Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMYILBE)

Drug Name
Modafinil Drug Info
Synonyms Provigil; Modiodal
Therapeutic ClassNeurology Agents
Cross-matching ID
PubChem CID
4236
ChEBI ID
CHEMBL1373
CAS Number
CAS 68693-11-8
TTD Drug ID
D07HQC
VARIDT Drug ID
DR00411
INTEDE Drug ID
DR1104
ACDINA Drug ID
D00442

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Spliceosome 2.31 0.00e+0 101/150 (67.33%) HNRNPM;SRSF7;HSPA1A;...
DNA replication 2.12 0.00e+0 34/36 (94.44%) MCM7;FEN1;LIG1;...
Epstein-Barr virus infection 1.93 7.31e-3 189/202 (93.56%) CCND3;ISG15;GADD45B;...
Ubiquitin mediated proteolysis 1.90 5.48e-3 87/140 (62.14%) KEAP1;MAP3K1;DDB2;...
Hepatitis B 1.89 4.39e-3 151/162 (93.21%) SMAD3;NFATC3;IRF7;...
p53 signaling pathway 1.88 3.66e-3 63/73 (86.3%) CCND3;GADD45B;IGFBP3;...
Mismatch repair 1.87 4.70e-3 22/23 (95.65%) MSH6;LIG1;RFC5;...
Hepatitis C 1.83 8.23e-3 139/157 (88.54%) MX1;OAS3;IRF7;...
Fanconi anemia pathway 1.83 7.31e-3 36/54 (66.67%) RAD51C;REV1;FANCI;...
Colorectal cancer 1.80 9.87e-3 84/86 (97.67%) GADD45B;SMAD3;MSH6;...
Ribosome biogenesis in eukaryotes 1.78 1.20e-2 52/108 (48.15%) PWP2;HEATR1;POP7;...
Herpes simplex virus 1 infection 1.74 1.65e-2 165/498 (33.13%) OAS3;BST2;IRF7;...
Regulation of lipolysis in adipocytes 1.71 2.28e-2 52/55 (94.55%) MGLL;PIK3R1;FABP4;...
Chronic myeloid leukemia 1.70 2.12e-2 72/76 (94.74%) GADD45B;SMAD3;PIK3R1;...
Small cell lung cancer 1.69 2.27e-2 90/92 (97.83%) COL4A2;GADD45B;PIK3R1;...
Cell cycle 1.67 3.09e-2 110/124 (88.71%) CCND3;GADD45B;SMAD3;...
Focal adhesion 1.66 3.23e-2 180/201 (89.55%) CCND3;COL4A2;FLNA;...
Measles 1.65 3.60e-2 133/139 (95.68%) CCND3;MX1;OAS3;...
Cellular senescence 1.65 3.46e-2 139/156 (89.1%) CCND3;GADD45B;SMAD3;...
Proteoglycans in cancer 1.65 3.29e-2 172/205 (83.9%) FLNA;ESR1;CAV1;...
RIG-I-like receptor signaling pathway 1.64 3.60e-2 64/70 (91.43%) ISG15;IRF7;MAP3K1;...
Pancreatic cancer 1.60 4.94e-2 75/76 (98.68%) GADD45B;SMAD3;STAT1;...
Ferroptosis -1.65 4.70e-2 36/41 (87.8%) FTL;ATG5;CYBB;...
Phagosome -1.67 3.86e-2 118/152 (77.63%) ATP6V1G1;SEC61A2;ATP6V1H;...
Neuroactive ligand-receptor interaction -1.68 3.94e-2 294/341 (86.22%) PLG;CYSLTR1;SSTR3;...
Nitrogen metabolism -1.68 4.19e-2 16/17 (94.12%) CA12;CPS1;CA6;...
Collecting duct acid secretion -1.69 4.16e-2 22/27 (81.48%) ATP6V0A1;SLC12A7;ATP6V1G1;...
Oxidative phosphorylation -1.70 4.21e-2 93/133 (69.92%) COX7C;SDHC;COX6B1;...
Epithelial cell signaling in Helicobacter pylori infect... -1.71 4.47e-2 62/70 (88.57%) CXCL2;ADAM10;ATP6V0A1;...
Folate biosynthesis -1.71 4.80e-2 23/26 (88.46%) ALPL;GPHN;ALPP;...
Pentose and glucuronate interconversions -1.74 3.79e-2 17/34 (50%) UGT2B17;UGDH;RPE;...
Complement and coagulation cascades -1.74 4.27e-2 76/85 (89.41%) PROS1;PROCR;CR2;...
Lysosome -1.81 2.93e-2 115/128 (89.84%) CTNS;ACP5;IGF2R;...
Hematopoietic cell lineage -1.91 4.57e-3 90/99 (90.91%) CR2;CD7;CD3E;...
Viral protein interaction with cytokine and cytokine re... -1.94 3.05e-3 84/100 (84%) CXCL2;TNFRSF14;CSF1;...
Steroid biosynthesis -1.96 4.57e-3 19/20 (95%) FDFT1;CYP51A1;DHCR24;...
Rheumatoid arthritis -2.11 0.00e+0 78/93 (83.87%) CD28;TLR4;CTSK;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H