Details of the Drug

General Information of Drug (ID: DMZIHKY)

Drug Name
XMD8-92
Synonyms XMD 8-92
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Drug Type
Small molecular drug
Structure
3D MOL is unavailable 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 474.6
Logarithm of the Partition Coefficient (xlogp) 3.5
Rotatable Bond Count (rotbonds) 5
Hydrogen Bond Donor Count (hbonddonor) 2
Hydrogen Bond Acceptor Count (hbondacc) 8
Chemical Identifiers
Formula
C26H30N6O3
IUPAC Name
2-[2-ethoxy-4-(4-hydroxypiperidin-1-yl)anilino]-5,11-dimethylpyrimido[4,5-b][1,4]benzodiazepin-6-one
Canonical SMILES
CCOC1=C(C=CC(=C1)N2CCC(CC2)O)NC3=NC=C4C(=N3)N(C5=CC=CC=C5C(=O)N4C)C
InChI
InChI=1S/C26H30N6O3/c1-4-35-23-15-17(32-13-11-18(33)12-14-32)9-10-20(23)28-26-27-16-22-24(29-26)30(2)21-8-6-5-7-19(21)25(34)31(22)3/h5-10,15-16,18,33H,4,11-14H2,1-3H3,(H,27,28,29)
InChIKey
QAPAJIZPZGWAND-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
46843772
ChEBI ID
CHEBI:60325
CAS Number
1234480-50-2
TTD ID
D0M0QQ
Combinatorial Drugs (CBD) Click to Jump to the Detailed CBD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Doublecortin-like kinase 2 (DCLK2) TTHK3MO DCLK2_HUMAN Inhibitor [1]
Extracellular signal-regulated kinase 5 (ERK5) TTU6FSC MK07_HUMAN Inhibitor [1]
Non-receptor tyrosine-protein kinase TNK1 (TNK1) TTWS7I3 TNK1_HUMAN Inhibitor [1]
Polo-like kinase 4 (PLK4) TTGPNZQ PLK4_HUMAN Inhibitor [1]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 28 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RPMI-3460/CS1 GDSC1 4.04 6.1277 2.4629 4.5717
EW-11 GDSC1 2.5652 4.8674 1.8541 14.6308
TC-71 GDSC1 2.8497 5.303 1.9148 12.9183
H-EMC-SS GDSC1 2.9299 6.7296 1.2813 17.308
ES5 GDSC1 3.1813 5.7288 1.9994 10.9343
SJSA-1 GDSC1 3.2182 6.1795 1.8058 12.2903
HuO9 GDSC1 3.275 6.0075 1.9398 11.0457
CHSA0011 GDSC1 3.305 5.68 2.1288 9.4632
EW-22 GDSC1 3.3493 4.9972 2.507 6.3287
CHSA0108 GDSC1 3.3807 6.5409 1.7612 12.032
MHH-ES-1 GDSC1 3.4293 5.3821 2.3799 7.0482
ES1 GDSC1 3.6607 5.6336 2.4348 5.8604
EW-24 GDSC1 3.776 7.5122 1.5921 11.9374
A-673 GDSC1 3.8402 6.8024 1.9925 8.7207
NOS-1 [Human HNSCC] GDSC1 3.8572 6.736 2.0378 8.3222
ES8 GDSC1 3.912 8.1133 1.3985 12.8966
CHSA8926 GDSC1 4.0004 6.5551 2.2299 6.4355
ES4 GDSC1 4.0208 6.3901 2.324 5.6662
U2OS GDSC1 4.0237 6.8141 2.1205 7.1985
ES7 GDSC1 4.0878 6.6313 2.2538 6.0134
NY GDSC1 4.0938 10.5949 0.307 19.2656
CAL-78 GDSC1 4.2149 8.4704 1.4487 11.5931
SK-PN-DW GDSC1 4.5721 6.7872 2.4869 3.2017
CADO-ES1 GDSC1 4.6065 10.2647 0.8542 14.4113
EW-7 GDSC1 5.218 7.0266 2.7113 0.9796
EW-16 GDSC1 5.3376 10.3279 1.3225 9.4454
ES6 GDSC1 6.0261 8.3396 2.5525 0.9719
EW-1 GDSC1 6.2625 8.1601 2.7091 0.3526
⏷ Show the Full List of 28 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 9 Cell Line(s) in Aero Dig Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ESO-26 GDSC1 2.8785 5.116 2.0329 11.8869
KYAE-1 GDSC1 3.2187 5.7623 2.0146 10.6746
OACP4 C GDSC1 3.4028 6.1842 1.9576 10.4438
KYSE-50 GDSC1 3.4922 5.5106 2.3661 6.9427
FLO-1 GDSC1 3.5236 6.187 2.0538 9.2767
SK-GT-4 GDSC1 3.5413 8.2393 1.0436 16.6235
TE-12 GDSC1 4.1217 7.5958 1.8093 9.2508
KYSE-220 GDSC1 5.0397 7.3906 2.478 2.4457
ESO-51 GDSC1 5.5561 7.3725 2.7217 0.6704
⏷ Show the Full List of 9 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 684 GDSC1 4.3124 7.748 1.87 8.2599
Cancer Drug Sensitivity Data Curated from 20 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
GI-ME-N GDSC1 1.4039 5.1436 0.5536 29.3576
NB69 GDSC1 1.8733 5.386 0.9263 24.5616
KP-N-YN GDSC1 2.1703 3.3816 2.0483 15.1999
CHP-212 GDSC1 2.9608 5.4502 1.9437 12.236
SK-N-DZ GDSC1 2.9927 4.3286 2.5234 7.6006
SJNB-6 GDSC1 3.051 8.0313 0.7378 20.4614
NB1 GDSC1 3.1661 5.0668 2.3165 8.5113
SJNB-13 GDSC1 3.4298 5.7489 2.1971 8.4819
SK-N-SH GDSC1 3.4386 6.6488 1.7547 11.8736
SJNB-14 GDSC1 3.4583 5.0628 2.5624 5.5145
SK-N-AS GDSC1 3.6773 6.763 1.8878 10.0411
SJNB-5 GDSC1 3.6928 6.2068 2.1757 7.7734
SiMa GDSC1 3.7453 6.4276 2.1062 8.1444
SJNB-10 GDSC1 3.8154 5.8185 2.4572 5.2259
TGW GDSC1 3.8539 5.9897 2.4012 5.5445
Kelly GDSC1 4.4499 6.2381 2.6619 2.2708
LA-N-6 GDSC1 4.4751 6.273 2.6605 2.2356
NH-12 GDSC1 4.5205 6.7979 2.4521 3.5421
SJNB-7 GDSC1 4.8368 12.6888 -0.1668 19.4779
NB(TU)1 GDSC1 5.3425 7.0248 2.7644 0.6602
⏷ Show the Full List of 20 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 26 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HCC2157 GDSC1 2.1105 4.1024 1.7276 17.7807
BT-474 GDSC1 3.0342 5.9791 1.7466 13.4537
Evsa-T GDSC1 3.3324 5.2237 2.3798 7.3914
JIMT-1 GDSC1 3.4161 6.2741 1.9236 10.6599
OCUB-M GDSC1 3.4656 5.8064 2.1973 8.3566
HCC38 GDSC1 3.7352 6.2288 2.1969 7.4753
MFM-223 GDSC1 3.816 5.4318 2.645 3.7925
HCC1428 GDSC1 3.9445 5.9772 2.4705 4.7662
HCC1569 GDSC1 4.0284 6.931 2.0669 7.5914
Hs 578T GDSC1 4.0471 7.8833 1.6138 10.9151
HCC1419 GDSC1 4.0605 6.7743 2.1658 6.7525
AU565 GDSC1 4.0797 6.9307 2.1034 7.169
MDA-MB-468 GDSC1 4.1715 6.0963 2.5627 3.5197
ZR-75-30 GDSC1 4.1848 6.3041 2.474 4.1306
EFM-192A GDSC1 4.2951 6.563 2.4229 4.2417
BT-20 GDSC1 4.4592 6.8038 2.4127 3.9456
HCC1937 GDSC1 4.6643 9.0354 1.4917 10.0099
MDA-MB-330 GDSC1 4.7172 7.8838 2.0724 5.7728
HCC1395 GDSC1 4.7891 8.2928 1.9269 6.6327
HCC202 GDSC1 4.8404 7.5216 2.3119 3.8553
MDA-MB-415 GDSC1 4.9421 11.5593 0.4629 15.8012
MDA-MB-175-VII GDSC1 5.2561 6.7041 2.8479 0.4264
HCC2218 GDSC1 5.4972 7.4804 2.6567 0.9702
BT-483 GDSC1 5.5338 7.3552 2.7191 0.695
UACC-893 GDSC1 5.6383 7.9118 2.551 1.3094
HCC1954 GDSC1 5.7186 7.7243 2.6567 0.7975
⏷ Show the Full List of 26 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 31 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
PFSK-1 GDSC1 2.5062 8.2625 0.1428 26.1474
8-MG-BA GDSC1 2.5994 4.7683 1.9341 13.8699
D-263MG GDSC1 2.9461 5.3339 1.9878 11.9542
GI-1 GDSC1 2.9498 5.3862 1.9653 12.1132
YH-13 GDSC1 3.0665 5.6699 1.9288 11.9272
SK-MG-1 GDSC1 3.3483 6.4845 1.7625 12.1389
M059J GDSC1 3.3532 6.5716 1.7231 12.4205
D-423MG GDSC1 3.3933 5.2313 2.426 6.8111
SF126 GDSC1 3.4072 5.8029 2.1518 8.9159
D-566MG GDSC1 3.4726 5.0997 2.5553 5.5218
CAS-1 GDSC1 3.5471 7.38 1.4773 13.5585
D-392MG GDSC1 3.6402 7.0739 1.7042 11.5567
Onda 10 GDSC1 3.674 6.4407 2.0454 8.8421
NMC-G1 GDSC1 3.6954 5.5772 2.4884 5.3384
D-542MG GDSC1 3.7292 7.1333 1.7441 10.9598
MOG-G-CCM GDSC1 3.7345 6.3639 2.1296 7.9979
GB-1 GDSC1 3.7543 5.5791 2.5303 4.8405
SF268 GDSC1 3.7555 6.994 1.8335 10.1992
ONS-76 GDSC1 3.804 6.2125 2.2561 6.8069
MOG-G-UVW GDSC1 3.8271 6.3322 2.2142 7.0599
DBTRG-05MG GDSC1 3.8667 6.9722 1.9285 9.1254
Hs 683 GDSC1 3.8977 6.2292 2.3157 6.0735
SNB-75 GDSC1 3.9378 10.371 0.2966 19.8403
Becker GDSC1 3.955 8.6613 1.1597 14.4216
SF295 GDSC1 3.987 8.0313 1.4959 11.958
D-247MG GDSC1 4.0059 8.4562 1.3001 13.2884
D-336MG GDSC1 4.0368 6.5973 2.235 6.2954
KNS-42 GDSC1 4.0386 7.0513 2.0156 7.9495
Onda 11 GDSC1 4.4712 6.8959 2.3777 4.1661
KINGS-1 GDSC1 5.2705 8.2664 2.2226 3.6484
SW1783 GDSC1 5.386 7.5293 2.5887 1.3869
⏷ Show the Full List of 31 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Digestive System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ETK-1 GDSC1 3.4709 7.5343 1.3386 14.8305
TGBC1TKB GDSC1 3.94 5.48 2.7042 3.0354
Cancer Drug Sensitivity Data Curated from 6 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RL95-2 GDSC1 2.4263 3.0861 2.3973 11.3809
ESS-1 GDSC1 3.6345 5.1668 2.6452 4.3059
MFE-319 GDSC1 3.8063 5.653 2.5312 4.6849
MFE-296 GDSC1 4.0984 8.4829 1.3565 12.6007
EN GDSC1 5.0548 6.4594 2.8579 0.5143
MFE-280 GDSC1 6.1207 8.3328 2.5933 0.7572
⏷ Show the Full List of 6 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 50 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
DG-75 GDSC1 1.2102 3.8021 0.8704 28.5731
NCI-H929 GDSC1 1.4225 3.9327 1.0552 26.1541
OCI-AML-3 GDSC1 1.4601 3.2507 1.3091 24.2548
SR GDSC1 1.5911 4.0834 1.1816 24.3685
NOMO-1 GDSC1 1.723 5.0374 0.9288 25.3274
H9 GDSC1 1.8951 3.3294 1.7627 18.7041
RL GDSC1 2.0228 4.0052 1.6728 18.631
SKM-1 GDSC1 2.0947 4.7555 1.4338 19.9716
NB4 GDSC1 2.1619 3.4405 2.0216 15.4299
GR-ST GDSC1 2.235 5.2781 1.337 19.9761
SU-DHL-10 GDSC1 2.2929 3.3916 2.1792 13.6135
AMO1 GDSC1 2.3085 4.0173 1.971 15.0035
MN-60 GDSC1 2.5874 5.249 1.694 15.7346
RS4;11 GDSC1 2.5998 5.463 1.6029 16.3598
JJN-3 GDSC1 2.6913 4.9625 1.931 13.4787
Daudi GDSC1 2.7342 4.0342 2.4062 9.677
WIL2 NS GDSC1 2.7374 4.6042 2.1463 11.6297
EoL-1 GDSC1 2.8064 3.9631 2.5115 8.542
BL-41 GDSC1 2.8491 6.7137 1.2175 18.0905
NALM-6 GDSC1 2.901 5.5169 1.8566 13.1514
RPMI-8402 GDSC1 2.9153 5.173 2.0389 11.6867
ALL-PO GDSC1 2.9421 6.5425 1.3851 16.5143
RPMI-8866 GDSC1 2.9791 4.2389 2.5537 7.4261
PL-21 GDSC1 3.0454 5.3617 2.0633 10.9665
MLMA GDSC1 3.0481 6.0951 1.701 13.745
SU-DHL-8 GDSC1 3.09 5.436 2.0659 10.7699
BE-13 GDSC1 3.1308 5.6025 2.0187 10.9785
DND-41 GDSC1 3.1802 5.638 2.0438 10.593
Namalwa GDSC1 3.2945 4.6503 2.6348 5.5192
Hs 445 GDSC1 3.3091 10.0209 -0.0383 23.8502
SK-MM-2 GDSC1 3.3096 6.7313 1.607 13.4548
KCL-22 GDSC1 3.3149 6.1736 1.8902 11.2821
Jurkat GDSC1 3.3405 4.9043 2.5462 6.0509
ALL-SIL GDSC1 3.3956 5.8194 2.134 9.096
OCI-Ly19 GDSC1 3.5445 5.9795 2.1737 8.2728
OCI-Ly7 GDSC1 3.5523 5.4237 2.4563 6.0361
ATN-1 GDSC1 3.5912 5.1591 2.617 4.6573
VAL GDSC1 3.606 6.3073 2.0589 8.9609
K-562 GDSC1 3.6099 5.4073 2.5084 5.4452
TUR GDSC1 3.6584 5.482 2.5079 5.2991
L-428 GDSC1 3.7009 5.9357 2.3159 6.6595
OCI-AML-5 GDSC1 3.7133 5.3482 2.6136 4.3185
LP-1 GDSC1 3.8856 5.9621 2.437 5.1819
TK [Human B-cell lymphoma] GDSC1 4.1416 6.2253 2.4833 4.1672
VL51 GDSC1 4.244 6.4993 2.4202 4.3817
Granta-519 GDSC1 4.2547 6.354 2.4948 3.8171
WSU-DLCL2 GDSC1 4.7018 5.7775 2.9682 0.3547
RC-K8 GDSC1 5.5275 6.9644 2.8575 0.2757
JURL-MK1 GDSC1 5.7072 7.1818 2.8472 0.2367
Farage GDSC1 5.7465 7.3348 2.8083 0.3104
⏷ Show the Full List of 50 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 19 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
LB996-RCC GDSC1 2.9191 5.7169 1.7742 13.7072
LB2241-RCC GDSC1 3.09 6.1 1.7352 13.3212
TK-10 GDSC1 3.1797 5.6569 2.0339 10.6723
LB1047-RCC GDSC1 3.569 6.3901 1.9886 9.6278
KTCTL-195 GDSC1 3.5736 6.2229 2.0755 8.9397
KTCTL-21 GDSC1 3.6102 6.1336 2.1486 8.2506
A-704 GDSC1 3.6343 6.0636 2.2019 7.7572
BB65-RCC GDSC1 3.6661 8.9234 0.8026 17.7565
KTCTL-140 GDSC1 3.7581 5.7954 2.4272 5.6236
KTCTL-13 GDSC1 3.8748 9.9857 0.4388 19.2437
VMRC-RCZ GDSC1 4.0271 6.8033 2.1282 7.1311
KTCTL-1M GDSC1 4.0368 6.7902 2.1414 7.0034
KMRC-20 GDSC1 4.6776 7.8962 2.0418 6.0821
KTCTL-26A GDSC1 4.6846 7.0713 2.4242 3.4046
NCC021 GDSC1 4.8445 7.3442 2.3932 3.3089
NCC010 GDSC1 4.9359 8.32 2.0056 5.7496
RXF 393L GDSC1 5.1242 8.1864 2.1768 4.2085
A-498 GDSC1 5.1897 6.6067 2.8574 0.4333
OS-RC-2 GDSC1 5.89 7.6405 2.754 0.3888
⏷ Show the Full List of 19 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 36 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RKO GDSC1 2.6882 5.6371 1.6015 15.983
CaR-1 GDSC1 2.8122 5.5941 1.7374 14.431
NCI-H716 GDSC1 3.0105 6.3064 1.5628 14.9327
GP5d GDSC1 3.0558 5.7083 1.9003 12.1899
SNU-407 GDSC1 3.0976 4.6976 2.4393 7.8184
NCI-H747 GDSC1 3.2787 6.8115 1.541 14.0608
SW48 GDSC1 3.2873 7.267 1.3204 15.6341
CCK-81 GDSC1 3.3188 5.7577 2.1014 9.6268
HCC2998 GDSC1 3.3212 5.0347 2.4649 6.7614
RCM-1 [Human ESC] GDSC1 3.3238 4.5686 2.7002 4.8966
NCI-H508 GDSC1 3.3277 5.7958 2.0898 9.6854
SNU-C2B GDSC1 3.388 6.0686 2.0033 10.1424
LoVo GDSC1 3.4101 5.8677 2.1218 9.1407
LS1034 GDSC1 3.4283 6.1696 1.9858 10.1352
C2BBe1 GDSC1 3.4441 5.3191 2.4232 6.6566
HT-29 GDSC1 3.4612 5.4959 2.3487 7.1843
HCT 116 GDSC1 3.4631 5.6384 2.2791 7.7237
SW626 GDSC1 3.4757 6.1339 2.042 9.5333
CL-11 GDSC1 3.4814 7.7253 1.2517 15.4077
SNU-C5 GDSC1 3.6987 6.5549 2.0077 9.0518
DiFi GDSC1 3.7285 6.2573 2.1778 7.6445
MDST8 GDSC1 3.7384 6.9795 1.8276 10.2995
SNU-C1 GDSC1 3.807 9.1517 0.8008 17.2794
SK-CO-1 GDSC1 3.8934 7.1832 1.8444 9.6784
T84 GDSC1 3.9377 6.0237 2.4434 4.9895
HT115 GDSC1 4.1732 5.7421 2.7261 2.3665
LS513 GDSC1 4.1746 6.3304 2.4551 4.2935
SNU-81 GDSC1 4.2041 6.7822 2.2603 5.6576
KM12 GDSC1 4.4792 7.335 2.1784 5.5737
SW620 GDSC1 4.4988 8.0621 1.8464 7.9314
HT-55 GDSC1 4.7091 7.5536 2.22 4.7543
CW-2 GDSC1 4.9041 7.2924 2.4486 2.8469
SW948 GDSC1 5.0413 6.6822 2.7678 0.89
HCT 15 GDSC1 5.1469 6.6674 2.8179 0.5979
LS180 GDSC1 5.1658 6.7852 2.7815 0.7255
LS123 GDSC1 5.6385 7.4013 2.7438 0.5437
⏷ Show the Full List of 36 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Leukemia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MO-T GDSC1 3.391 5.6731 2.2034 8.5687
Cancer Drug Sensitivity Data Curated from 4 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JHH-1 GDSC1 2.9405 5.9529 1.6765 14.3618
SNU-387 GDSC1 3.1948 6.3579 1.6968 13.2093
Huh-7 GDSC1 3.8069 6.7013 2.0174 8.6339
HuH-1 GDSC1 4.0847 6.3516 2.3859 5.0308
Cancer Drug Sensitivity Data Curated from 95 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SBC-1 GDSC1 1.8159 4.1527 1.3951 21.6838
SBC-3 GDSC1 1.9923 4.8349 1.2939 21.4744
RERF-LC-KJ GDSC1 2.1782 3.8675 1.8916 16.2525
EPLC-272H GDSC1 2.6719 5.9194 1.4484 17.1838
NCI-H290 GDSC1 2.8738 5.2843 1.9462 12.5757
NCI-H446 GDSC1 2.917 5.1584 2.0477 11.6109
NCI-H292 GDSC1 3.0167 5.5353 1.9516 11.9488
EMC-BAC-2 GDSC1 3.0589 6.3274 1.5947 14.5033
NCI-H847 GDSC1 3.1772 7.1852 1.2684 16.422
NCI-H2347 GDSC1 3.2101 5.985 1.8961 11.6263
NCI-H810 GDSC1 3.3139 5.4096 2.2714 8.3117
IA-LM GDSC1 3.3419 8.1983 0.9003 18.3019
NCI-H2722 GDSC1 3.3556 5.9392 2.0413 9.9625
HCC78 GDSC1 3.3582 5.9809 2.0226 10.0989
LCLC-97TM1 GDSC1 3.3879 5.5008 2.287 7.9237
NCI-H2595 GDSC1 3.3929 6.4813 1.801 11.6846
Calu-3 GDSC1 3.4049 6.5776 1.7627 11.9327
LXF 289 GDSC1 3.4529 5.9544 2.1132 9.0576
NCI-H650 GDSC1 3.4719 5.166 2.5217 5.7878
NCI-H2810 GDSC1 3.4722 6.8858 1.6636 12.4429
NCI-H2803 GDSC1 3.499 6.6474 1.8043 11.2837
NCI-H226 GDSC1 3.5105 5.8547 2.209 8.1116
DMS 53 GDSC1 3.5389 6.5054 1.9072 10.3575
HARA [Human squamous cell lung carcinoma] GDSC1 3.5572 6.9261 1.712 11.7815
NCI-H2804 GDSC1 3.5694 6.8968 1.7363 11.5557
VMRC-LCD GDSC1 3.5843 5.4343 2.4756 5.7824
NCI-H1792 GDSC1 3.5879 5.9257 2.2345 7.6543
NCI-H1304 GDSC1 3.5881 10.9908 -0.293 24.0861
DMS 114 GDSC1 3.5938 6.9356 1.7364 11.4718
A-549 GDSC1 3.627 5.4839 2.4835 5.5859
CAL-12T GDSC1 3.6292 7.4388 1.5136 13.0076
NCI-H1563 GDSC1 3.632 5.8168 2.3225 6.8252
NCI-H1155 GDSC1 3.6477 5.9449 2.2711 7.1757
NCI-H1568 GDSC1 3.6553 6.7532 1.8756 10.2078
NCI-H1975 GDSC1 3.6694 6.2046 2.159 7.9774
LC-1/sq GDSC1 3.6787 8.1949 1.176 15.2384
LOU-NH91 GDSC1 3.6956 6.9179 1.8251 10.4586
NCI-H1694 GDSC1 3.6976 5.6408 2.4587 5.5613
NCI-H2591 GDSC1 3.7197 6.5592 2.0216 8.8775
LB647-SCLC GDSC1 3.7323 6.2113 2.2034 7.4346
NCI-H2369 GDSC1 3.7524 6.797 1.9289 9.4836
NCI-H2122 GDSC1 3.8197 5.9259 2.4079 5.5916
SK-LU-1 GDSC1 3.8446 5.7033 2.5337 4.5591
NCI-H720 GDSC1 3.8948 5.717 2.5616 4.2111
LK-2 GDSC1 3.9198 7.298 1.8075 9.8738
HCC15 GDSC1 3.9228 6.8646 2.023 8.2358
RERF-LC-MS GDSC1 3.9251 5.8908 2.4988 4.6042
NCI-H1355 GDSC1 3.9262 6.4332 2.2366 6.5958
NCI-H1437 GDSC1 3.953 6.0563 2.4382 4.9872
NCI-H2461 GDSC1 3.9672 8.3428 1.3269 13.2244
NCI-H2731 GDSC1 3.9747 7.8147 1.5937 11.2867
SW1271 GDSC1 4.0102 7.1743 1.9349 8.6417
SK-MES-1 GDSC1 4.0146 6.7358 2.1522 6.9852
NCI-H82 GDSC1 4.0431 6.198 2.4314 4.7991
SW1573 GDSC1 4.1017 8.0556 1.5693 11.0711
ABC-1 GDSC1 4.1029 6.6289 2.2653 5.8867
NCI-H1944 GDSC1 4.1204 8.2911 1.4673 11.7476
PC-14 GDSC1 4.131 6.7235 2.239 6.0084
RERF-LC-Sq1 GDSC1 4.1546 7.0164 2.1142 6.8804
NCI-H2110 GDSC1 4.1901 7.5985 1.8569 8.6999
NCI-H1876 GDSC1 4.245 7.9448 1.7273 9.4964
EKVX GDSC1 4.256 7.5002 1.9508 7.8194
EMC-BAC-1 GDSC1 4.2725 7.8013 1.8165 8.7646
NCI-H1915 GDSC1 4.2903 6.8878 2.2671 5.3889
NCI-H841 GDSC1 4.2994 6.8254 2.3024 5.1071
NCI-H524 GDSC1 4.3128 7.3595 2.0573 6.8785
HCC366 GDSC1 4.3352 6.4325 2.508 3.5438
NCI-H1755 GDSC1 4.3929 6.9369 2.31 4.8278
NCI-H2087 GDSC1 4.4153 7.8289 1.9017 7.7496
NCI-H1436 GDSC1 4.4263 7.199 2.2084 5.4838
NCI-H441 GDSC1 4.4366 7.1454 2.2401 5.2295
NCI-H460 GDSC1 4.4614 6.1364 2.7125 1.9286
NCI-H2795 GDSC1 4.5265 7.9456 1.9205 7.3237
NCI-H345 GDSC1 4.5347 5.4261 3.0306 0.249
NCI-H513 GDSC1 4.5767 6.7386 2.5112 3.0293
Lu-65 GDSC1 4.6845 6.5991 2.6312 2.07
NCI-H1993 GDSC1 4.7041 8.8085 1.6274 8.9558
NCI-H2066 GDSC1 4.7658 6.5912 2.6761 1.6823
NCI-H2141 GDSC1 4.7768 6.2301 2.8278 0.8692
NCI-H1648 GDSC1 4.7824 7.3697 2.3466 3.7354
COLO 668 GDSC1 4.8509 6.9738 2.5577 2.2563
NCI-H1770 GDSC1 4.8602 6.3972 2.7993 0.9196
NCI-H2869 GDSC1 4.9905 7.2871 2.4966 2.4092
NCI-H2291 GDSC1 5.0304 7.0482 2.6166 1.6599
COR-L23 GDSC1 5.1111 7.2029 2.592 1.6905
NCI-H196 GDSC1 5.2654 6.7801 2.8238 0.4993
COR-L95 GDSC1 5.2842 6.7405 2.8456 0.4183
DMS 273 GDSC1 5.3695 6.8887 2.825 0.4359
IST-SL2 GDSC1 5.4173 7.8377 2.4791 1.9139
NCI-H1781 GDSC1 5.4865 7.2559 2.7368 0.6623
SHP-77 GDSC1 5.6884 7.2325 2.8228 0.2978
NCI-H1623 GDSC1 5.8099 7.8629 2.6423 0.7874
NCI-H1688 GDSC1 5.9038 7.8623 2.6798 0.5988
A-427 GDSC1 6.4174 8.7173 2.5695 0.6625
NCI-H1651 GDSC1 6.5253 8.3073 2.752 0.1934
⏷ Show the Full List of 95 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 12 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KYSE-410 GDSC1 2.3739 6.6124 0.8324 22.7448
OE21 GDSC1 2.6879 5.6796 1.5804 16.1414
TE-10 GDSC1 3.0969 5.0504 2.2637 9.197
TE-5 GDSC1 3.3336 5.9223 2.0315 10.1183
KYSE-450 GDSC1 3.6695 5.1217 2.6927 3.8363
TE-8 GDSC1 3.8209 6.6082 2.0739 8.1573
EC-GI-10 GDSC1 3.8236 6.5588 2.1002 7.9471
TE-9 GDSC1 3.8591 6.7178 2.0482 8.2365
TE-1 GDSC1 3.8876 7.6417 1.6135 11.4178
KYSE-140 GDSC1 4.0197 6.6194 2.2123 6.5145
KYSE-150 GDSC1 4.666 6.8092 2.53 2.7402
TE-4 GDSC1 5.9528 7.9189 2.6784 0.5759
⏷ Show the Full List of 12 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 18 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
OC 314 GDSC1 2.1394 5.6442 1.0717 22.2752
OVTOKO GDSC1 3.2485 6.2062 1.8182 12.0817
JHOS-2 GDSC1 3.2517 6.079 1.8844 11.5602
DOV13 GDSC1 3.2689 6.6328 1.6221 13.4924
OVCAR-8 GDSC1 3.3845 7.493 1.2883 15.502
OV-90 GDSC1 3.4266 6.0116 2.0633 9.5384
TOV-112D GDSC1 3.5348 7.8786 1.2185 15.4494
OVCAR-3 GDSC1 3.5849 6.0495 2.1707 8.1619
Kuramochi GDSC1 3.5957 7.8161 1.2987 14.6714
A2780 GDSC1 3.6152 5.6192 2.4076 6.2146
TYK-nu GDSC1 3.6348 5.5996 2.4321 5.9617
OVK18 GDSC1 3.6574 6.258 2.1232 8.2935
OV56 GDSC1 3.7221 5.428 2.5809 4.5442
OVKATE GDSC1 3.9778 9.7706 0.6266 17.7841
TOV-21G GDSC1 4.0278 8.73 1.1813 14.0387
OVISE GDSC1 4.1657 7.6402 1.8192 9.0491
OVCAR-4 GDSC1 4.3477 7.9333 1.805 8.6386
ES-2 GDSC1 5.407 6.6729 2.9149 0.1906
⏷ Show the Full List of 18 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 11 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuP-T4 GDSC1 1.9569 4.7441 1.2974 21.6298
SU.86.86 GDSC1 2.9915 5.8907 1.7527 13.5779
Panc 02.03 GDSC1 3.3278 5.5281 2.2237 8.6358
AsPC-1 GDSC1 3.6116 8.0875 1.176 15.4726
PL4 GDSC1 3.6434 5.9142 2.283 7.0968
Capan-1 GDSC1 3.7773 5.6504 2.5119 4.9154
HuP-T3 GDSC1 3.8457 6.4777 2.1564 7.4483
Hs 766T GDSC1 3.8906 6.7767 2.0425 8.184
QGP-1 GDSC1 4.0188 5.9222 2.5466 4.0033
MZ-PC-1 GDSC1 4.1851 7.3584 1.9699 7.8741
Capan-2 GDSC1 5.9951 7.7551 2.7526 0.3496
⏷ Show the Full List of 11 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
IST-Mes1 GDSC1 1.879 4.6543 1.2556 22.3215
NCI-H28 GDSC1 3.9014 6.4219 2.2243 6.7618
MSTO-211H GDSC1 4.7393 7.1742 2.4094 3.3985
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
LNCaP clone FGC GDSC1 3.0865 5.895 1.8343 12.5771
VCaP GDSC1 3.2332 5.4183 2.1989 9.1793
22Rv1 GDSC1 5.2421 8.0728 2.2915 3.2642
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-253 GDSC1 4.7947 6.7782 2.612 2.016
Cancer Drug Sensitivity Data Curated from 37 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
G-mel GDSC1 2.1674 5.8906 0.9829 22.7334
A101D GDSC1 2.2425 8.7413 -0.3327 29.5848
WM35 GDSC1 2.4057 4.3982 1.9096 14.9683
UACC-62 GDSC1 2.4335 6.3715 1.0056 21.3427
451Lu GDSC1 2.8937 5.7895 1.7153 14.2591
COLO 800 GDSC1 3.0288 5.4649 1.9973 11.5456
LOX-IMVI GDSC1 3.1337 4.8701 2.3858 8.0935
A-375 GDSC1 3.1886 6.0205 1.86 11.9856
SK-MEL-30 GDSC1 3.2196 5.8916 1.9508 11.1668
A2058 GDSC1 3.3416 12.1485 -1.075 28.251
MMAc-SF GDSC1 3.3772 6.2629 1.8973 11.0012
IGR-1 GDSC1 3.4175 7.3881 1.3679 14.8135
SK-MEL-2 GDSC1 3.4347 7.8308 1.1607 16.2109
SK-MEL-28 GDSC1 3.4564 7.4708 1.3584 14.7407
SK-MEL-5 GDSC1 3.4642 6.143 2.0282 9.6805
MZ-MEL-2 GDSC1 3.4674 7.3252 1.4402 14.111
CP50-MEL-B GDSC1 3.4748 9.8822 0.1682 22.1633
RVH-421 GDSC1 3.6117 6.695 1.8703 10.3935
GAK GDSC1 3.62 6.3848 2.0312 9.1284
LB373-MEL-D GDSC1 3.6903 7.1833 1.689 11.5024
SK-MEL-3 GDSC1 3.6908 5.5026 2.5216 5.0946
VMRC-MELG GDSC1 3.7438 7.0535 1.795 10.5288
WM1552C GDSC1 3.8118 5.8454 2.4414 5.3571
WM115 GDSC1 3.8822 7.0766 1.8886 9.3797
SH-4 GDSC1 3.9112 6.2502 2.3151 6.0393
SK-MEL-1 GDSC1 3.9585 5.5902 2.6643 3.2832
LB2518-MEL GDSC1 3.9624 5.9376 2.5017 4.4832
RPMI-7951 GDSC1 3.9903 8.2521 1.3893 12.7104
Hs 938.T GDSC1 4.0062 7.6743 1.6864 10.5079
WM278 GDSC1 4.0307 8.1559 1.4672 12.0272
IST-MEL1 GDSC1 4.1411 7.7321 1.7567 9.5831
Hs 940.T GDSC1 4.2281 6.733 2.2996 5.3056
WT2-iPS GDSC1 4.4744 9.4772 1.1439 12.92
A-388 GDSC1 4.6867 8.1232 1.9411 6.7769
COLO 829 GDSC1 4.879 7.4281 2.3753 3.3626
COLO 783 GDSC1 4.8994 6.5138 2.7709 1.015
EquiPSC Line K2 GDSC1 3.4655 11.0501 -0.4232 25.1246
⏷ Show the Full List of 37 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Small Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuTu 80 GDSC1 4.3777 6.3684 2.5626 3.0735
Cancer Drug Sensitivity Data Curated from 11 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SW872 GDSC1 2.229 4.1086 1.85 16.2867
SW982 GDSC1 2.7322 6.753 1.0932 19.4412
SK-LMS-1 GDSC1 2.9154 6.2159 1.5236 15.6082
RKN GDSC1 3.3056 4.6739 2.6323 5.4984
MES-SA GDSC1 3.3981 4.8539 2.6185 5.2779
STS-0421 GDSC1 3.4214 6.3244 1.9028 10.8015
G-401 GDSC1 3.6545 5.5403 2.4763 5.5569
SW684 GDSC1 3.6645 6.9234 1.7981 10.7667
EW-8 GDSC1 4.1372 8.0295 1.6082 10.6823
Rh30 GDSC1 4.4887 11.9995 -0.087 20.1152
VA-ES-BJ GDSC1 4.7893 6.617 2.677 1.6445
⏷ Show the Full List of 11 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 14 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NUGC-4 GDSC1 2.4502 7.712 0.3639 25.2025
MKN28 GDSC1 2.7914 6.1944 1.4227 16.8625
AGS GDSC1 2.9144 5.6928 1.7818 13.6683
HGC-27 GDSC1 2.9298 5.9355 1.6755 14.4123
SK-GT-2 GDSC1 3.6179 8.1625 1.1437 15.6725
NCI-N87 GDSC1 3.7739 6.1854 2.2471 6.9675
SNU-16 GDSC1 3.8385 10.2925 0.2572 20.3956
TMK-1 GDSC1 3.8612 7.2661 1.7793 10.2693
HSC-39 GDSC1 3.9118 5.7339 2.565 4.1406
IM95 GDSC1 3.9239 6.1187 2.3879 5.449
KATO III GDSC1 4.8752 7.1851 2.4796 2.6999
SNU-5 GDSC1 5.1854 6.8518 2.7644 0.7795
MKN7 GDSC1 5.7779 7.6023 2.7251 0.5254
SNG-M GDSC1 2.6666 5.6212 1.589 16.1699
⏷ Show the Full List of 14 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 13 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CAL-62 GDSC1 1.778 5.6964 0.6891 26.5385
BHT-101 GDSC1 2.0791 4.8095 1.394 20.3329
K5 GDSC1 2.8624 4.8276 2.1587 10.9834
KMH-2 GDSC1 2.9032 5.5367 1.8488 13.2021
IHH-4 GDSC1 3.0411 9.3441 0.0738 24.2994
CGTH-W-1 GDSC1 3.3338 5.4491 2.2682 8.2648
ASH-3 GDSC1 3.335 5.9594 2.0141 10.2486
8305C GDSC1 3.4815 5.9401 2.1433 8.7236
WRO GDSC1 3.684 6.6918 1.9284 9.7092
8505C GDSC1 3.7032 7.2722 1.6549 11.7139
FTC-133 GDSC1 3.8656 5.4604 2.6648 3.513
TT GDSC1 4.2916 7.3724 2.0367 7.0865
TT2609-C02 GDSC1 4.5114 6.6311 2.522 3.0831
⏷ Show the Full List of 13 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 17 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
PCI-04B GDSC1 2.2768 4.72 1.6348 17.6207
CAL-27 GDSC1 2.5375 4.8739 1.8239 14.9848
HSC-4 GDSC1 2.6564 7.3519 0.7285 22.1487
LB771-HNC GDSC1 2.9064 6.0312 1.6072 15.0221
DOK GDSC1 2.9965 4.7217 2.3353 9.0456
HSC-2 GDSC1 3.0374 5.1503 2.161 10.2376
JHU-022 GDSC1 3.1666 31.7659 -11.0297 42.7248
FaDu GDSC1 3.1785 5.955 1.8841 11.8387
NCI-H3118 GDSC1 3.5125 5.391 2.4416 6.2817
SCC-15 GDSC1 3.5601 6.1932 2.0796 8.9527
BICR 10 GDSC1 3.719 8.4456 1.083 15.7341
CAL-33 GDSC1 3.7813 5.8234 2.4303 5.5317
PCI-06A GDSC1 3.9092 6.3736 2.2535 6.5159
PCI-30 GDSC1 3.9789 8.4906 1.2626 13.6364
SCC-4 GDSC1 3.9874 6.8609 2.0717 7.674
UPCI-SCC-090 GDSC1 4.1076 8.5212 1.3445 12.6567
JHU-029 GDSC1 4.1818 6.7297 2.2704 5.64
⏷ Show the Full List of 17 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 6 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KU-19-19 GDSC1 1.943 4.0304 1.578 19.7245
T24 GDSC1 2.9581 5.4213 1.9555 12.155
639V GDSC1 3.3608 5.2427 2.3938 7.1798
SW1710 GDSC1 3.3633 6.473 1.7807 11.9458
HT-1197 GDSC1 3.595 5.4855 2.4585 5.882
RT-4 GDSC1 4.4856 8.5408 1.6071 9.6856
⏷ Show the Full List of 6 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 18 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
OV17R GDSC1 2.5586 5.3442 1.6207 16.411
OVCA433 GDSC1 2.6752 6.4432 1.1942 18.9872
NT2-D1 GDSC1 2.8988 5.6242 1.8016 13.5813
KGN GDSC1 3.0876 5.7189 1.923 11.889
LB831-BLC GDSC1 3.2191 8.051 0.8712 18.9562
OVCA420 GDSC1 3.2239 5.0585 2.3706 7.8645
PEO1 GDSC1 3.3598 6.2961 1.8662 11.3036
DoTc2 4510 GDSC1 3.3749 6.1216 1.966 10.4783
SKN GDSC1 3.476 6.3392 1.9397 10.3249
HEC-1 GDSC1 3.6024 6.6814 1.8698 10.4285
C-4-I GDSC1 3.6319 5.6117 2.424 6.0346
HEY GDSC1 3.6489 5.634 2.4258 5.9672
NEC8 GDSC1 4.1682 7.4316 1.9225 8.2747
UWB1.289 GDSC1 4.2812 9.3439 1.0682 14.004
JHOS-3 GDSC1 4.6977 6.8709 2.5204 2.7463
PWR-1E GDSC1 5.1629 6.9032 2.7351 0.9241
JEG-3 GDSC1 5.4052 8.1457 2.3452 2.6837
ACC-OV7 GDSC1 5.953 8.8403 2.3252 2.0756
⏷ Show the Full List of 18 Cancer Drug Sensitivity Data of This Drug

References

1 Pharmacological inhibition of BMK1 suppresses tumor growth through promyelocytic leukemia protein. Cancer Cell. 2010 Sep 14;18(3):258-67.