Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMZIHKY)

Drug Name
XMD8-92 Drug Info
Synonyms XMD 8-92
Cross-matching ID
PubChem CID
46843772
ChEBI ID
CHEMBL60325
CAS Number
CAS 1234480-50-2
TTD Drug ID
D0M0QQ

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Oxidative phosphorylation 2.11 0.00e+0 93/133 (69.92%) ATP6V0D1;ATP6V1D;ATP6V1A;...
Collecting duct acid secretion 1.91 1.74e-2 22/27 (81.48%) CA2;ATP6V0D1;ATP6V1D;...
Vibrio cholerae infection 1.89 1.94e-2 44/50 (88%) ATP6V0D1;ATP6V1D;ATP6V1A;...
Pyruvate metabolism 1.88 1.45e-2 41/47 (87.23%) DLD;PCK1;GLO1;...
Prion disease 1.86 1.40e-2 209/273 (76.56%) CAV2;MAPK1;SLC25A4;...
Fatty acid elongation 1.82 2.13e-2 19/27 (70.37%) ELOVL5;ACOT7;HACD3;...
Huntington disease 1.80 3.32e-2 233/306 (76.14%) RCOR1;SLC25A4;PSMD6;...
Propanoate metabolism 1.80 2.91e-2 30/34 (88.24%) DLD;PCCB;ABAT;...
Endocytosis 1.76 3.49e-2 198/252 (78.57%) DNAJC6;CAV2;RAB11FIP1;...
Synaptic vesicle cycle 1.75 3.84e-2 63/78 (80.77%) ATP6V0D1;ATP6V1D;STXBP1;...
Allograft rejection -1.67 4.67e-2 32/38 (84.21%) HLA-DRB1;CD40LG;HLA-A;...
NF-kappa B signaling pathway -1.73 3.54e-2 90/104 (86.54%) CARD10;GADD45A;TAB1;...
Graft-versus-host disease -1.73 3.84e-2 32/42 (76.19%) KIR3DL1;HLA-DRB1;KLRD1;...
Complement and coagulation cascades -1.75 3.69e-2 76/85 (89.41%) F8;PROS1;SERPING1;...
Cytokine-cytokine receptor interaction -1.75 4.21e-2 246/295 (83.39%) CXCR6;CXCL12;TNFRSF9;...
IL-17 signaling pathway -1.78 3.51e-2 84/94 (89.36%) IL17RC;PTGS2;IKBKB;...
Primary immunodeficiency -1.91 6.74e-3 33/38 (86.84%) IGLL1;TAP1;ICOS;...
Ferroptosis -1.91 8.42e-3 36/41 (87.8%) CYBB;PRNP;SLC39A14;...
Viral protein interaction with cytokine and cytokine re... -2.03 2.81e-3 84/100 (84%) CCL4;TNFRSF14;CCL5;...
ECM-receptor interaction -2.04 0.00e+0 80/88 (90.91%) COL9A2;LAMB2;COL4A1;...
Staphylococcus aureus infection -2.14 0.00e+0 72/95 (75.79%) SELP;C1QB;HLA-DRB1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone marrow
Neuroblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SH-SY5Y CVCL_0019 Homo sapiens 0.04uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.04uM - 10uM 6H, 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.08uM - 10uM 6H, 24H
SK-BR-3 CVCL_0033 Homo sapiens 0.08uM - 10uM 6H, 24H
Breast carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BT-20 CVCL_0178 Homo sapiens 0.08uM - 10uM 6H, 24H
Hs 578T CVCL_0332 Homo sapiens 0.08uM - 10uM 6H, 24H
Normal (Epithelial)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HME1 CVCL_2950 Homo sapiens 0.04uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.04uM - 10uM 6H, 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.04uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.04uM - 10uM 6H, 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 0.04uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.04uM - 10uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.04uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.04uM - 10uM 6H, 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.04uM - 10uM 6H, 24H
A549/Asc-1 CVCL_YA87 Homo sapiens 0.04uM - 10uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 0.04uM - 10uM 6H, 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.04uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.04uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.04uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.04uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.04uM - 10uM 6H, 24H
SK-L CVCL_1699 Homo sapiens 0.04uM - 10uM 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.04uM - 10uM 24H