Details of the Drug

General Information of Drug (ID: DM0GZTD)

• Drug Name: L-ornithine phenylacetate
• Synonyms: L-ornthine phenylacetate; OCR-002; UCL-L1V; L-ornithine phenylacetate (injectable, acute hepatic encephalopathy); Nitrogen metabolism modulator (injectable, AHE), Ocera; Nitrogen metabolism modulator (injectable, acute hepatic encephalopathy), Ocera; Nitrogen metabolism modulator (injectable, acute hepatic encephalopathy), UCL; Nitrogen metabolism modulator (injectable, hyperammonemia), Ocera; L-ornithine phenylacetate (injectable, AHE), Ocera; L-ornithine phenylacetate (injectable, acute hepatic encephalopathy), Ocera; L-ornithine phenylacetate (injectable, hyperammonemia), Ocera

Indication

Disease Entry	ICD 11	Status	REF
Acute liver failure	DB91	Phase 2	[1]

• Drug Type: Small molecular drug
• #Ro5 Violations (Lipinski): 0:
  Molecular Weight; 268.31
  Logarithm of the Partition Coefficient; Not Available
  Rotatable Bond Count; 6
  Hydrogen Bond Donor Count; 4
  Hydrogen Bond Acceptor Count; 6
• Chemical Identifiers:
  Formula: C13H20N2O4
  IUPAC Name: (2S)-2,5-diaminopentanoic acid;2-phenylacetic acid
  Canonical SMILES: C1=CC=C(C=C1)CC(=O)O.C(C[C@@H](C(=O)O)N)CN
  InChI: InChI=1S/C8H8O2.C5H12N2O2/c9-8(10)6-7-4-2-1-3-5-7;6-3-1-2-4(7)5(8)9/h1-5H,6H2,(H,9,10);4H,1-3,6-7H2,(H,8,9)/t;4-/m.0/s1
  InChIKey: LRSYFEZBIMVWRY-VWMHFEHESA-N
• Cross-matching ID:
  PubChem CID: 44247677
  CAS Number: 952154-79-9
  TTD ID: D06HFI

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Nuclear factor NF-kappa-B (NFKB)	TTSXVID	NFKB1_HUMAN ; NFKB2_HUMAN ; TF65_HUMAN ; RELB_HUMAN ; REL_HUMAN	Modulator	[2]

References

• [1] ClinicalTrials.gov (NCT01634230) Emergency Use of OCR-002 in Acute Liver Failure. U.S. National Institutes of Health.
• [2] Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.