Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMYNPK8)

Drug Name
Hexylcarbamoyl fluorouracil Drug Info
Synonyms Carmofur; HCFU; Yamaful; 1-hexylcarbamoyl-5-fluorouracil
Cross-matching ID
PubChem CID
2577
ChEBI ID
CHEMBL460499
CAS Number
CAS 61422-45-5
TTD Drug ID
D00IKH

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
p53 signaling pathway 1.92 2.49e-2 63/73 (86.3%) CCNB1;CDKN1A;GADD45A;...
Steroid biosynthesis -2.07 5.67e-3 19/20 (95%) SQLE;EBP;CYP51A1;...
Protein processing in endoplasmic reticulum -2.27 0.00e+0 127/171 (74.27%) HSPA6;SKP1;DNAJC10;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H