Details of the Drug

General Information of Drug (ID: DMUZNF0)

Drug Name
Tridolgosir
Synonyms
Swainsonine; Swainsonine hydrochloride; Tridolgosir hydrochloride; Carbohydrate processing inhibitors, GLYCODesign; GD-0039; Transforming growth factor beta inhibitors, GLYCODesign; GD-0039 analogs, GlycoDESIGN
Indication
Disease Entry ICD 11 Status REF
Solid tumour/cancer 2A00-2F9Z Discontinued in Phase 2 [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 173.21
Logarithm of the Partition Coefficient (xlogp) -1.3
Rotatable Bond Count (rotbonds) 0
Hydrogen Bond Donor Count (hbonddonor) 3
Hydrogen Bond Acceptor Count (hbondacc) 4
Adverse Drug Reaction (ADR)
ADR Term Variation Related DOT DOT ID REF
Skin and subcutaneous tissue disorders Not Available MAN2A1 OTPM5EAH [2]
Chemical Identifiers
Formula
C8H15NO3
IUPAC Name
(1S,2R,8R,8aR)-1,2,3,5,6,7,8,8a-octahydroindolizine-1,2,8-triol
Canonical SMILES
C1C[C@H]([C@@H]2[C@@H]([C@@H](CN2C1)O)O)O
InChI
InChI=1S/C8H15NO3/c10-5-2-1-3-9-4-6(11)8(12)7(5)9/h5-8,10-12H,1-4H2/t5-,6-,7-,8-/m1/s1
InChIKey
FXUAIOOAOAVCGD-WCTZXXKLSA-N
Cross-matching ID
PubChem CID
51683
ChEBI ID
CHEMBL9367
CAS Number
72741-87-8
UNII
RSY4RK37KQ
DrugBank ID
DB02034
TTD ID
D0S1AD
Drug-Molecule Activity Atlas (DMA)NEW Click to Jump to the Detailed DMA Information of This Drug
Drug Pharmacogenomic Perturbation (DPP)NEW Click to Jump to the Detailed DPP Information of This Drug
Drug ADMET Endpoint Profile (DAE)NEW Click to Jump to the Detailed DAE Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Golgi alpha-mannosidase II (MAN2A1) TT34DCN MA2A1_HUMAN Inhibitor [3]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Alpha-mannosidase 2 (MAN2A1) OTPM5EAH MA2A1_HUMAN Drug Response [2]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

References

1 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800010383)
2 ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.
3 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800010383)