Details of the Drug Reposition

General Information of This Drug (ID: DMLNCE0)

Drug Name
Cetuximab   DMLNCE0
Synonyms Erbitux; Cetuximab (genetical recombination); Erbitux (TN); Cetuximab (USAN/INN); Cetuximab (genetical recombination) (JAN); novel EGFR mAb inhibitors
Therapeutic Class
Anticancer Agents
Drug Type
Antibody

Information on Drug Reposition of This Drug

Molecular Interaction Atlas (MIA)
4 Approved Indication(s)
Indication Name Indication ID ICD-11 Status REF
Laryngeal squamous cell carcinoma DIS9UUVF N.A. Approved [1]
Salivary gland squamous cell carcinoma DISDI0CT N.A. Approved [2]
Plasma cell myeloma DIS0DFZ0 2A83.1 Approved [3]
Lung cancer DISCM4YA 2C25.0 Approved [4]
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4 Discontinued in Phase 2 Indication(s)
Indication Name Indication ID ICD-11 Status REF
Carcinoma of esophagus DISS6G4D N.A. Discontinued in Phase 2 [5]
Colorectal neoplasm DISR1UCN N.A. Discontinued in Phase 2 [6]
Oral cavity squamous cell carcinoma DISQVJVA 2B6E.0 Discontinued in Phase 2 [7]
Colorectal cancer DISNH7P9 2B91.Z Discontinued in Phase 2 [8]
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3 Investigative Indication(s)
Indication Name Indication ID ICD-11 Status REF
Pharyngeal squamous cell carcinoma DISWZMVP N.A. Investigative [9]
Gastric cancer DISXGOUK 2B72 Investigative [10]
Colon cancer DISVC52G 2B90.Z Investigative [11]
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References

1 Cetuximab enhances oridonin-induced apoptosis through mitochondrial pathway and endoplasmic reticulum stress in laryngeal squamous cell carcinoma cells. Toxicol In Vitro. 2020 Sep;67:104885.
2 Patient-derived head and neck cancer organoids allow treatment stratification and serve as a tool for biomarker validation and identification. Med. 2023 May 12;4(5):290-310.e12.
3 SOT101 induces NK cell cytotoxicity and potentiates antibody-dependent cell cytotoxicity and anti-tumor activity. Front Immunol. 2022 Oct 10;13:989895.
4 Cetuximab for treating non-small cell lung cancer. Expert Opin Biol Ther. 2018 Apr;18(4):483-493.
5 Clinical Trial of Sodium Phenylbutyrate in Children With Spinal Muscular Atrophy Types II or III
6 ClinicalTrials.gov (NCT00373581) Effects of Vigabatrin on Cocaine Self-Administration
7 ClinicalTrials.gov (NCT02029417) Omacetaxine Mepesuccinate, Cytarabine, and Decitabine in Treating Older Patients With Newly Diagnosed Acute Myeloid Leukemia
8 Adjuvant Zoledronic Acid in High Risk Giant Cell Tumour of Bone (GCT)
9 Head and neck squamous cell carcinoma. Nat Rev Dis Primers. 2020 Nov 26;6(1):92.
10 Assessment of a HER2 scoring system for colorectal cancer: results from a validation study. Mod Pathol. 2015 Nov;28(11):1481-91.
11 Colon cancer. Crit Rev Oncol Hematol. 2010 May;74(2):106-33.