Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMZ2LGD)

Drug Name
Pramoxine Drug Info
Synonyms
Pramoxine hydrochloride; 637-58-1; Pramoxine HCl; Pramocaine hydrochloride; Prax Lotion; Tronolane; Tronothane hydrochloride; ProctoFoam-NS; Pramocaine (hydrochloride); UNII-88AYB867L5; HSDB 7220; EINECS 211-293-1; NSC 25573; Pramoxine hydrochloride [USP]; MLS000028604; Morpholine, 4-[3-(4-butoxyphenoxy)propyl]-, hydrochloride; 88AYB867L5; 4-(3-(p-Butoxyphenoxy)propyl)morpholine hydrochloride; p-Butoxyphenyl gamma-morpholinopropyl ether hydrochloride; gamma-Morpholinopropyl 4-n-butoxyphenyl ether hydrochloride; SMR000058670
Cross-matching ID
PubChem CID
4886
ChEBI ID
CHEMBL1198
CAS Number
CAS 140-65-8
TTD Drug ID
D0V4UF

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Protein digestion and absorption 1.96 1.06e-2 78/103 (75.73%) COL4A5;COL9A3;COL15A1;...
Adherens junction 1.96 5.31e-3 63/71 (88.73%) CDH1;PTPRF;YES1;...
ECM-receptor interaction 1.90 1.42e-2 80/88 (90.91%) TNC;COL4A5;COL9A3;...
Notch signaling pathway 1.83 3.98e-2 49/59 (83.05%) APH1A;NOTCH2;DTX4;...
Complement and coagulation cascades -1.85 3.76e-2 76/85 (89.41%) C4BPA;F9;PROS1;...
Ribosome -2.15 9.39e-3 113/158 (71.52%) RPL19;RPL27A;RPL27;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 6.66uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H