Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMZA45C)

Drug Name
BX-912 Drug Info
Synonyms BX 912; BX912
Cross-matching ID
PubChem CID
11754511
ChEBI ID
CHEMBL3916849
CAS Number
CAS 702674-56-4
TTD Drug ID
D0IX7Y

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
ECM-receptor interaction 2.39 0.00e+0 80/88 (90.91%) FN1;LAMB1;SPP1;...
Amoebiasis 2.00 6.45e-3 99/102 (97.06%) PLCB1;TGFB1;CXCL8;...
Leishmaniasis 1.98 4.30e-3 67/77 (87.01%) TGFB1;NFKBIA;MARCKSL1;...
Hematopoietic cell lineage 1.88 1.29e-2 90/99 (90.91%) IL7R;ITGAM;IL4R;...
IL-17 signaling pathway 1.88 1.03e-2 84/94 (89.36%) S100A8;MMP9;CCL20;...
Th1 and Th2 cell differentiation 1.83 1.50e-2 80/92 (86.96%) JAG1;NFKBIA;IL4R;...
Relaxin signaling pathway 1.82 1.29e-2 114/129 (88.37%) MMP9;PLCB1;TGFB1;...
Protein digestion and absorption 1.82 1.29e-2 78/103 (75.73%) COL15A1;CPB1;COL1A1;...
Tuberculosis 1.81 1.58e-2 159/180 (88.33%) TGFB1;ITGAM;CALML5;...
AGE-RAGE signaling pathway in diabetic complications 1.80 1.42e-2 97/100 (97%) PLCB1;TGFB1;CXCL8;...
Bladder cancer 1.80 1.29e-2 40/41 (97.56%) MMP9;CXCL8;VEGFA;...
Hepatitis B 1.80 1.29e-2 151/162 (93.21%) MMP9;TGFB1;NFKBIA;...
Toxoplasmosis 1.79 1.39e-2 103/112 (91.96%) TGFB1;BIRC3;NFKBIA;...
Chemokine signaling pathway 1.79 1.47e-2 163/192 (84.9%) CCL20;PLCB1;NFKBIA;...
Chagas disease 1.77 1.89e-2 93/102 (91.18%) PLCB1;TGFB1;NFKBIA;...
Focal adhesion 1.76 1.77e-2 180/201 (89.55%) BIRC3;FN1;LAMB1;...
TNF signaling pathway 1.76 1.75e-2 103/112 (91.96%) MMP9;CCL20;JAG1;...
Salivary secretion 1.75 1.86e-2 76/93 (81.72%) LYZ;PLCB1;GUCY1A1;...
Small cell lung cancer 1.73 2.17e-2 90/92 (97.83%) BIRC3;NFKBIA;FN1;...
PD-L1 expression and PD-1 checkpoint pathway in cancer 1.70 3.10e-2 79/89 (88.76%) NFKBIA;PPP3CA;IFNGR1;...
Human T-cell leukemia virus 1 infection 1.70 3.13e-2 197/219 (89.95%) MMP7;TGFB1;NFKBIA;...
Th17 cell differentiation 1.69 3.40e-2 95/107 (88.79%) TGFB1;NFKBIA;IL4R;...
Cytokine-cytokine receptor interaction 1.69 3.25e-2 246/295 (83.39%) CCL20;TGFB1;IL7R;...
Staphylococcus aureus infection 1.68 3.28e-2 72/95 (75.79%) KRT14;ITGAM;KRT23;...
Viral protein interaction with cytokine and cytokine re... 1.68 3.15e-2 84/100 (84%) CCL20;CXCL8;CX3CL1;...
Human papillomavirus infection 1.68 3.03e-2 284/331 (85.8%) JAG1;FN1;PTGS2;...
Ribosome biogenesis in eukaryotes 1.67 2.96e-2 52/108 (48.15%) NXT1;DKC1;GTPBP4;...
PI3K-Akt signaling pathway 1.67 2.86e-2 317/354 (89.55%) AREG;DDIT4;NTRK2;...
Toll-like receptor signaling pathway 1.65 3.60e-2 94/104 (90.38%) NFKBIA;CXCL8;CCL5;...
Malaria 1.65 3.74e-2 44/50 (88%) SDC2;TGFB1;CXCL8;...
Peroxisome -1.81 2.82e-2 72/82 (87.8%) DAO;SLC27A2;ACOT8;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.04uM - 10uM 3H, 6H, 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.04uM - 10uM 3H, 6H, 24H
SK-BR-3 CVCL_0033 Homo sapiens 0.04uM - 10uM 3H, 6H, 24H
Breast carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BT-20 CVCL_0178 Homo sapiens 0.04uM - 10uM 3H, 6H, 24H
Hs 578T CVCL_0332 Homo sapiens 0.04uM - 10uM 3H, 6H, 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.04uM - 10uM 3H, 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.04uM - 10uM 6H, 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.04uM - 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.04uM - 10uM 6H, 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.04uM - 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 0.04uM - 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.04uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 0.37uM - 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.04uM - 10uM 6H, 24H