Details of the Drug

General Information of Drug (ID: DMW4XKQ)

Drug Name
7-nitro-1H-indazole
Synonyms
7-Nitroindazole; 7-nitroindazole; 7-Nitro-1H-indazole; 2942-42-9; 1H-Indazole, 7-nitro-; 7-nitro-indazole; 7-NI; UNII-UX0N37CMVH; CCRIS 3309; EINECS 220-934-4; NSC 72843; UX0N37CMVH; BRN 0006809; MLS000028452; CHEMBL247378; PQCAUHUKTBHUSA-UHFFFAOYSA-N; MFCD00022789; SMR000058266; 7NI; 2h-indazole,7-nitro-; SR-01000075512; 7- Nitroindazole; 7-Nitroisoindazole; Tocris-0602; PubChem14009; AC1L1CGU; Spectrum3_001980; Spectrum2_001715; Opera_ID_1690; Lopac-N-7778; ACMC-209h8w; AC1Q1Y3U; 7-Nitroindazole, > NCIOpen2_000477; Lopac0_000839; BSPBio_003580
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 163.13
Logarithm of the Partition Coefficient (xlogp) 1.8
Rotatable Bond Count (rotbonds) 0
Hydrogen Bond Donor Count (hbonddonor) 1
Hydrogen Bond Acceptor Count (hbondacc) 3
Chemical Identifiers
Formula
C7H5N3O2
IUPAC Name
7-nitro-1H-indazole
Canonical SMILES
C1=CC2=C(C(=C1)[N+](=O)[O-])NN=C2
InChI
InChI=1S/C7H5N3O2/c11-10(12)6-3-1-2-5-4-8-9-7(5)6/h1-4H,(H,8,9)
InChIKey
PQCAUHUKTBHUSA-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
1893
CAS Number
2942-42-9
UNII
UX0N37CMVH
DrugBank ID
DB02207
TTD ID
D03WOZ

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Nitric-oxide synthase brain (NOS1) TTZUFI5 NOS1_HUMAN Inhibitor [2]
Nitric-oxide synthase endothelial (NOS3) TTCM4B3 NOS3_HUMAN Inhibitor [3]
Nitric-oxide synthase inducible (NOS2) TTF10I9 NOS2_HUMAN Inhibitor [3]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Nitric-oxide synthase inducible (NOS2) DTT NOS2 4.24E-02 -0.27 -0.88
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MCF-7 CTRP1 9.575 11.5153 7.3709 2.0832
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SF295 CTRP1 6.8468 8.5691 4.4765 1.0893
GaMG CTRP1 7.887 9.3385 4.5964 0.1296
LN-229 CTRP1 10.2011 15.357 6.0033 10.6371
Cancer Drug Sensitivity Data Curated from 10 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HEC-265 CTRP1 5.7919 8.6661 3.8236 8.3906
HEC-6 CTRP1 7.1281 8.3756 4.658 0.2092
MFE-319 CTRP1 7.1464 11.0016 3.5942 6.5179
HEC-108 CTRP1 7.3612 8.8398 4.5815 0.3091
HEC-59 CTRP1 7.3964 8.8974 4.5743 0.3136
HEC-251 CTRP1 7.6142 9.0126 4.612 0.1626
KLE CTRP1 7.7323 9.4166 4.5159 0.3297
HEC-151 CTRP1 8.7903 12.5376 6.3961 11.9584
JHUEM-2 CTRP1 9.0244 11.5704 7.0279 5.9571
Ishikawa (Heraklio) 02 ER- CTRP1 6.6427 9.0375 4.1829 3.2657
⏷ Show the Full List of 10 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 24 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
BL-70 CTRP1 6.0562 7.5269 4.5234 1.9434
MC116 CTRP1 6.2313 7.1638 4.7515 0.3711
NU-DUL-1 CTRP1 6.6889 10.6804 5.4843 28.4322
P3HR-1 CTRP1 6.8803 8.3956 4.5567 0.6783
HT CTRP1 7.0439 8.3608 4.6326 0.3065
KE-97 CTRP1 7.1072 8.6679 4.5469 0.5521
Ku812 CTRP1 7.2232 8.8221 4.5361 0.518
AMO1 CTRP1 7.6971 8.2551 7.5973 5.951
SU-DHL-5 CTRP1 7.7112 8.4786 7.518 6.5361
SKM-1 CTRP1 7.9895 11.0188 6.5208 14.0248
GDM-1 CTRP1 8.328 10.4954 7.057 7.9675
RPMI-8226 CTRP1 8.3341 10.4375 7.0904 7.6481
PL21 CTRP1 8.5168 9.8417 7.5142 3.3065
KMS-11 CTRP1 8.5917 10.5567 7.2214 5.6053
WSU-DLCL2 CTRP1 8.6923 11.3874 6.8885 8.1645
LP-1 CTRP1 8.7482 10.4405 7.3819 3.7693
NOMO-1 CTRP1 8.896 11.7746 6.844 7.8858
EJM CTRP1 9.2806 11.15 7.3736 2.5931
MOLM-16 CTRP1 9.3442 10.6937 7.5964 1.0207
OCI-Ly10 CTRP1 9.406 12.3326 6.9131 5.8668
U-937 CTRP1 9.5667 11.8281 7.233 3.0528
SU-DHL-4 CTRP1 9.5989 10.9453 7.6098 0.682
THP-1 CTRP1 10.3213 11.7909 7.584 0.3191
OCI-AML-3 CTRP1 10.7511 20.1841 4.0669 20.1462
⏷ Show the Full List of 24 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
VMRC-RCW CTRP1 7.9361 9.5268 4.5503 0.1926
RCC10RGB CTRP1 9.2172 12.7373 6.6004 8.9145
Cancer Drug Sensitivity Data Curated from 37 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SW48 CTRP1 6.5735 9.7515 3.8225 6.1576
DLD-1 CTRP1 6.592 7.8586 4.6395 0.5569
GP2d CTRP1 6.6185 8.5343 4.3845 1.9246
LS411N CTRP1 6.7292 8.7147 4.364 1.8869
COLO205 CTRP1 6.7864 10.3903 3.6583 6.8965
SW480 CTRP1 7.1477 10.4886 6.0207 22.133
LS513 CTRP1 7.4104 9.0264 4.5342 0.4209
SK-CO-1 CTRP1 7.5512 9.3922 4.457 0.5959
SNU-C2A CTRP1 7.6099 10.1767 4.1851 1.7763
C2BBe1 CTRP1 7.7002 9.5769 4.4477 0.5415
LS180 CTRP1 8.1751 10.3798 6.9938 9.1182
SW948 CTRP1 8.1804 10.868 6.7543 11.2138
SW620 CTRP1 8.2079 9.5186 7.4492 4.9088
SNU-C5 CTRP1 8.7269 11.601 6.809 8.7308
SNU-C4 CTRP1 8.777 10.2156 7.504 2.6949
RCM-1 [Human ESC] CTRP1 8.9243 10.3554 7.5265 2.1858
HT-55 CTRP1 8.9441 10.7559 7.3572 3.4628
HCT 116 CTRP1 9.0446 10.4667 7.5433 1.8239
CW-2 CTRP1 9.1266 14.1468 5.8525 14.9388
MDST8 CTRP1 9.174 11.2379 7.2745 3.5704
HT115 CTRP1 9.2891 10.6516 7.5878 1.1416
CL-34 CTRP1 9.3087 10.9172 7.4879 1.7429
COLO 320 CTRP1 9.3629 12.5615 6.7794 7.0512
LS123 CTRP1 9.5367 13.2491 6.5678 8.2539
COLO 678 CTRP1 9.5506 12.0308 7.1352 3.8043
HT-29 CTRP1 9.5795 10.7894 7.6601 0.482
KM12 CTRP1 9.6179 11.5249 7.3882 1.9024
HCT 8 CTRP1 9.7385 15.6282 5.5661 14.9215
LoVo CTRP1 9.8148 11.8306 7.3577 1.8022
SNU-175 CTRP1 9.9534 11.5111 7.5434 0.6765
CL-40 CTRP1 10.1338 11.723 7.5373 0.5704
SNU-61 CTRP1 10.1546 12.032 7.4307 1.0073
SNU-81 CTRP1 10.158 11.7402 7.5405 0.543
NCI-H508 CTRP1 10.261 11.8695 7.5336 0.5042
RKO CTRP1 10.2615 11.8814 7.5295 0.518
SNU-1040 CTRP1 10.4055 16.0845 5.7925 11.5328
SW403 CTRP1 10.6482 19.843 1.6413 11.0763
⏷ Show the Full List of 37 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 4 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JHH-6 CTRP1 6.239 7.261 4.7184 0.5057
SNU-449 CTRP1 6.853 8.9309 4.335 1.8867
SNU-398 CTRP1 8.797 10.4039 7.4295 3.2468
Hep-G2 CTRP1 8.9802 10.4014 7.5371 1.9927
Cancer Drug Sensitivity Data Curated from 91 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H1568 CTRP1 5.338 10.1146 2.7597 18.523
SHP-77 CTRP1 6.4021 8.1919 4.4195 2.0458
NCI-H1930 CTRP1 6.4959 8.4358 4.3642 2.2604
NCI-H1915 CTRP1 6.5699 8.4378 4.4007 1.8963
NCI-H810 CTRP1 6.5763 11.3432 3.0738 11.8953
NCI-H1355 CTRP1 6.6479 11.4391 3.0762 11.6639
BEN CTRP1 6.6692 7.5563 4.7753 0.1059
HCC44 CTRP1 6.7439 8.5349 4.4439 1.3872
LCLC-103H CTRP1 6.7522 7.8157 4.7161 0.206
NCI-H1437 CTRP1 6.7886 9.1001 4.2327 2.6502
NCI-H522 CTRP1 6.7898 8.8874 4.3223 2.0593
NCI-H82 CTRP1 6.8056 13.5472 2.1676 17.1936
RERF-LC-KJ CTRP1 6.8128 8.2845 4.5706 0.6733
NCI-H2126 CTRP1 6.8137 8.1595 4.6171 0.485
KNS-62 CTRP1 6.8664 9.5294 4.0896 3.5021
NCI-H2029 CTRP1 6.8772 8.495 4.518 0.8543
NCI-H1975 CTRP1 6.8775 9.308 4.1901 2.7857
DV-90 CTRP1 6.8879 8.8518 4.3834 1.5508
LC-1/sq-SF CTRP1 6.8883 8.474 4.5306 0.7864
NCI-H2405 CTRP1 6.9159 10.0315 3.8965 4.8009
COR-L279 CTRP1 6.922 8.6064 4.4945 0.9235
NCI-H358 CTRP1 6.945 9.9342 3.9556 4.3081
Lu-99 CTRP1 6.9479 8.3192 4.6113 0.422
COR-L88 CTRP1 6.9739 9.5016 4.1575 2.841
Calu-3 CTRP1 6.9742 8.8626 4.4181 1.2551
Lu-65 CTRP1 6.9778 9.2175 4.2776 2.0607
COLO 668 CTRP1 6.9981 9.1045 4.333 1.7002
ChaGo-K-1 CTRP1 7.0147 9.5906 4.1406 2.8851
LCLC-97TM1 CTRP1 7.0858 9.7033 4.1292 2.8427
NCI-H1666 CTRP1 7.1143 14.7475 1.8022 18.3256
NCI-H1435 CTRP1 7.1291 8.9958 4.4337 1.0169
NCI-H650 CTRP1 7.1646 9.0413 4.4313 0.9948
NCI-H1573 CTRP1 7.1979 9.1751 4.3943 1.1406
NCI-H2286 CTRP1 7.2112 8.7798 4.5467 0.4883
HARA [Human squamous cell lung carcinoma] CTRP1 7.2762 8.93 4.5177 0.5506
NCI-H23 CTRP1 7.292 9.3226 4.3779 1.128
NCI-H2009 CTRP1 7.3013 9.5141 4.3079 1.4725
EPLC-272H CTRP1 7.3284 9.6118 4.2816 1.5821
NCI-H1048 CTRP1 7.3508 11.0171 3.7033 5.2894
Calu-6 CTRP1 7.3832 9.3705 4.398 0.9525
NCI-H1792 CTRP1 7.3895 11.9301 3.3164 7.958
NCI-H1373 CTRP1 7.4327 9.9764 4.1842 1.9969
HCC78 CTRP1 7.4376 12.2227 3.2117 8.5824
NCI-H727 CTRP1 7.4412 9.2947 4.4495 0.6948
HCC33 CTRP1 7.4441 8.6802 4.6649 0.115
DMS 273 CTRP1 7.463 8.7999 4.6313 0.1656
NCI-H1944 CTRP1 7.4983 10.6933 3.9211 3.5263
NCI-H1793 CTRP1 7.5363 9.3356 4.4716 0.5545
LXF 289 CTRP1 7.5382 9.4953 4.4144 0.763
A-549 CTRP1 7.5813 11.4384 3.645 5.2367
NCI-H661 CTRP1 7.6488 9.5854 4.4249 0.6494
VMRC-LCD CTRP1 7.7217 9.1407 4.606 0.1482
EBC-1 CTRP1 7.9149 9.502 4.5513 0.196
NCI-H1299 CTRP1 8.0152 9.5573 4.5672 0.1474
NCI-H1105 CTRP1 8.1694 11.8613 6.249 15.5155
NCI-H1836 CTRP1 8.1987 11.8904 6.2584 15.3187
NCI-H2122 CTRP1 8.3468 11.2653 6.6889 11.1286
HCC4006 CTRP1 8.4841 11.1336 6.86 9.1326
HCC2108 CTRP1 8.7983 14.3414 5.5106 18.4463
COR-L51 CTRP1 8.8784 14.9951 5.2479 19.814
NCI-H2342 CTRP1 9.0418 13.3914 6.1608 12.9468
NCI-H1781 CTRP1 9.1198 14.4751 5.6863 16.1224
HCC1359 CTRP1 9.1361 10.1431 7.7199 0.5961
NCI-H2110 CTRP1 9.1867 25.7845 0.1175 35.3838
CAL-12T CTRP1 9.2189 11.8179 7.0357 5.365
COR-L23 CTRP1 9.2672 11.1883 7.3495 2.7968
NCI-H3255 CTRP1 9.3182 14.479 5.8282 14.472
NCI-H596 CTRP1 9.3467 12.7936 6.6596 8.059
NCI-H1755 CTRP1 9.4315 14.3897 5.9516 13.2297
COLO 699 CTRP1 9.5122 11.9607 7.1447 3.8147
HCC1195 CTRP1 9.5141 11.1763 7.4812 1.4733
NCI-H1963 CTRP1 9.5357 13.5135 6.4423 9.2341
HCC15 CTRP1 9.5586 14.3655 6.0509 12.1165
NCI-H2141 CTRP1 9.6856 11.293 7.5133 1.0739
HCC827 CTRP1 9.7208 11.6254 7.3966 1.6982
NCI-H2081 CTRP1 9.7222 11.2965 7.5279 0.9582
SK-LU-1 CTRP1 9.7324 12.3903 7.0776 3.8527
SCLC-21H CTRP1 9.7684 11.0707 7.6317 0.4605
NCI-H2023 CTRP1 9.895 12.0497 7.3066 2.0017
NCI-H1876 CTRP1 9.9902 11.4795 7.5697 0.5449
HCC2935 CTRP1 9.9942 11.8984 7.4129 1.2604
NCI-H1694 CTRP1 10.0523 11.4012 7.6216 0.3346
NCI-H460 CTRP1 10.0538 15.1261 6.0174 10.9339
NCI-H2030 CTRP1 10.0808 15.5229 5.8475 12.0379
Sq-1 CTRP1 10.0837 11.198 7.7027 0.1325
NCI-H841 CTRP1 10.1005 11.6013 7.5685 0.4791
NCI-H2172 CTRP1 10.2191 16.4324 5.5067 13.8961
NCI-H2073 CTRP1 10.4551 18.5193 4.6659 18.0683
NCI-H441 CTRP1 10.4871 17.3229 5.2607 14.6676
T3M-10 CTRP1 10.8889 20.2409 4.1346 19.4747
HCC1833 CTRP1 10.9672 12.6836 7.5081 0.2663
⏷ Show the Full List of 91 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KYSE-140 CTRP1 6.2147 10.2207 3.3661 10.7892
KYSE-450 CTRP1 7.1252 8.2167 4.7107 0.1099
KYSE-410 CTRP1 7.2148 9.5381 4.2593 1.8457
Cancer Drug Sensitivity Data Curated from 26 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JHOS-4 CTRP1 6.5085 9.128 4.0678 4.4068
OVMANA CTRP1 6.5973 8.1491 4.5305 1.0821
COV318 CTRP1 6.9106 8.0553 4.6904 0.2098
EFO-21 CTRP1 6.9487 8.4346 4.5698 0.5733
HEY A8 CTRP1 7.3089 8.5262 4.6701 0.1351
SK-OV-3 CTRP1 7.3951 8.8042 4.606 0.2367
A2780 CTRP1 8.6484 10.416 7.3281 4.5088
COV434 CTRP1 8.6826 11.7733 6.6924 9.8743
TYK-nu CTRP1 9.0276 10.7507 7.4089 2.8586
COV362 CTRP1 9.0311 11.8934 6.8788 7.1813
OVCAR-4 CTRP1 9.1755 12.1673 6.8441 7.0483
RMUG-S CTRP1 9.2085 13.933 6.0161 13.4787
OVCAR-8 CTRP1 9.335 12.2079 6.9269 5.9396
COV644 CTRP1 9.4222 11.0385 7.4935 1.5297
JHOC-5 CTRP1 9.4543 11.9485 7.1171 4.1514
OAW42 CTRP1 9.6773 10.6347 7.7516 0.15
OV-90 CTRP1 9.6877 11.4727 7.4428 1.4661
IGROV-1 CTRP1 9.7924 14.2036 6.2832 9.7237
OVKATE CTRP1 9.8383 11.3878 7.5424 0.7772
RMG-I CTRP1 9.8715 13.5913 6.6176 6.9959
OV7 CTRP1 9.9848 11.7252 7.4758 0.9532
EFO-27 CTRP1 10.2244 11.8258 7.5353 0.5204
Caov-3 CTRP1 10.5052 11.9074 7.6097 0.1952
OVK18 CTRP1 10.794 17.7914 5.2396 13.9788
JHOM-1 CTRP1 10.908 17.0811 5.6432 11.2343
SNU-840 CTRP1 10.9959 12.6667 7.5239 0.226
⏷ Show the Full List of 26 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 10 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HPAC CTRP1 6.7171 8.7988 4.3232 2.1667
PaTu 8902 CTRP1 6.8272 8.1488 4.6262 0.4427
SUIT-2 CTRP1 6.9032 8.3123 4.5966 0.5022
QGP-1 CTRP1 6.9119 8.5914 4.4959 0.9263
CFPAC-1 CTRP1 7.2914 9.2481 4.406 0.9964
Panc 03.27 CTRP1 7.4519 9.1345 4.5114 0.4703
KP-3 CTRP1 7.4677 11.4527 3.5761 5.9454
Panc 10.05 CTRP1 7.482 9.2053 4.4976 0.4987
HuP-T4 CTRP1 7.7851 9.8887 4.3679 0.7704
Capan-2 CTRP1 7.8152 11.5134 3.7361 4.1992
⏷ Show the Full List of 10 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H2052 CTRP1 6.8094 9.0383 4.2692 2.3722
NCI-H28 CTRP1 7.2498 9.2286 4.3959 1.0822
MSTO-211H CTRP1 7.4814 9.4342 4.4142 0.8052
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
PaCa-3 CTRP1 6.9972 9.2162 4.2874 1.9728
Cancer Drug Sensitivity Data Curated from 9 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 741 CTRP1 6.2837 9.206 3.8955 6.3286
Hs 852.T CTRP1 6.7213 9.3009 4.1106 3.6336
Hs 944.T CTRP1 6.9814 8.4213 4.5874 0.4852
G-361 CTRP1 7.1213 13.374 2.4691 14.41
SK-MEL-28 CTRP1 9.0744 9.9435 7.7699 0.4178
Hs 936.T CTRP1 9.692 18.0978 1.876 11.6972
SK-MEL-1 CTRP1 9.7097 10.9577 7.6499 0.4319
SK-MEL-5 CTRP1 10.3361 18.2562 4.7107 18.1706
A-375 CTRP1 10.395 17.0623 5.3237 14.5418
⏷ Show the Full List of 9 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
G-401 CTRP1 7.6172 10.6808 3.9854 2.9289
RKN CTRP1 8.8662 10.408 7.4694 2.7566
HT-1080 CTRP1 9.1719 13.5884 6.1579 12.5373
Cancer Drug Sensitivity Data Curated from 7 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SH-10-TC CTRP1 6.2558 7.7683 4.5238 1.5918
Fu97 CTRP1 6.7747 11.0691 3.3351 9.3838
NUGC-4 CTRP1 7.1347 9.6495 4.1758 2.4638
MKN74 CTRP1 7.28 9.5657 4.2781 1.6585
MKN7 CTRP1 7.429 9.1491 4.4975 0.5289
AGS CTRP1 8.5074 11.9575 6.4696 12.3787
SNG-M CTRP1 7.5217 9.2789 4.4863 0.5136
⏷ Show the Full List of 7 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HSC-2 CTRP1 6.9043 8.2132 4.6327 0.3757
SCC-9 CTRP1 9.7455 12.9158 6.8504 5.527
Cancer Drug Sensitivity Data Curated from 5 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HT-1376 CTRP1 6.4721 8.753 4.2142 3.3789
UM-UC-3 CTRP1 6.7622 8.8385 4.329 2.059
KMBC-2 CTRP1 7.1581 10.6562 3.7555 5.3167
RT-4 CTRP1 7.8106 9.3655 4.5611 0.2049
5637 CTRP1 7.9342 9.8093 4.4528 0.4124

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5127).
2 Fluorinated indazoles as novel selective inhibitors of nitric oxide synthase (NOS): synthesis and biological evaluation. Bioorg Med Chem. 2009 Sep 1;17(17):6180-7.
3 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.