Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMWA8B0)

Drug Name
JZL184 Drug Info
Synonyms JZL 184; JZL-184
Cross-matching ID
PubChem CID
25021165
ChEBI ID
CHEMBL576786
CAS Number
CAS 1101854-58-3
TTD Drug ID
D0G0MZ

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Cell cycle 2.05 6.94e-3 110/124 (88.71%) CCNE2;CDC20;PTTG1;...
Spliceosome 2.00 3.47e-3 101/150 (67.33%) HSPA8;LSM6;PUF60;...
Fanconi anemia pathway 1.95 4.63e-3 36/54 (66.67%) HES1;REV1;REV3L;...
DNA replication 1.86 1.21e-2 34/36 (94.44%) POLE2;MCM6;MCM4;...
Propanoate metabolism 1.81 2.08e-2 30/34 (88.24%) PCCA;ECHDC1;SUCLA2;...
Proteasome 1.75 3.01e-2 44/46 (95.65%) POMP;PSMA2;PSME1;...
Oocyte meiosis 1.74 3.07e-2 90/129 (69.77%) CCNE2;CDC20;PTTG1;...
Base excision repair 1.72 3.21e-2 29/33 (87.88%) POLE2;PARP2;NEIL1;...
Homologous recombination 1.69 4.63e-2 35/41 (85.37%) BARD1;SSBP1;RAD54B;...
Progesterone-mediated oocyte maturation 1.68 4.44e-2 75/100 (75%) PIK3R1;CDC25A;IGF1;...
IL-17 signaling pathway -1.71 4.37e-2 84/94 (89.36%) IL17RA;MAPK8;ELAVL1;...
TNF signaling pathway -1.74 3.21e-2 103/112 (91.96%) MAPK8;JUNB;VEGFC;...
Rheumatoid arthritis -1.76 2.36e-2 78/93 (83.87%) ICAM1;HLA-DRB1;IL1A;...
Cell adhesion molecules -1.78 2.47e-2 118/148 (79.73%) CLDN15;F11R;CNTN1;...
Sulfur metabolism -1.84 1.15e-2 9/10 (90%) PAPSS2;ETHE1;SQOR;...
Protein processing in endoplasmic reticulum -1.88 9.35e-3 127/171 (74.27%) ERO1B;CRYAB;LMAN1;...
Asthma -1.88 8.73e-3 25/31 (80.65%) CCL11;TNF;EPX;...
Hematopoietic cell lineage -1.95 2.62e-3 90/99 (90.91%) ITGA5;IL1B;CD19;...
Staphylococcus aureus infection -1.99 3.27e-3 72/95 (75.79%) ITGAM;C2;DEFA4;...
Cytokine-cytokine receptor interaction -2.03 0.00e+0 246/295 (83.39%) TNFRSF13B;CCL22;TNFRSF4;...
Intestinal immune network for IgA production -2.26 0.00e+0 38/48 (79.17%) HLA-DRA;MADCAM1;TNFRSF13B;...
Viral protein interaction with cytokine and cytokine re... -2.31 0.00e+0 84/100 (84%) IL18R1;IL6;CXCR4;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-673 CVCL_0080 Homo sapiens 12uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 12uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CL-34 CVCL_1123 Homo sapiens 12uM 6H
HT-29 CVCL_0320 Homo sapiens 12uM 6H, 24H
LoVo CVCL_0399 Homo sapiens 12uM 6H
MDST8 CVCL_1400 Homo sapiens 12uM 6H
NCI-H508 CVCL_1561 Homo sapiens 12uM 6H
SNU-1040 CVCL_5001 Homo sapiens 12uM 6H
SNU-C4 CVCL_5008 Homo sapiens 12uM 6H
SNU-C5 CVCL_5009 Homo sapiens 12uM 6H
SW480 CVCL_0546 Homo sapiens 12uM 6H
SW620 CVCL_0547 Homo sapiens 12uM 6H
SW948 CVCL_0550 Homo sapiens 12uM 6H
Colorectal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCT 116 CVCL_0291 Homo sapiens 12uM 6H
HT115 CVCL_1294 Homo sapiens 12uM 6H
RKO CVCL_0504 Homo sapiens 12uM 6H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 12uM 6H
SNG-M CVCL_1707 Homo sapiens 12uM 6H
Endometrial carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHUEM-2 CVCL_1327 Homo sapiens 12uM 6H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 12uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 12uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 12uM 6H, 24H
DV-90 CVCL_1184 Homo sapiens 12uM 6H
SK-LU-1 CVCL_0624 Homo sapiens 12uM 6H
Lung adenosquamous carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H596 CVCL_1571 Homo sapiens 12uM 6H
Lung large cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COR-L23 CVCL_1133 Homo sapiens 12uM 6H
T3M-10 CVCL_1729 Homo sapiens 12uM 6H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC15 CVCL_1253 Homo sapiens 12uM 6H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1299 CVCL_0060 Homo sapiens 12uM 6H
HCC515 CVCL_5134 Homo sapiens 12uM 6H, 24H
NCI-H2073 CVCL_1523 Homo sapiens 12uM 6H
Small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1694 CVCL_1495 Homo sapiens 12uM 6H
NCI-H1836 CVCL_1502 Homo sapiens 12uM 6H
Lymph node
Diffuse large B-cell lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
WSU-DLCL2 CVCL_1787 Homo sapiens 12uM 6H
Ovary
Ovarian carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
EFO-27 CVCL_1194 Homo sapiens 12uM 6H
OV7 CVCL_1623 Homo sapiens 12uM 6H
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
RMG-I CVCL_1663 Homo sapiens 12uM 6H
Ovarian mucinous cystadenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COV644 CVCL_2011 Homo sapiens 12uM 6H
RMUG-S CVCL_1666 Homo sapiens 12uM 6H
Ovarian undifferentiated carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
TYK-nu CVCL_1774 Homo sapiens 12uM 6H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 12uM 6H
Acute myeloid leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NOMO-1 CVCL_1609 Homo sapiens 12uM 6H
PL-21 CVCL_2161 Homo sapiens 12uM 6H
SKM-1 CVCL_0010 Homo sapiens 12uM 6H
Pleural effusion
Histiocytic lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-937 CVCL_0007 Homo sapiens 12uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 12uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 12uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 12uM 6H, 24H
SK-MEL-1 CVCL_0523 Homo sapiens 12uM 6H
SK-MEL-28 CVCL_0526 Homo sapiens 12uM 6H
Stomach
Gastric adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
AGS CVCL_0139 Homo sapiens 12uM 6H