Details of Disease

General Information of Disease (ID: DISBJQKZ)

Disease Name	Amenorrhea
Synonyms	amenorrhea (disease); amenorrhea; amenia; absence of menstruation
Disease Class	GA20: Menstrual cycle bleeding disorder
Definition	The absence of menses in a woman who has achieved reproductive age.
Disease Hierarchy	DISXEPZF: Gynecological disease DISBJQKZ: Amenorrhea
ICD Code	ICD-11 ICD-11: GA20.0 ICD-10 ICD-10: N91, N91.2
Disease Identifiers	MONDO ID MONDO_0001836 MESH ID D000568 UMLS CUI C0002453 MedGen ID 8016 HPO ID HP:0000141 SNOMED CT ID 14302001

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)

This Disease is Treated as An Indication in 4 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Dexpanthenol	DMUTSRW	Approved	Small molecular drug	[1]
Gonadorelin	DMAQ469	Approved	Small molecular drug	[2]
Lisuride	DMCME17	Approved	Small molecular drug	[3]
Progesterone	DMUY35B	Approved	Small molecular drug	[4]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 7 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
FSHB	TT13GFV	moderate	Biomarker	[5]
CPB2	TTP18AY	Strong	Biomarker	[6]
CYP17A1	TTRA5BZ	Strong	Biomarker	[7]
CYP19A1	TTSZLWK	Strong	Biomarker	[8]
POR	TTOQ9GZ	Strong	Biomarker	[9]
PRL	TTJ2TSA	Strong	Biomarker	[10]
PYY	TTVFJLX	Strong	Biomarker	[11]
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⏷ Show the Full List of 7 DTT(s)

References

1	Riboflavin FDA Label
2	Gonadorelin FDA Label
3	Pregnancy with macroprolactinoma. J Coll Physicians Surg Pak. 2008 Dec;18(12):787-8.
4	FDA Approved Drug Products from FDA Official Website. 2019. Application Number: (ANDA) 075906.
5	Primary amenorrhoea and infertility due to a mutation in the beta-subunit of follicle-stimulating hormone.Nat Genet. 1993 Sep;5(1):83-6. doi: 10.1038/ng0993-83.
6	The effects of short-term raloxifene therapy on fibrinolysis markers: TAFI, tPA, and PAI-1.Acta Obstet Gynecol Scand. 2005 Oct;84(10):987-91. doi: 10.1111/j.0001-6349.2005.00817.x.
7	Partial 17alpha-hydroxylase/17,20-lyase deficiency-clinical report of five Chinese 46,XX cases. Gynecol Endocrinol. 2008 Jul;24(7):362-7. doi: 10.1080/09513590802194051.
8	Molecular basis of aromatase deficiency in an adult female with sexual infantilism and polycystic ovaries.Proc Natl Acad Sci U S A. 1993 Dec 15;90(24):11673-7. doi: 10.1073/pnas.90.24.11673.
9	Mutant P450 oxidoreductase causes disordered steroidogenesis with and without Antley-Bixler syndrome.Nat Genet. 2004 Mar;36(3):228-30. doi: 10.1038/ng1300. Epub 2004 Feb 1.
10	Effects of sulpiride induced hyperprolactinaemia in patients with Turner's syndrome.Clin Endocrinol (Oxf). 1980 Jul;13(1):9-16. doi: 10.1111/j.1365-2265.1980.tb01017.x.
11	Elevated PYY is associated with energy deficiency and indices of subclinical disordered eating in exercising women with hypothalamic amenorrhea.Appetite. 2009 Feb;52(1):184-92. doi: 10.1016/j.appet.2008.09.016. Epub 2008 Sep 25.