Details of the Drug Reposition

General Information of This Drug (ID: DMYLOVR)

• Drug Name: Aciclovir (DMYLOVR)
• Synonyms: acyclovir; Acycloguanosine; 59277-89-3; Zovirax; Vipral; Virorax; Wellcome-248U; 9-[(2-Hydroxyethoxy)methyl]guanine; Aciclovirum; Zovir; Aciclovirum [Latin]; Sitavig; Aciclovier; Zyclir; 9-HYROXYETHOXYMETHYLGUANINE; Aciclovirum [INN-Latin]; 2-Amino-9-((2-hydroxyethoxy)methyl)-1H-purin-6(9H)-one; W-248-U; 9-(2-Hydroxyethoxy)methylguanine; Acyclovir-side chain-2-3H; ACYCLOVIR SODIUM; 9-((2-Hydroxyethoxy)methyl)guanine; Acicloftal; Cargosil; BW-248U; UNII-X4HES1O11F; DRG-0008; NSC 645011; CHEBI:2453; CCRIS 1953; Iontophoretic acyclovir
• Therapeutic Class: Antiviral Agents
• Drug Type: Small molecular drug

Information on Drug Reposition of This Drug

4 Approved Indication(s)

Indication Name	Indication ID	ICD-11	Status	REF
Herpes simplex encephalitis	DISGX28I	N.A.	Approved	[1]
Virus infection	DISFYSIV	1A24-1D9Z	Approved	[2]
Varicella	DISN73RD	1E90	Approved	[3]
Genital herpes	DISAP666	1A94	Approved	[4]

1 Discontinued in Phase 3 Indication(s)

Indication Name	Indication ID	ICD-11	Status	REF
Herpes zoster	DISNSMNY	1E91	Discontinued in Phase 3	[5]

References

• [1] Management of suspected viral encephalitis in adults--Association of British Neurologists and British Infection Association National Guidelines. J Infect. 2012 Apr;64(4):347-73.
• [2] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4829).
• [3] Neonatal varicella. Arch Dis Child. 2023 Oct 31:archdischild-2022-324820.
• [4] Genital herpes. BMJ Clin Evid. 2011 Apr 15;2011:1603.
• [5] Daily Isoniazid to Prevent Tuberculosis in Infants Born to Mothers With HIV