Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMWE60C)

• Drug Name: Rufinamide Drug Info
• Synonyms: 106308-44-5; Inovelon; Banzel; 1-(2,6-Difluorobenzyl)-1H-1,2,3-triazole-4-carboxamide; CGP-33101; Cgp 33101; Xilep; 1-[(2,6-difluorophenyl)methyl]-1H-1,2,3-Triazole-4-carboxamide; RUF-331; UNII-WFW942PR79; RUF 331; 1-[(2,6-difluorophenyl)methyl]triazole-4-carboxamide; WFW942PR79; C10H8F2N4O; E 2080; POGQSBRIGCQNEG-UHFFFAOYSA-N; 1H-1,2,3-Triazole-4-carboxamide, 1-[(2,6-difluorophenyl)methyl]-; NCGC00165883-02; E2080; DSSTox_CID_26506; DSSTox_RID_81675; DSSTox_GSID_46506; Banzel; Banzel, Rufinamide; E-2080; SYN-111; Rufinamide (USAN/INN); Inovelon/Banzel
• Cross-matching ID:
  PubChem CID: 129228
  ChEBI ID: CHEMBL1201754
  CAS Number: CAS 106308-44-5
  TTD Drug ID: D0MD2L
  INTEDE Drug ID: DR1450
  ACDINA Drug ID: D00610

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Steroid biosynthesis	2.04	1.59e-2	19/20 (95%)	DHCR7;NSDHL;TM7SF2;...
Insulin secretion	-1.74	4.79e-2	75/86 (87.21%)	KCNMB2;CACNA1D;ADCYAP1;...
Primary immunodeficiency	-1.76	4.37e-2	33/38 (86.84%)	CD40LG;DCLRE1C;CD8B;...
Thyroid hormone synthesis	-1.77	3.83e-2	66/75 (88%)	ATP1A1;TPO;TTF1;...
Antigen processing and presentation	-1.77	4.08e-2	60/78 (76.92%)	KIR2DL3;HSPA1L;HLA-A;...
NF-kappa B signaling pathway	-1.78	4.89e-2	90/104 (86.54%)	GADD45A;TNFSF11;LYN;...
Epithelial cell signaling in Helicobacter pylori infect...	-1.82	3.79e-2	62/70 (88.57%)	SRC;ATP6V1H;CXCR1;...
Regulation of lipolysis in adipocytes	-1.82	4.27e-2	52/55 (94.55%)	PIK3R1;PDE3B;ADRB3;...
Mineral absorption	-1.91	2.33e-2	48/60 (80%)	SLC30A1;ATP2B2;MT1M;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	0.01uM - 10uM	24H	Hide ▲

Cervix

Cervical adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HeLa	CVCL_0030	Homo sapiens	0.01uM - 10uM	24H	Hide ▲

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Pancreas

Pancreatic carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
YAPC	CVCL_1791	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	0.01uM - 10uM	24H	Show ▼