Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMX34L7)

Drug Name
Proquazone Drug Info
Synonyms
PROQUAZONE; Arthrex; Biarison; 22760-18-5; Proquazonum [INN-Latin]; Sandoz 43-715; Proquazona [INN-Spanish]; UNII-42VPJ2980S; SaH 43-715; 7-Methyl-1-(1-methylethyl)-4-phenyl-2(1H)-quinazolinone; EINECS 245-203-7; BRN 0889725; RU 43715; 42VPJ2980S; Isopropyl-7-methyl-4-phenyl-2(1H)-quinazolinone; 1-Isopropyl-7-methyl-4-phenyl-2(1H)-quinazolinone; 2(1H)-Quinazolinone, 1-isopropyl-7-methyl-4-phenyl-; 2(1H)-Quinazolinone, 7-methyl-1-(1-methylethyl)-4-phenyl-; C18H18N2O; 7-methyl-1-(1-methylethyl)-4-phenylquinazolin-2(1H)-one
Cross-matching ID
PubChem CID
31508
ChEBI ID
CHEMBL268501
CAS Number
CAS 22760-18-5
TTD Drug ID
D0J6WW

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Graft-versus-host disease 1.91 1.06e-2 32/42 (76.19%) IL6;PRF1;HLA-DQA1;...
Ribosome 1.88 2.12e-2 113/158 (71.52%) RPS4Y1;RPS5;MRPL17;...
Th1 and Th2 cell differentiation 1.85 2.47e-2 80/92 (86.96%) FOS;PPP3CA;GATA3;...
Mineral absorption 1.83 2.91e-2 48/60 (80%) MT1F;MT1E;MT1X;...
Drug metabolism 1.81 3.39e-2 78/151 (51.66%) NAT1;HPRT1;ADH5;...
Staphylococcus aureus infection 1.80 3.35e-2 72/95 (75.79%) C3;HLA-DQA1;C2;...
Allograft rejection 1.79 3.17e-2 32/38 (84.21%) PRF1;HLA-DQA1;HLA-DRB1;...
Th17 cell differentiation 1.76 3.97e-2 95/107 (88.79%) IL1R1;FOS;PPP3CA;...
Inflammatory bowel disease 1.75 4.11e-2 58/65 (89.23%) IL6;GATA3;HLA-DQA1;...
Calcium signaling pathway -1.73 4.00e-2 213/240 (88.75%) CACNA1A;ADCY9;P2RX5;...
Salivary secretion -1.73 4.30e-2 76/93 (81.72%) CST2;KCNMA1;ADCY9;...
Thyroid hormone synthesis -1.79 2.66e-2 66/75 (88%) ATP1B4;PAX8;ADCY1;...
Glycerolipid metabolism -1.81 1.32e-2 44/61 (72.13%) LIPG;ALDH3A2;AGPAT4;...
Aldosterone synthesis and secretion -1.83 9.40e-3 85/98 (86.73%) ATP1B4;AGT;ADCY1;...
GnRH secretion -1.83 1.25e-2 60/64 (93.75%) CACNA1G;ITPR2;RAF1;...
Adrenergic signaling in cardiomyocytes -1.89 1.41e-2 130/150 (86.67%) CACNG2;ATP1B4;AGT;...
Cortisol synthesis and secretion -2.06 0.00e+0 58/65 (89.23%) CREB5;CYP11A1;CACNA1S;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SK-ES-1 CVCL_0627 Homo sapiens 1.11uM - 10uM 24H
Brain
Glioma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
GI-1 CVCL_1230 Homo sapiens 1.11uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MDA-MB-468 CVCL_0419 Homo sapiens 1.11uM - 10uM 24H
Breast ductal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
T-47D CVCL_0553 Homo sapiens 1.11uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SNU-407 CVCL_5004 Homo sapiens 1.11uM - 10uM 24H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 1.11uM - 10uM 24H
HEC-1-A CVCL_0293 Homo sapiens 1.11uM - 10uM 24H
HEC-251 CVCL_2928 Homo sapiens 1.11uM - 10uM 24H
HEC-265 CVCL_2929 Homo sapiens 1.11uM - 10uM 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CJM CVCL_U797 Homo sapiens 1.11uM - 10uM 24H
Liver
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHH-5 CVCL_1320 Homo sapiens 1.11uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1573 CVCL_1483 Homo sapiens 1.11uM - 10uM 24H
NCI-H838 CVCL_1594 Homo sapiens 1.11uM - 10uM 24H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BEN CVCL_1081 Homo sapiens 1.11uM - 10uM 24H
HCC95 CVCL_1276 Homo sapiens 1.11uM - 10uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H2110 CVCL_1529 Homo sapiens 1.11uM - 10uM 24H
Muscle
Rhabdomyosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-204 CVCL_0134 Homo sapiens 1.11uM - 10uM 24H
Ovary
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
OVTOKO CVCL_3114 Homo sapiens 1.11uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
22Rv1 CVCL_1045 Homo sapiens 1.11uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
IGR-37 CVCL_1303 Homo sapiens 1.11uM - 10uM 24H
Mel-HO CVCL_1402 Homo sapiens 1.11uM - 10uM 24H
SH-4 CVCL_1692 Homo sapiens 1.11uM - 10uM 24H
Urinary bladder
Bladder carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BC-3C CVCL_1079 Homo sapiens 1.11uM - 10uM 24H
Bladder transitional cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CAL-29 CVCL_1109 Homo sapiens 1.11uM - 10uM 24H