Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMVIMQX)

Drug Name
ZSTK474 Drug Info
Synonyms
ZSTK474; 475110-96-4; ZSTK-474; 4,4'-(6-(2-(Difluoromethyl)-1H-benzo[d]imidazol-1-yl)-1,3,5-triazine-2,4-diyl)dimorpholine; ZSTK 474; TCMDC-137004; UNII-K0068GK39A; CHEMBL586702; CHEBI:90545; K0068GK39A; 2-(2-difluoromethylbenzimidazol-1-yl)-4,6-dimorpholino-1,3,5-triazine; 2-(2-Difluoromethylbenzimidazol-1-yl)-4,6-bis(morpholino)-1,3,5-triazine; AK-40326; 2-(Difluoromethyl)-1-(4,6-Dimorpholin-4-Yl-1,3,5-Triazin-2-Yl)-1h-Benzimidazole; C19H21F2N7O2; 2wxl; PubChem22461; SCHEMBL373282; QCR-72; GTPL7965; CTK8B6247; SYN1099
Therapeutic ClassAnticancer Agents
Cross-matching ID
PubChem CID
11647372
ChEBI ID
CHEMBL586702
CAS Number
CAS 475110-96-4
TTD Drug ID
D0O1LD

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Neomycin, kanamycin and gentamicin biosynthesis -1.63 4.94e-2 5/5 (100%) GCK;HK2;HKDC1;...
Alanine, aspartate and glutamate metabolism -1.64 4.29e-2 27/37 (72.97%) PPAT;GFPT2;ASS1;...
Folate biosynthesis -1.67 3.47e-2 23/26 (88.46%) GPHN;TPH1;ALPP;...
Rheumatoid arthritis -1.68 3.44e-2 78/93 (83.87%) CTLA4;MMP3;IL15;...
Ferroptosis -1.71 2.31e-2 36/41 (87.8%) CYBB;ACSL3;SLC11A2;...
Terpenoid backbone biosynthesis -1.71 2.28e-2 18/22 (81.82%) MVD;PCYOX1;ICMT;...
Amino sugar and nucleotide sugar metabolism -1.72 2.05e-2 38/48 (79.17%) GCK;HK2;CYB5R2;...
Starch and sucrose metabolism -1.72 2.15e-2 25/36 (69.44%) GBA3;GCK;HK2;...
IL-17 signaling pathway -1.75 1.41e-2 84/94 (89.36%) FADD;MAPK6;SRSF1;...
Protein export -1.78 7.47e-3 17/23 (73.91%) SRPRA;SEC63;SEC61A2;...
Galactose metabolism -1.81 7.05e-3 26/31 (83.87%) GCK;HK2;PFKL;...
Biosynthesis of unsaturated fatty acids -1.84 5.64e-3 21/27 (77.78%) ACOX1;HACD3;HACD2;...
Glutathione metabolism -1.86 5.04e-3 43/57 (75.44%) ANPEP;GSTT2;GPX7;...
Prion disease -1.86 5.43e-3 209/273 (76.56%) PSMB3;NCF2;NDUFS6;...
Glycolysis / Gluconeogenesis -1.92 3.53e-3 56/67 (83.58%) BPGM;GCK;HK2;...
Collecting duct acid secretion -1.93 3.85e-3 22/27 (81.48%) ATP4A;ATP6V1B2;ATP4B;...
Legionellosis -1.93 4.23e-3 51/57 (89.47%) CASP3;CXCL3;EEF1A2;...
Antigen processing and presentation -1.95 3.14e-3 60/78 (76.92%) HSP90AB1;HSPA8;HLA-F;...
Ribosome biogenesis in eukaryotes -1.95 3.53e-3 52/108 (48.15%) TCOF1;RAN;GNL2;...
Citrate cycle (TCA cycle) -1.96 2.02e-3 30/30 (100%) DLD;ACO2;SDHB;...
Arginine and proline metabolism -1.97 2.35e-3 39/50 (78%) CKMT2;CNDP2;ALDH1B1;...
Vibrio cholerae infection -2.01 2.82e-3 44/50 (88%) ATP6V1B2;ATP6V1E1;ARF1;...
Proteasome -2.04 3.53e-3 44/46 (95.65%) PSME2;PSMB3;PSME4;...
Steroid biosynthesis -2.24 0.00e+0 19/20 (95%) SOAT1;CYP27B1;NSDHL;...
Fructose and mannose metabolism -2.26 0.00e+0 30/33 (90.91%) KHK;ALDOB;GMPPA;...
Protein processing in endoplasmic reticulum -2.31 0.00e+0 127/171 (74.27%) TRAF2;PLAA;RAD23B;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone marrow
Chronic myeloid leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HAP1 CVCL_Y019 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 BRD4 (-) 1 CVCL_SF59 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 CDK4 (-) 1 CVCL_SI36 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 HDAC5 (-) 1 CVCL_SR11 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 ITGA4 (-) 1 CVCL_ST27 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 MAPK8 (-) 1 CVCL_SW99 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 PIK3CA (-) 1 CVCL_TD60 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 PRKACA (-) 1 CVCL_TG70 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 PRKCQ (-) CVCL_TG92 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 RELA (-) 1 CVCL_TI75 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 SRC (-) 1 CVCL_TQ36 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 TP53 (-) 1 CVCL_RJ70 Homo sapiens 0.66uM - 3.33uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.04uM - 10uM 3H, 6H, 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.04uM - 10uM 3H, 6H, 24H
SK-BR-3 CVCL_0033 Homo sapiens 0.04uM - 10uM 3H, 6H, 24H
Breast carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BT-20 CVCL_0178 Homo sapiens 0.04uM - 10uM 3H, 6H, 24H
Hs 578T CVCL_0332 Homo sapiens 0.04uM - 10uM 3H, 6H, 24H
Fibrocystic breast disease
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A (Parent) CVCL_0598 Homo sapiens 1.11uM - 10uM 3H, 6H, 12H, 24H
Normal (Epithelial)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HME1 CVCL_2950 Homo sapiens 0.04uM - 10uM 3H, 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.04uM - 10uM 3H, 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.04uM - 10uM 6H, 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.04uM - 10uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
1HAEo- CVCL_0128 Homo sapiens 10uM 24H
NL20 CVCL_0461 Homo sapiens 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.04uM - 10uM 6H, 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.04uM - 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 0.04uM - 10uM 6H, 24H
Normal (Fibroblast)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HFL1 CVCL_4295 Homo sapiens 10uM 24H
IMR-90 CVCL_0347 Homo sapiens 10uM 24H
WI-38 CVCL_0579 Homo sapiens 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
LNCaP CVCL_0395 Homo sapiens 0.04uM - 10uM 3H, 24H
PC-3 CVCL_0035 Homo sapiens 0.04uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.04uM - 10uM 6H, 24H