Details of the Drug Reposition

General Information of This Drug (ID: DMCME17)

• Drug Name: Lisuride (DMCME17)
• Synonyms: Lisurida; Lisuridum; Lysurid; Lysuride; Lisuride [INN]; Lysuride Hydrogen Maleate; Methylergol Carbamide; Arolac (TN); Cuvalit (TN); Dipergon (TN); Dopergin (TN); Dopergine (TN); Lisurida [INN-Spanish]; Lisuride (INN); Lisuridum [INN-Latin]; Lysenyl Forte (TN); Prolacam (TN); Revanil (TN); Lisuride Maleate (1:1); N'-((8alpha)-9,10-Didehydro-6-methylergolin-8-yl)-N,N-diethylurea; 1,1-diethyl-3-[(8alpha)-6-methyl-9,10-didehydroergolin-8-yl]urea; 3-(9,10-Didehydro-6-methylergolin-8alpha-yl)-1,1-diethylurea
• Therapeutic Class: Antiparkinson Agents
• Drug Type: Small molecular drug

Information on Drug Reposition of This Drug

4 Approved Indication(s)

Indication Name	Indication ID	ICD-11	Status	REF
Migraine disorder	DISFCQTG	N.A.	Approved	[1]
Acromegaly	DISCC73U	5A60.0	Approved	[2]
Parkinson disease	DISQVHKL	8A00.0	Approved	[3]
Amenorrhea	DISBJQKZ	GA20.0	Approved	[4]

1 Phase 3 Indication(s)

Indication Name	Indication ID	ICD-11	Status	REF
Fibrosis	DIS6FM27	GA14-GC01	Phase 3	[5]

References

• [1] Is the 5-HT(7) receptor involved in the pathogenesis and prophylactic treatment of migraine?. Eur J Pharmacol. 2002 Mar 29;439(1-3):1-11.
• [2] [Treatment of hyperprolactinemia and acromegaly with lisuride]. Harefuah. 1989 Jun 15;116(12):634-7.
• [3] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 43).
• [4] Pregnancy with macroprolactinoma. J Coll Physicians Surg Pak. 2008 Dec;18(12):787-8.
• [5] ClinicalTrials.gov (NCT00408915) Continuous Application of Lisuride in Parkinson's Disease by Subcutaneous Infusion. U.S. National Institutes of Health.