Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMYUQJ8)

Drug Name
ONX-0914 Drug Info
Synonyms PR-957; Immunoproteasome inhibitors (hematological cancer/autoimmune disease), Proteolix Inc/ Onyx Pharmaceuticals Inc
Cross-matching ID
PubChem CID
23642227
ChEBI ID
CHEMBL3237875
CAS Number
CAS 960374-59-8
TTD Drug ID
D0Q4MO

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Spliceosome 2.40 0.00e+0 101/150 (67.33%) HSPA1A;HSPA8;HSPA6;...
Protein processing in endoplasmic reticulum 2.38 0.00e+0 127/171 (74.27%) HERPUD1;HSPA1A;HSPA8;...
Antigen processing and presentation 2.27 0.00e+0 60/78 (76.92%) HSPA1A;HSPA8;HSPA6;...
Phagosome 1.97 4.33e-3 118/152 (77.63%) TUBB2A;TLR4;SFTPA2;...
Ferroptosis 1.89 5.19e-3 36/41 (87.8%) HMOX1;FTH1;SAT1;...
PPAR signaling pathway 1.87 4.33e-3 66/74 (89.19%) SCD;HMGCS1;OLR1;...
Steroid biosynthesis 1.81 1.73e-2 19/20 (95%) SC5D;DHCR24;SQLE;...
RNA transport 1.80 1.51e-2 128/186 (68.82%) FXR1;FUS;NXF1;...
Mineral absorption 1.77 1.83e-2 48/60 (80%) HMOX1;MT1M;FTH1;...
Glyoxylate and dicarboxylate metabolism 1.73 2.42e-2 23/30 (76.67%) GLUL;ACAT2;PCCB;...
Coronavirus disease 1.70 4.17e-2 215/232 (92.67%) CFB;C5AR1;TLR4;...
Measles 1.69 4.18e-2 133/139 (95.68%) HSPA1A;HSPA8;HSPA6;...
Biosynthesis of unsaturated fatty acids 1.66 4.95e-2 21/27 (77.78%) SCD;FADS1;ACAA1;...
Legionellosis 1.65 4.67e-2 51/57 (89.47%) HSPA1A;HSPA8;HSPA6;...
Hypertrophic cardiomyopathy -1.79 4.85e-2 81/90 (90%) CACNG4;AGT;PRKAB2;...
Glycosylphosphatidylinositol (GPI)-anchor biosynthesis -1.84 3.99e-2 20/26 (76.92%) PIGL;PIGC;PIGB;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 1.11uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 1.11uM - 10uM 24H