Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMVP4E5)

Drug Name
AZD6482 Drug Info
Synonyms
AZD6482; 1173900-33-8; AZD 6482; (R)-2-(1-(7-methyl-2-morpholino-4-oxo-4H-pyrido[1,2-a]pyrimidin-9-yl)ethylamino)benzoic acid; 2-[[(1R)-1-[7-Methyl-2-(4-morpholinyl)-4-oxo-4H-pyrido[1,2-a]pyrimidin-9-yl]ethyl]amino]benzoic acid; AZD-6482; CHEMBL2165191; UNII-78G6MP5PZ5; 78G6MP5PZ5; 2-({(1R)-1-[7-Methyl-2-(morpholin-4-yl)-4-oxo-4H-pyrido[1,2-a]pyrimidin-9-yl]ethyl}amino)benzoic acid; 2-{[(1R)-1-[7-methyl-2-(morpholin-4-yl)-4-oxopyrido[1,2-a]pyrimidin-9-yl]ethyl]amino}benzoic acid
Cross-matching ID
PubChem CID
44137675
ChEBI ID
CHEMBL91359
CAS Number
CAS 1173900-33-8
TTD Drug ID
D0D0QA

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Complement and coagulation cascades 2.36 0.00e+0 76/85 (89.41%) PLAT;TFPI;F2R;...
Staphylococcus aureus infection 2.00 3.40e-3 72/95 (75.79%) KRT13;C1QB;CFD;...
DNA replication 1.87 1.81e-2 34/36 (94.44%) PCNA;POLD4;POLE2;...
Base excision repair 1.78 3.23e-2 29/33 (87.88%) PCNA;POLD4;POLE2;...
Systemic lupus erythematosus 1.74 3.94e-2 45/135 (33.33%) C1QB;C7;C1S;...
MicroRNAs in cancer 1.70 4.30e-2 146/310 (47.1%) CDKN1B;SOX4;MARCKS;...
Terpenoid backbone biosynthesis -1.68 4.01e-2 18/22 (81.82%) HMGCS2;MVD;PCYOX1;...
Biosynthesis of unsaturated fatty acids -1.68 4.27e-2 21/27 (77.78%) ELOVL4;FADS1;HACD3;...
Bile secretion -1.68 4.58e-2 68/90 (75.56%) PRKACA;AQP9;ATP1B1;...
Neomycin, kanamycin and gentamicin biosynthesis -1.69 4.49e-2 5/5 (100%) HKDC1;HK3;HK1;...
Thiamine metabolism -1.75 2.97e-2 12/15 (80%) TPK1;ACP1;AK2;...
Glycine, serine and threonine metabolism -1.80 2.07e-2 31/40 (77.5%) MAOB;SHMT2;PSPH;...
Protein export -1.83 1.99e-2 17/23 (73.91%) SEC61B;SRP72;SEC61A1;...
IL-17 signaling pathway -1.85 1.58e-2 84/94 (89.36%) GSK3B;CCL17;FOSB;...
Arginine and proline metabolism -1.86 1.78e-2 39/50 (78%) CKM;NOS2;ALDH2;...
Ribosome biogenesis in eukaryotes -1.95 4.07e-3 52/108 (48.15%) RAN;TCOF1;IMP4;...
Steroid biosynthesis -1.97 4.75e-3 19/20 (95%) NSDHL;CYP27B1;SOAT2;...
Fructose and mannose metabolism -1.98 5.70e-3 30/33 (90.91%) PMM2;GMPPA;AKR1B1;...
Mineral absorption -2.18 0.00e+0 48/60 (80%) ATP2B1;ATP1B1;ATP1A1;...
Ferroptosis -2.19 0.00e+0 36/41 (87.8%) FTL;STEAP3;ACSL3;...
Protein processing in endoplasmic reticulum -2.27 0.00e+0 127/171 (74.27%) EDEM1;DNAJC1;ERO1A;...
Proteasome -2.34 0.00e+0 44/46 (95.65%) POMP;PSMB2;PSMB1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone marrow
Chronic myeloid leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HAP1 CVCL_Y019 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 CDK4 (-) 1 CVCL_SI36 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 HDAC5 (-) 1 CVCL_SR11 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 ITGA4 (-) 1 CVCL_ST27 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 MAPK8 (-) 1 CVCL_SW99 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 PIK3CA (-) 1 CVCL_TD60 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 PRKACA (-) 1 CVCL_TG70 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 PRKCQ (-) CVCL_TG92 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 RELA (-) 1 CVCL_TI75 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 SRC (-) 1 CVCL_TQ36 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 TP53 (-) 1 CVCL_RJ70 Homo sapiens 0.66uM - 3.33uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.04uM - 10uM 3H, 6H, 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.04uM - 10uM 3H, 6H, 24H
SK-BR-3 CVCL_0033 Homo sapiens 0.04uM - 10uM 3H, 6H, 24H
Breast carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BT-20 CVCL_0178 Homo sapiens 0.04uM - 10uM 3H, 6H, 24H
Hs 578T CVCL_0332 Homo sapiens 0.04uM - 10uM 3H, 6H, 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.04uM - 10uM 3H, 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.04uM - 10uM 6H, 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.04uM - 10uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
1HAEo- CVCL_0128 Homo sapiens 10uM 24H
NL20 CVCL_0461 Homo sapiens 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.04uM - 10uM 6H, 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.04uM - 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 0.04uM - 10uM 6H, 24H
Normal (Fibroblast)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HFL1 CVCL_4295 Homo sapiens 10uM 24H
IMR-90 CVCL_0347 Homo sapiens 10uM 24H
WI-38 CVCL_0579 Homo sapiens 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.04uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.04uM - 10uM 6H, 24H