Details of the Drug

General Information of Drug (ID: DMUZNF0)

Drug Name

Tridolgosir

Synonyms

Swainsonine; Swainsonine hydrochloride; Tridolgosir hydrochloride; Carbohydrate processing inhibitors, GLYCODesign; GD-0039; Transforming growth factor beta inhibitors, GLYCODesign; GD-0039 analogs, GlycoDESIGN

Indication

Disease Entry	ICD 11	Status	REF
Solid tumour/cancer	2A00-2F9Z	Discontinued in Phase 2	[1]
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Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

#Ro5 Violations (Lipinski): 0

Molecular Weight (mw)

173.21

Logarithm of the Partition Coefficient (xlogp)

-1.3

Rotatable Bond Count (rotbonds)

Hydrogen Bond Donor Count (hbonddonor)

Hydrogen Bond Acceptor Count (hbondacc)

Adverse Drug Reaction (ADR)

ADR Term	Variation	Related DOT	DOT ID	REF
Metastases to liver	Not Available	MAN2B1	OTL062QO	[2]
Skin and subcutaneous tissue disorders	Not Available	MAN2A1	OTPM5EAH	[2]
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Chemical Identifiers

Formula: C8H15NO3
IUPAC Name: (1S,2R,8R,8aR)-1,2,3,5,6,7,8,8a-octahydroindolizine-1,2,8-triol
Canonical SMILES: C1C[C@H]([C@@H]2[C@@H]([C@@H](CN2C1)O)O)O
InChI: InChI=1S/C8H15NO3/c10-5-2-1-3-9-4-6(11)8(12)7(5)9/h5-8,10-12H,1-4H2/t5-,6-,7-,8-/m1/s1
InChIKey: FXUAIOOAOAVCGD-WCTZXXKLSA-N

Cross-matching ID

PubChem CID: 51683
ChEBI ID: CHEBI:9367
CAS Number: 72741-87-8
UNII: RSY4RK37KQ
DrugBank ID: DB02034
TTD ID: D0S1AD

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Golgi alpha-mannosidase II (MAN2A1)	TT34DCN	MA2A1_HUMAN	Inhibitor	[3]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Alpha-mannosidase 2 (MAN2A1)	OTPM5EAH	MA2A1_HUMAN	Drug Response	[2]
Lysosomal alpha-mannosidase (MAN2B1)	OTL062QO	MA2B1_HUMAN	Drug Response	[2]

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Molecular Interaction Atlas (MIA)

MIA Detail

Jump to Detail Molecular Interaction Atlas of This Drug

References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800010383)
2	ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.
3	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800010383)