Details of the Drug Reposition

General Information of This Drug (ID: DMNEXZF)

• Drug Name: Cefamandole (DMNEXZF)
• Synonyms: Cefadole; Cefamandolum; Cefamandole (USAN/INN); (6R,7R)-7-(R)-Mandelamido-3-(((1-methyl-1H-tetrazol-5-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-carboxylic acid; (6R,7R)-7-[[(2R)-2-hydroxy-2-phenylacetyl]amino]-3-[(1-methyltetrazol-5-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; (6R,7R)-7-{[(2R)-2-hydroxy-2-phenylacetyl]amino}-3-{[(1-methyl-1H-tetrazol-5-yl)sulfanyl]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; (6R,7R)-7-{[(2R)-2-hydroxy-2-phenylacetyl]amino}-3-{[(1-methyl-1H-tetrazol-5-yl)thio]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; 7beta-[(2R)-2-hydroxy-2-phenylacetamido]-3-{[(1-methyl-1H-tetrazol-5-yl)sulfanyl]methyl}ceph-3-em-4-carboxylic acid
• Therapeutic Class: Antibiotics
• Drug Type: Small molecular drug

Information on Drug Reposition of This Drug

7 Approved Indication(s)

Indication Name	Indication ID	ICD-11	Status	REF
Staphylococcus aureus infection	DISK6PTH	N.A.	Approved	[1]
Staphylococcal pneumonia	DIS28ZSZ	N.A.	Approved	[1]
Peritonitis	DISMCMLQ	N.A.	Approved	[1]
Microorganisms infection	DISKAIXX	1A00-1A09	Approved	[2]
Bacteremia	DIS6N9RZ	1A73	Approved	[1]
Pneumonia	DIS8EF3M	CA40	Approved	[1]
Urinary tract infection	DISMT6UV	GC08	Approved	[1]

2 Discontinued in Phase 2 Indication(s)

Indication Name	Indication ID	ICD-11	Status	REF
Bacterial urinary tract infection	DISNNJTF	N.A.	Discontinued in Phase 2	[3]
Escherichia coli infection	DISPP65M	1A03	Discontinued in Phase 2	[4]

References

• [1] Cefamandole FDA Label
• [2] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
• [3] Safety Study of Gleevec in Children With Pulmonary Hypertension
• [4] Gemcitabine, Cisplatin, Plus Lenalidomide as First-line Therapy for Patients With Metastatic Urothelial Carcinoma