Details of the Drug

General Information of Drug (ID: DMLNCE0)

Drug Name
Cetuximab
Synonyms Erbitux; Cetuximab (genetical recombination); Erbitux (TN); Cetuximab (USAN/INN); Cetuximab (genetical recombination) (JAN); novel EGFR mAb inhibitors
Indication
Disease Entry ICD 11 Status REF
Colorectal cancer 2B91.Z Approved [1]
Laryngeal squamous cell carcinoma N.A. Approved [2]
Lung cancer 2C25.0 Approved [3]
Plasma cell myeloma 2A83.1 Approved [4]
Salivary gland squamous cell carcinoma N.A. Approved [5]
Colon cancer 2B90.Z Investigative [6]
Gastric cancer 2B72 Investigative [7]
Pharyngeal squamous cell carcinoma N.A. Investigative [8]
⏷ Show the Full List of Indication(s)
Therapeutic Class
Anticancer Agents
Affected Organisms
Humans and other mammals
ATC Code
L01FE01: Cetuximab
L01FE: EGFR (Epidermal Growth Factor Receptor) inhibitors
L01F: MONOCLONAL ANTIBODIES AND ANTIBODY DRUG CONJUGATES
L01: ANTINEOPLASTIC AGENTS
L: ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
Drug Type
Antibody
Sequence
>heavy chain
QVQLKQSGPGLVQPSQSLSITCTVSGFSLTNYGVHWVRQSPGKGLEWLGVIWSGGNTDYN
TPFTSRLSINKDNSKSQVFFKMNSLQSNDTAIYYCARALTYYDYEFAYWGQGTLVTVSAA
STKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSG
LYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGP
SVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNS
TYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDEL
TKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQ
QGNVFSCSVMHEALHNHYTQKSLSLSPGK
>light chain
DILLTQSPVILSVSPGERVSFSCRASQSIGTNIHWYQQRTNGSPRLLIKYASESISGIPS
RFSGSGSGTDFTLSINSVESEDIADYYCQQNNNWPTTFGAGTKLELKRTVAAPSVFIFPP
SDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLT
LSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC
ADMET Property
Absorption Tmax
The time to maximum plasma concentration (Tmax) is 3 h [9]
Clearance
The sytemic clearance of drug is 0.103 L/h [10]
Half-life
The concentration or amount of drug in body reduced by one-half in 112 hours [9]
Metabolism
The drug is metabolized via the reticuloendothelial system and protein catabolism by a target\mediated disposition pathway [11]
Adverse Drug Reaction (ADR)
ADR Term Variation Related DOT DOT ID REF
Neoplasm related morbidities Not Available EGFR OTAPLO1S [12]
Cross-matching ID
UNII
PQX0D8J21J
DrugBank ID
DB00002
TTD ID
D0N5OV
Repurposed Drugs (RPD) Click to Jump to the Detailed RPD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Epidermal growth factor receptor (EGFR) TTGKNB4 EGFR_HUMAN Not Available [13]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Epidermal growth factor receptor (EGFR) OTAPLO1S EGFR_HUMAN Drug Response [12]
Low affinity immunoglobulin gamma Fc region receptor II-a (FCGR2A) OT0OUDUT FCG2A_HUMAN Drug Response [14]
Low affinity immunoglobulin gamma Fc region receptor III-A (FCGR3A) OTOWXCF3 FCG3A_HUMAN Drug Response [14]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Colorectal cancer
ICD Disease Classification 2B91.Z
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Epidermal growth factor receptor (EGFR) DTT EGFR 1.04E-65 -0.89 -1.53
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 37 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RPMI-3460/CS1 GDSC1 8.161 18.1195 1.6638 21.7807
EW-22 GDSC1 6.5528 11.023 3.962 14.2389
CADO-ES1 GDSC1 7.0339 9.2006 5.1912 3.8341
SK-PN-DW GDSC1 7.3744 10.455 4.8207 5.6995
EW-1 GDSC1 7.4223 11.5981 4.3114 9.1946
ES1 GDSC1 7.4696 9.5318 5.2924 2.3132
NOS-1 [Human HNSCC] GDSC1 7.6548 11.0933 4.6987 5.9206
ES8 GDSC1 7.7226 11.452 4.5746 6.6255
ES6 GDSC1 7.7939 13.2358 3.778 11.8013
HuO-3N1 GDSC1 7.7974 10.463 5.0644 3.1949
CHSA0108 GDSC1 7.8102 10.4942 5.0577 3.215
CHSA8926 GDSC1 7.8464 10.2175 5.1953 2.3166
EW-16 GDSC1 7.8486 14.5032 3.2045 15.1438
HOS GDSC1 7.8682 15.9613 2.5082 18.803
MHH-ES-1 GDSC1 7.8824 10.654 5.0272 3.2846
ES4 GDSC1 7.8911 11.9449 4.4506 7.0935
SaOS-2 GDSC1 7.9406 10.0417 5.3138 1.5346
TC-71 GDSC1 7.9611 9.7086 5.454 0.8505
SJSA-1 GDSC1 7.98 15.3717 2.8754 16.6115
NY GDSC1 7.98 11.5065 4.7042 5.2006
U2OS GDSC1 7.982 18.4111 1.3889 23.3316
A-673 GDSC1 8.0067 9.3376 5.6085 0.2889
CAL-72 GDSC1 8.0433 9.4334 5.5883 0.3266
EW-24 GDSC1 8.0626 9.2771 5.6498 0.1757
SK-ES-1 GDSC1 8.0693 9.6666 5.5142 0.5408
ES7 GDSC1 8.139 12.1833 4.4912 6.2876
EW-13 GDSC1 8.1963 9.942 5.4634 0.6373
CHSA0011 GDSC1 8.2034 14.2472 3.5691 12.0602
CAL-78 GDSC1 8.2581 12.7328 4.3117 7.2157
H-EMC-SS GDSC1 8.4037 22.5703 -0.3474 27.7152
EW-18 GDSC1 8.5053 10.3708 5.4285 0.5664
ES5 GDSC1 8.6262 12.0553 4.8161 3.3828
EW-7 GDSC1 8.7336 10.5856 5.4387 0.4227
G-292 clone A141B1 GDSC1 8.8233 19.1391 1.6401 20.1997
EW-3 GDSC1 8.9042 11.3681 5.22 1.0487
HuO9 GDSC1 8.9633 11.7128 5.1135 1.4415
EW-11 GDSC1 9.3207 11.6888 5.2676 0.6267
⏷ Show the Full List of 37 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 150 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JM1 GDSC1 8.3998 10.022 5.5133 0.37
MLMA GDSC1 4.3013 9.734 2.5999 31.7984
Hs 445 GDSC1 6.9839 9.125 5.1952 3.9184
WSU-DLCL2 GDSC1 7.0791 8.3534 5.5916 1.1175
NB4 GDSC1 7.1112 8.8486 5.396 2.2687
BL-41 GDSC1 7.1155 9.8539 4.9376 5.4733
ATN-1 GDSC1 7.1335 12.4008 3.7185 14.0417
QIMR-WIL GDSC1 7.1414 10.0146 4.8786 5.8389
Farage GDSC1 7.1868 9.721 5.0448 4.5331
TK [Human B-cell lymphoma] GDSC1 7.2341 9.3113 5.2597 2.9422
ARH-77 GDSC1 7.3195 10.4428 4.7917 6.0351
P31/FUJ GDSC1 7.3365 8.4537 5.6681 0.478
MHH-CALL-2 GDSC1 7.3435 9.1804 5.377 1.9945
MC116 GDSC1 7.4407 8.2721 5.7731 0.1153
HEL GDSC1 7.4882 14.7907 2.805 18.3711
RPMI-8402 GDSC1 7.5127 9.2195 5.4453 1.3586
K-562 GDSC1 7.5148 9.2956 5.4151 1.5216
SU-DHL-10 GDSC1 7.5248 8.7795 5.6234 0.5114
RC-K8 GDSC1 7.5281 10.1339 5.0599 3.714
LP-1 GDSC1 7.5397 9.5284 5.3302 1.9748
RPMI-6666 GDSC1 7.5572 9.2445 5.4562 1.2466
JSC-1 GDSC1 7.5612 11.9273 4.2472 9.2806
SR GDSC1 7.5716 9.188 5.4856 1.0807
SU-DHL-16 GDSC1 7.5737 9.1195 5.5137 0.9417
OCI-AML-2 GDSC1 7.5936 8.9693 5.5804 0.6287
Raji GDSC1 7.6093 9.1708 5.5094 0.9264
SKM-1 GDSC1 7.6224 9.0241 5.5716 0.6412
KE-37 GDSC1 7.6354 9.0876 5.553 0.7079
Jurkat GDSC1 7.6367 9.2934 5.4733 1.0708
A3/Kawakami GDSC1 7.6384 8.6791 5.7037 0.1993
CESS GDSC1 7.6401 9.4395 5.4163 1.3566
GA-10 GDSC1 7.6505 9.1668 5.529 0.7981
DEL GDSC1 7.6631 8.5489 5.757 0.0891
SUP-M2 GDSC1 7.674 8.7823 5.6806 0.2424
SU-DHL-5 GDSC1 7.6787 8.7148 5.7059 0.1797
SUP-T1 GDSC1 7.6823 9.723 5.3202 1.8289
KY821 GDSC1 7.6834 9.2771 5.5006 0.8949
P32/ISH GDSC1 7.686 9.0166 5.6006 0.484
Ramos.2G6.4C10 GDSC1 7.703 8.9331 5.6378 0.35
HT GDSC1 7.7031 8.7761 5.6935 0.1993
Karpas-422 GDSC1 7.7236 8.9299 5.6468 0.3124
NU-DUL-1 GDSC1 7.7396 9.5606 5.4139 1.2536
Karpas-299 GDSC1 7.7458 10.0226 5.2264 2.2825
SU-DHL-6 GDSC1 7.7458 9.5113 5.4364 1.1352
OCI-M1 GDSC1 7.7644 8.9932 5.6397 0.313
MOLM-13 GDSC1 7.773 9.5596 5.4295 1.1398
OCI-AML-5 GDSC1 7.8002 9.0675 5.6268 0.333
ME1 GDSC1 7.8119 9.0738 5.629 0.3209
Jiyoye GDSC1 7.8168 9.8303 5.3412 1.5395
Daudi GDSC1 7.8254 9.4174 5.5076 0.7394
L-540 GDSC1 7.8258 9.3081 5.5489 0.5774
WSU-NHL GDSC1 7.842 9.2548 5.5751 0.4734
KMS-11 GDSC1 7.8849 10.5073 5.0919 2.8786
AMO1 GDSC1 7.8889 9.1059 5.6463 0.2416
ML-2 GDSC1 7.8961 9.3116 5.5757 0.4393
CCRF-CEM GDSC1 7.9082 9.4525 5.5287 0.595
HL-60 GDSC1 7.9257 9.1747 5.6358 0.253
IM-9 GDSC1 7.9347 9.2195 5.6233 0.2808
P12-Ichikawa GDSC1 7.9373 9.1868 5.6358 0.2484
RL GDSC1 7.9468 9.3995 5.5635 0.4495
P30/OHK GDSC1 7.9476 9.3347 5.5872 0.3754
DB GDSC1 7.9498 9.9018 5.374 1.2236
NOMO-1 GDSC1 7.9583 9.152 5.6555 0.196
YT GDSC1 7.9725 9.4516 5.5546 0.4637
U266B1 GDSC1 8.0064 9.7744 5.4481 0.8376
OCI-AML-3 GDSC1 8.0138 9.506 5.5509 0.452
Kasumi-1 GDSC1 8.0223 9.5807 5.5271 0.5258
MOLT-16 GDSC1 8.0253 9.7358 5.4706 0.7313
RPMI-8226 GDSC1 8.0294 9.6564 5.502 0.6099
CA46 GDSC1 8.0418 10.6635 5.1064 2.5512
NCI-H929 GDSC1 8.0544 9.9183 5.4134 0.9433
Namalwa GDSC1 8.0588 9.9759 5.3932 1.0282
EoL-1 GDSC1 8.0591 9.508 5.5677 0.3769
A4/Fukuda GDSC1 8.0611 9.644 5.5192 0.5289
OPM-2 GDSC1 8.0742 9.576 5.549 0.425
Karpas-231 GDSC1 8.0781 9.2077 5.6788 0.1208
JURL-MK1 GDSC1 8.0919 9.5092 5.5797 0.3282
CML-T1 GDSC1 8.0986 9.3473 5.6385 0.1874
MOLP-8 GDSC1 8.1037 9.5886 5.5558 0.3894
L-363 GDSC1 8.1064 9.3988 5.6236 0.2159
LC4-1 GDSC1 8.1079 10.362 5.2628 1.6032
HAL-01 GDSC1 8.1085 10.1899 5.3315 1.2636
TUR GDSC1 8.111 9.9054 5.4422 0.7781
ALL-SIL GDSC1 8.1252 9.6706 5.5346 0.4422
EB2 GDSC1 8.1466 9.946 5.4417 0.7533
RCH-ACV GDSC1 8.1612 10.0017 5.4268 0.8007
697 GDSC1 8.1747 9.5924 5.5811 0.2897
SU-DHL-4 GDSC1 8.1813 9.482 5.6218 0.1961
MV4-11 GDSC1 8.188 9.6525 5.5649 0.3255
SU-DHL-8 GDSC1 8.1905 9.4994 5.6191 0.1987
CMK GDSC1 8.2036 9.2688 5.7012 0.0694
BV-173 GDSC1 8.2098 9.833 5.5086 0.4771
THP-1 GDSC1 8.218 9.7074 5.5567 0.3342
KOPN-8 GDSC1 8.2364 9.8459 5.5142 0.4455
KG-1 GDSC1 8.245 9.8535 5.5148 0.4395
DG-75 GDSC1 8.2506 9.8257 5.5269 0.4012
MOLT-13 GDSC1 8.2588 9.8796 5.5107 0.4446
OCI-Ly19 GDSC1 8.2652 10.2308 5.3835 0.8928
Loucy GDSC1 8.2676 9.6002 5.612 0.1902
HC-1 GDSC1 8.2678 9.8719 5.5169 0.4216
RPMI-8866 GDSC1 8.2737 9.9154 5.5035 0.4585
Reh GDSC1 8.2796 9.7527 5.5635 0.2917
EM-2 GDSC1 8.291 9.6439 5.6053 0.1963
MEG-01 GDSC1 8.294 10.2099 5.4033 0.7923
MOLM-16 GDSC1 8.294 10.0731 5.4541 0.6069
EHEB GDSC1 8.2961 10.4807 5.3007 1.2225
BE-13 GDSC1 8.3006 9.7864 5.5595 0.2935
L-1236 GDSC1 8.3107 10.4883 5.3041 1.1934
ST486 GDSC1 8.3135 10.0081 5.4854 0.4929
SUP-HD1 GDSC1 8.3319 10.3112 5.3809 0.8513
JeKo-1 GDSC1 8.3362 9.5789 5.6431 0.1209
EJM GDSC1 8.3373 9.9491 5.5157 0.3916
CRO-AP2 GDSC1 8.3449 9.9787 5.5081 0.4096
CTB-1 GDSC1 8.3906 10.1616 5.4598 0.5312
DND-41 GDSC1 8.3942 10.4135 5.3682 0.854
CTV-1 GDSC1 8.4016 10.0564 5.5018 0.4006
JVM-2 GDSC1 8.4373 10.8099 5.2345 1.3906
RS4;11 GDSC1 8.4531 10.1094 5.5023 0.3761
Karpas-1106P GDSC1 8.4675 10.1741 5.4848 0.4173
JJN-3 GDSC1 8.4854 9.8702 5.5967 0.161
KCL-22 GDSC1 8.4984 9.9954 5.5586 0.2277
ALL-PO GDSC1 8.5108 10.9101 5.2277 1.3504
HDLM-2 GDSC1 8.5259 10.2223 5.4896 0.3781
H9 GDSC1 8.5265 10.1419 5.518 0.307
PL-21 GDSC1 8.5283 10.5658 5.3661 0.7659
U-698-M GDSC1 8.5342 10.3459 5.4487 0.4886
SUP-B8 GDSC1 8.5372 10.1496 5.5192 0.3003
JVM-3 GDSC1 8.5398 10.3393 5.4532 0.4727
Sc-1 GDSC1 8.5447 10.0055 5.5716 0.1899
ROS-50 GDSC1 8.5549 10.5163 5.395 0.6477
Karpas-620 GDSC1 8.5636 9.7885 5.6506 0.0749
Karpas-45 GDSC1 8.5661 10.3136 5.4723 0.4066
MHH-PREB-1 GDSC1 8.5745 9.9942 5.5858 0.1583
BALL-1 GDSC1 8.5797 10.7655 5.3125 0.9319
L-428 GDSC1 8.5831 10.1805 5.5251 0.271
MOLT-4 GDSC1 8.5939 9.8493 5.6407 0.0813
NALM-6 GDSC1 8.6075 10.1897 5.5308 0.251
HH [Human lymphoma] GDSC1 8.6207 10.5948 5.3922 0.6179
GR-ST GDSC1 8.6208 10.8865 5.2839 1.0136
VL51 GDSC1 8.6822 10.6208 5.4066 0.5386
KM-H2 GDSC1 8.692 10.179 5.5642 0.1664
NKM-1 GDSC1 8.7472 10.8103 5.3633 0.6389
MN-60 GDSC1 8.756 10.7472 5.3895 0.5519
Ku812 GDSC1 8.8699 10.3002 5.5846 0.1046
KMOE-2 GDSC1 8.8726 10.588 5.4886 0.2558
GDM-1 GDSC1 8.9542 11.0717 5.3489 0.5717
LAMA-84 GDSC1 8.9705 10.645 5.5036 0.2016
PF-382 GDSC1 9.0412 10.5784 5.5503 0.1191
BC-1 GDSC1 9.15 10.84 5.5002 0.1671
Mono-Mac-6 GDSC1 9.3871 12.2093 5.1032 1.1414
⏷ Show the Full List of 150 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 11 Cell Line(s) in Aero Dig Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KYSE-220 GDSC1 6.297 25.1579 -3.3056 38.0528
KYAE-1 GDSC1 7.5101 9.9604 5.127 3.3028
KYSE-50 GDSC1 7.5636 15.4989 2.5124 19.6454
ESO-51 GDSC1 7.6667 10.0665 5.1662 2.7746
ESO-26 GDSC1 7.7393 11.1705 4.7145 5.6275
HCE-4 GDSC1 8.0068 20.0343 0.6067 25.9664
SK-GT-4 GDSC1 8.1693 23.3243 -0.8981 29.6103
OACP4 C GDSC1 8.2511 10.6296 5.2217 1.6489
OACM5.1 C GDSC1 8.3292 10.4853 5.3133 1.1355
FLO-1 GDSC1 8.4564 11.649 4.9013 3.1389
TE-12 GDSC1 8.8282 14.4853 3.8527 8.9018
⏷ Show the Full List of 11 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 684 GDSC1 8.7559 10.7973 5.3714 0.6081
Cancer Drug Sensitivity Data Curated from 22 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SJNB-14 GDSC1 -0.4474 22.2866 -7.967 55.909
SJNB-12 GDSC1 3.0742 32.0078 -9.4914 48.0526
KP-N-YN GDSC1 4.4346 13.2548 1.0206 36.5243
NB1 GDSC1 5.1322 10.2195 3.1527 24.9649
SK-N-DZ GDSC1 6.5424 12.9302 3.0041 20.284
SK-N-FI GDSC1 7.0253 13.5195 3.0863 18.2353
SJNB-10 GDSC1 7.1155 10.0114 4.8632 6.0154
Kelly GDSC1 7.3664 10.5402 4.7759 6.0369
SK-N-SH GDSC1 7.408 20.3249 0.0032 29.288
SJNB-13 GDSC1 7.424 9.9737 5.0717 3.8395
LA-N-6 GDSC1 7.4658 9.7509 5.1948 2.9398
TGW GDSC1 7.5419 9.7742 5.2261 2.6075
SK-N-MC-IXC GDSC1 7.5539 8.6717 5.6746 0.3163
NB(TU)1 GDSC1 7.7814 9.6759 5.387 1.3428
CHP-126 GDSC1 7.8929 10.0466 5.2892 1.7228
GOTO GDSC1 7.8994 12.3189 4.2818 8.2155
IMR-5 GDSC1 7.9114 9.8273 5.3861 1.2053
SJNB-7 GDSC1 7.978 10.1119 5.303 1.5471
SJNB-5 GDSC1 8.2344 21.9589 -0.1728 27.6599
GI-ME-N GDSC1 8.3732 12.4052 4.5273 5.5878
SiMa GDSC1 8.5017 10.4813 5.3867 0.7098
SK-N-BE(2)-M17 GDSC1 8.593 10.3589 5.4663 0.4107
⏷ Show the Full List of 22 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuCC-T1 GDSC1 6.9804 10.935 4.325 10.3203
Cancer Drug Sensitivity Data Curated from 46 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MDA-MB-468 GDSC1 5.1624 16.074 0.2742 35.4863
CAL-85-1 GDSC1 6.9363 13.249 3.1525 18.1386
MDA-MB-175-VII GDSC1 7.0246 14.566 2.5672 21.0028
HDQ-P1 GDSC1 7.0928 13.6423 3.0766 18.0785
CAL-120 GDSC1 7.123 8.862 5.3966 2.243
CAL-51 GDSC1 7.1308 13.6125 3.1199 17.7143
HCC70 GDSC1 7.1618 10.6653 4.5823 7.9474
HCC38 GDSC1 7.1959 16.4074 1.7853 24.0048
MDA-MB-361 GDSC1 7.3282 10.1331 4.9415 4.9484
OCUB-M GDSC1 7.3714 12.0564 4.0562 11.0983
BT-20 GDSC1 7.379 20.5266 -0.1199 29.687
Hs 578T GDSC1 7.4364 16.5372 1.9049 22.7951
EFM-192A GDSC1 7.4714 15.1336 2.624 19.3575
HCC1419 GDSC1 7.5019 10.2078 5.0116 4.0921
BT-483 GDSC1 7.5944 15.6114 2.4799 19.7159
MDA-MB-415 GDSC1 7.6238 13.8273 3.3743 14.769
DU4475 GDSC1 7.6597 8.9965 5.5974 0.513
BT-474 GDSC1 7.6742 9.158 5.5425 0.7192
MDA-MB-453 GDSC1 7.7358 10.0952 5.1904 2.514
HCC1428 GDSC1 7.7373 9.5173 5.4301 1.1751
MDA-MB-231 GDSC1 7.7544 10.8835 4.8538 4.6518
HCC1500 GDSC1 7.7945 9.488 5.4672 0.9416
HCC1569 GDSC1 7.8121 11.0549 4.8101 4.8295
MFM-223 GDSC1 7.8282 9.6755 5.4086 1.1833
HCC202 GDSC1 7.8464 10.7833 4.9509 3.8352
CAMA-1 GDSC1 7.8742 9.6264 5.4482 0.9526
HCC1937 GDSC1 8.017 13.855 3.632 12.1438
HCC1187 GDSC1 8.0247 9.5292 5.5468 0.459
MDA-MB-157 GDSC1 8.0294 10.5516 5.1472 2.3328
MRK-nu-1 GDSC1 8.0331 9.486 5.5656 0.3961
HCC2157 GDSC1 8.1709 9.576 5.5854 0.2805
Evsa-T GDSC1 8.1801 9.7729 5.5188 0.4614
BT-549 GDSC1 8.2014 10.4241 5.2808 1.4104
T-47D GDSC1 8.2016 10.022 5.4358 0.7355
HCC2218 GDSC1 8.2388 10.0917 5.425 0.7498
HCC1395 GDSC1 8.2609 14.5395 3.4682 12.5245
HCC1954 GDSC1 8.2944 13.8777 3.8029 10.3978
UACC-893 GDSC1 8.353 10.8362 5.1859 1.7145
EFM-19 GDSC1 8.6549 10.7299 5.3562 0.7182
MCF-7 GDSC1 8.6574 10.4851 5.4458 0.4377
MDA-MB-330 GDSC1 8.676 10.7672 5.3509 0.7233
MDA-MB-436 GDSC1 8.7814 11.5272 5.106 1.6485
COLO 824 GDSC1 8.8397 10.8047 5.4008 0.478
HCC1143 GDSC1 9.0274 11.5542 5.2009 1.0312
HCC1806 GDSC1 9.2433 17.1263 2.8849 13.4599
JIMT-1 GDSC1 9.2838 22.9284 0.1229 24.3906
⏷ Show the Full List of 46 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 51 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MOG-G-CCM GDSC1 5.7226 17.051 0.2678 33.5882
GB-1 GDSC1 6.4772 8.5877 5.1096 5.8961
A-172 GDSC1 6.8663 10.7262 4.3448 10.5143
D-542MG GDSC1 6.9254 12.7571 3.3878 16.7753
SF268 GDSC1 7.0189 9.3242 5.1244 4.3482
MOG-G-UVW GDSC1 7.1597 9.394 5.1788 3.6468
CAS-1 GDSC1 7.1663 9.3045 5.2235 3.3234
GI-1 GDSC1 7.1943 10.8316 4.5245 8.2801
YKG-1 GDSC1 7.285 11.107 4.4539 8.547
T98G GDSC1 7.3168 25.3584 -2.5768 34.737
D-263MG GDSC1 7.3235 9.1973 5.3591 2.1372
SF295 GDSC1 7.3238 9.1536 5.3781 2.0189
Daoy GDSC1 7.3343 17.5513 1.3242 25.3748
SK-MG-1 GDSC1 7.3416 10.0869 4.971 4.7105
DK-MG GDSC1 7.4134 12.7611 3.7439 13.0595
NMC-G1 GDSC1 7.4274 19.3595 0.4982 27.8402
GaMG GDSC1 7.5727 11.0002 4.6911 6.157
D-502MG GDSC1 7.6023 13.5628 3.4877 14.1421
LN-18 GDSC1 7.6409 8.6943 5.6993 0.2088
KS-1 [Human Krukenberg tumour] GDSC1 7.6467 11.8193 4.3546 8.3252
SNB-75 GDSC1 7.6529 10.3475 5.0355 3.6392
U-118MG GDSC1 7.658 10.27 5.0727 3.3868
LN-229 GDSC1 7.6649 9.6678 5.3346 1.7711
LNZTA3WT4 GDSC1 7.7565 9.3948 5.4868 0.8887
Onda 11 GDSC1 7.7683 13.7631 3.5067 13.5694
M059J GDSC1 7.8122 9.9538 5.2884 1.832
D-423MG GDSC1 7.8136 10.6895 4.974 3.7451
D-392MG GDSC1 7.818 12.6424 4.077 9.7848
YH-13 GDSC1 7.8569 9.3878 5.5319 0.6193
8-MG-BA GDSC1 7.8746 10.5756 5.057 3.111
D283 Med GDSC1 7.8793 9.4244 5.5273 0.6204
D-336MG GDSC1 7.8855 10.3034 5.1789 2.3556
ONS-76 GDSC1 7.9377 16.5731 2.2591 19.8018
Onda 10 GDSC1 7.947 12.3648 4.2904 8.047
LN-405 GDSC1 7.9897 9.8555 5.4097 1.0178
AM-38 GDSC1 8.0539 9.8522 5.4385 0.8381
D-247MG GDSC1 8.0626 11.3943 4.8014 4.4067
42-MG-BA GDSC1 8.0841 13.5653 3.8141 10.8342
U-251MG GDSC1 8.0847 16.9008 2.2051 19.652
Becker GDSC1 8.1226 11.4575 4.8068 4.2631
SF126 GDSC1 8.2198 14.8957 3.2706 13.7855
KINGS-1 GDSC1 8.2642 11.3872 4.9135 3.3601
H4 GDSC1 8.2649 11.7016 4.7778 4.1954
DBTRG-05MG GDSC1 8.3557 10.4392 5.3424 0.9884
KNS-81-FD GDSC1 8.4204 10.1264 5.484 0.4421
U-87MG ATCC GDSC1 8.4266 22.603 -0.3464 27.6587
KNS-42 GDSC1 8.4447 9.9886 5.5416 0.2821
SW1088 GDSC1 8.5736 10.2466 5.4987 0.3356
SF539 GDSC1 8.6178 10.3179 5.49 0.3397
KALS-1 GDSC1 8.7707 11.2514 5.2083 1.2027
Hs 683 GDSC1 9.7363 22.6356 0.5842 21.9599
⏷ Show the Full List of 51 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Digestive System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TGBC24TKB GDSC1 7.212 23.7483 -1.8574 33.8039
TGBC1TKB GDSC1 7.4669 10.9303 4.6571 6.6425
ETK-1 GDSC1 7.4757 11.9739 4.1675 10.0534
Cancer Drug Sensitivity Data Curated from 7 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RL95-2 GDSC1 7.6105 14.4026 3.0844 16.4919
KLE GDSC1 7.6116 9.9711 5.1781 2.7924
EN GDSC1 7.6706 13.1457 3.7372 12.3905
MFE-319 GDSC1 7.7234 21.1512 -0.1626 28.9026
MFE-296 GDSC1 7.9164 10.999 4.8945 4.0727
ESS-1 GDSC1 8.282 18.1342 1.7444 21.1345
AN3-CA GDSC1 8.3213 10.3206 5.373 0.8911
⏷ Show the Full List of 7 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 31 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
LB2241-RCC GDSC1 4.4678 25.2953 -4.9273 43.7231
TK-10 GDSC1 4.6924 27.9829 -6.0737 43.8485
KTCTL-140 GDSC1 6.2762 22.9618 -2.2248 36.6888
LB1047-RCC GDSC1 7.0166 16.3608 1.6692 25.0147
769-P GDSC1 7.0843 31.1852 -5.6733 38.819
LB996-RCC GDSC1 7.1316 18.4731 0.7081 28.0306
A-498 GDSC1 7.1582 9.1443 5.291 2.8789
KTCTL-195 GDSC1 7.1827 20.5711 -0.2966 30.6526
KTCTL-13 GDSC1 7.3577 17.002 1.6147 24.2079
SW156 GDSC1 7.3725 26.0996 -2.9021 35.0975
KTCTL-26A GDSC1 7.3928 13.303 3.4649 14.8795
KTCTL-1M GDSC1 7.4828 16.7403 1.8395 22.9345
A-704 GDSC1 7.5319 11.6733 4.3486 8.6527
BFTC-909 GDSC1 7.586 9.2625 5.4624 1.1811
UO-31 GDSC1 7.6855 13.538 3.558 13.4789
BB65-RCC GDSC1 7.7928 15.8146 2.5253 18.9285
CAL-54 GDSC1 7.8191 16.1978 2.3567 19.672
NCC021 GDSC1 7.9083 16.2168 2.4122 19.1591
RCC10RGB GDSC1 8.0007 18.6282 1.2958 23.6296
RXF 393L GDSC1 8.0213 20.6633 0.3068 26.8427
KTCTL-21 GDSC1 8.1036 17.0223 2.1592 19.8107
SW13 GDSC1 8.1365 9.9714 5.4279 0.8151
KMRC-20 GDSC1 8.1452 10.4579 5.2415 1.6689
SN12C GDSC1 8.2463 10.213 5.3824 0.9127
HA7-RCC GDSC1 8.3038 14.4095 3.5581 11.8797
NCC010 GDSC1 8.5053 11.2487 5.0908 2.0253
OS-RC-2 GDSC1 8.5382 10.3658 5.4431 0.5034
786-O GDSC1 8.8316 20.5588 0.9551 22.7572
ACHN GDSC1 8.8789 18.3073 2.0807 18.1917
Caki-1 GDSC1 9.2018 30.6765 -3.7526 32.6704
VMRC-RCZ GDSC1 9.8214 20.8857 1.4828 18.542
⏷ Show the Full List of 31 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 44 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
DiFi GDSC1 0.2236 4.9364 -0.0439 66.1597
HCC2998 GDSC1 2.9387 10.5888 0.8523 44.1981
RCM-1 [Human ESC] GDSC1 3.1018 8.735 1.8401 41.4071
HT115 GDSC1 3.1474 24.2144 -5.5577 47.1568
HCT 116 GDSC1 4.3351 6.1447 4.1497 22.5304
SW48 GDSC1 5.1108 18.7398 -1.1 38.2515
SW1116 GDSC1 6.0019 15.2507 1.4028 29.3173
C2BBe1 GDSC1 6.0672 16.2797 0.9428 30.5932
LS411N GDSC1 6.5179 8.9735 4.95 7.0063
NCI-H508 GDSC1 6.9108 10.4013 4.5355 8.9844
HT-29 GDSC1 6.9199 12.2355 3.6415 15.1983
T84 GDSC1 7.1275 9.6703 5.0313 4.7659
MDST8 GDSC1 7.1554 8.7565 5.4601 1.7842
LS180 GDSC1 7.188 10.9896 4.4443 8.876
SNU-1040 GDSC1 7.2338 11.3192 4.3169 9.6612
NCI-H747 GDSC1 7.2998 14.005 3.0524 17.5816
SW1463 GDSC1 7.3628 17.2988 1.4715 24.745
CCK-81 GDSC1 7.4444 14.4469 2.9418 17.7643
COLO205 GDSC1 7.4983 9.0151 5.521 0.985
SNU-61 GDSC1 7.5807 10.4459 4.95 4.3509
SNU-407 GDSC1 7.7127 14.7851 2.971 16.8324
SW948 GDSC1 7.7332 9.8257 5.3027 1.8581
CW-2 GDSC1 7.7444 13.2982 3.7144 12.3383
LS513 GDSC1 7.7495 10.0299 5.2252 2.2839
GP5d GDSC1 7.7628 15.1609 2.8235 17.4863
SNU-C1 GDSC1 7.7679 9.7342 5.3571 1.5146
KM12 GDSC1 7.8102 9.627 5.4197 1.1486
LoVo GDSC1 7.8383 19.3682 0.8088 25.7585
SW837 GDSC1 7.8993 15.8013 2.6088 18.2159
SK-CO-1 GDSC1 7.9075 9.5453 5.4935 0.7311
SW1417 GDSC1 7.964 9.764 5.434 0.9341
LS123 GDSC1 7.9668 17.8831 1.6375 22.4056
CL-11 GDSC1 8.0259 14.5063 3.3258 13.9662
COLO 678 GDSC1 8.0488 20.9404 0.1905 27.111
SW620 GDSC1 8.1328 10.7764 5.1048 2.4297
SNU-C2B GDSC1 8.1407 10.6901 5.1446 2.1947
RKO GDSC1 8.1475 12.9194 4.1578 8.4655
LS1034 GDSC1 8.1573 9.5947 5.5739 0.3152
SW626 GDSC1 8.1886 11.0058 5.0366 2.744
CaR-1 GDSC1 8.3276 10.3678 5.3577 0.9482
SNU-81 GDSC1 8.3499 10.9843 5.1246 2.0352
SNU-C5 GDSC1 8.4192 10.2707 5.4313 0.6078
NCI-H716 GDSC1 8.6688 10.5107 5.4409 0.4457
COLO 320HSR GDSC1 8.6807 10.184 5.5586 0.1784
⏷ Show the Full List of 44 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Leukemia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MO-T GDSC1 8.178 9.9334 5.4592 0.6646
Cancer Drug Sensitivity Data Curated from 14 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JHH-1 GDSC1 3.4649 39.5619 -12.9125 47.8437
JHH-6 GDSC1 6.698 17.0114 1.0926 28.0885
HuH-1 GDSC1 7.3579 11.8365 4.153 10.4707
JHH-2 GDSC1 7.4117 9.1432 5.4275 1.5919
SNU-398 GDSC1 7.686 9.9555 5.2241 2.3872
Hep-G2/C3A GDSC1 7.9006 9.4558 5.5243 0.6165
Hep 3B2.1-7 GDSC1 8.0069 10.4224 5.1898 2.1218
JHH-7 GDSC1 8.0566 9.843 5.4431 0.8171
HLE GDSC1 8.1247 10.6185 5.1663 2.0956
SNU-423 GDSC1 8.1378 9.8785 5.4633 0.6773
JHH-4 GDSC1 8.1624 9.9231 5.4567 0.6847
SK-HEP-1 GDSC1 8.2144 9.4949 5.6291 0.1725
Huh-7 GDSC1 8.7402 22.6325 -0.1276 26.3396
SNU-449 GDSC1 9.1067 11.0338 5.4189 0.3272
⏷ Show the Full List of 14 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 166 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H292 GDSC1 0.2858 57.546 -24.6526 51.6789
NCI-H3255 GDSC1 1.8468 22.8323 -6.0638 50.4986
NCI-H647 GDSC1 2.5979 5.6916 2.3727 43.8123
NCI-H1568 GDSC1 3.8318 14.8308 -0.3084 41.576
EMC-BAC-1 GDSC1 3.9603 13.8935 0.2692 40.1459
ABC-1 GDSC1 4.1971 8.2376 3.1847 29.4299
NCI-H1666 GDSC1 4.5096 15.1616 0.1485 38.1579
SK-MES-1 GDSC1 5.1214 32.1894 -7.8079 43.8325
PaCa-3 GDSC1 6.1004 26.9871 -4.3832 39.6269
CAL-12T GDSC1 6.1373 20.2538 -0.986 35.0122
SBC-5 GDSC1 6.3865 11.2977 3.694 16.6252
DMS 53 GDSC1 6.4148 16.86 0.9391 29.4738
NCI-H196 GDSC1 6.4478 9.8786 4.4491 11.0563
RERF-LC-Sq1 GDSC1 6.5349 14.2325 2.3486 23.6566
NCI-H226 GDSC1 6.6022 11.4119 3.807 15.1349
NCI-H1975 GDSC1 6.6077 16.4812 1.2846 27.717
NCI-H1944 GDSC1 6.7162 17.9602 0.6336 29.4741
Lu-99A GDSC1 6.7284 25.8494 -3.297 37.0594
NCI-H2066 GDSC1 6.802 21.4925 -1.0608 33.3478
NCI-H1436 GDSC1 6.8383 9.49 4.9265 6.267
NCI-H1563 GDSC1 6.844 9.6843 4.8366 6.9263
NCI-H2869 GDSC1 7.0361 10.1314 4.7531 7.0286
NCI-H1694 GDSC1 7.1028 10.6006 4.5732 8.1721
EKVX GDSC1 7.117 18.2142 0.8256 27.7038
NCI-H2731 GDSC1 7.2186 16.1609 1.9251 23.3552
COR-L95 GDSC1 7.2305 9.7492 5.0586 4.3378
NCI-H1155 GDSC1 7.233 8.9725 5.4081 1.9807
NCI-H345 GDSC1 7.2437 8.1499 5.7431 0.2713
NCI-H460 GDSC1 7.246 9.672 5.1035 3.9892
NCI-H358 GDSC1 7.2636 12.166 3.9272 12.2765
HCC78 GDSC1 7.2653 16.1716 1.9556 23.0856
SHP-77 GDSC1 7.3048 9.9809 4.9973 4.6064
BEN GDSC1 7.3102 8.19 5.7542 0.2055
NCI-H810 GDSC1 7.3634 10.0299 5.0103 4.3882
NCI-H520 GDSC1 7.3642 9.8539 5.0909 3.8298
NCI-H841 GDSC1 7.3733 11.5755 4.2891 9.4806
NCI-H2444 GDSC1 7.3975 9.0614 5.4545 1.4581
NCI-H847 GDSC1 7.4062 8.9409 5.5081 1.155
NCI-H1341 GDSC1 7.4311 9.4423 5.3105 2.2631
NCI-H2818 GDSC1 7.436 12.7258 3.777 12.7804
NCI-H2291 GDSC1 7.438 11.1566 4.5319 7.5999
NCI-H1755 GDSC1 7.4433 15.6558 2.3456 20.8021
NCI-H524 GDSC1 7.4563 9.808 5.1644 3.1563
NCI-H720 GDSC1 7.461 9.1228 5.4601 1.3442
HCC827 GDSC1 7.4656 9.7254 5.206 2.8676
IA-LM GDSC1 7.4786 10.3615 4.9279 4.7147
NCI-H1838 GDSC1 7.4894 13.4025 3.4857 14.4736
NCI-H1688 GDSC1 7.5075 9.9264 5.1406 3.2182
Calu-3 GDSC1 7.5207 12.5976 3.8982 11.75
NCI-H1355 GDSC1 7.5288 22.5671 -1.018 31.412
LCLC-97TM1 GDSC1 7.5315 10.9454 4.6909 6.253
SW1271 GDSC1 7.5522 14.45 3.019 17.0248
NCI-H2081 GDSC1 7.5561 9.5469 5.3308 1.947
EPLC-272H GDSC1 7.5807 12.87 3.8081 12.177
NCI-H23 GDSC1 7.5845 19.7033 0.449 27.5613
NCI-H1781 GDSC1 7.595 9.4077 5.4078 1.4578
NCI-H596 GDSC1 7.5963 16.0535 2.2637 20.7402
NCI-H1876 GDSC1 7.6029 9.4038 5.4132 1.4189
NCI-H1092 GDSC1 7.6069 9.3478 5.4378 1.2839
COR-L88 GDSC1 7.6317 9.342 5.4517 1.184
COR-L23 GDSC1 7.6428 9.0336 5.5766 0.6052
COR-L321 GDSC1 7.6452 8.9418 5.6119 0.4705
NCI-H2347 GDSC1 7.6595 10.8535 4.8115 5.1332
NCI-H2110 GDSC1 7.6733 22.2103 -0.7275 30.412
NCI-H2461 GDSC1 7.7083 13.4549 3.614 13.068
HCC44 GDSC1 7.717 18.5342 1.1296 24.9953
NCI-H1792 GDSC1 7.7179 9.6705 5.3592 1.5656
NCI-H1770 GDSC1 7.7225 9.6721 5.3608 1.5513
PC-14 GDSC1 7.727 15.5577 2.6034 18.7244
SBC-3 GDSC1 7.7291 9.9869 5.233 2.2681
CPC-N GDSC1 7.7301 9.7318 5.34 1.6546
NCI-H1648 GDSC1 7.7509 11.2192 4.6992 5.7075
NCI-H1793 GDSC1 7.7624 12.1222 4.2866 8.5093
LC-2/ad GDSC1 7.773 12.2712 4.2232 8.914
NCI-H838 GDSC1 7.7731 11.6424 4.5177 6.9026
EMC-BAC-2 GDSC1 7.778 11.8939 4.4036 7.6731
NCI-H187 GDSC1 7.78 8.8069 5.7105 0.1394
NCI-H1623 GDSC1 7.7918 15.1219 2.8633 17.1932
NCI-H2591 GDSC1 7.7933 13.2925 3.7504 11.9791
NCI-H2030 GDSC1 7.7995 12.5145 4.1254 9.5076
LC-1/sq GDSC1 7.7998 12.8824 3.9509 10.6645
NCI-H290 GDSC1 7.8187 10.2559 5.1648 2.5397
DMS 79 GDSC1 7.8366 9.6122 5.4373 1.0384
NCI-H526 GDSC1 7.8375 9.0625 5.6426 0.2719
NCI-H1105 GDSC1 7.8411 9.8609 5.3402 1.5149
NCI-H2135 GDSC1 7.8523 9.6204 5.441 1.006
UMC-11 GDSC1 7.8538 9.8522 5.3497 1.4507
NCI-H1993 GDSC1 7.8737 9.8327 5.3668 1.3409
DMS 273 GDSC1 7.8775 9.5705 5.4713 0.8486
NCI-H1304 GDSC1 7.8851 9.6852 5.4302 1.0239
NCI-H322M GDSC1 7.8956 11.3333 4.7332 5.1766
NCI-H2722 GDSC1 7.8966 13.5113 3.7154 11.932
NCI-H2087 GDSC1 7.9165 13.7775 3.6013 12.593
RERF-LC-MS GDSC1 7.9284 9.9797 5.3331 1.4495
NCI-H2009 GDSC1 7.9326 10.2766 5.2137 2.0885
A-427 GDSC1 7.933 18.5598 1.2792 23.8718
NCI-H2141 GDSC1 7.9363 9.7221 5.4382 0.9403
Lu-165 GDSC1 7.9421 9.3734 5.5711 0.4278
NCI-H2369 GDSC1 7.9736 9.8626 5.3999 1.0776
COR-L279 GDSC1 7.9802 9.5832 5.5092 0.617
NCI-H2122 GDSC1 7.9976 9.7451 5.4555 0.814
LCLC-103H GDSC1 8.0065 9.3805 5.5933 0.3296
HOP-62 GDSC1 8.0141 10.3221 5.2346 1.8647
NCI-H82 GDSC1 8.0302 9.5579 5.5385 0.4827
NCI-H727 GDSC1 8.0415 10.9423 4.9874 3.2676
NCI-H661 GDSC1 8.0459 10.1149 5.333 1.321
Lu-65 GDSC1 8.0512 10.0418 5.3642 1.1674
NCI-H2342 GDSC1 8.0695 14.453 3.3811 13.5271
Calu-6 GDSC1 8.0732 9.7233 5.4948 0.6062
NCI-H522 GDSC1 8.0798 9.8656 5.4443 0.794
NCI-H1435 GDSC1 8.0864 9.7599 5.4866 0.6273
NCI-H146 GDSC1 8.0895 9.8769 5.444 0.7874
NCI-H1703 GDSC1 8.1034 10.3487 5.266 1.5915
NCI-H2085 GDSC1 8.1053 11.7889 4.6497 5.3128
NCI-H1581 GDSC1 8.1146 9.4966 5.5925 0.2852
Lu-139 GDSC1 8.1209 9.9517 5.4289 0.8236
NCI-H2172 GDSC1 8.127 9.9713 5.424 0.8385
HCC366 GDSC1 8.1299 19.3998 1.0118 24.3076
NCI-H1651 GDSC1 8.1418 10.6363 5.1673 2.0679
HARA [Human squamous cell lung carcinoma] GDSC1 8.1503 16.8879 2.2583 19.2309
HCC15 GDSC1 8.1703 10.289 5.3201 1.2553
SBC-1 GDSC1 8.1725 9.8101 5.5024 0.5182
NCI-H69 GDSC1 8.1767 10.1974 5.3586 1.074
ChaGo-K-1 GDSC1 8.1845 14.7952 3.2949 13.7354
LK-2 GDSC1 8.2056 9.6722 5.5645 0.3191
Ms-1 GDSC1 8.2072 9.8131 5.5148 0.4592
KNS-62 GDSC1 8.2181 9.344 5.6812 0.0907
NCI-H2595 GDSC1 8.2184 10.244 5.3586 1.0365
HOP-92 GDSC1 8.2316 11.4139 4.8848 3.5873
IST-SL2 GDSC1 8.2382 10.739 5.1714 1.9241
LXF 289 GDSC1 8.2403 15.0541 3.2086 14.0879
SK-LU-1 GDSC1 8.255 9.8975 5.5028 0.4706
NCI-H441 GDSC1 8.2563 10.5913 5.2394 1.5547
NCI-H1836 GDSC1 8.2713 9.9598 5.4866 0.5128
NCI-H1869 GDSC1 8.2772 18.3821 1.6196 21.6544
IST-SL1 GDSC1 8.2986 10.0708 5.4568 0.5949
NCI-H1693 GDSC1 8.343 10.2117 5.4226 0.6861
NCI-H446 GDSC1 8.3432 10.147 5.4465 0.6025
COR-L32 GDSC1 8.3688 10.2021 5.4365 0.621
NCI-H209 GDSC1 8.4146 10.7043 5.2657 1.2694
DMS 114 GDSC1 8.4158 20.4288 0.7168 24.5771
NCI-H2170 GDSC1 8.4216 10.8863 5.1973 1.5834
EBC-1 GDSC1 8.4247 10.5668 5.3229 1.0121
Lu-135 GDSC1 8.4405 10.1316 5.4897 0.4161
NCI-H2227 GDSC1 8.4934 10.066 5.5324 0.2858
NCI-H211 GDSC1 8.5004 10.4218 5.408 0.6368
NCI-H835 GDSC1 8.5119 10.4822 5.3904 0.6901
COLO 668 GDSC1 8.5181 10.1316 5.5186 0.3089
NCI-H1573 GDSC1 8.5472 10.5736 5.3708 0.7364
A-549 GDSC1 8.5561 18.1172 1.9481 19.5704
NCI-H2029 GDSC1 8.559 10.2805 5.4814 0.3855
NCI-H513 GDSC1 8.5593 18.3133 1.8551 19.9615
NCI-H3122 GDSC1 8.5614 10.6981 5.3302 0.8767
VMRC-LCD GDSC1 8.5714 10.1118 5.5446 0.2338
NCI-H1915 GDSC1 8.5883 10.33 5.4748 0.3901
NCI-H2373 GDSC1 8.5962 10.3668 5.4647 0.4136
NCI-H1048 GDSC1 8.6348 10.0305 5.5944 0.1325
RERF-LC-KJ GDSC1 8.6675 21.2181 0.5138 24.6159
NCI-H2405 GDSC1 8.6859 19.0797 1.572 20.8097
NCI-H1299 GDSC1 8.7881 10.8399 5.3685 0.5995
Lu-134-A GDSC1 8.7961 10.7493 5.4041 0.4893
SW1573 GDSC1 8.8145 19.5719 1.4237 21.0772
COR-L105 GDSC1 8.8665 17.9883 2.2257 17.5653
NCI-H2023 GDSC1 9.03 18.5256 2.079 17.8378
LOU-NH91 GDSC1 9.1235 19.0228 1.9039 18.3826
NCI-H650 GDSC1 9.1686 25.6883 -1.3143 28.3367
⏷ Show the Full List of 166 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Lymphoma Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CBTCi002-A GDSC1 7.7955 10.6164 4.9962 3.6342
Cancer Drug Sensitivity Data Curated from 22 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
OE21 GDSC1 0.597 44.839 -18.0634 51.785
KYSE-450 GDSC1 5.2937 24.0992 -3.6188 40.7703
T.T GDSC1 6.5121 22.0816 -1.5908 35.0836
KYSE-520 GDSC1 6.5884 26.0817 -3.5276 37.6522
TE-5 GDSC1 7.3806 25.419 -2.5562 34.5616
TE-15 GDSC1 7.4391 10.5038 4.8384 5.4268
TE-9 GDSC1 7.4609 10.6828 4.7689 5.867
OE19 GDSC1 7.513 11.8214 4.2656 9.2782
TE-1 GDSC1 7.5191 18.7336 0.8798 26.3906
TE-6 GDSC1 7.6065 16.2641 2.1675 21.1519
KYSE-270 GDSC1 7.6583 15.5406 2.5616 19.1287
KYSE-70 GDSC1 7.8111 16.0153 2.4403 19.293
OE33 GDSC1 7.9149 16.0586 2.4943 18.7422
EC-GI-10 GDSC1 7.963 18.7793 1.1933 24.1041
KYSE-150 GDSC1 8.0344 10.7435 5.0688 2.7844
KYSE-180 GDSC1 8.2689 17.9979 1.8015 20.9316
TE-10 GDSC1 8.4692 19.5281 1.1977 22.7791
TE-4 GDSC1 8.4794 10.279 5.4517 0.508
TE-11 GDSC1 8.6268 10.5483 5.4115 0.5532
TE-8 GDSC1 9.0294 10.9404 5.4233 0.3441
COLO 680N GDSC1 9.2009 20.8757 1.0628 21.5086
KYSE-510 GDSC1 10.4169 21.7018 1.4873 17.2818
⏷ Show the Full List of 22 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 28 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RMG-I GDSC1 1.5512 18.6638 -4.3153 51.5348
OVTOKO GDSC1 5.3931 23.0947 -3.0322 39.9397
FU-OV-1 GDSC1 5.7125 29.234 -5.8311 41.6015
Caov-4 GDSC1 7.0015 14.3257 2.6686 20.5637
OC 314 GDSC1 7.0916 12.9979 3.3938 16.2179
OVISE GDSC1 7.1044 9.1821 5.2424 3.321
TOV-21G GDSC1 7.2718 22.4075 -1.1412 32.3065
ES-2 GDSC1 7.2739 11.4497 4.2816 9.8015
OV56 GDSC1 7.3124 13.5204 3.3 16.1133
DOV13 GDSC1 7.371 9.6317 5.1946 3.1159
OVCAR-8 GDSC1 7.4676 12.8821 3.7233 13.0388
Kuramochi GDSC1 7.5339 12.752 3.8327 12.1443
OVCAR-3 GDSC1 7.5446 9.5441 5.3261 1.9916
EFO-21 GDSC1 7.5485 11.6233 4.3833 8.3695
OVK18 GDSC1 7.657 9.4094 5.4363 1.2331
OVCAR-5 GDSC1 7.7317 14.1488 3.2943 14.943
OAW42 GDSC1 7.7594 8.9958 5.6369 0.3237
JHOS-4 GDSC1 7.8456 10.1617 5.2184 2.1834
SK-OV-3 GDSC1 7.915 9.9668 5.3321 1.4702
OV-90 GDSC1 7.9862 9.9208 5.3827 1.1452
OVCAR-4 GDSC1 8.1874 10.2331 5.3494 1.1048
OAW28 GDSC1 8.1916 11.9938 4.6075 5.4201
TYK-nu GDSC1 8.2652 10.179 5.4031 0.8148
TOV-112D GDSC1 8.516 10.406 5.4199 0.5881
A2780 GDSC1 8.5398 10.2209 5.4953 0.3576
IGROV-1 GDSC1 8.7312 17.4048 2.4139 17.0117
EFO-27 GDSC1 8.7331 10.4885 5.4727 0.3373
JHOS-2 GDSC1 8.7989 10.371 5.5365 0.1872
⏷ Show the Full List of 28 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 25 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SU.86.86 GDSC1 5.0112 51.9052 -17.7554 46.5353
Capan-2 GDSC1 6.9562 10.2032 4.6637 7.9071
AsPC-1 GDSC1 7.1188 13.0241 3.4012 16.0891
Hs 766T GDSC1 7.4178 10.7836 4.6946 6.4936
PSN1 GDSC1 7.4299 9.9197 5.0995 3.6395
PaTu 8988t GDSC1 7.4723 8.6312 5.6573 0.4224
MIA PaCa-2 GDSC1 7.5774 10.5501 4.9008 4.6934
KP-2 GDSC1 7.6964 8.7299 5.7071 0.1713
PL4 GDSC1 7.7755 10.3049 5.1212 2.8755
KP-3 GDSC1 7.7989 24.5902 -1.8132 32.3542
CFPAC-1 GDSC1 7.8233 10.1351 5.2183 2.2161
HPAF-II GDSC1 7.8608 10.4442 5.1063 2.8289
Panc 10.05 GDSC1 7.9139 13.2315 3.8605 10.9625
Panc 08.13 GDSC1 7.9845 17.0969 2.0365 20.6806
YAPC GDSC1 8.0171 9.3423 5.6107 0.2789
MZ-PC-1 GDSC1 8.1356 10.4705 5.232 1.7297
Panc 03.27 GDSC1 8.2928 9.7816 5.5583 0.2993
KP-4 GDSC1 8.3202 9.7677 5.5731 0.2545
SW1990 GDSC1 8.3511 17.8307 1.9421 20.1203
KP-1N GDSC1 8.3938 10.8124 5.214 1.5318
QGP-1 GDSC1 8.4258 10.18 5.4668 0.4905
SUIT-2 GDSC1 8.4296 17.1048 2.3504 18.07
PaTu 8902 GDSC1 8.4859 24.8661 -1.4205 30.036
BxPC-3 GDSC1 8.7332 10.5969 5.4345 0.434
Panc 02.03 GDSC1 8.9808 21.3331 0.6842 23.3245
⏷ Show the Full List of 25 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H2452 GDSC1 8.2228 10.3782 5.3085 1.2576
MPP 89 GDSC1 8.2685 9.967 5.4828 0.5264
Cancer Drug Sensitivity Data Curated from 5 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
LNCaP clone FGC GDSC1 4.7152 9.1772 3.2658 26.2714
VCaP GDSC1 6.3442 8.6168 4.9955 7.196
22Rv1 GDSC1 8.5449 10.6703 5.3339 0.8749
PC-3 GDSC1 8.8217 10.9505 5.3414 0.6671
DU145 GDSC1 8.9345 20.1004 1.2516 21.4419
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-253 GDSC1 7.7244 10.9437 4.809 5.0153
Cancer Drug Sensitivity Data Curated from 52 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 783 GDSC1 6.1383 11.3701 3.4564 19.0467
SK-MEL-28 GDSC1 6.3681 7.9208 5.3571 4.308
SK-MEL-2 GDSC1 6.6331 13.7997 2.6427 21.8964
UACC-62 GDSC1 6.8581 8.5238 5.3955 2.7727
WT2-iPS GDSC1 7.0655 14.1945 2.7827 19.77
WM35 GDSC1 7.121 15.3646 2.2452 22.2421
WM793 GDSC1 7.1257 8.945 5.3614 2.4696
MMAc-SF GDSC1 7.1456 13.0088 3.4285 15.8398
LB2518-MEL GDSC1 7.1908 13.2617 3.3376 16.2546
LB373-MEL-D GDSC1 7.2151 10.9626 4.4758 8.5758
WM278 GDSC1 7.2168 11.0201 4.4494 8.7615
IGR-37 GDSC1 7.2904 9.1734 5.3518 2.2386
MZ-MEL-7 GDSC1 7.3151 11.6909 4.1937 10.3053
A101D GDSC1 7.3493 12.4702 3.8399 12.6131
Mel Ho GDSC1 7.3654 12.8004 3.6906 13.5403
M14 GDSC1 7.3979 17.0165 1.6383 23.9975
SK-MEL-3 GDSC1 7.462 13.4537 3.4411 14.8252
Hs 940.T GDSC1 7.4874 9.3501 5.3788 1.7658
Hs 938.T GDSC1 7.4995 9.9491 5.126 3.3286
SH-4 GDSC1 7.6172 11.0079 4.715 5.8905
SK-MEL-1 GDSC1 7.6346 8.86 5.6377 0.3885
IPC-298 GDSC1 7.6564 8.9148 5.6263 0.4134
IST-MEL1 GDSC1 7.7297 10.1168 5.1779 2.5998
G-361 GDSC1 7.761 9.25 5.544 0.6434
COLO 679 GDSC1 7.8236 9.3958 5.515 0.7107
RVH-421 GDSC1 7.8246 8.8862 5.6992 0.1484
CP66-MEL GDSC1 7.8277 9.1406 5.611 0.3659
COLO 800 GDSC1 7.8386 9.5425 5.4653 0.9093
G-mel GDSC1 7.8703 10.0677 5.2697 1.8589
451Lu GDSC1 7.8818 18.799 1.1229 24.5727
SK-MEL-5 GDSC1 7.8859 13.7174 3.6094 12.623
SK-MEL-24 GDSC1 7.8903 9.6842 5.4328 1.0068
CP50-MEL-B GDSC1 7.9151 9.3692 5.5621 0.4728
DJM-1 GDSC1 7.9562 9.9342 5.364 1.2651
MeWo GDSC1 7.959 13.1246 3.9409 10.3293
SK-MEL-31 GDSC1 7.964 9.3902 5.5736 0.4082
GAK GDSC1 7.9669 9.4958 5.5362 0.529
A-388 GDSC1 7.9705 13.0908 3.9644 10.1481
UACC-257 GDSC1 8.0537 9.6229 5.524 0.5171
Mel JuSo GDSC1 8.0664 9.8014 5.4629 0.7306
A-375 GDSC1 8.0683 15.0879 3.0746 15.2893
A-431 GDSC1 8.0694 10.7872 5.0682 2.7348
MZ-MEL-2 GDSC1 8.084 10.6077 5.1508 2.2362
HMV-II GDSC1 8.1574 12.1982 4.4953 6.2226
COLO 792 GDSC1 8.2692 10.1204 5.4267 0.7217
WM1552C GDSC1 8.2753 18.93 1.3497 22.7085
LOX-IMVI GDSC1 8.5389 10.287 5.4715 0.421
HT-144 GDSC1 8.5516 18.1385 1.9346 19.6407
CHL-1 GDSC1 8.7623 10.2966 5.549 0.1752
SK-MEL-30 GDSC1 8.8487 21.6359 0.441 24.4151
WM115 GDSC1 9.0082 22.3001 0.2314 24.6879
EquiPSC Line K2 GDSC1 7.0261 18.0888 0.8164 27.9976
⏷ Show the Full List of 52 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Small Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuTu 80 GDSC1 7.941 10.6447 5.0624 2.9695
Cancer Drug Sensitivity Data Curated from 22 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SW684 GDSC1 7.284 11.3401 4.3413 9.3516
SW872 GDSC1 7.4262 20.8426 -0.2402 29.8691
GCT GDSC1 7.4754 13.9061 3.2297 16.048
Rh30 GDSC1 7.5186 9.5268 5.3201 2.0667
SW982 GDSC1 7.5712 10.0927 5.1026 3.35
EW-8 GDSC1 7.734 16.2216 2.2827 20.2589
MES-SA GDSC1 7.7614 9.132 5.5882 0.4787
VA-ES-BJ GDSC1 7.7885 9.5049 5.458 0.9894
G-401 GDSC1 7.8595 13.5416 3.6758 12.2776
MFH-ino GDSC1 7.8602 12.3409 4.2466 8.5452
Rh18 GDSC1 7.8843 9.5031 5.4998 0.7242
KYM-1 GDSC1 7.8915 9.2455 5.5978 0.3725
HT-1080 GDSC1 7.938 9.487 5.5279 0.5775
RKN GDSC1 7.9769 18.2842 1.4476 23.1223
STS-0421 GDSC1 8.1057 13.487 3.8652 10.4567
Hs 633.T GDSC1 8.1249 9.6163 5.554 0.3844
G-402 GDSC1 8.1366 10.8793 5.0635 2.663
Rh41 GDSC1 8.274 20.2365 0.7066 24.9651
SK-LMS-1 GDSC1 8.3714 10.1524 5.4556 0.5554
SK-UT-1 GDSC1 8.5909 10.4742 5.4243 0.5328
A-204 GDSC1 9.1949 11.2412 5.3789 0.3868
RD GDSC1 9.3415 11.5749 5.3159 0.4841
⏷ Show the Full List of 22 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 22 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NUGC-4 GDSC1 -3.258 13.3926 -6.7549 66.4614
NUGC-3 GDSC1 6.8552 22.4399 -1.4909 34.0281
MKN1 GDSC1 7.0552 15.5103 2.122 23.0014
SNU-5 GDSC1 7.3747 9.138 5.4111 1.7413
TGBC11TKB GDSC1 7.4657 9.1974 5.4317 1.4946
MKN45 GDSC1 7.53 8.6237 5.6827 0.3043
SNU-16 GDSC1 7.6613 8.9917 5.5999 0.503
23132/87 GDSC1 7.6777 9.2418 5.5118 0.8497
MKN7 GDSC1 7.7946 11.2607 4.7065 5.5648
Hs 746.T GDSC1 7.7987 14.5183 3.1621 15.5236
SCH GDSC1 7.813 9.0884 5.6242 0.3342
NCI-N87 GDSC1 7.9724 11.6949 4.6145 5.8137
RERF-GC-1B GDSC1 7.975 11.0552 4.9023 3.9167
HSC-39 GDSC1 8.0237 9.4449 5.5768 0.3681
SNU-1 GDSC1 8.0667 9.67 5.5119 0.5503
Fu97 GDSC1 8.0819 10.0393 5.3786 1.0719
SK-GT-2 GDSC1 8.1219 13.0396 4.0857 8.9954
HGC-27 GDSC1 8.2956 9.9887 5.4855 0.5025
OCUM-1 GDSC1 8.3562 10.5317 5.3071 1.1386
ECC10 GDSC1 8.6275 10.0657 5.5801 0.1556
RF-48 GDSC1 8.6388 10.2616 5.5172 0.2696
SNG-M GDSC1 7.2555 10.3897 4.7755 6.3061
⏷ Show the Full List of 22 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 14 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ASH-3 GDSC1 7.2273 14.9297 2.5417 20.5011
K5 GDSC1 7.2288 15.8684 2.0779 22.6648
FTC-133 GDSC1 7.3733 10.3263 4.8799 5.2825
BHT-101 GDSC1 7.4414 8.9273 5.53 1.0024
WRO GDSC1 7.5697 10.4865 4.9252 4.5426
TT2609-C02 GDSC1 7.688 9.8746 5.2595 2.1723
IHH-4 GDSC1 7.7473 9.9626 5.2525 2.1269
8305C GDSC1 7.8253 11.2742 4.7186 5.419
HTC-C3 GDSC1 7.892 12.7413 4.0786 9.5912
CAL-62 GDSC1 8.0263 9.5547 5.5381 0.4864
ML-1 [Human leukemia] GDSC1 8.0581 10.1002 5.3443 1.2542
TT GDSC1 8.1544 9.5026 5.605 0.2406
B-CPAP GDSC1 8.4346 9.7913 5.6057 0.158
KMH-2 GDSC1 8.8999 10.808 5.4221 0.3957
⏷ Show the Full List of 14 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 36 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H3118 GDSC1 0.2351 15.7077 -4.1992 56.2094
JHU-029 GDSC1 0.7445 25.9831 -8.6278 52.7886
HSC-4 GDSC1 3.109 24.4264 -5.6972 47.2866
HSC-2 GDSC1 4.5362 14.774 0.3642 37.6198
SCC-15 GDSC1 5.2882 12.8942 1.9679 29.9183
SAS GDSC1 5.4267 22.3322 -2.6226 39.3967
SAT [Human HNSCC] GDSC1 5.4269 26.5478 -4.7291 41.4014
HSC-3 GDSC1 5.5151 25.5783 -4.1699 40.7413
SCC-9 GDSC1 5.819 21.2147 -1.7323 37.1577
UPCI-SCC-090 GDSC1 5.9515 24.972 -3.4998 39.0762
PCI-15A GDSC1 6.4717 17.2772 0.777 29.7932
HO-1-N-1 GDSC1 7.0387 14.207 2.756 19.9941
OSC-19 GDSC1 7.2191 9.5024 5.1648 3.6197
BB30-HNC GDSC1 7.3121 19.3336 0.4213 28.3842
Ca9-22 GDSC1 7.4796 17.9756 1.2254 25.316
SCC-4 GDSC1 7.4882 13.0821 3.6407 13.509
PCI-30 GDSC1 7.6396 13.6172 3.4875 14.0398
BHY GDSC1 7.7549 23.9755 -1.5417 31.9393
BICR 10 GDSC1 7.8111 11.4929 4.6101 6.1858
PCI-04B GDSC1 7.8132 18.143 1.3953 23.7641
SCC-25 GDSC1 7.8956 18.0145 1.52 23.0623
BB49-HNC GDSC1 7.9432 10.725 5.029 3.1717
KOSC-2 GDSC1 7.9542 11.3724 4.7495 4.9515
CAL-27 GDSC1 7.9598 15.7611 2.6716 17.7313
PE/CA-PJ15 GDSC1 8.045 15.4739 2.8715 16.4577
HO-1-u-1 GDSC1 8.066 11.2306 4.8753 3.9272
Detroit 562 GDSC1 8.066 9.8419 5.4475 0.7919
PCI-38 GDSC1 8.1161 19.4681 0.9679 24.4951
OSC-20 GDSC1 8.1367 17.9575 1.7254 21.5943
KON GDSC1 8.1635 15.2999 3.038 15.2413
LB771-HNC GDSC1 8.1677 18.0316 1.7117 21.5684
PCI-06A GDSC1 8.2265 17.6795 1.9266 20.5118
JHU-022 GDSC1 8.3034 18.8737 1.3978 22.4539
BICR 22 GDSC1 8.3707 10.0687 5.4856 0.4621
BICR 78 GDSC1 8.7816 19.9507 1.216 21.9414
SKN-3 GDSC1 9.0889 11.024 5.4159 0.34
⏷ Show the Full List of 36 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CAL-29 GDSC1 6.7892 14.8093 2.263 23.2098
639V GDSC1 6.9325 14.0504 2.7521 20.3519
SW780 GDSC1 7.0645 15.2992 2.2341 22.468
SW1710 GDSC1 7.4762 10.2223 4.9899 4.2923
BFTC-905 GDSC1 7.5668 9.0508 5.5375 0.8375
647V GDSC1 7.5835 14.3952 3.0685 16.6586
RT-112 GDSC1 7.7971 14.5228 3.1587 15.5473
KU-19-19 GDSC1 7.9466 9.3332 5.5874 0.3754
HT-1197 GDSC1 7.9612 9.3564 5.5847 0.3761
UM-UC-3 GDSC1 8.1155 17.0121 2.1727 19.7174
J82 GDSC1 8.1851 9.9425 5.4587 0.6617
HT-1376 GDSC1 8.3905 14.6697 3.4916 12.0671
TCCSUP GDSC1 8.4473 33.1233 -5.5514 36.2455
RT-4 GDSC1 8.4981 9.9972 5.5579 0.2292
5637 GDSC1 8.695 18.6067 1.8083 19.8203
T24 GDSC1 9.4073 19.9471 1.6532 18.7762
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 34 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
OVMIU GDSC1 3.6835 19.8448 -2.9128 44.5688
OVCA420 GDSC1 4.7949 23.2737 -3.6352 42.029
BPH-1 GDSC1 6.6701 19.8364 -0.3404 32.1606
UWB1.289 GDSC1 6.8986 21.7425 -1.1077 33.1886
HEC-1 GDSC1 6.945 12.3943 3.5819 15.5019
OVCA433 GDSC1 7.0242 25.1795 -2.7225 35.6173
CAL-39 GDSC1 7.2056 16.2234 1.8841 23.5669
OMC-1 [Human cervical carcinoma] GDSC1 7.2445 12.0243 3.9826 11.9566
Ca Ski GDSC1 7.3242 11.005 4.529 7.908
HeLa GDSC1 7.4309 8.8957 5.5378 0.9752
SKG-IIIa GDSC1 7.4465 10.9274 4.6455 6.7737
PWR-1E GDSC1 7.4802 9.8866 5.143 3.2531
PEO1 GDSC1 7.5004 10.2257 5.0026 4.1561
SiSo GDSC1 7.5471 14.2211 3.1273 16.4302
SiHa GDSC1 7.5829 8.5928 5.7135 0.1969
SW962 GDSC1 7.6215 12.4969 4.0155 10.699
ME-180 GDSC1 7.6439 11.2772 4.6068 6.5824
DSH1 GDSC1 7.6645 10.1892 5.1117 3.1236
SW954 GDSC1 7.6698 9.6647 5.3383 1.7437
LB831-BLC GDSC1 7.7562 20.5899 0.1411 27.998
JEG-3 GDSC1 7.8121 9.6459 5.413 1.1789
JAR GDSC1 7.9313 9.5431 5.5042 0.6709
TC-YIK GDSC1 7.9348 9.5068 5.5192 0.6116
HT-3 GDSC1 8.0798 16.6325 2.3325 19.0721
SKN GDSC1 8.1013 10.1545 5.3422 1.2204
HEY GDSC1 8.1186 10.3502 5.2725 1.5416
JHOS-3 GDSC1 8.1236 15.6025 2.8642 16.2874
NT2-D1 GDSC1 8.1395 9.9328 5.4437 0.7507
C-33 A GDSC1 8.423 10.2453 5.442 0.57
MS751 GDSC1 8.5222 10.0322 5.5545 0.2288
KGN GDSC1 8.6028 11.286 5.1209 1.7632
OV17R GDSC1 8.762 16.126 3.0451 13.7142
SW756 GDSC1 9.0865 20.636 1.0986 21.6448
ACC-OV7 GDSC1 9.464 12.1556 5.1541 0.9068
⏷ Show the Full List of 34 Cancer Drug Sensitivity Data of This Drug

Drug-Drug Interaction (DDI) Information of This Drug

Coadministration of a Drug Treating the Disease Different from Cetuximab (Comorbidity)
DDI Drug Name DDI Drug ID Severity Mechanism Comorbidity REF
Rabeprazole DMMZXIW Moderate Increased risk of hypomagnesemia by the combination of Cetuximab and Rabeprazole. Bacterial infection [1A00-1C4Z] [15]
Dexlansoprazole DM1DBV5 Moderate Increased risk of hypomagnesemia by the combination of Cetuximab and Dexlansoprazole. Gastro-oesophageal reflux disease [DA22] [15]
Omeprazole DM471KJ Moderate Increased risk of hypomagnesemia by the combination of Cetuximab and Omeprazole. Gastro-oesophageal reflux disease [DA22] [15]
Pantoprazole DMSVOCZ Moderate Increased risk of hypomagnesemia by the combination of Cetuximab and Pantoprazole. Gastro-oesophageal reflux disease [DA22] [15]
Thalidomide DM70BU5 Major Additive thrombogenic effects by the combination of Cetuximab and Thalidomide. Multiple myeloma [2A83] [16]
Methoxsalen DME8FZ9 Moderate Increased risk of photosensitivity reactions by the combination of Cetuximab and Methoxsalen. Mycosis fungoides [2B01] [17]
Omacetaxine mepesuccinate DMPU2WX Moderate Additive immunosuppressive effects by the combination of Cetuximab and Omacetaxine mepesuccinate. Myeloproliferative neoplasm [2A20] [18]
Esomeprazole DM7BN0X Moderate Increased risk of hypomagnesemia by the combination of Cetuximab and Esomeprazole. Peptic ulcer [DA61] [15]
Verteporfin DMIY6DB Moderate Increased risk of photosensitivity reactions by the combination of Cetuximab and Verteporfin. Psoriasis [EA90] [19]
⏷ Show the Full List of 9 DDI Information of This Drug

References

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3 Cetuximab for treating non-small cell lung cancer. Expert Opin Biol Ther. 2018 Apr;18(4):483-493.
4 SOT101 induces NK cell cytotoxicity and potentiates antibody-dependent cell cytotoxicity and anti-tumor activity. Front Immunol. 2022 Oct 10;13:989895.
5 Patient-derived head and neck cancer organoids allow treatment stratification and serve as a tool for biomarker validation and identification. Med. 2023 May 12;4(5):290-310.e12.
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8 Head and neck squamous cell carcinoma. Nat Rev Dis Primers. 2020 Nov 26;6(1):92.
9 FDA Approved Drug Products: ERBITUX (cetuximab) injection, for intravenous use
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13 Molecular inhibition of angiogenesis and metastatic potential in human squamous cell carcinomas after epidermal growth factor receptor blockade. Mol Cancer Ther. 2002 May;1(7):507-14.
14 FCGR2A and FCGR3A polymorphisms associated with clinical outcome of epidermal growth factor receptor expressing metastatic colorectal cancer patients treated with single-agent cetuximab. J Clin Oncol. 2007 Aug 20;25(24):3712-8. doi: 10.1200/JCO.2006.08.8021.
15 FDA. U.S. Food and Drug Administration "FDA Drug Safety Communication: Low magnesium levels can be associated with long-term use of proton pump inhibitor drugs (PPIs).".
16 Figg WD, Arlen P, Gulley J, et al. "A randomized phase II trial of docetaxel (taxotere) plus thalidomide in androgen-independent prostate cancer." Semin Oncol 28(4 Suppl 15) (2001): 62-6. [PMID: 11685731]
17 Cerner Multum, Inc. "Australian Product Information.".
18 Product Information. Synribo (omacetaxine). Teva Pharmaceuticals USA, North Wales, PA.
19 Cerner Multum, Inc. "UK Summary of Product Characteristics.".