Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMWO5ZR)

Drug Name
Cediranib Drug Info
Synonyms
Recentin; AZD 2171; AZD2171; M6294; AZD-2171; ZD-2171; AZD2171, Recentin, Cediranib; Cediranib (USAN/INN); 4-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-6-methoxy-7-(3-pyrrolidin-1-ylpropoxy)quinazoline; 4-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-6-methoxy-7-[3-(pyrrolidin-1-yl)propoxy]quinazoline
Therapeutic ClassAnticancer Agents
Cross-matching ID
PubChem CID
9933475
ChEBI ID
CHEMBL94782
CAS Number
CAS 288383-20-0
TTD Drug ID
D09VMI
INTEDE Drug ID
DR1886

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Steroid biosynthesis 2.51 0.00e+0 19/20 (95%) MSMO1;SQLE;NSDHL;...
Oxidative phosphorylation 2.40 0.00e+0 93/133 (69.92%) ATP6V0E1;ATP6V0D1;NDUFA6;...
Lysosome 2.30 0.00e+0 115/128 (89.84%) NEU1;NPC2;GM2A;...
Terpenoid backbone biosynthesis 2.19 0.00e+0 18/22 (81.82%) IDI1;HMGCS1;HMGCR;...
Vibrio cholerae infection 2.05 1.80e-3 44/50 (88%) ATP6V0E1;ATP6V0D1;ATP6V0C;...
Glycosaminoglycan degradation 1.90 1.20e-2 19/19 (100%) HGSNAT;GNS;HPSE;...
Metabolism of xenobiotics by cytochrome P450 1.88 1.03e-2 49/77 (63.64%) AKR1C1;EPHX1;GSTA4;...
PPAR signaling pathway 1.85 1.13e-2 66/74 (89.19%) SCD;HMGCS1;FADS2;...
Steroid hormone biosynthesis 1.84 1.00e-2 43/61 (70.49%) AKR1C3;AKR1C2;AKR1C1;...
Glutathione metabolism 1.82 1.08e-2 43/57 (75.44%) IDH1;G6PD;GSTA4;...
Other glycan degradation 1.82 1.07e-2 13/18 (72.22%) NEU1;AGA;GLB1;...
Biosynthesis of unsaturated fatty acids 1.76 2.48e-2 21/27 (77.78%) SCD;FADS2;HACD1;...
Sphingolipid metabolism 1.75 2.78e-2 32/49 (65.31%) NEU1;DEGS1;PSAP;...
Non-alcoholic fatty liver disease 1.68 4.70e-2 126/155 (81.29%) LEPR;EIF2AK3;ADIPOQ;...
Collecting duct acid secretion 1.66 4.91e-2 22/27 (81.48%) ATP6V0E1;ATP6V0D1;ATP6V0C;...
Diabetic cardiomyopathy 1.65 4.88e-2 162/203 (79.8%) G6PD;NDUFA6;CD36;...
Amoebiasis -1.73 4.63e-2 99/102 (97.06%) CD1A;COL4A6;ACTN1;...
Small cell lung cancer -1.80 1.86e-2 90/92 (97.83%) LAMC1;ITGA2;PTK2;...
PI3K-Akt signaling pathway -1.82 1.79e-2 317/354 (89.55%) RELA;CREB3L2;IL7;...
Ribosome -1.84 2.24e-2 113/158 (71.52%) RPS28;RPL24;RPL35A;...
ECM-receptor interaction -1.91 7.45e-3 80/88 (90.91%) THBS2;ITGA6;LAMA4;...
Ribosome biogenesis in eukaryotes -1.95 5.59e-3 52/108 (48.15%) RCL1;GNL2;NHP2;...
RNA transport -2.10 0.00e+0 128/186 (68.82%) THOC7;SENP2;EIF4E;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 0.12uM - 10uM 6H, 24H, 48H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 6H, 24H, 48H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 6H, 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
1HAEo- CVCL_0128 Homo sapiens 10uM 24H
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
NL20 CVCL_0461 Homo sapiens 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 6H, 24H, 48H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H
Normal (Fibroblast)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HFL1 CVCL_4295 Homo sapiens 10uM 24H
IMR-90 CVCL_0347 Homo sapiens 10uM 24H
WI-38 CVCL_0579 Homo sapiens 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.04uM - 10uM 6H, 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.01uM - 10uM 24H