Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMVO9WM)

Drug Name
DG041 Drug Info
Synonyms DTSI; D-000151746; DG-041
Cross-matching ID
PubChem CID
11296282
ChEBI ID
CHEMBL565591
CAS Number
CAS 861238-35-9
TTD Drug ID
D08QHS

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Glycine, serine and threonine metabolism 2.01 1.26e-2 31/40 (77.5%) PSAT1;PHGDH;CBS;...
Protein processing in endoplasmic reticulum 1.92 1.57e-2 127/171 (74.27%) HERPUD1;SEC24D;DDIT3;...
Cysteine and methionine metabolism 1.88 1.47e-2 43/50 (86%) PSAT1;PHGDH;CBS;...
Ribosome biogenesis in eukaryotes 1.87 1.10e-2 52/108 (48.15%) NOL6;GNL2;GAR1;...
Amino sugar and nucleotide sugar metabolism 1.80 2.64e-2 38/48 (79.17%) GFPT1;PMM2;PGM3;...
Protein export 1.79 2.20e-2 17/23 (73.91%) SRPRB;SRP54;SRP72;...
Pantothenate and CoA biosynthesis 1.79 1.98e-2 14/21 (66.67%) ALDH2;COASY;PPCS;...
Arginine and proline metabolism 1.70 4.16e-2 39/50 (78%) PYCR1;ODC1;CNDP2;...
Intestinal immune network for IgA production 1.70 3.77e-2 38/48 (79.17%) TNFRSF17;PIGR;ICOS;...
Alanine, aspartate and glutamate metabolism 1.68 3.65e-2 27/37 (72.97%) ASNS;GFPT1;ASS1;...
Melanogenesis -1.61 4.90e-2 74/101 (73.27%) MAPK3;MC1R;ADCY8;...
Apelin signaling pathway -1.62 4.46e-2 117/137 (85.4%) GNA13;MEF2D;TFAM;...
Hepatocellular carcinoma -1.64 3.97e-2 135/168 (80.36%) FRAT1;SOS2;MAP2K1;...
Gastric acid secretion -1.65 3.79e-2 63/76 (82.89%) SSTR2;SST;ADCY8;...
Diabetic cardiomyopathy -1.65 3.66e-2 162/203 (79.8%) MPC2;COX5A;PIK3R2;...
Gap junction -1.66 3.64e-2 72/88 (81.82%) SOS2;MAP2K1;SOS1;...
Human papillomavirus infection -1.66 3.74e-2 284/331 (85.8%) LAMB1;CCNE1;PIK3R2;...
Platelet activation -1.66 3.93e-2 106/124 (85.48%) ROCK2;ROCK1;MAPK3;...
Rap1 signaling pathway -1.68 3.63e-2 184/210 (87.62%) MAP2K1;RALGDS;PFN1;...
Aldosterone-regulated sodium reabsorption -1.69 3.53e-2 34/37 (91.89%) ATP1A1;PRKCG;IGF1;...
Axon guidance -1.70 3.33e-2 151/182 (82.97%) PIK3CD;FZD3;SEMA6A;...
Notch signaling pathway -1.70 3.45e-2 49/59 (83.05%) KAT2A;TLE4;CTBP1;...
Glycosaminoglycan degradation -1.70 3.68e-2 19/19 (100%) GUSB;HEXA;GLB1;...
Hippo signaling pathway -1.72 3.15e-2 120/186 (64.52%) PPP1CC;TGFB1;BBC3;...
Fc gamma R-mediated phagocytosis -1.72 3.40e-2 79/97 (81.44%) SYK;PRKCG;ARPC5L;...
Longevity regulating pathway -1.73 3.56e-2 90/151 (59.6%) ADIPOR1;APPL1;PIK3R2;...
Oxidative phosphorylation -1.73 3.89e-2 93/133 (69.92%) COX5A;NDUFB11;SDHD;...
Antigen processing and presentation -1.73 4.28e-2 60/78 (76.92%) CD8A;HSP90AB1;TNF;...
ABC transporters -1.75 3.53e-2 37/45 (82.22%) ABCC1;ABCA2;DEFB1;...
Collecting duct acid secretion -1.75 3.79e-2 22/27 (81.48%) ATP6V0D1;ATP6V0E1;ATP6V0E2;...
Pathways in cancer -1.77 4.14e-2 474/531 (89.27%) MAPK9;TXNRD1;PDGFA;...
Complement and coagulation cascades -1.77 4.60e-2 76/85 (89.41%) VWF;PROC;PROS1;...
Thyroid hormone signaling pathway -1.85 2.21e-2 112/121 (92.56%) NOTCH2;MAP2K1;THRA;...
Nitrogen metabolism -1.91 6.90e-3 16/17 (94.12%) GLUD1;GLUD2;CA12;...
Sphingolipid signaling pathway -1.93 4.60e-3 106/119 (89.08%) OPRD1;TRAF2;RAC3;...
Lysosome -1.96 6.90e-3 115/128 (89.84%) SLC11A1;CLTA;AP4M1;...
Sphingolipid metabolism -2.07 0.00e+0 32/49 (65.31%) SPTLC1;CERS4;SMPD1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-673 CVCL_0080 Homo sapiens 40uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 40uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CL-34 CVCL_1123 Homo sapiens 40uM 6H
HT-29 CVCL_0320 Homo sapiens 40uM 6H, 24H
LoVo CVCL_0399 Homo sapiens 40uM 6H
MDST8 CVCL_1400 Homo sapiens 40uM 6H
NCI-H508 CVCL_1561 Homo sapiens 40uM 6H
SNU-1040 CVCL_5001 Homo sapiens 40uM 6H
SNU-C4 CVCL_5008 Homo sapiens 40uM 6H
SNU-C5 CVCL_5009 Homo sapiens 40uM 6H
SW480 CVCL_0546 Homo sapiens 40uM 6H
SW620 CVCL_0547 Homo sapiens 40uM 6H
SW948 CVCL_0550 Homo sapiens 40uM 6H
Colorectal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCT 116 CVCL_0291 Homo sapiens 40uM 6H
HT115 CVCL_1294 Homo sapiens 40uM 6H
RKO CVCL_0504 Homo sapiens 40uM 6H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 40uM 6H
SNG-M CVCL_1707 Homo sapiens 40uM 6H
Endometrial carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHUEM-2 CVCL_1327 Homo sapiens 40uM 6H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 40uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 40uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 40uM 6H, 24H
DV-90 CVCL_1184 Homo sapiens 40uM 6H
SK-LU-1 CVCL_0624 Homo sapiens 40uM 6H
Lung adenosquamous carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H596 CVCL_1571 Homo sapiens 40uM 6H
Lung large cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COR-L23 CVCL_1133 Homo sapiens 40uM 6H
T3M-10 CVCL_1729 Homo sapiens 40uM 6H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC15 CVCL_1253 Homo sapiens 40uM 6H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1299 CVCL_0060 Homo sapiens 40uM 6H
HCC515 CVCL_5134 Homo sapiens 40uM 6H, 24H
NCI-H2073 CVCL_1523 Homo sapiens 40uM 6H
Small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1694 CVCL_1495 Homo sapiens 40uM 6H
NCI-H1836 CVCL_1502 Homo sapiens 40uM 6H
Lymph node
Diffuse large B-cell lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
WSU-DLCL2 CVCL_1787 Homo sapiens 40uM 6H
Ovary
Ovarian carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
EFO-27 CVCL_1194 Homo sapiens 40uM 6H
OV7 CVCL_1623 Homo sapiens 40uM 6H
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
RMG-I CVCL_1663 Homo sapiens 40uM 6H
Ovarian mucinous cystadenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COV644 CVCL_2011 Homo sapiens 40uM 6H
RMUG-S CVCL_1666 Homo sapiens 40uM 6H
Ovarian undifferentiated carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
TYK-nu CVCL_1774 Homo sapiens 40uM 6H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 40uM 6H
Acute myeloid leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NOMO-1 CVCL_1609 Homo sapiens 40uM 6H
PL-21 CVCL_2161 Homo sapiens 40uM 6H
SKM-1 CVCL_0010 Homo sapiens 40uM 6H
Pleural effusion
Histiocytic lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-937 CVCL_0007 Homo sapiens 40uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 40uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 40uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 40uM 6H, 24H
SK-MEL-1 CVCL_0523 Homo sapiens 40uM 6H
SK-MEL-28 CVCL_0526 Homo sapiens 40uM 6H
Stomach
Gastric adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
AGS CVCL_0139 Homo sapiens 40uM 6H