Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMWYE7A)

Drug Name
Protoporphyrin IX Drug Info
Synonyms
protoporphyrin IX; protoporphyrin; 553-12-8; Ooporphyrin; Protoporpyrin IX; Porphyrinogen IX; Protoporphyrin IX disodium; Kammerer's prophyrin; ppIX; Protoporphyrin IX (VAN); H2ppIX; Kammerer's porphyrin; MLS001074731; UNII-C2K325S808; NSC2632; NSC 2632; EINECS 209-033-7; 3,7,12,17-Tetramethyl-8,13-divinyl-2,18-porphinedipropionic acid; SMR000127405; 21H,23H-Porphine-2,18-dipropanoic acid, 7,12-diethenyl-3,8,13,17-tetramethyl-; CHEMBL267548; CHEBI:15430; C34H34N4O4
Cross-matching ID
PubChem CID
4971
ChEBI ID
CHEMBL15430
CAS Number
CAS 553-12-8
TTD Drug ID
D0AF3A
VARIDT Drug ID
DR01454

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Intestinal immune network for IgA production 2.24 0.00e+0 38/48 (79.17%) CD40;HLA-DPA1;HLA-DRA;...
Allograft rejection 1.92 2.30e-2 32/38 (84.21%) CD40;HLA-DPA1;HLA-DRA;...
Autoimmune thyroid disease 1.88 2.15e-2 46/53 (86.79%) CD40;HLA-DPA1;HLA-DRA;...
Viral protein interaction with cytokine and cytokine re... 1.86 1.84e-2 84/100 (84%) CXCL14;CXCL13;CCL17;...
Cell adhesion molecules 1.85 1.47e-2 118/148 (79.73%) CD40;VCAM1;HLA-DPA1;...
Proteasome 1.83 1.38e-2 44/46 (95.65%) PSMA3;PSMA5;PSMA6;...
Type I diabetes mellitus 1.75 3.55e-2 38/43 (88.37%) HLA-DPA1;HLA-DRA;HLA-DOB;...
Asthma 1.73 4.03e-2 25/31 (80.65%) CD40;HLA-DPA1;HLA-DRA;...
Pyrimidine metabolism 1.73 3.79e-2 40/56 (71.43%) NT5E;DCTPP1;UCK2;...
Staphylococcus aureus infection 1.70 4.51e-2 72/95 (75.79%) KRT14;HLA-DPA1;HLA-DRA;...
Galactose metabolism -1.79 4.87e-2 26/31 (83.87%) PGM1;B4GALT2;G6PC2;...
Biosynthesis of unsaturated fatty acids -1.89 2.53e-2 21/27 (77.78%) HACD2;SCD;HSD17B4;...
Steroid biosynthesis -1.93 1.62e-2 19/20 (95%) DHCR24;NSDHL;LSS;...
Insulin resistance -2.03 2.17e-2 96/108 (88.89%) PIK3CB;SLC27A2;AKT1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 1.11uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 1.11uM - 10uM 24H