Details of the Drug

General Information of Drug (ID: DMVXTZG)

Drug Name
MK-591
Synonyms
Quiflapon; Quiflapon [INN]; L 686708; MK 0591; MK 591; L-686708; MK-0591; L-686,708; 3-(1-(4-chlorobenzyl-3-(t-butylthio)-5-(quinolin-2-ylmethoxy)indol-2-yl))-2,2-dimethyl propanoic acid; 3-(tert-Butylthio)-1-(p-chlorobenzyl)-alpha,alpha-dimethyl-5-(2-quinolylmethoxy)indole-2-propionic acid; 3-(tert-butylthio)-1-(p-chlorobenzyl)-a,a-dimethyl-5-(2-quinolylmethoxy)indole-2-propionic acid; 3-[3-tert-butylsulfanyl-1-[(4-chlorophenyl)methyl]-5-(quinolin-2-ylmethoxy)indol-2-yl]-2,2-dimethylpropanoic acid
Indication
Disease Entry ICD 11 Status REF
Asthma CA23 Discontinued in Phase 2 [1]
Drug Type
Small molecular drug
Structure
3D MOL is unavailable 2D MOL
#Ro5 Violations (Lipinski):
1		 Molecular Weight 609.2
Logarithm of the Partition Coefficient Not Available
Rotatable Bond Count 10
Hydrogen Bond Donor Count 0
Hydrogen Bond Acceptor Count 5
Chemical Identifiers
Formula
C34H34ClN2NaO3S
IUPAC Name
sodium;3-[3-tert-butylsulfanyl-1-[(4-chlorophenyl)methyl]-5-(quinolin-2-ylmethoxy)indol-2-yl]-2,2-dimethylpropanoate
Canonical SMILES
CC(C)(C)SC1=C(N(C2=C1C=C(C=C2)OCC3=NC4=CC=CC=C4C=C3)CC5=CC=C(C=C5)Cl)CC(C)(C)C(=O)[O-].[Na+]
InChI
InChI=1S/C34H35ClN2O3S.Na/c1-33(2,3)41-31-27-18-26(40-21-25-15-12-23-8-6-7-9-28(23)36-25)16-17-29(27)37(20-22-10-13-24(35)14-11-22)30(31)19-34(4,5)32(38)39;/h6-18H,19-21H2,1-5H3,(H,38,39);/q;+1/p-1
InChIKey
YPURUCMVRRNPHJ-UHFFFAOYSA-M
Cross-matching ID
PubChem CID
23672584
CAS Number
147030-01-1
TTD ID
D0M0QX

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Arachidonate 5-lipoxygenase (5-LOX) TT2J34L LOX5_HUMAN Inhibitor [2]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Asthma
ICD Disease Classification CA23
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Arachidonate 5-lipoxygenase (5-LOX) DTT ALOX5 4.15E-01 -0.06 -0.15
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
U2OS CTRP1 7.1441 10.3485 6.0844 21.6655
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MCF-7 CTRP1 6.6086 10.7087 5.3919 29.473
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SF295 CTRP1 5.1299 6.9383 4.1777 7.6511
LN-229 CTRP1 5.4768 8.3059 5.1698 38.6248
GaMG CTRP1 7.1444 8.4423 4.6408 0.2436
Cancer Drug Sensitivity Data Curated from 10 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HEC-151 CTRP1 3.0885 4.8222 3.0856 70.1972
JHUEM-2 CTRP1 4.8599 7.0493 4.7826 45.9522
HEC-108 CTRP1 4.867 6.5011 4.1722 8.8215
HEC-265 CTRP1 4.9432 5.7013 4.6369 4.311
MFE-319 CTRP1 5.1084 6.2007 4.5287 4.5774
KLE CTRP1 5.1293 7.0883 4.1023 8.3298
HEC-6 CTRP1 5.1428 6.122 4.5956 3.8408
HEC-251 CTRP1 5.227 6.3939 4.5258 4.1517
HEC-59 CTRP1 5.2483 6.406 4.5359 3.9849
Ishikawa (Heraklio) 02 ER- CTRP1 5.9555 7.9786 4.2614 4.2109
⏷ Show the Full List of 10 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 24 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NU-DUL-1 CTRP1 3.2484 7.1536 3.0256 63.863
LP-1 CTRP1 3.8522 6.2878 3.8034 59.2221
RPMI-8226 CTRP1 4.1133 5.8516 4.1026 56.2066
HT CTRP1 4.1168 4.893 4.0708 13.7968
SKM-1 CTRP1 4.1684 5.3254 4.1678 55.562
KMS-11 CTRP1 4.2205 6.8287 4.1304 54.3469
WSU-DLCL2 CTRP1 4.255 4.9239 4.255 54.3405
BL-70 CTRP1 4.5099 5.2734 4.39 8.7717
MC116 CTRP1 4.5478 5.0722 4.4975 7.6786
THP-1 CTRP1 4.5725 6.23 4.5578 49.8097
OCI-AML-3 CTRP1 4.6808 6.4228 4.6588 48.3001
KE-97 CTRP1 4.9177 5.7654 4.582 4.9206
GDM-1 CTRP1 5.0576 6.6155 5.0373 42.9862
PL21 CTRP1 5.1265 6.9785 5.076 42.161
SU-DHL-5 CTRP1 5.1699 5.9045 5.1698 41.2717
P3HR-1 CTRP1 5.2637 6.4381 4.5316 3.9685
Ku812 CTRP1 5.2837 6.7457 4.3948 5.1168
NOMO-1 CTRP1 5.453 6.2986 5.4522 37.2326
U-937 CTRP1 5.593 7.0471 5.5619 35.4414
MOLM-16 CTRP1 6.2032 7.8387 6.0893 27.3445
EJM CTRP1 6.8762 11.3233 5.3602 28.1184
AMO1 CTRP1 7.0641 8.2987 6.8994 15.4734
SU-DHL-4 CTRP1 8.1504 13.8777 5.2254 22.7886
OCI-Ly10 CTRP1 9.2402 16.7696 4.6446 21.9154
⏷ Show the Full List of 24 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
VMRC-RCW CTRP1 5.4638 7.7086 4.0545 7.4979
RCC10RGB CTRP1 6.4333 8.9915 5.9651 26.7375
Cancer Drug Sensitivity Data Curated from 37 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SW620 CTRP1 4.2823 6.6914 4.2145 53.6363
LS180 CTRP1 4.2936 7.0127 4.1808 53.3638
SW48 CTRP1 4.4822 5.8547 4.1169 11.2226
SW480 CTRP1 4.4991 6.8966 4.4186 50.7874
SK-CO-1 CTRP1 4.7111 5.9947 4.2769 8.6329
DLD-1 CTRP1 4.8406 5.9202 4.4351 6.596
COLO205 CTRP1 5.0061 6.0235 4.5319 4.9723
LS513 CTRP1 5.0291 6.0514 4.5376 4.8231
LS411N CTRP1 5.0504 6.322 4.4202 5.7915
C2BBe1 CTRP1 5.1497 6.7882 4.2687 6.7539
HCT 116 CTRP1 5.2051 7.5043 5.0764 41.4345
GP2d CTRP1 5.3991 6.7955 4.4552 4.1836
SW948 CTRP1 5.4485 8.2009 5.1701 38.8604
SNU-C4 CTRP1 5.5208 8.0356 5.2953 37.6202
COLO 320 CTRP1 5.5259 10.0197 4.5908 40.5051
CW-2 CTRP1 5.6485 8.2848 5.3633 36.2222
SNU-C5 CTRP1 5.7589 7.8291 5.6076 33.8895
SNU-C2A CTRP1 5.8175 8.7517 3.8002 8.506
KM12 CTRP1 5.822 8.2959 5.5491 33.7899
SNU-175 CTRP1 6.0706 7.9758 5.9111 29.5573
SNU-1040 CTRP1 6.0761 9.0957 5.5443 31.9861
HCT 8 CTRP1 6.1179 8.447 5.8232 29.8517
SW403 CTRP1 6.1475 8.8322 3.984 5.9772
SNU-81 CTRP1 6.3391 8.2347 6.1312 26.1163
NCI-H508 CTRP1 6.448 8.3048 6.228 24.6657
HT-55 CTRP1 6.4907 9.2001 5.9419 26.5415
SNU-61 CTRP1 6.6041 9.0022 6.1418 24.335
LoVo CTRP1 6.6612 9.2006 6.1204 24.1488
RCM-1 [Human ESC] CTRP1 6.8155 9.2144 6.2751 22.0155
COLO 678 CTRP1 7.1693 9.0519 6.7106 16.4082
LS123 CTRP1 7.1811 10.9514 5.8289 23.3724
HT115 CTRP1 7.297 8.7705 6.9643 13.5515
RKO CTRP1 7.4696 8.1126 7.4004 8.9424
CL-34 CTRP1 7.6614 9.1449 7.1572 9.9369
HT-29 CTRP1 7.7996 8.7888 7.4604 6.5735
CL-40 CTRP1 7.8057 9.6241 7.0564 10.1377
MDST8 CTRP1 8.9575 15.6739 4.9719 21.1427
⏷ Show the Full List of 37 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 4 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-398 CTRP1 4.6049 6.4446 4.5782 49.3632
SNU-449 CTRP1 5.2442 7.2772 4.1001 7.8982
JHH-6 CTRP1 5.5537 7.9691 3.9928 7.7273
Hep-G2 CTRP1 7.5301 8.4149 7.3568 8.9246
Cancer Drug Sensitivity Data Curated from 91 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H1105 CTRP1 2.9389 6.5555 2.7983 67.6557
NCI-H1963 CTRP1 3.1561 4.9759 3.1516 69.1669
NCI-H1694 CTRP1 3.6605 6.1539 3.6144 61.6067
NCI-H1048 CTRP1 3.8594 4.7491 3.8195 17.4261
SHP-77 CTRP1 3.9894 5.8619 3.6049 18.3188
NCI-H1666 CTRP1 4.1329 5.1249 4.0296 14.0076
NCI-H2141 CTRP1 4.1767 5.9442 4.1639 55.3153
HCC44 CTRP1 4.1858 5.7529 3.856 15.0953
LXF 289 CTRP1 4.2008 5.6536 3.9126 14.5372
NCI-H1573 CTRP1 4.2934 5.898 3.9054 14.0671
NCI-H82 CTRP1 4.3065 5.0856 4.2303 11.3214
NCI-H841 CTRP1 4.3112 7.0175 4.199 53.1462
NCI-H810 CTRP1 4.3889 5.61 4.128 11.6508
NCI-H1568 CTRP1 4.4602 6.1883 3.9414 12.8545
NCI-H1355 CTRP1 4.4997 6.2361 3.9576 12.5077
T3M-10 CTRP1 4.646 7.0079 4.5597 48.8486
NCI-H2342 CTRP1 4.6694 7.9894 4.3785 48.7055
NCI-H2029 CTRP1 4.7402 5.5117 4.5324 6.2525
NCI-H1930 CTRP1 4.7456 6.3708 4.1265 9.7949
HCC2108 CTRP1 4.7533 7.0426 4.6694 47.4109
Lu-99 CTRP1 4.787 6.2044 4.2462 8.5328
NCI-H661 CTRP1 4.8735 6.6729 4.0926 9.5051
VMRC-LCD CTRP1 4.8924 6.0273 4.4298 6.3985
Lu-65 CTRP1 4.8992 6.0401 4.4296 6.3691
COR-L279 CTRP1 4.906 5.9577 4.4764 5.9187
NCI-H2286 CTRP1 4.9307 6.16 4.3981 6.5082
NCI-H1299 CTRP1 4.9479 6.1681 4.4092 6.3313
HARA [Human squamous cell lung carcinoma] CTRP1 4.96 6.1275 4.4401 5.9995
EBC-1 CTRP1 4.984 6.6359 4.2071 7.9917
LCLC-103H CTRP1 5.0496 6.2389 4.4611 5.4259
NCI-H596 CTRP1 5.0558 7.1498 4.9775 43.2679
NCI-H23 CTRP1 5.0971 7.3307 3.9547 9.7803
NCI-H358 CTRP1 5.1128 6.245 4.5102 4.7268
NCI-H1437 CTRP1 5.1134 6.9508 4.158 7.8945
NCI-H2023 CTRP1 5.1189 9.6739 4.3002 44.513
A-549 CTRP1 5.1494 6.6501 4.3374 6.137
NCI-H727 CTRP1 5.1524 6.9761 4.1771 7.5663
DMS 273 CTRP1 5.1581 6.2059 4.5658 4.0495
LC-1/sq-SF CTRP1 5.1712 6.2477 4.5553 4.0949
NCI-H1944 CTRP1 5.1781 7.2498 4.0611 8.504
NCI-H1975 CTRP1 5.1807 6.6751 4.3499 5.9029
ChaGo-K-1 CTRP1 5.2035 7.0959 4.1583 7.5348
NCI-H1373 CTRP1 5.2147 6.4552 4.486 4.5533
NCI-H1435 CTRP1 5.2309 7.1451 4.1555 7.4545
NCI-H2122 CTRP1 5.2564 6.7476 5.2349 40.1707
NCI-H522 CTRP1 5.2619 6.9694 4.2671 6.3376
NCI-H1792 CTRP1 5.2811 6.7927 4.3695 5.3519
NCI-H2009 CTRP1 5.3013 7.2694 4.1486 7.2504
HCC78 CTRP1 5.3352 6.6826 4.4642 4.3186
NCI-H1793 CTRP1 5.3652 8.0186 3.8259 9.8667
Calu-6 CTRP1 5.4225 6.7892 4.4749 3.9357
CAL-12T CTRP1 5.4271 9.6301 4.6448 41.1005
COLO 668 CTRP1 5.4326 7.6372 4.0663 7.5038
NCI-H441 CTRP1 5.5116 8.5787 5.1215 38.5657
HCC4006 CTRP1 5.5283 9.0696 4.9676 39.1076
HCC1195 CTRP1 5.7045 9.5151 4.9845 37.662
COLO 699 CTRP1 5.7294 9.1966 5.1355 36.7785
NCI-H1876 CTRP1 5.7404 8.7713 5.3037 35.8357
Calu-3 CTRP1 5.7487 7.8716 4.1776 5.4962
HCC1833 CTRP1 5.773 8.7373 5.3509 35.3291
NCI-H2073 CTRP1 5.8179 10.0595 4.879 37.2791
NCI-H650 CTRP1 5.8258 7.2454 4.5193 2.4581
BEN CTRP1 5.837 9.0007 3.6928 9.3483
KNS-62 CTRP1 6.0003 7.4187 4.5404 1.9287
RERF-LC-KJ CTRP1 6.0401 7.7224 4.4286 2.6794
SCLC-21H CTRP1 6.0626 9.7194 5.2776 33.6335
NCI-H2081 CTRP1 6.1046 8.7629 5.6996 30.7871
NCI-H2405 CTRP1 6.1048 8.4193 4.1497 4.7355
NCI-H1836 CTRP1 6.1208 8.7286 5.7294 30.4758
NCI-H1755 CTRP1 6.1751 9.2715 5.58 31.0811
NCI-H2126 CTRP1 6.2006 8.0377 4.3789 2.7145
LCLC-97TM1 CTRP1 6.2362 8.5109 4.1874 4.1078
NCI-H1781 CTRP1 6.476 8.5168 6.1878 24.7917
HCC827 CTRP1 6.5215 8.5517 6.2247 24.2165
SK-LU-1 CTRP1 6.6569 8.3391 6.444 21.6473
NCI-H1915 CTRP1 6.8468 8.603 4.4633 1.1585
HCC33 CTRP1 6.9132 8.3412 4.5899 0.5204
COR-L51 CTRP1 6.9206 8.7157 6.5912 18.8413
EPLC-272H CTRP1 6.928 8.9887 4.347 1.7105
HCC15 CTRP1 6.9322 9.3702 6.3276 20.916
HCC2935 CTRP1 6.9935 11.7202 5.279 27.9558
NCI-H460 CTRP1 7.0306 8.0106 6.9495 15.2955
DV-90 CTRP1 7.0347 13.9649 2.1256 16.7488
HCC1359 CTRP1 7.0473 7.6898 7.0295 14.5803
COR-L23 CTRP1 7.2341 8.329 7.0728 13.0282
NCI-H2172 CTRP1 7.2816 11.3759 5.7152 23.6504
NCI-H2030 CTRP1 7.3122 11.5497 5.6579 23.8873
COR-L88 CTRP1 7.3532 9.0116 4.5179 0.5039
NCI-H3255 CTRP1 7.5584 8.8298 7.2049 10.0545
Sq-1 CTRP1 7.5923 8.4367 7.4132 8.0933
NCI-H2110 CTRP1 8.6558 18.6058 3.2742 29.6376
⏷ Show the Full List of 91 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KYSE-140 CTRP1 4.7935 6.1544 4.2768 8.2296
KYSE-410 CTRP1 4.9016 5.9873 4.4578 6.1054
KYSE-450 CTRP1 5.1843 6.782 4.2994 6.3427
Cancer Drug Sensitivity Data Curated from 26 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JHOM-1 CTRP1 3.823 7.6906 3.5312 57.9317
OVCAR-8 CTRP1 3.8299 6.4264 3.7657 59.3336
A2780 CTRP1 3.8525 5.4825 3.8474 59.8854
HEY A8 CTRP1 4.2736 5.5517 4.0307 13.1321
OVKATE CTRP1 4.4428 6.0011 4.4342 51.6341
OVCAR-4 CTRP1 4.6246 7.7651 4.3869 49.2104
OVK18 CTRP1 4.6471 8.492 4.2088 49.0407
RMG-I CTRP1 4.9179 7.8896 4.6757 45.5958
JHOC-5 CTRP1 5.202 7.3741 5.0978 41.365
COV434 CTRP1 5.2848 6.9352 5.2483 39.855
SK-OV-3 CTRP1 5.3648 6.734 4.4605 4.2511
JHOS-4 CTRP1 5.3696 7.0187 4.3243 5.44
OV-90 CTRP1 5.4017 7.5862 5.273 38.7298
IGROV-1 CTRP1 5.4633 7.0419 5.4256 37.3305
RMUG-S CTRP1 5.8029 8.7672 5.3726 34.9816
SNU-840 CTRP1 6.2011 10.0546 5.2773 32.6964
TYK-nu CTRP1 6.2723 8.3964 6.0075 27.4811
COV318 CTRP1 6.3586 7.1372 4.8088 0.1276
OVMANA CTRP1 6.5774 8.1306 4.5288 1.1145
EFO-21 CTRP1 6.8011 8.3118 4.5556 0.7499
Caov-3 CTRP1 7.0885 7.9774 7.021 14.3654
OAW42 CTRP1 7.2481 8.0806 7.168 12.1858
COV644 CTRP1 7.2835 8.3714 7.1107 12.4189
EFO-27 CTRP1 7.3045 9.9661 6.4216 18.109
OV7 CTRP1 7.6461 8.5547 7.4177 7.7513
COV362 CTRP1 10.4171 12.1066 7.5082 0.4999
⏷ Show the Full List of 26 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 10 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CFPAC-1 CTRP1 4.5907 5.8598 4.2233 9.7224
HPAC CTRP1 4.7808 6.1807 4.2522 8.5092
SUIT-2 CTRP1 5.0615 6.1378 4.5216 4.8319
KP-3 CTRP1 5.2311 8.1215 3.6686 11.7546
HuP-T4 CTRP1 5.3764 7.2912 4.1951 6.5632
Panc 03.27 CTRP1 5.5265 7.0444 4.4236 4.0548
QGP-1 CTRP1 5.5556 7.39 4.2768 5.2375
Capan-2 CTRP1 5.5852 7.5051 4.2418 5.4483
PaTu 8902 CTRP1 6.8732 8.0834 4.667 0.2866
Panc 10.05 CTRP1 7.6915 9.5964 4.4374 0.5804
⏷ Show the Full List of 10 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MSTO-211H CTRP1 4.6198 5.8401 4.2612 9.2398
NCI-H28 CTRP1 6.014 7.7981 4.3796 3.1173
NCI-H2052 CTRP1 6.6295 9.0151 4.1855 3.2725
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
PaCa-3 CTRP1 5.487 6.5718 4.6225 2.474
Cancer Drug Sensitivity Data Curated from 9 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
G-361 CTRP1 4.7899 6.1913 4.2554 8.4366
Hs 944.T CTRP1 5.1796 6.2469 4.5622 4.0012
SK-MEL-5 CTRP1 5.366 6.7573 5.3482 38.5883
COLO 741 CTRP1 5.3935 7.43 4.1393 6.9971
Hs 852.T CTRP1 5.9793 7.8104 4.3535 3.4063
Hs 936.T CTRP1 6.2784 7.3725 4.6927 0.5892
A-375 CTRP1 6.5604 8.4699 6.2953 23.4227
SK-MEL-28 CTRP1 6.6642 7.06 6.664 19.9258
SK-MEL-1 CTRP1 7.5328 8.4402 7.3493 8.9706
⏷ Show the Full List of 9 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RKN CTRP1 4.6262 6.4774 4.598 49.0686
G-401 CTRP1 4.8286 6.2107 4.2813 8.0231
HT-1080 CTRP1 6.8035 9.3203 6.2172 22.5439
Cancer Drug Sensitivity Data Curated from 7 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
AGS CTRP1 3.9956 7.5686 3.7481 56.3478
MKN74 CTRP1 5.4009 7.797 3.9634 8.5268
NUGC-4 CTRP1 5.5803 7.4732 4.2538 5.3593
SH-10-TC CTRP1 5.617 7.2633 4.3799 4.1579
Fu97 CTRP1 5.6668 7.4503 4.324 4.4887
MKN7 CTRP1 5.6963 7.5388 4.3015 4.594
SNG-M CTRP1 6.1237 9.0409 3.87 6.9827
⏷ Show the Full List of 7 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HSC-2 CTRP1 5.0391 5.941 4.6012 4.2074
SCC-9 CTRP1 6.3671 10.2346 5.3672 31.1089
Cancer Drug Sensitivity Data Curated from 5 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
UM-UC-3 CTRP1 4.574 5.9448 4.1673 10.2962
RT-4 CTRP1 4.6753 5.7889 4.3398 8.2647
5637 CTRP1 4.7132 6.6545 3.9574 11.45
HT-1376 CTRP1 4.9615 6.5097 4.2508 7.6953
KMBC-2 CTRP1 5.313 7.0093 4.2865 5.9765

References

1 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001712)
2 Antileukotriene therapy for asthma. Am J Health Syst Pharm. 1996 Dec 1;53(23):2821-30; quiz 2877-8.