Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMYQUIP)

Drug Name
PAC1 Drug Info
Synonyms PAC-1
Cross-matching ID
PubChem CID
135421197
ChEBI ID
CHEMBL591429
CAS Number
CAS 315183-21-2
TTD Drug ID
D01YIF

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Glycolysis / Gluconeogenesis 2.41 0.00e+0 56/67 (83.58%) ENO2;ALDOC;HK2;...
Fructose and mannose metabolism 2.40 0.00e+0 30/33 (90.91%) ALDOC;HK2;PFKFB3;...
HIF-1 signaling pathway 2.34 0.00e+0 105/109 (96.33%) ENO2;SLC2A1;ALDOC;...
Mitophagy 2.21 0.00e+0 56/68 (82.35%) BNIP3;BNIP3L;JUN;...
Central carbon metabolism in cancer 2.10 0.00e+0 67/70 (95.71%) SLC2A1;HK2;PFKP;...
Pentose phosphate pathway 2.07 0.00e+0 25/30 (83.33%) ALDOC;PFKP;GPI;...
Starch and sucrose metabolism 2.06 0.00e+0 25/36 (69.44%) HK2;GBE1;GPI;...
Galactose metabolism 1.96 4.84e-3 26/31 (83.87%) HK2;PFKP;PGM1;...
Renal cell carcinoma 1.95 4.30e-3 68/69 (98.55%) SLC2A1;VEGFA;EGLN3;...
Nitrogen metabolism 1.92 6.45e-3 16/17 (94.12%) CA9;CA12;CA2;...
Glucagon signaling pathway 1.91 5.86e-3 89/107 (83.18%) SLC2A1;PFKP;PKM;...
Type II diabetes mellitus 1.90 6.45e-3 42/46 (91.3%) HK2;PKM;HK1;...
PI3K-Akt signaling pathway 1.85 9.92e-3 317/354 (89.55%) DDIT4;VEGFA;GYS1;...
Focal adhesion 1.83 2.12e-2 180/201 (89.55%) VEGFA;JUN;COL4A5;...
Small cell lung cancer 1.81 1.98e-2 90/92 (97.83%) PTGS2;CDKN1A;COL4A5;...
Shigellosis 1.81 1.85e-2 180/246 (73.17%) BNIP3;HK2;TNIP1;...
Neomycin, kanamycin and gentamicin biosynthesis 1.81 1.97e-2 5/5 (100%) HK2;HK1
C-type lectin receptor signaling pathway 1.80 2.29e-2 93/104 (89.42%) PTGS2;JUN;ITPR3;...
Fluid shear stress and atherosclerosis 1.79 2.24e-2 123/139 (88.49%) VEGFA;JUN;GSTP1;...
Relaxin signaling pathway 1.76 3.29e-2 114/129 (88.37%) VEGFA;JUN;COL4A5;...
Insulin signaling pathway 1.75 3.38e-2 121/137 (88.32%) HK2;GYS1;HK1;...
Autophagy 1.75 3.23e-2 113/169 (66.86%) BNIP3;DDIT4;MAP2K1;...
MicroRNAs in cancer 1.71 3.98e-2 146/310 (47.1%) DDIT4;VEGFA;PTGS2;...
Oxytocin signaling pathway 1.71 4.03e-2 128/154 (83.12%) PTGS2;JUN;CDKN1A;...
TNF signaling pathway 1.71 4.18e-2 103/112 (91.96%) PTGS2;JUN;MAP2K1;...
Steroid hormone biosynthesis -1.63 3.48e-2 43/61 (70.49%) HSD17B12;COMT;CYP1A1;...
Citrate cycle (TCA cycle) -1.63 3.52e-2 30/30 (100%) PDHA1;IDH3A;SUCLG1;...
Systemic lupus erythematosus -1.65 3.40e-2 45/135 (33.33%) SNRPD1;C5;HLA-DRA;...
Synthesis and degradation of ketone bodies -1.65 3.50e-2 9/10 (90%) ACAT1;ACAT2;HMGCS1
Complement and coagulation cascades -1.69 2.75e-2 76/85 (89.41%) KLKB1;C2;C8G;...
Basal transcription factors -1.71 2.49e-2 37/45 (82.22%) TAF6;MNAT1;GTF2E1;...
RNA transport -1.89 4.31e-3 128/186 (68.82%) RAN;NUP107;EIF4E;...
Progesterone-mediated oocyte maturation -1.90 3.02e-3 75/100 (75%) ADCY3;ANAPC2;GNAI3;...
Terpenoid backbone biosynthesis -1.95 1.21e-3 18/22 (81.82%) PDSS1;ACAT1;FDPS;...
Ribosome biogenesis in eukaryotes -1.98 1.51e-3 52/108 (48.15%) RAN;GNL2;CSNK2A2;...
Proteasome -2.23 0.00e+0 44/46 (95.65%) PSMA3;PSMD7;PSMB10;...
Steroid biosynthesis -2.37 0.00e+0 19/20 (95%) HSD17B7;SC5D;LBR;...
Spliceosome -2.37 0.00e+0 101/150 (67.33%) PRPF3;DDX5;RBMXL2;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-673 CVCL_0080 Homo sapiens 10uM 6H
SK-ES-1 CVCL_0627 Homo sapiens 1.11uM - 10uM 24H
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Brain
Glioma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
GI-1 CVCL_1230 Homo sapiens 1.11uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
MDA-MB-468 CVCL_0419 Homo sapiens 1.11uM - 10uM 24H
Breast ductal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
T-47D CVCL_0553 Homo sapiens 1.11uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CL-34 CVCL_1123 Homo sapiens 10uM 6H
HT-29 CVCL_0320 Homo sapiens 10uM 6H, 24H
LoVo CVCL_0399 Homo sapiens 10uM 6H
MDST8 CVCL_1400 Homo sapiens 10uM 6H
NCI-H508 CVCL_1561 Homo sapiens 10uM 6H
SNU-1040 CVCL_5001 Homo sapiens 10uM 6H
SNU-407 CVCL_5004 Homo sapiens 1.11uM - 10uM 24H
SNU-C4 CVCL_5008 Homo sapiens 10uM 6H
SNU-C5 CVCL_5009 Homo sapiens 10uM 6H
SW480 CVCL_0546 Homo sapiens 10uM 6H
SW620 CVCL_0547 Homo sapiens 10uM 6H
SW948 CVCL_0550 Homo sapiens 10uM 6H
Colorectal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCT 116 CVCL_0291 Homo sapiens 10uM 6H
HT115 CVCL_1294 Homo sapiens 10uM 6H
RKO CVCL_0504 Homo sapiens 10uM 6H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 1.11uM - 10uM 6H, 24H
HEC-1-A CVCL_0293 Homo sapiens 1.11uM - 10uM 24H
HEC-251 CVCL_2928 Homo sapiens 1.11uM - 10uM 24H
HEC-265 CVCL_2929 Homo sapiens 1.11uM - 10uM 24H
SNG-M CVCL_1707 Homo sapiens 10uM 6H
Endometrial carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHUEM-2 CVCL_1327 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CJM CVCL_U797 Homo sapiens 1.11uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHH-5 CVCL_1320 Homo sapiens 1.11uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
DV-90 CVCL_1184 Homo sapiens 10uM 6H
NCI-H1573 CVCL_1483 Homo sapiens 1.11uM - 10uM 24H
NCI-H838 CVCL_1594 Homo sapiens 1.11uM - 10uM 24H
SK-LU-1 CVCL_0624 Homo sapiens 10uM 6H
Lung adenosquamous carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H596 CVCL_1571 Homo sapiens 10uM 6H
Lung large cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COR-L23 CVCL_1133 Homo sapiens 10uM 6H
T3M-10 CVCL_1729 Homo sapiens 10uM 6H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BEN CVCL_1081 Homo sapiens 1.11uM - 10uM 24H
HCC15 CVCL_1253 Homo sapiens 10uM 6H
HCC95 CVCL_1276 Homo sapiens 1.11uM - 10uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1299 CVCL_0060 Homo sapiens 10uM 6H
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
NCI-H2073 CVCL_1523 Homo sapiens 10uM 6H
NCI-H2110 CVCL_1529 Homo sapiens 1.11uM - 10uM 24H
Small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1694 CVCL_1495 Homo sapiens 10uM 6H
NCI-H1836 CVCL_1502 Homo sapiens 10uM 6H
Lymph node
Diffuse large B-cell lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
WSU-DLCL2 CVCL_1787 Homo sapiens 10uM 6H
Muscle
Rhabdomyosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-204 CVCL_0134 Homo sapiens 1.11uM - 10uM 24H
Ovary
Ovarian carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
EFO-27 CVCL_1194 Homo sapiens 10uM 6H
OV7 CVCL_1623 Homo sapiens 10uM 6H
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
OVTOKO CVCL_3114 Homo sapiens 1.11uM - 10uM 24H
RMG-I CVCL_1663 Homo sapiens 10uM 6H
Ovarian mucinous cystadenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COV644 CVCL_2011 Homo sapiens 10uM 6H
RMUG-S CVCL_1666 Homo sapiens 10uM 6H
Ovarian undifferentiated carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
TYK-nu CVCL_1774 Homo sapiens 10uM 6H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 10uM 6H
Acute myeloid leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NOMO-1 CVCL_1609 Homo sapiens 10uM 6H
PL-21 CVCL_2161 Homo sapiens 10uM 6H
SKM-1 CVCL_0010 Homo sapiens 10uM 6H
Pleural effusion
Histiocytic lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-937 CVCL_0007 Homo sapiens 10uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
22Rv1 CVCL_1045 Homo sapiens 1.11uM - 10uM 24H
PC-3 CVCL_0035 Homo sapiens 1.11uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 1.11uM - 10uM 6H, 24H
IGR-37 CVCL_1303 Homo sapiens 1.11uM - 3.33uM 24H
Mel-HO CVCL_1402 Homo sapiens 1.11uM - 10uM 24H
SH-4 CVCL_1692 Homo sapiens 1.11uM - 10uM 24H
SK-MEL-1 CVCL_0523 Homo sapiens 10uM 6H
SK-MEL-28 CVCL_0526 Homo sapiens 10uM 6H
Stomach
Gastric adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
AGS CVCL_0139 Homo sapiens 10uM 6H
Urinary bladder
Bladder carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BC-3C CVCL_1079 Homo sapiens 1.11uM - 10uM 24H
Bladder transitional cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CAL-29 CVCL_1109 Homo sapiens 1.11uM - 10uM 24H