GD-0039 analogs, GlycoDESIGN
Cross-matching ID
PubChem CID
51683
ChEBI ID
CHEMBL9367
CAS Number
CAS 72741-87-8
TTD Drug ID
D0S1AD

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Ribosome 2.32 0.00e+0 113/158 (71.52%) MRPS16;MRPL15;RPL36AL;...
DNA replication 2.06 2.89e-3 34/36 (94.44%) PCNA;RPA3;POLE2;...
Oxidative phosphorylation 1.92 5.78e-3 93/133 (69.92%) NDUFAB1;NDUFA9;ATP5MG;...
One carbon pool by folate 1.87 7.22e-3 15/20 (75%) TYMS;DHFR;MTHFD1;...
Chagas disease -1.72 1.46e-2 93/102 (91.18%) RELA;MAPK14;TLR6;...
Regulation of actin cytoskeleton -1.72 1.51e-2 185/218 (84.86%) PDGFC;ARHGEF6;GNA13;...
ErbB signaling pathway -1.74 1.52e-2 79/85 (92.94%) CRK;PLCG2;MAPK3;...
AGE-RAGE signaling pathway in diabetic complications -1.76 1.53e-2 97/100 (97%) NFKB1;AGTR1;EDN1;...
Small cell lung cancer -1.77 1.48e-2 90/92 (97.83%) BAK1;LAMA2;COL4A1;...
Hypertrophic cardiomyopathy -1.80 8.54e-3 81/90 (90%) MYL3;ITGA10;EDN1;...
Galactose metabolism -1.80 7.71e-3 26/31 (83.87%) HK3;HKDC1;AKR1B1;...
Influenza A -1.80 7.42e-3 156/172 (90.7%) SLC25A4;PML;TPSD1;...
MicroRNAs in cancer -1.82 5.17e-3 146/310 (47.1%) NFKB1;RASSF1;CASP3;...
Parathyroid hormone synthesis, secretion and action -1.83 5.42e-3 98/106 (92.45%) MAPK3;PLD1;RHOA;...
Human papillomavirus infection -1.84 3.56e-3 284/331 (85.8%) RELN;TCF7L2;PPP2R3A;...
Neutrophil extracellular trap formation -1.84 3.74e-3 101/189 (53.44%) PLCG2;FPR1;MAPK3;...
Legionellosis -1.84 3.95e-3 51/57 (89.47%) NFKB1;HSF1;CASP3;...
Bladder cancer -1.84 4.19e-3 40/41 (97.56%) RASSF1;DAPK3;HBEGF;...
Apelin signaling pathway -1.87 4.45e-3 117/137 (85.4%) ITPR1;SMAD3;PRKAB1;...
PI3K-Akt signaling pathway -1.87 3.79e-3 317/354 (89.55%) LPAR6;IRS1;PPP2CB;...
C-type lectin receptor signaling pathway -1.88 3.05e-3 93/104 (89.42%) IKBKE;TNF;PRKCD;...
Amoebiasis -1.90 2.19e-3 99/102 (97.06%) CASP3;SERPINB4;PRDX1;...
Bacterial invasion of epithelial cells -1.90 2.37e-3 59/77 (76.62%) CAV3;DNM1;SHC1;...
Phagosome -1.92 1.29e-3 118/152 (77.63%) TAP1;ATP6V0A4;ATP6V0D1;...
Proteoglycans in cancer -1.97 0.00e+0 172/205 (83.9%) ARHGEF12;FAS;DROSHA;...
Inflammatory bowel disease -1.97 0.00e+0 58/65 (89.23%) HLA-DRB1;IL22;TBX21;...
Toxoplasmosis -1.98 0.00e+0 103/112 (91.96%) NOS2;HLA-DOA;MAPK9;...
Tuberculosis -1.98 0.00e+0 159/180 (88.33%) EEA1;NOS2;HLA-DOA;...
Pertussis -2.12 0.00e+0 64/76 (84.21%) MAPK3;RHOA;TICAM1;...
Leishmaniasis -2.13 0.00e+0 67/77 (87.01%) NOS2;HLA-DOA;HLA-DPB1;...
Toll-like receptor signaling pathway -2.17 0.00e+0 94/104 (90.38%) CD40;RELA;MAPK14;...
Focal adhesion -2.22 0.00e+0 180/201 (89.55%) CCND2;CAV3;RAF1;...
Osteoclast differentiation -2.23 0.00e+0 117/127 (92.13%) CYLD;LILRB1;MITF;...
ECM-receptor interaction -2.36 0.00e+0 80/88 (90.91%) LAMA2;AGRN;COL2A1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 12uM 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 12uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 12uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 12uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 12uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 12uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 12uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 12uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 12uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 12uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 12uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 12uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 12uM 24H