Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMZKPI8)

Drug Name
TAK-715 Drug Info
Synonyms P38 MAP kinase inhibitor (rheumatoid arthritis), Takeda
Cross-matching ID
PubChem CID
9952773
ChEBI ID
CHEMBL363648
CAS Number
CAS 303162-79-0
TTD Drug ID
D0O6ZO

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
DNA replication 2.53 0.00e+0 34/36 (94.44%) POLE2;MCM6;FEN1;...
Fanconi anemia pathway 2.30 0.00e+0 36/54 (66.67%) FANCI;BRCA1;BLM;...
Pyrimidine metabolism 2.24 0.00e+0 40/56 (71.43%) TYMS;RRM2;DPYD;...
Cell cycle 2.23 0.00e+0 110/124 (88.71%) CDC20;MCM6;CDK1;...
Drug metabolism 2.10 0.00e+0 78/151 (51.66%) RRM2;DPYD;HPRT1;...
Homologous recombination 2.05 0.00e+0 35/41 (85.37%) RBBP8;POLD3;BARD1;...
One carbon pool by folate 1.94 1.15e-3 15/20 (75%) TYMS;DHFR;MTHFD1;...
Mismatch repair 1.93 2.01e-3 22/23 (95.65%) PCNA;RFC3;MSH2;...
Nucleotide excision repair 1.91 3.57e-3 40/47 (85.11%) POLE2;PCNA;RFC3;...
Purine metabolism 1.87 4.02e-3 102/129 (79.07%) RRM2;GUCY1A1;HPRT1;...
Non-homologous end-joining 1.81 1.17e-2 11/13 (84.62%) FEN1;DNTT;MRE11;...
Base excision repair 1.79 1.34e-2 29/33 (87.88%) POLE2;FEN1;PCNA;...
Propanoate metabolism 1.76 1.48e-2 30/34 (88.24%) DLD;ABAT;LDHB;...
Tryptophan metabolism 1.75 1.55e-2 35/42 (83.33%) DLD;ALDH7A1;EHHADH;...
Oocyte meiosis 1.68 3.64e-2 90/129 (69.77%) CDC20;CDK1;BUB1;...
D-Glutamine and D-glutamate metabolism 1.65 4.22e-2 5/5 (100%) GLUD2;DGLUCY;GLUD1;...
Oxidative phosphorylation -1.67 4.63e-2 93/133 (69.92%) ATP4B;NDUFV1;COX7B;...
Cholesterol metabolism -1.68 4.48e-2 44/50 (88%) SCARB1;VDAC2;CD36;...
Glycerophospholipid metabolism -1.68 4.77e-2 71/98 (72.45%) DGKQ;PLA2G2F;PGS1;...
Protein processing in endoplasmic reticulum -1.70 4.35e-2 127/171 (74.27%) EIF2AK1;HSPA5;CUL1;...
Lysosome -1.70 4.83e-2 115/128 (89.84%) ASAH1;DNASE2B;ABCB9;...
Vibrio cholerae infection -1.73 3.20e-2 44/50 (88%) ATP6V1E1;SEC61A2;SEC61A1;...
Synaptic vesicle cycle -1.79 2.01e-2 63/78 (80.77%) ATP6V1D;SLC6A1;SLC18A2;...
Longevity regulating pathway -1.85 1.28e-2 90/151 (59.6%) FOXA2;NFKB1;ATF6B;...
Sphingolipid metabolism -1.88 1.28e-2 32/49 (65.31%) SGPL1;SPTLC1;GAL3ST1;...
Ferroptosis -1.94 9.60e-3 36/41 (87.8%) TF;GPX4;FTH1;...
Autophagy -2.03 0.00e+0 113/169 (66.86%) RRAS;PPP2CB;MAP2K1;...
Mineral absorption -2.25 0.00e+0 48/60 (80%) TF;MT1E;FTH1;...
Mitophagy -2.40 0.00e+0 56/68 (82.35%) RPS27A;FIS1;BECN1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 0.12uM - 10uM 6H, 24H, 48H
Bone marrow
Chronic myeloid leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
K-562 CVCL_0004 Homo sapiens 0.01uM - 10uM 4H, 24H
Multiple myeloma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
KMS-34 CVCL_1333 Homo sapiens 0.01uM - 10uM 24H
Neuroblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SH-SY5Y CVCL_0019 Homo sapiens 0.04uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 6H, 24H, 48H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 6H, 24H
SK-BR-3 CVCL_0033 Homo sapiens 0.08uM - 10uM 6H, 24H
Breast carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BT-20 CVCL_0178 Homo sapiens 0.08uM - 10uM 6H, 24H
Hs 578T CVCL_0332 Homo sapiens 0.08uM - 10uM 6H, 24H
Normal (Epithelial)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HME1 CVCL_2950 Homo sapiens 0.04uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 6H, 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 6H, 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 0.04uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.04uM - 10uM 6H, 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 6H, 24H, 48H
A549/Asc-1 CVCL_YA87 Homo sapiens 0.04uM - 10uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 0.04uM - 10uM 6H, 24H
Lymph node
Burkitt lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BJAB CVCL_5711 Homo sapiens 0.01uM - 10uM 4H
Diffuse large B-cell lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HBL-1 CVCL_4213 Homo sapiens 0.01uM - 10uM 4H, 24H
OCI-Ly10 CVCL_8795 Homo sapiens 0.01uM - 10uM 24H
OCI-Ly19 CVCL_8797 Homo sapiens 0.01uM - 10uM 4H, 24H
OCI-Ly3 CVCL_8796 Homo sapiens 0.01uM - 10uM 4H, 24H
TMD8 CVCL_A440 Homo sapiens 0.01uM - 10uM 4H, 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute B-lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NALM-6 CVCL_0092 Homo sapiens 0.01uM - 10uM 24H
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 4H, 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 6H, 24H
SK-L CVCL_1699 Homo sapiens 0.04uM - 10uM 24H
SK-MEL-5 CVCL_0527 Homo sapiens 0.01uM - 10uM 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.04uM - 10uM 24H