Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMW4XKQ)

Drug Name
7-nitro-1H-indazole Drug Info
Synonyms
7-Nitroindazole; 7-nitroindazole; 7-Nitro-1H-indazole; 2942-42-9; 1H-Indazole, 7-nitro-; 7-nitro-indazole; 7-NI; UNII-UX0N37CMVH; CCRIS 3309; EINECS 220-934-4; NSC 72843; UX0N37CMVH; BRN 0006809; MLS000028452; CHEMBL247378; PQCAUHUKTBHUSA-UHFFFAOYSA-N; MFCD00022789; SMR000058266; 7NI; 2h-indazole,7-nitro-; SR-01000075512; 7- Nitroindazole; 7-Nitroisoindazole; Tocris-0602; PubChem14009; AC1L1CGU; Spectrum3_001980; Spectrum2_001715; Opera_ID_1690; Lopac-N-7778; ACMC-209h8w; AC1Q1Y3U; 7-Nitroindazole, > NCIOpen2_000477; Lopac0_000839; BSPBio_003580
Cross-matching ID
PubChem CID
1893
ChEBI ID
CHEMBL247378
CAS Number
CAS 2942-42-9
TTD Drug ID
D03WOZ

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Ubiquinone and other terpenoid-quinone biosynthesis 1.94 5.93e-3 9/11 (81.82%) TAT;COQ3;COQ7;...
Spliceosome 1.85 1.78e-2 101/150 (67.33%) PUF60;HSPA8;SNRPG;...
Ribosome 1.83 1.78e-2 113/158 (71.52%) MRPL15;MRPS12;MRPS11;...
RNA polymerase 1.81 1.63e-2 23/31 (74.19%) POLR2B;POLR3K;POLR2L;...
Caffeine metabolism 1.78 1.66e-2 5/6 (83.33%) NAT1;CYP2A6;NAT2;...
Ribosome biogenesis in eukaryotes 1.77 1.58e-2 52/108 (48.15%) RPP40;NXT1;IMP3;...
Drug metabolism 1.67 4.06e-2 78/151 (51.66%) NAT1;NME1;ADH1C;...
mRNA surveillance pathway 1.67 4.37e-2 71/98 (72.45%) NXT1;GSPT2;ETF1;...
Parkinson disease 1.66 3.95e-2 176/249 (70.68%) PPIF;SNCAIP;NDUFAB1;...
Huntington disease 1.66 3.73e-2 233/306 (76.14%) PPIF;GPX7;NDUFAB1;...
RIG-I-like receptor signaling pathway 1.62 4.47e-2 64/70 (91.43%) CXCL8;FADD;RIPK1;...
TGF-beta signaling pathway 1.61 4.54e-2 81/94 (86.17%) FST;SKP1;SMAD3;...
RNA transport 1.61 4.33e-2 128/186 (68.82%) CLNS1A;RPP40;NXT1;...
Basal cell carcinoma -1.63 4.51e-2 41/63 (65.08%) DVL3;GSK3B;FZD10;...
mTOR signaling pathway -1.63 4.64e-2 114/154 (74.03%) RPS6KA2;TSC1;PIK3CB;...
Salivary secretion -1.64 4.25e-2 76/93 (81.72%) ATP2B4;MUC5B;TRPV6;...
Circadian entrainment -1.65 4.21e-2 85/97 (87.63%) RYR1;KCNJ6;ITPR1;...
Gastric acid secretion -1.65 4.41e-2 63/76 (82.89%) ITPR1;ACTB;ATP1B1;...
Cholinergic synapse -1.65 4.62e-2 99/113 (87.61%) CREB5;KCNJ6;ITPR1;...
Thyroid hormone synthesis -1.65 4.78e-2 66/75 (88%) ITPR2;GSR;CANX;...
Relaxin signaling pathway -1.66 4.70e-2 114/129 (88.37%) ARRB2;GNG12;COL4A5;...
Cortisol synthesis and secretion -1.68 4.53e-2 58/65 (89.23%) ITPR2;CREB5;ITPR1;...
PI3K-Akt signaling pathway -1.68 4.58e-2 317/354 (89.55%) PDGFC;PPP2CB;EGF;...
ECM-receptor interaction -1.71 3.83e-2 80/88 (90.91%) DSPP;ITGA2;AGRN;...
Sphingolipid metabolism -1.74 3.23e-2 32/49 (65.31%) DEGS1;SGPL1;GAL3ST1;...
Carbohydrate digestion and absorption -1.74 3.28e-2 37/47 (78.72%) HK1;AKT1;ATP1B3;...
Glycine, serine and threonine metabolism -1.76 3.04e-2 31/40 (77.5%) GATM;AMT;ALAS1;...
Phagosome -1.78 2.34e-2 118/152 (77.63%) ITGB1;ATP6V0E1;HGS;...
Ferroptosis -1.81 2.32e-2 36/41 (87.8%) GSS;CYBB;PRNP;...
Vibrio cholerae infection -1.82 2.42e-2 44/50 (88%) SEC61A1;ADCY9;TJP2;...
Rheumatoid arthritis -1.84 2.13e-2 78/93 (83.87%) ATP6V0E1;ACP5;IL1A;...
Phosphatidylinositol signaling system -1.84 2.23e-2 82/97 (84.54%) DGKG;ITPKA;PIP4K2C;...
Protein processing in endoplasmic reticulum -1.88 2.19e-2 127/171 (74.27%) ATF6;TRAM1;RPN2;...
Insulin secretion -1.89 2.13e-2 75/86 (87.21%) INS;KCNMA1;ADCY6;...
Parathyroid hormone synthesis, secretion and action -1.93 5.10e-3 98/106 (92.45%) JUND;MEF2D;VDR;...
Lysosome -2.00 0.00e+0 115/128 (89.84%) CD68;CTSB;CLN3;...
Collecting duct acid secretion -2.08 0.00e+0 22/27 (81.48%) SLC4A1;ATP6V1E1;ATP6V1C1;...
Protein digestion and absorption -2.17 0.00e+0 78/103 (75.73%) KCNK5;COL8A2;ACE2;...
Steroid biosynthesis -2.29 0.00e+0 19/20 (95%) NSDHL;CYP27B1;HSD17B7;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-673 CVCL_0080 Homo sapiens 80uM 6H
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM - 80uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CL-34 CVCL_1123 Homo sapiens 80uM 6H
HT-29 CVCL_0320 Homo sapiens 10uM - 80uM 6H, 24H
LoVo CVCL_0399 Homo sapiens 80uM 6H
MDST8 CVCL_1400 Homo sapiens 80uM 6H
NCI-H508 CVCL_1561 Homo sapiens 80uM 6H
SNU-1040 CVCL_5001 Homo sapiens 80uM 6H
SNU-C4 CVCL_5008 Homo sapiens 80uM 6H
SNU-C5 CVCL_5009 Homo sapiens 80uM 6H
SW480 CVCL_0546 Homo sapiens 80uM 6H
SW620 CVCL_0547 Homo sapiens 80uM 6H
SW948 CVCL_0550 Homo sapiens 80uM 6H
Colorectal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCT 116 CVCL_0291 Homo sapiens 80uM 6H
HT115 CVCL_1294 Homo sapiens 80uM 6H
RKO CVCL_0504 Homo sapiens 80uM 6H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 80uM 6H
SNG-M CVCL_1707 Homo sapiens 80uM 6H
Endometrial carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHUEM-2 CVCL_1327 Homo sapiens 80uM 6H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM - 80uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM - 80uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM - 80uM 6H, 24H
DV-90 CVCL_1184 Homo sapiens 80uM 6H
SK-LU-1 CVCL_0624 Homo sapiens 80uM 6H
Lung adenosquamous carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H596 CVCL_1571 Homo sapiens 80uM 6H
Lung large cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COR-L23 CVCL_1133 Homo sapiens 80uM 6H
T3M-10 CVCL_1729 Homo sapiens 80uM 6H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC15 CVCL_1253 Homo sapiens 80uM 6H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1299 CVCL_0060 Homo sapiens 80uM 6H
HCC515 CVCL_5134 Homo sapiens 10uM - 80uM 6H, 24H
NCI-H2073 CVCL_1523 Homo sapiens 80uM 6H
Small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1694 CVCL_1495 Homo sapiens 80uM 6H
NCI-H1836 CVCL_1502 Homo sapiens 80uM 6H
Lymph node
Diffuse large B-cell lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
WSU-DLCL2 CVCL_1787 Homo sapiens 80uM 6H
Ovary
Ovarian carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
EFO-27 CVCL_1194 Homo sapiens 80uM 6H
OV7 CVCL_1623 Homo sapiens 80uM 6H
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
RMG-I CVCL_1663 Homo sapiens 80uM 6H
Ovarian mucinous cystadenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COV644 CVCL_2011 Homo sapiens 80uM 6H
RMUG-S CVCL_1666 Homo sapiens 80uM 6H
Ovarian undifferentiated carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
TYK-nu CVCL_1774 Homo sapiens 80uM 6H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 80uM 6H
Acute myeloid leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NOMO-1 CVCL_1609 Homo sapiens 80uM 6H
PL-21 CVCL_2161 Homo sapiens 80uM 6H
SKM-1 CVCL_0010 Homo sapiens 80uM 6H
Pleural effusion
Histiocytic lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-937 CVCL_0007 Homo sapiens 80uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM - 80uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM - 80uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM - 80uM 6H, 24H
SK-MEL-1 CVCL_0523 Homo sapiens 80uM 6H
SK-MEL-28 CVCL_0526 Homo sapiens 80uM 6H
Stomach
Gastric adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
AGS CVCL_0139 Homo sapiens 80uM 6H