Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMZHB37)

Drug Name
GSK2110183 Drug Info
Cross-matching ID
PubChem CID
46843057
ChEBI ID
CHEMBL2219422
CAS Number
CAS 1047644-62-1
TTD Drug ID
D02NXM

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Epithelial cell signaling in Helicobacter pylori infect... -1.62 4.18e-2 62/70 (88.57%) PLCG1;TJP1;MAPK10;...
Glycolysis / Gluconeogenesis -1.63 4.21e-2 56/67 (83.58%) G6PC3;ALDOC;ENO1;...
Protein processing in endoplasmic reticulum -1.63 4.35e-2 127/171 (74.27%) DNAJC10;RAD23A;DNAJC1;...
Tryptophan metabolism -1.65 4.09e-2 35/42 (83.33%) KYNU;TPH1;AOC1;...
Phenylalanine metabolism -1.69 2.59e-2 14/17 (82.35%) GOT1;PAH;HPD;...
Arginine and proline metabolism -1.69 2.74e-2 39/50 (78%) AOC1;SMOX;MAOB;...
Primary bile acid biosynthesis -1.70 2.47e-2 15/17 (88.24%) CYP27A1;CYP39A1;CH25H;...
Thiamine metabolism -1.71 2.48e-2 12/15 (80%) TPK1;ACP1;AK1;...
Glycine, serine and threonine metabolism -1.72 2.48e-2 31/40 (77.5%) MAOB;ALAS2;SRR;...
IL-17 signaling pathway -1.72 2.49e-2 84/94 (89.36%) CCL20;TRAF4;MAPK10;...
Mineral absorption -1.82 1.02e-2 48/60 (80%) MT1HL1;ATOX1;MT1H;...
Pathways of neurodegeneration -1.84 8.01e-3 354/475 (74.53%) ATP5PF;SLC25A4;NDUFA4L2;...
Bile secretion -1.84 7.65e-3 68/90 (75.56%) SLCO1B3;ABCB1;SLC9A1;...
Ferroptosis -1.85 7.21e-3 36/41 (87.8%) TP53;GSS;ALOX15;...
Amyotrophic lateral sclerosis -1.88 5.34e-3 267/364 (73.35%) MAPK11;NDUFA3;DAXX;...
Spliceosome -1.91 4.51e-3 101/150 (67.33%) SNRNP70;SF3B2;FUS;...
Protein export -1.92 5.15e-3 17/23 (73.91%) SEC61A1;SEC61G;SRPRA;...
Prion disease -2.06 2.00e-3 209/273 (76.56%) VDAC3;KIF5C;PPP3CC;...
Huntington disease -2.19 0.00e+0 233/306 (76.14%) ATP5PF;SLC25A4;NDUFA4L2;...
Oxidative phosphorylation -2.21 0.00e+0 93/133 (69.92%) PPA2;NDUFB6;PPA1;...
Ribosome -2.26 0.00e+0 113/158 (71.52%) MRPL34;RPL37A;RPS4X;...
Parkinson disease -2.50 0.00e+0 176/249 (70.68%) ATP5PF;SLC25A4;NDUFA4L2;...
Proteasome -2.51 0.00e+0 44/46 (95.65%) POMP;PSMD8;PSMD4;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone marrow
Chronic myeloid leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
K-562 CVCL_0004 Homo sapiens 0.01uM - 10uM 4H, 24H
Multiple myeloma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
KMS-34 CVCL_1333 Homo sapiens 0.01uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 6H, 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 6H, 24H
Lymph node
Burkitt lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BJAB CVCL_5711 Homo sapiens 0.01uM - 10uM 4H
Diffuse large B-cell lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HBL-1 CVCL_4213 Homo sapiens 0.01uM - 10uM 4H, 24H
OCI-Ly10 CVCL_8795 Homo sapiens 0.01uM - 10uM 24H
OCI-Ly19 CVCL_8797 Homo sapiens 0.01uM - 10uM 4H, 24H
OCI-Ly3 CVCL_8796 Homo sapiens 0.01uM - 10uM 4H, 24H
TMD8 CVCL_A440 Homo sapiens 0.01uM - 10uM 4H, 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 6H, 24H
Peripheral blood
Acute B-lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NALM-6 CVCL_0092 Homo sapiens 0.01uM - 10uM 24H
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 4H, 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 6H, 24H
SK-MEL-5 CVCL_0527 Homo sapiens 0.01uM - 10uM 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.04uM - 10uM 24H