Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMXL3CD)

• Drug Name: NVP-ADW742 Drug Info
• Synonyms: NVP-ADW742; 475488-23-4; ADW-742; 475489-15-7; UNII-MXS2N5862L; ADW742; MXS2N5862L; CHEMBL399021; 5-(3-(Benzyloxy)phenyl)-7-((1r,3r)-3-(pyrrolidin-1-ylmethyl)-cyclobutyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine; 5-(3-(Benzyloxy)phenyl)-7-(cis-3-(pyrrolidin-1-ylmethyl)cyclobutyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine; C28H31N5O; 5-(3-Benzyloxyphenyl)-7-[trans-3-[(pyrrolidin-1-yl)methyl]cyclobutyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine
• Cross-matching ID:
  PubChem CID: 9825149
  ChEBI ID: CHEMBL1988370
  CAS Number: CAS 475488-23-4
  TTD Drug ID: D06NMZ

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Steroid biosynthesis	2.14	0.00e+0	19/20 (95%)	DHCR24;NSDHL;SQLE;...
Parkinson disease	-1.93	8.54e-3	176/249 (70.68%)	NDUFA9;COX5B;COX8A;...
Protein processing in endoplasmic reticulum	-1.94	8.00e-3	127/171 (74.27%)	SEC31A;GANAB;ATF4;...
Protein export	-1.99	3.56e-3	17/23 (73.91%)	SPCS1;SEC63;SRPRA;...
Oxidative phosphorylation	-2.07	0.00e+0	93/133 (69.92%)	COX6A1;ATP6V0A4;NDUFB1;...
Proteasome	-2.08	0.00e+0	44/46 (95.65%)	PSMA4;PSMD6;PSMC5;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Fibrocystic breast disease

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF-10A (Parent)	CVCL_0598	Homo sapiens	1.11uM - 10uM	3H, 6H, 12H, 24H	Hide ▲

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	1.11uM - 10uM	24H	Hide ▲

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	1.11uM - 3.33uM	24H	Show ▼