Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMVXTZG)

Drug Name
MK-591 Drug Info
Synonyms
Quiflapon; Quiflapon [INN]; L 686708; MK 0591; MK 591; L-686708; MK-0591; L-686,708; 3-(1-(4-chlorobenzyl-3-(t-butylthio)-5-(quinolin-2-ylmethoxy)indol-2-yl))-2,2-dimethyl propanoic acid; 3-(tert-Butylthio)-1-(p-chlorobenzyl)-alpha,alpha-dimethyl-5-(2-quinolylmethoxy)indole-2-propionic acid; 3-(tert-butylthio)-1-(p-chlorobenzyl)-a,a-dimethyl-5-(2-quinolylmethoxy)indole-2-propionic acid; 3-[3-tert-butylsulfanyl-1-[(4-chlorophenyl)methyl]-5-(quinolin-2-ylmethoxy)indol-2-yl]-2,2-dimethylpropanoic acid
Cross-matching ID
PubChem CID
23672584
ChEBI ID
CHEMBL313489
CAS Number
CAS 147030-01-1
TTD Drug ID
D0M0QX

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Steroid hormone biosynthesis 1.88 6.24e-3 43/61 (70.49%) CYP1B1;UGT2B17;HSD17B8;...
Gap junction -1.66 3.38e-2 72/88 (81.82%) GRM5;DRD1;GNAI1;...
Cytokine-cytokine receptor interaction -1.66 3.49e-2 246/295 (83.39%) IL2RA;LIF;IFNGR1;...
Synaptic vesicle cycle -1.67 3.30e-2 63/78 (80.77%) ATP6V1G1;AP2M1;ATP6V1E1;...
Phosphatidylinositol signaling system -1.67 3.25e-2 82/97 (84.54%) MTMR1;PIK3CA;INPP4A;...
Rheumatoid arthritis -1.68 3.11e-2 78/93 (83.87%) ANGPT1;HLA-DOB;TNFSF11;...
Circadian entrainment -1.68 3.22e-2 85/97 (87.63%) GRIA4;GNB5;GNAQ;...
Regulation of actin cytoskeleton -1.69 3.26e-2 185/218 (84.86%) PAK5;ITGB2;NCKAP1L;...
GnRH secretion -1.70 3.29e-2 60/64 (93.75%) GABBR1;PIK3CA;PIK3CD;...
Bacterial invasion of epithelial cells -1.75 1.84e-2 59/77 (76.62%) ITGA5;PIK3CA;DOCK1;...
Insulin secretion -1.80 1.00e-2 75/86 (87.21%) RAPGEF4;ATP1B3;GNAQ;...
Chemokine signaling pathway -1.81 1.11e-2 163/192 (84.9%) CXCL14;GNAI1;PF4;...
Amoebiasis -1.84 4.61e-3 99/102 (97.06%) LAMB1;LAMC1;PIK3CA;...
Asthma -1.85 3.45e-3 25/31 (80.65%) HLA-DOA;IL3;HLA-DPA1;...
Salivary secretion -1.85 3.95e-3 76/93 (81.72%) ATP1B3;GNAQ;CALML4;...
Type I diabetes mellitus -1.86 4.61e-3 38/43 (88.37%) HLA-DOB;IFNG;FASLG;...
Collecting duct acid secretion -1.88 5.53e-3 22/27 (81.48%) ATP6V1G1;CLCNKB;ATP4B;...
Neutrophil extracellular trap formation -1.90 6.91e-3 101/189 (53.44%) ITGB2;PLCG1;ITGA2B;...
Viral protein interaction with cytokine and cytokine re... -1.91 9.21e-3 84/100 (84%) CXCL14;PF4;CSF1R;...
Endocrine and other factor-regulated calcium reabsorpti... -1.96 0.00e+0 49/53 (92.45%) ATP1A2;PTH1R;ATP1B3;...
Gastric acid secretion -2.05 0.00e+0 63/76 (82.89%) ATP1A2;HRH2;ACTB;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-673 CVCL_0080 Homo sapiens 80uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 80uM 6H, 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CL-34 CVCL_1123 Homo sapiens 80uM 6H
HT-29 CVCL_0320 Homo sapiens 0.01uM - 80uM 6H, 24H
LoVo CVCL_0399 Homo sapiens 80uM 6H
MDST8 CVCL_1400 Homo sapiens 80uM 6H
NCI-H508 CVCL_1561 Homo sapiens 80uM 6H
SNU-1040 CVCL_5001 Homo sapiens 80uM 6H
SNU-C4 CVCL_5008 Homo sapiens 80uM 6H
SNU-C5 CVCL_5009 Homo sapiens 80uM 6H
SW480 CVCL_0546 Homo sapiens 80uM 6H
SW620 CVCL_0547 Homo sapiens 80uM 6H
SW948 CVCL_0550 Homo sapiens 80uM 6H
Colorectal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCT 116 CVCL_0291 Homo sapiens 80uM 6H
HT115 CVCL_1294 Homo sapiens 80uM 6H
RKO CVCL_0504 Homo sapiens 80uM 6H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 80uM 6H
SNG-M CVCL_1707 Homo sapiens 80uM 6H
Endometrial carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHUEM-2 CVCL_1327 Homo sapiens 80uM 6H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 80uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 80uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 80uM 6H, 24H
DV-90 CVCL_1184 Homo sapiens 80uM 6H
SK-LU-1 CVCL_0624 Homo sapiens 80uM 6H
Lung adenosquamous carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H596 CVCL_1571 Homo sapiens 80uM 6H
Lung large cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COR-L23 CVCL_1133 Homo sapiens 80uM 6H
T3M-10 CVCL_1729 Homo sapiens 80uM 6H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC15 CVCL_1253 Homo sapiens 80uM 6H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1299 CVCL_0060 Homo sapiens 80uM 6H
HCC515 CVCL_5134 Homo sapiens 80uM 6H, 24H
NCI-H2073 CVCL_1523 Homo sapiens 80uM 6H
Small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1694 CVCL_1495 Homo sapiens 80uM 6H
NCI-H1836 CVCL_1502 Homo sapiens 80uM 6H
Lymph node
Diffuse large B-cell lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
WSU-DLCL2 CVCL_1787 Homo sapiens 80uM 6H
Ovary
Ovarian carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
EFO-27 CVCL_1194 Homo sapiens 80uM 6H
OV7 CVCL_1623 Homo sapiens 80uM 6H
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
RMG-I CVCL_1663 Homo sapiens 80uM 6H
Ovarian mucinous cystadenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COV644 CVCL_2011 Homo sapiens 80uM 6H
RMUG-S CVCL_1666 Homo sapiens 80uM 6H
Ovarian undifferentiated carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
TYK-nu CVCL_1774 Homo sapiens 80uM 6H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.04uM - 80uM 6H, 24H
Acute myeloid leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NOMO-1 CVCL_1609 Homo sapiens 80uM 6H
PL-21 CVCL_2161 Homo sapiens 80uM 6H
SKM-1 CVCL_0010 Homo sapiens 80uM 6H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.04uM - 10uM 24H
Pleural effusion
Histiocytic lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-937 CVCL_0007 Homo sapiens 80uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 80uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 80uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 80uM 6H, 24H
SK-MEL-1 CVCL_0523 Homo sapiens 80uM 6H
SK-MEL-28 CVCL_0526 Homo sapiens 80uM 6H
Stomach
Gastric adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
AGS CVCL_0139 Homo sapiens 80uM 6H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.04uM - 10uM 24H