Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMVHJLX)

Drug Name
Perospirone Drug Info
Synonyms Lullan; SM-9018
Cross-matching ID
PubChem CID
115368
ChEBI ID
CHEMBL94777
CAS Number
CAS 150915-41-6
TTD Drug ID
D0F6GV
INTEDE Drug ID
DR1263

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Complement and coagulation cascades 2.16 0.00e+0 76/85 (89.41%) F13A1;SERPINA1;SERPINB2;...
Glycolysis / Gluconeogenesis 2.04 0.00e+0 56/67 (83.58%) PKM;ALDOB;ALDH3A2;...
Pentose phosphate pathway 1.95 2.99e-3 25/30 (83.33%) PGD;TKT;ALDOB;...
PPAR signaling pathway 1.90 4.48e-3 66/74 (89.19%) SCD;PPARG;CD36;...
Antigen processing and presentation -1.80 2.22e-2 60/78 (76.92%) NFYC;KIR2DS4;KIR2DL1;...
Autoimmune thyroid disease -1.86 1.85e-2 46/53 (86.79%) TSHB;CD40;HLA-G;...
Graft-versus-host disease -1.87 1.77e-2 32/42 (76.19%) KIR2DL1;KIR2DL3;HLA-G;...
Allograft rejection -1.89 1.66e-2 32/38 (84.21%) CD40;HLA-G;PRF1;...
Glycosaminoglycan degradation -1.92 1.11e-2 19/19 (100%) GLB1;HYAL3;GALNS;...
Cell adhesion molecules -1.92 1.66e-2 118/148 (79.73%) CD40;F11R;CD6;...
Type I diabetes mellitus -2.12 0.00e+0 38/43 (88.37%) HLA-G;PRF1;IL1B;...
×

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H